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Protein

Annexin B9

Gene

AnxB9

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase
  • calcium-dependent phospholipid binding Source: FlyBase
  • calcium ion binding Source: InterPro
  • spectrin binding Source: FlyBase

GO - Biological processi

  • basolateral protein localization Source: FlyBase
  • endosome transport via multivesicular body sorting pathway Source: FlyBase
  • maintenance of cell polarity Source: FlyBase
  • regulation of multivesicular body size involved in endosome transport Source: FlyBase
  • wing disc dorsal/ventral pattern formation Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin B9
Alternative name(s):
Annexin IX
Annexin-9
Gene namesi
Name:AnxB9
Synonyms:AnnIX
ORF Names:CG5730
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000083. AnxB9.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: FlyBase
  • endomembrane system Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675161 – 324Annexin B9Add BLAST324

Proteomic databases

PaxDbiP22464.
PRIDEiP22464.

Expressioni

Developmental stagei

Expressed throughout development with highest expression seen in adults.1 Publication

Gene expression databases

BgeeiFBgn0000083.
ExpressionAtlasiP22464. baseline.
GenevisibleiP22464. DM.

Interactioni

GO - Molecular functioni

  • actin binding Source: FlyBase
  • spectrin binding Source: FlyBase

Protein-protein interaction databases

BioGridi67463. 9 interactors.
DIPiDIP-20322N.
IntActiP22464. 4 interactors.
MINTiMINT-345601.
STRINGi7227.FBpp0088506.

Structurei

3D structure databases

ProteinModelPortaliP22464.
SMRiP22464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 90Annexin 1Add BLAST61
Repeati102 – 162Annexin 2Add BLAST61
Repeati185 – 246Annexin 3Add BLAST62
Repeati261 – 321Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.By similarity

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
InParanoidiP22464.
KOiK17095.
OMAiEQSFGKP.
OrthoDBiEOG091G0H6H.
PhylomeDBiP22464.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P22464-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSAEYYPFK CTPTVYPADP FDPVEDAAIL RKAMKGFGTD EKAIIEILAR
60 70 80 90 100
RGIVQRLEIA EAFKTSYGKD LISDLKSELG GKFEDVILAL MTPLPQFYAQ
110 120 130 140 150
ELHDAISGLG TDEEAIIEIL CTLSNYGIKT IAQFYEQSFG KSLESDLKGD
160 170 180 190 200
TSGHFKRLCV SLVQGNRDEN QGVDEAAAIA DAQALHDAGE GQWGTDESTF
210 220 230 240 250
NSILITRSYQ QLRQIFLEYE NLSGNDIEKA IKREFSGSVE KGFLAIVKCC
260 270 280 290 300
KSKIDYFSER LHDSMAGMGT KDKTLIRIIV SRSEIDLGDI KEAFQNKYGK
310 320
SLESWIKEDA ETDIGYVLVT LTAW
Length:324
Mass (Da):36,058
Last modified:December 1, 2000 - v2
Checksum:i6DBF1021A7CC0DCA
GO
Isoform b (identifier: P22464-2) [UniParc]FASTAAdd to basket
Also known as: B, D

The sequence of this isoform differs from the canonical sequence as follows:
     308-324: EDAETDIGYVLVTLTAW → DDLSGDYSYVLQCLASY

Show »
Length:324
Mass (Da):36,074
Checksum:i644D4C01AF54DDB3
GO
Isoform c (identifier: P22464-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     308-324: EDAETDIGYVLVTLTAW → GDTSGDYKRALLAIVGF

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):35,945
Checksum:i66547B16DC2533D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13P → H in AAN71504 (PubMed:12537569).Curated1
Sequence conflicti268M → L in AAG12161 (Ref. 1) Curated1
Sequence conflicti268M → L in AAA28370 (PubMed:2141610).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009664308 – 324EDAET…TLTAW → DDLSGDYSYVLQCLASY in isoform b. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_009665308 – 324EDAET…TLTAW → GDTSGDYKRALLAIVGF in isoform c. 2 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261718 mRNA. Translation: AAF69016.1.
AY007377 mRNA. Translation: AAG12161.1.
AE014297 Genomic DNA. Translation: AAF55841.1.
AE014297 Genomic DNA. Translation: AAN13848.1.
AE014297 Genomic DNA. Translation: AAS65188.1.
AE014297 Genomic DNA. Translation: AAS65189.1.
AY118504 mRNA. Translation: AAM49873.1.
BT001749 mRNA. Translation: AAN71504.1.
BT044420 mRNA. Translation: ACH92485.1.
M34068 mRNA. Translation: AAA28370.1.
PIRiA42234. LUFF9.
RefSeqiNP_001262796.1. NM_001275867.1. [P22464-3]
NP_001262797.1. NM_001275868.1. [P22464-3]
NP_476603.1. NM_057255.3. [P22464-2]
NP_476604.1. NM_057256.4. [P22464-1]
NP_996252.1. NM_206530.2. [P22464-2]
NP_996253.1. NM_206531.2. [P22464-3]
UniGeneiDm.4864.

Genome annotation databases

EnsemblMetazoaiFBtr0089517; FBpp0088505; FBgn0000083. [P22464-1]
GeneIDi42492.
KEGGidme:Dmel_CG5730.
UCSCiCG5730-RD. d. melanogaster.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261718 mRNA. Translation: AAF69016.1.
AY007377 mRNA. Translation: AAG12161.1.
AE014297 Genomic DNA. Translation: AAF55841.1.
AE014297 Genomic DNA. Translation: AAN13848.1.
AE014297 Genomic DNA. Translation: AAS65188.1.
AE014297 Genomic DNA. Translation: AAS65189.1.
AY118504 mRNA. Translation: AAM49873.1.
BT001749 mRNA. Translation: AAN71504.1.
BT044420 mRNA. Translation: ACH92485.1.
M34068 mRNA. Translation: AAA28370.1.
PIRiA42234. LUFF9.
RefSeqiNP_001262796.1. NM_001275867.1. [P22464-3]
NP_001262797.1. NM_001275868.1. [P22464-3]
NP_476603.1. NM_057255.3. [P22464-2]
NP_476604.1. NM_057256.4. [P22464-1]
NP_996252.1. NM_206530.2. [P22464-2]
NP_996253.1. NM_206531.2. [P22464-3]
UniGeneiDm.4864.

3D structure databases

ProteinModelPortaliP22464.
SMRiP22464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67463. 9 interactors.
DIPiDIP-20322N.
IntActiP22464. 4 interactors.
MINTiMINT-345601.
STRINGi7227.FBpp0088506.

Proteomic databases

PaxDbiP22464.
PRIDEiP22464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089517; FBpp0088505; FBgn0000083. [P22464-1]
GeneIDi42492.
KEGGidme:Dmel_CG5730.
UCSCiCG5730-RD. d. melanogaster.

Organism-specific databases

CTDi42492.
FlyBaseiFBgn0000083. AnxB9.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
InParanoidiP22464.
KOiK17095.
OMAiEQSFGKP.
OrthoDBiEOG091G0H6H.
PhylomeDBiP22464.

Miscellaneous databases

ChiTaRSiAnnIX. fly.
GenomeRNAii42492.
PROiP22464.

Gene expression databases

BgeeiFBgn0000083.
ExpressionAtlasiP22464. baseline.
GenevisibleiP22464. DM.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXB9_DROME
AccessioniPrimary (citable) accession number: P22464
Secondary accession number(s): A4V371
, B5RJE6, Q8IGJ8, Q969D3, Q9NG55, Q9VDF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.