Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cornifin-B

Gene

SPRR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • epidermis development Source: ProtInc
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Cornifin-B
Alternative name(s):
14.9 kDa pancornulin
Small proline-rich protein IB
Short name:
SPR-IB
Gene namesi
Name:SPRR1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11260. SPRR1B.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: ProtInc
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36089.

Polymorphism and mutation databases

BioMutaiSPRR1B.
DMDMi84028265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8989Cornifin-BPRO_0000149996Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

MaxQBiP22528.
PaxDbiP22528.
PRIDEiP22528.

2D gel databases

UCD-2DPAGEP22528.

PTM databases

PhosphoSiteiP22528.

Expressioni

Tissue specificityi

Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.

Developmental stagei

Expressed during differentiation of squamous cells.

Inductioni

By carcinogenic agents and by UV light. During squamous differentiation of epidermal keratinocytes.

Gene expression databases

BgeeiP22528.
CleanExiHS_SPRR1B.
GenevisibleiP22528. HS.

Interactioni

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB

Protein-protein interaction databases

BioGridi112577. 2 interactions.
IntActiP22528. 3 interactions.
STRINGi9606.ENSP00000306461.

Structurei

3D structure databases

ProteinModelPortaliP22528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati3 – 14121Add
BLAST
Repeati18 – 29122Add
BLAST
Repeati31 – 3881
Repeati39 – 4682
Repeati47 – 5483
Repeati55 – 6284
Repeati63 – 7085
Repeati71 – 7886

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3 – 29272 X 12 AA approximate repeatsAdd
BLAST
Regioni31 – 78486 X 8 AA approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JH2M. Eukaryota.
ENOG410XUVY. LUCA.
GeneTreeiENSGT00730000111065.
HOGENOMiHOG000059526.
HOVERGENiHBG079213.
InParanoidiP22528.
OMAiKEACAPQ.
OrthoDBiEOG773XKP.
PhylomeDBiP22528.
TreeFamiTF338205.

Family and domain databases

InterProiIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PTHR23263:SF49. PTHR23263:SF49. 1 hit.

Sequencei

Sequence statusi: Complete.

P22528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQQQKQPC TPPPQLQQQQ VKQPCQPPPQ EPCIPKTKEP CHPKVPEPCH
60 70 80
PKVPEPCQPK VPEPCHPKVP EPCPSIVTPA PAQQKTKQK
Length:89
Mass (Da):9,888
Last modified:December 20, 2005 - v2
Checksum:i8B10DF32103496D3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111T → I.5 Publications
Corresponds to variant rs3795382 [ dbSNP | Ensembl ].
VAR_021099
Natural varianti23 – 231Q → H.1 Publication
VAR_002164
Natural varianti61 – 611V → L.1 Publication
VAR_002165
Natural varianti80 – 801A → P.1 Publication
VAR_002166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19888 mRNA. Translation: AAA36636.1.
M21300 mRNA. Translation: AAA36637.1.
M21301 mRNA. Translation: AAA36638.1.
M84757 Genomic DNA. Translation: AAA36643.1.
AK312191 mRNA. Translation: BAG35124.1.
AY787223 Genomic DNA. Translation: AAV40826.1.
AL356867 Genomic DNA. Translation: CAI19805.1.
BC056240 mRNA. Translation: AAH56240.1.
CCDSiCCDS30863.1.
PIRiA46709.
RefSeqiNP_003116.2. NM_003125.2.
UniGeneiHs.1076.

Genome annotation databases

EnsembliENST00000307098; ENSP00000306461; ENSG00000169469.
GeneIDi6699.
KEGGihsa:6699.
UCSCiuc001fba.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19888 mRNA. Translation: AAA36636.1.
M21300 mRNA. Translation: AAA36637.1.
M21301 mRNA. Translation: AAA36638.1.
M84757 Genomic DNA. Translation: AAA36643.1.
AK312191 mRNA. Translation: BAG35124.1.
AY787223 Genomic DNA. Translation: AAV40826.1.
AL356867 Genomic DNA. Translation: CAI19805.1.
BC056240 mRNA. Translation: AAH56240.1.
CCDSiCCDS30863.1.
PIRiA46709.
RefSeqiNP_003116.2. NM_003125.2.
UniGeneiHs.1076.

3D structure databases

ProteinModelPortaliP22528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112577. 2 interactions.
IntActiP22528. 3 interactions.
STRINGi9606.ENSP00000306461.

PTM databases

PhosphoSiteiP22528.

Polymorphism and mutation databases

BioMutaiSPRR1B.
DMDMi84028265.

2D gel databases

UCD-2DPAGEP22528.

Proteomic databases

MaxQBiP22528.
PaxDbiP22528.
PRIDEiP22528.

Protocols and materials databases

DNASUi6699.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307098; ENSP00000306461; ENSG00000169469.
GeneIDi6699.
KEGGihsa:6699.
UCSCiuc001fba.4. human.

Organism-specific databases

CTDi6699.
GeneCardsiSPRR1B.
H-InvDBHIX0023650.
HGNCiHGNC:11260. SPRR1B.
MIMi182266. gene.
neXtProtiNX_P22528.
PharmGKBiPA36089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JH2M. Eukaryota.
ENOG410XUVY. LUCA.
GeneTreeiENSGT00730000111065.
HOGENOMiHOG000059526.
HOVERGENiHBG079213.
InParanoidiP22528.
OMAiKEACAPQ.
OrthoDBiEOG773XKP.
PhylomeDBiP22528.
TreeFamiTF338205.

Miscellaneous databases

ChiTaRSiSPRR1B. human.
GeneWikiiSPRR1B.
GenomeRNAii6699.
NextBioi26119.
PROiP22528.
SOURCEiSearch...

Gene expression databases

BgeeiP22528.
CleanExiHS_SPRR1B.
GenevisibleiP22528. HS.

Family and domain databases

InterProiIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PTHR23263:SF49. PTHR23263:SF49. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes."
    Kartasova T., van de Putte P.
    Mol. Cell. Biol. 8:2195-2203(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-11; HIS-23; LEU-61 AND PRO-80.
    Tissue: Keratinocyte.
  2. "Isolation and characterization of the human spr1 gene and its regulation of expression by phorbol ester and cyclic AMP."
    An G., Wu R.
    J. Biol. Chem. 268:10977-10982(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-11.
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-11.
    Tissue: Tongue.
  4. NIEHS SNPs program
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-11.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-11.
  7. "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation."
    Greco M.A., Lorand L., Lane W.S., Baden H.P., Parameswaran K.N.P., Kvedar J.C.
    J. Invest. Dermatol. 104:204-210(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-36 AND 53-85, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Keratinocyte.

Entry informationi

Entry nameiSPR1B_HUMAN
AccessioniPrimary (citable) accession number: P22528
Secondary accession number(s): B2R5H7
, P22529, P22530, Q5T524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: December 20, 2005
Last modified: May 11, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.