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Protein

Chromosome partition protein MukE

Gene

mukE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, DNA condensation

Enzyme and pathway databases

BioCyciEcoCyc:EG11252-MONOMER.
ECOL316407:JW0906-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome partition protein MukE
Alternative name(s):
Protein KicA
Gene namesi
Name:mukE
Synonyms:kicA, ycbA
Ordered Locus Names:b0923, JW0906
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11252. mukE.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067921 – 234Chromosome partition protein MukEAdd BLAST234

Proteomic databases

PaxDbiP22524.
PRIDEiP22524.

Interactioni

Subunit structurei

Forms a hexameric complex with MukF, (MukF-(MukE)2)2, which forms a ternary complex with MukB. The complex formation is stimulated by calcium or magnesium.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
mukFP602934EBI-554672,EBI-554679

Protein-protein interaction databases

BioGridi4261869. 77 interactors.
DIPiDIP-10274N.
IntActiP22524. 11 interactors.
MINTiMINT-1227862.
STRINGi511145.b0923.

Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 19Combined sources8
Helixi23 – 31Combined sources9
Helixi41 – 59Combined sources19
Turni60 – 62Combined sources3
Beta strandi63 – 67Combined sources5
Beta strandi73 – 77Combined sources5
Beta strandi85 – 87Combined sources3
Helixi90 – 104Combined sources15
Helixi106 – 111Combined sources6
Beta strandi114 – 116Combined sources3
Helixi117 – 127Combined sources11
Helixi130 – 137Combined sources8
Beta strandi138 – 140Combined sources3
Helixi145 – 164Combined sources20
Beta strandi167 – 170Combined sources4
Beta strandi172 – 180Combined sources9
Helixi182 – 188Combined sources7
Helixi189 – 192Combined sources4
Beta strandi193 – 195Combined sources3
Helixi197 – 206Combined sources10
Beta strandi209 – 212Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EUHX-ray2.90C/D/E/F1-234[»]
3RPUX-ray3.60D/E/G/H/Y/Z10-234[»]
ProteinModelPortaliP22524.
SMRiP22524.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22524.

Family & Domainsi

Sequence similaritiesi

Belongs to the MukE family.Curated

Phylogenomic databases

eggNOGiENOG4105DAH. Bacteria.
COG3095. LUCA.
HOGENOMiHOG000278254.
KOiK03804.

Family and domain databases

HAMAPiMF_01802. MukE. 1 hit.
InterProiIPR007385. Scp_MukE.
[Graphical view]
PfamiPF04288. MukE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTNIEQVM PVKLAQALAN PLFPALDSAL RSGRHIGLDE LDNHAFLMDF
60 70 80 90 100
QEYLEEFYAR YNVELIRAPE GFFYLRPRST TLIPRSVLSE LDMMVGKILC
110 120 130 140 150
YLYLSPERLA NEGIFTQQEL YDELLTLADE AKLLKLVNNR STGSDVDRQK
160 170 180 190 200
LQEKVRSSLN RLRRLGMVWF MGHDSSKFRI TESVFRFGAD VRAGDDPREA
210 220 230
QRRLIRDGEA MPIENHLQLN DETEENQPDS GEEE
Length:234
Mass (Da):26,974
Last modified:November 24, 2009 - v5
Checksum:i1E771144C58207DD
GO

Sequence cautioni

The sequence BAA05458 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA35669 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA40775 differs from that shown. Reason: Frameshift at position 105.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26440 Genomic DNA. Translation: BAA05458.1. Different initiation.
U00096 Genomic DNA. Translation: AAC74009.2.
AP009048 Genomic DNA. Translation: BAA35669.2. Different initiation.
X57550 Genomic DNA. Translation: CAA40775.1. Frameshift.
PIRiB64832.
RefSeqiNP_415443.2. NC_000913.3.
WP_001295347.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74009; AAC74009; b0923.
BAA35669; BAA35669; BAA35669.
GeneIDi945550.
KEGGiecj:JW0906.
eco:b0923.
PATRICi32117059. VBIEscCol129921_0954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26440 Genomic DNA. Translation: BAA05458.1. Different initiation.
U00096 Genomic DNA. Translation: AAC74009.2.
AP009048 Genomic DNA. Translation: BAA35669.2. Different initiation.
X57550 Genomic DNA. Translation: CAA40775.1. Frameshift.
PIRiB64832.
RefSeqiNP_415443.2. NC_000913.3.
WP_001295347.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EUHX-ray2.90C/D/E/F1-234[»]
3RPUX-ray3.60D/E/G/H/Y/Z10-234[»]
ProteinModelPortaliP22524.
SMRiP22524.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261869. 77 interactors.
DIPiDIP-10274N.
IntActiP22524. 11 interactors.
MINTiMINT-1227862.
STRINGi511145.b0923.

Proteomic databases

PaxDbiP22524.
PRIDEiP22524.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74009; AAC74009; b0923.
BAA35669; BAA35669; BAA35669.
GeneIDi945550.
KEGGiecj:JW0906.
eco:b0923.
PATRICi32117059. VBIEscCol129921_0954.

Organism-specific databases

EchoBASEiEB1232.
EcoGeneiEG11252. mukE.

Phylogenomic databases

eggNOGiENOG4105DAH. Bacteria.
COG3095. LUCA.
HOGENOMiHOG000278254.
KOiK03804.

Enzyme and pathway databases

BioCyciEcoCyc:EG11252-MONOMER.
ECOL316407:JW0906-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP22524.
PROiP22524.

Family and domain databases

HAMAPiMF_01802. MukE. 1 hit.
InterProiIPR007385. Scp_MukE.
[Graphical view]
PfamiPF04288. MukE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUKE_ECOLI
AccessioniPrimary (citable) accession number: P22524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 24, 2009
Last modified: November 2, 2016
This is version 132 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.