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Protein

Annexin B10

Gene

AnxB10

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase
  • calcium-dependent phospholipid binding Source: FlyBase
  • calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Protein family/group databases

TCDBi1.A.31.1.1. the annexin (annexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin B10
Alternative name(s):
Annexin X
Annexin-10
Gene namesi
Name:AnxB10
Synonyms:AnnX
ORF Names:CG9579
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000084. AnxB10.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675171 – 321Annexin B10Add BLAST321

Proteomic databases

PaxDbiP22465.
PRIDEiP22465.

Expressioni

Gene expression databases

BgeeiFBgn0000084.
GenevisibleiP22465. DM.

Interactioni

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

BioGridi59312. 107 interactors.
IntActiP22465. 1 interactor.
STRINGi7227.FBpp0291143.

Structurei

3D structure databases

ProteinModelPortaliP22465.
SMRiP22465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 84Annexin 1Add BLAST61
Repeati96 – 156Annexin 2Add BLAST61
Repeati180 – 241Annexin 3Add BLAST62
Repeati256 – 317Annexin 4Add BLAST62

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.By similarity

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
InParanoidiP22465.
OMAiYKAMNGA.
OrthoDBiEOG091G0H6H.
PhylomeDBiP22465.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: P22465-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEYKPVPTVK DAAPFDASQD AQVLRAAMKG FGTDEQEIID VLVGRSNQQR
60 70 80 90 100
QTIKAVYEAE FERDLVDDLK DELGGKFEDV IVGLMMPPVE YLCKQLHAAM
110 120 130 140 150
AGIGTEEATL VEILCTKTNE EMAQIVAVYE ERYQRPLAEQ MCSETSGFFR
160 170 180 190 200
RLLTLIVTGV RDGLDTPVDV GQAKEQAAQL YSAGEAKLGT DEEVFNRIMS
210 220 230 240 250
HASFPQLRLV FEEYKVLSGQ TIEQAIKHEM SDELHEAMMA IVECVQSPAA
260 270 280 290 300
FFANRLYKAM NGAGTDDATL IRIIVSRSEI DLETIKQEFE RIYNRTLHSA
310 320
VVDAETSGDY KRALTALLGS A
Length:321
Mass (Da):35,706
Last modified:February 19, 2014 - v3
Checksum:iD722C6D872978A02
GO
Isoform A (identifier: P22465-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-303: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):35,590
Checksum:iFF204A52B7B8268E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216V → E in AAB51186 (Ref. 7) Curated1
Sequence conflicti220Q → H in ADX35905 (Ref. 6) Curated1
Sequence conflicti235H → HD in AAB51186 (Ref. 7) Curated1
Sequence conflicti291R → Q in AAB51186 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053652303Missing in isoform A. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34069 mRNA. Translation: AAA28371.1.
X78323 Genomic DNA. Translation: CAA55126.1.
AE014298 Genomic DNA. Translation: AAF45380.1.
AE014298 Genomic DNA. Translation: ACZ95337.1.
AY061328 mRNA. Translation: AAL28876.1.
BT125926 mRNA. Translation: ADX35905.1.
L41945 Genomic DNA. Translation: AAB51186.1.
PIRiB42234. LUFF10.
RefSeqiNP_001162804.1. NM_001169333.2. [P22465-1]
NP_476615.1. NM_057267.4. [P22465-2]
UniGeneiDm.19746.

Genome annotation databases

EnsemblMetazoaiFBtr0301931; FBpp0291143; FBgn0000084. [P22465-1]
GeneIDi33019.
KEGGidme:Dmel_CG9579.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34069 mRNA. Translation: AAA28371.1.
X78323 Genomic DNA. Translation: CAA55126.1.
AE014298 Genomic DNA. Translation: AAF45380.1.
AE014298 Genomic DNA. Translation: ACZ95337.1.
AY061328 mRNA. Translation: AAL28876.1.
BT125926 mRNA. Translation: ADX35905.1.
L41945 Genomic DNA. Translation: AAB51186.1.
PIRiB42234. LUFF10.
RefSeqiNP_001162804.1. NM_001169333.2. [P22465-1]
NP_476615.1. NM_057267.4. [P22465-2]
UniGeneiDm.19746.

3D structure databases

ProteinModelPortaliP22465.
SMRiP22465.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59312. 107 interactors.
IntActiP22465. 1 interactor.
STRINGi7227.FBpp0291143.

Protein family/group databases

TCDBi1.A.31.1.1. the annexin (annexin) family.

Proteomic databases

PaxDbiP22465.
PRIDEiP22465.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0301931; FBpp0291143; FBgn0000084. [P22465-1]
GeneIDi33019.
KEGGidme:Dmel_CG9579.

Organism-specific databases

CTDi33019.
FlyBaseiFBgn0000084. AnxB10.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
InParanoidiP22465.
OMAiYKAMNGA.
OrthoDBiEOG091G0H6H.
PhylomeDBiP22465.

Miscellaneous databases

GenomeRNAii33019.
PROiP22465.

Gene expression databases

BgeeiFBgn0000084.
GenevisibleiP22465. DM.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANX10_DROME
AccessioniPrimary (citable) accession number: P22465
Secondary accession number(s): E1JJR8
, E8NH50, Q27586, Q9W5W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: February 19, 2014
Last modified: November 30, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.