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Protein

Histone H1t

Gene

HIST1H1T

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).Curated1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei56Important for nucleosome binding propertiesBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • nucleosome assembly Source: InterPro
  • spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33208-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1t
Alternative name(s):
Testicular H1 histone
Gene namesi
Name:HIST1H1T
Synonyms:H1FT, H1T
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4720. HIST1H1T.

Subcellular locationi

GO - Cellular componenti

  • nucleosome Source: InterPro
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3010.
OpenTargetsiENSG00000187475.
PharmGKBiPA29098.

Polymorphism and mutation databases

BioMutaiHIST1H1T.
DMDMi34395930.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001959102 – 207Histone H1tAdd BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei58CitrullineBy similarity1
Modified residuei143PhosphoserineBy similarity1
Modified residuei159PhosphothreonineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei181PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated in early spermatids.By similarity
Citrullination at Arg-58 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

EPDiP22492.
MaxQBiP22492.
PaxDbiP22492.
PeptideAtlasiP22492.
PRIDEiP22492.

PTM databases

iPTMnetiP22492.
PhosphoSitePlusiP22492.
SwissPalmiP22492.

Expressioni

Tissue specificityi

Testis-specific.2 Publications

Developmental stagei

This histone is a testis-specific H1 variant that appears during meiosis in spermatogenesis.1 Publication

Gene expression databases

BgeeiENSG00000187475.
CleanExiHS_HIST1H1T.
GenevisibleiP22492. HS.

Interactioni

Protein-protein interaction databases

BioGridi109265. 88 interactors.
IntActiP22492. 15 interactors.
MINTiMINT-6611232.
STRINGi9606.ENSP00000341214.

Structurei

3D structure databases

ProteinModelPortaliP22492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 113H15PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
GeneTreeiENSGT00670000097781.
HOGENOMiHOG000251627.
HOVERGENiHBG009035.
InParanoidiP22492.
KOiK11275.
OMAiQERVGMS.
OrthoDBiEOG091G0XGD.
PhylomeDBiP22492.
TreeFamiTF313664.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22492-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETVPAASA SAGVAAMEKL PTKKRGRKPA GLISASRKVP NLSVSKLITE
60 70 80 90 100
ALSVSQERVG MSLVALKKAL AAAGYDVEKN NSRIKLSLKS LVNKGILVQT
110 120 130 140 150
RGTGASGSFK LSKKVIPKST RSKAKKSVSA KTKKLVLSRD SKSPKTAKTN
160 170 180 190 200
KRAKKPRATT PKTVRSGRKA KGAKGKQQQK SPVKARASKS KLTQHHEVNV

RKATSKK
Length:207
Mass (Da):22,019
Last modified:January 23, 2007 - v4
Checksum:i9CF27B275DA29B48
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04931014V → L.1 PublicationCorresponds to variant rs198844dbSNPEnsembl.1
Natural variantiVAR_04931152L → F.Corresponds to variant rs2051542dbSNPEnsembl.1
Natural variantiVAR_049312178Q → K.1 PublicationCorresponds to variant rs198845dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60094 Genomic DNA. Translation: AAA35944.1.
M97755 Genomic DNA. Translation: AAA19936.1.
AF531301 Genomic DNA. Translation: AAN06701.1.
BC069517 mRNA. Translation: AAH69517.2.
CCDSiCCDS34349.1.
PIRiJH0550.
RefSeqiNP_005314.2. NM_005323.3.
UniGeneiHs.533293.

Genome annotation databases

EnsembliENST00000338379; ENSP00000341214; ENSG00000187475.
GeneIDi3010.
KEGGihsa:3010.
UCSCiuc003ngj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60094 Genomic DNA. Translation: AAA35944.1.
M97755 Genomic DNA. Translation: AAA19936.1.
AF531301 Genomic DNA. Translation: AAN06701.1.
BC069517 mRNA. Translation: AAH69517.2.
CCDSiCCDS34349.1.
PIRiJH0550.
RefSeqiNP_005314.2. NM_005323.3.
UniGeneiHs.533293.

3D structure databases

ProteinModelPortaliP22492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109265. 88 interactors.
IntActiP22492. 15 interactors.
MINTiMINT-6611232.
STRINGi9606.ENSP00000341214.

PTM databases

iPTMnetiP22492.
PhosphoSitePlusiP22492.
SwissPalmiP22492.

Polymorphism and mutation databases

BioMutaiHIST1H1T.
DMDMi34395930.

Proteomic databases

EPDiP22492.
MaxQBiP22492.
PaxDbiP22492.
PeptideAtlasiP22492.
PRIDEiP22492.

Protocols and materials databases

DNASUi3010.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338379; ENSP00000341214; ENSG00000187475.
GeneIDi3010.
KEGGihsa:3010.
UCSCiuc003ngj.4. human.

Organism-specific databases

CTDi3010.
DisGeNETi3010.
GeneCardsiHIST1H1T.
HGNCiHGNC:4720. HIST1H1T.
MIMi142712. gene.
neXtProtiNX_P22492.
OpenTargetsiENSG00000187475.
PharmGKBiPA29098.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
GeneTreeiENSGT00670000097781.
HOGENOMiHOG000251627.
HOVERGENiHBG009035.
InParanoidiP22492.
KOiK11275.
OMAiQERVGMS.
OrthoDBiEOG091G0XGD.
PhylomeDBiP22492.
TreeFamiTF313664.

Enzyme and pathway databases

BioCyciZFISH:G66-33208-MONOMER.

Miscellaneous databases

GeneWikiiHIST1H1T.
GenomeRNAii3010.
PROiP22492.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187475.
CleanExiHS_HIST1H1T.
GenevisibleiP22492. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH1T_HUMAN
AccessioniPrimary (citable) accession number: P22492
Secondary accession number(s): Q6ISI1, Q8IUE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 144 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.