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Protein

Colicin V secretion/processing ATP-binding protein CvaB

Gene

cvaB

Organism
Escherichia coli
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved, in conjunction with CvaA, in the secretion of colicin V.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei32PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi526 – 533ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processBacteriocin transport, Protein transport, Transport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiC39.005
TCDBi3.A.1.110.2 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Colicin V secretion/processing ATP-binding protein CvaB (EC:3.4.22.-)
Gene namesi
Name:cvaB
Encoded oniPlasmid IncFI ColV3-K300 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei92 – 112HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei176 – 196HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei211 – 231HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei289 – 311HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei315 – 334HelicalPROSITE-ProRule annotationAdd BLAST20
Transmembranei412 – 432HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000922381 – 698Colicin V secretion/processing ATP-binding protein CvaBAdd BLAST698

Proteomic databases

PRIDEiP22520

Structurei

3D structure databases

ProteinModelPortaliP22520
SMRiP22520
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 145Peptidase C39PROSITE-ProRule annotationAdd BLAST120
Domaini176 – 458ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST283
Domaini492 – 698ABC transporterPROSITE-ProRule annotationAdd BLAST207

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd02419 Peptidase_C39C, 1 hit
Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR033838 CvaB_peptidase
IPR027417 P-loop_NTPase
IPR005074 Peptidase_C39
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
PF03412 Peptidase_C39, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS50990 PEPTIDASE_C39, 1 hit

Sequencei

Sequence statusi: Complete.

P22520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNRNFRQII NLLDLRWQRR VPVIHQTETA ECGLACLAMI CGHFGKNIDL
60 70 80 90 100
IYLRRKFNLS ARGATLAGIN GIAEQLGMAT RALSLELDEL RVLKTPCILH
110 120 130 140 150
WDFSHFVVLV SVKRNRYVLH DPARGIRYIS REEMSRYFTG VALEVWPGSE
160 170 180 190 200
FQSETLQTRI SLRSLINSIY GIKRTLAKIF CLSVVIEAIN LLMPVGTQLV
210 220 230 240 250
MDHAIPAGDR GLLTLISAAL MFFILLKAAT STLRAWSSLV MSTLINVQWQ
260 270 280 290 300
SGLFDHLLRL PLAFFERRKL GDIQSRFDSL DTLRATFTTS VIGFIMDSIM
310 320 330 340 350
VVGVCVMMLL YGGYLTWIVL CFTTIYIFIR LVTYGNYRQI SEECLVREAR
360 370 380 390 400
AASYFMETLY GIATVKIQGM VGIRGAHWLN MKIDAINSGI KLTRMDLLFG
410 420 430 440 450
GINTFVTACD QIVILWLGAG LVIDNQMTIG MFVAFSSFRG QFSERVASLT
460 470 480 490 500
SFLLQLRIMS LHNERIADIA LHEKEEKKPE IEIVADMGPI SLETNGLSYR
510 520 530 540 550
YDSQSAPIFS ALSLSVAPGE SVAITGASGA GKTTLMKVLC GLFEPDSGRV
560 570 580 590 600
LINGIDIRQI GINNYHRMIA CVMQDDRLFS GSIRENICGF AEEMDEEWMV
610 620 630 640 650
ECARASHIHD VIMNMPMGYE TLIGELGEGL SGGQKQRIFI ARALYRKPGI
660 670 680 690
LFMDEATSAL DSESEHFVNV AIKNMNITRV IIAHRETTLR TVDRVISI
Length:698
Mass (Da):78,246
Last modified:August 1, 1991 - v1
Checksum:i47FC40510AF5D28A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57524 Genomic DNA Translation: CAA40744.1
AJ223631 Genomic DNA Translation: CAA11515.1
PIRiS12272 IKEC5B
RefSeqiWP_000184924.1, NZ_PUDY01000062.1

Similar proteinsi

Entry informationi

Entry nameiCVAB_ECOLX
AccessioniPrimary (citable) accession number: P22520
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid
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Main funding by: National Institutes of Health