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Protein

Colicin V secretion/processing ATP-binding protein CvaB

Gene

cvaB

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved, in conjunction with CvaA, in the secretion of colicin V.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei32 – 321PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi526 – 5338ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Bacteriocin transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiC39.005.
TCDBi3.A.1.110.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Colicin V secretion/processing ATP-binding protein CvaB (EC:3.4.22.-)
Gene namesi
Name:cvaB
Encoded oniPlasmid IncFI ColV3-K300 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei92 – 11221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei176 – 19621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei211 – 23121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei289 – 31123HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei315 – 33420HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei412 – 43221HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Colicin V secretion/processing ATP-binding protein CvaBPRO_0000092238Add
BLAST

Proteomic databases

PRIDEiP22520.

Structurei

3D structure databases

ProteinModelPortaliP22520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 145120Peptidase C39PROSITE-ProRule annotationAdd
BLAST
Domaini176 – 458283ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini492 – 698207ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation
Contains 1 peptidase C39 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005074. Peptidase_C39.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF03412. Peptidase_C39. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS50990. PEPTIDASE_C39. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNRNFRQII NLLDLRWQRR VPVIHQTETA ECGLACLAMI CGHFGKNIDL
60 70 80 90 100
IYLRRKFNLS ARGATLAGIN GIAEQLGMAT RALSLELDEL RVLKTPCILH
110 120 130 140 150
WDFSHFVVLV SVKRNRYVLH DPARGIRYIS REEMSRYFTG VALEVWPGSE
160 170 180 190 200
FQSETLQTRI SLRSLINSIY GIKRTLAKIF CLSVVIEAIN LLMPVGTQLV
210 220 230 240 250
MDHAIPAGDR GLLTLISAAL MFFILLKAAT STLRAWSSLV MSTLINVQWQ
260 270 280 290 300
SGLFDHLLRL PLAFFERRKL GDIQSRFDSL DTLRATFTTS VIGFIMDSIM
310 320 330 340 350
VVGVCVMMLL YGGYLTWIVL CFTTIYIFIR LVTYGNYRQI SEECLVREAR
360 370 380 390 400
AASYFMETLY GIATVKIQGM VGIRGAHWLN MKIDAINSGI KLTRMDLLFG
410 420 430 440 450
GINTFVTACD QIVILWLGAG LVIDNQMTIG MFVAFSSFRG QFSERVASLT
460 470 480 490 500
SFLLQLRIMS LHNERIADIA LHEKEEKKPE IEIVADMGPI SLETNGLSYR
510 520 530 540 550
YDSQSAPIFS ALSLSVAPGE SVAITGASGA GKTTLMKVLC GLFEPDSGRV
560 570 580 590 600
LINGIDIRQI GINNYHRMIA CVMQDDRLFS GSIRENICGF AEEMDEEWMV
610 620 630 640 650
ECARASHIHD VIMNMPMGYE TLIGELGEGL SGGQKQRIFI ARALYRKPGI
660 670 680 690
LFMDEATSAL DSESEHFVNV AIKNMNITRV IIAHRETTLR TVDRVISI
Length:698
Mass (Da):78,246
Last modified:August 1, 1991 - v1
Checksum:i47FC40510AF5D28A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57524 Genomic DNA. Translation: CAA40744.1.
AJ223631 Genomic DNA. Translation: CAA11515.1.
PIRiS12272. IKEC5B.
RefSeqiWP_000184924.1. NZ_LRXC01000076.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57524 Genomic DNA. Translation: CAA40744.1.
AJ223631 Genomic DNA. Translation: CAA11515.1.
PIRiS12272. IKEC5B.
RefSeqiWP_000184924.1. NZ_LRXC01000076.1.

3D structure databases

ProteinModelPortaliP22520.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC39.005.
TCDBi3.A.1.110.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PRIDEiP22520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005074. Peptidase_C39.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF03412. Peptidase_C39. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS50990. PEPTIDASE_C39. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genetic analysis of an MDR-like export system: the secretion of colicin V."
    Gilson L., Mahanty H.K., Kolter R.
    EMBO J. 9:3875-3884(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization of a hemoglobin protease secreted by the pathogenic Escherichia coli strain EB1."
    Otto B.R., van Dooren S.J.M., Nuijens J.H., Luirink J., Oudega B.
    J. Exp. Med. 188:1091-1103(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 373-698.

Entry informationi

Entry nameiCVAB_ECOLX
AccessioniPrimary (citable) accession number: P22520
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.