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Protein

Annexin B9

Gene

AnxB9

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase
  • calcium-dependent phospholipid binding Source: FlyBase
  • calcium ion binding Source: InterPro
  • spectrin binding Source: FlyBase

GO - Biological processi

  • endosome transport via multivesicular body sorting pathway Source: FlyBase
  • maintenance of cell polarity Source: FlyBase
  • regulation of multivesicular body size involved in endosome transport Source: FlyBase
  • wing disc dorsal/ventral pattern formation Source: FlyBase

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin B9
Alternative name(s):
Annexin IX
Annexin-9
Gene namesi
Name:AnxB9
Synonyms:AnnIX
ORF Names:CG5730
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000083 AnxB9

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675161 – 324Annexin B9Add BLAST324

Proteomic databases

PaxDbiP22464
PRIDEiP22464

Expressioni

Developmental stagei

Expressed throughout development with highest expression seen in adults.1 Publication

Gene expression databases

BgeeiFBgn0000083
ExpressionAtlasiP22464 differential
GenevisibleiP22464 DM

Interactioni

GO - Molecular functioni

  • actin binding Source: FlyBase
  • spectrin binding Source: FlyBase

Protein-protein interaction databases

BioGridi67463, 11 interactors
DIPiDIP-20322N
IntActiP22464, 7 interactors
STRINGi7227.FBpp0088506

Structurei

3D structure databases

ProteinModelPortaliP22464
SMRiP22464
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 90Annexin 1Add BLAST61
Repeati102 – 162Annexin 2Add BLAST61
Repeati185 – 246Annexin 3Add BLAST62
Repeati261 – 321Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.By similarity

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
InParanoidiP22464
KOiK17095
OMAiFRGDMED
OrthoDBiEOG091G0H6H
PhylomeDBiP22464

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 3 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P22464-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSAEYYPFK CTPTVYPADP FDPVEDAAIL RKAMKGFGTD EKAIIEILAR
60 70 80 90 100
RGIVQRLEIA EAFKTSYGKD LISDLKSELG GKFEDVILAL MTPLPQFYAQ
110 120 130 140 150
ELHDAISGLG TDEEAIIEIL CTLSNYGIKT IAQFYEQSFG KSLESDLKGD
160 170 180 190 200
TSGHFKRLCV SLVQGNRDEN QGVDEAAAIA DAQALHDAGE GQWGTDESTF
210 220 230 240 250
NSILITRSYQ QLRQIFLEYE NLSGNDIEKA IKREFSGSVE KGFLAIVKCC
260 270 280 290 300
KSKIDYFSER LHDSMAGMGT KDKTLIRIIV SRSEIDLGDI KEAFQNKYGK
310 320
SLESWIKEDA ETDIGYVLVT LTAW
Length:324
Mass (Da):36,058
Last modified:December 1, 2000 - v2
Checksum:i6DBF1021A7CC0DCA
GO
Isoform b (identifier: P22464-2) [UniParc]FASTAAdd to basket
Also known as: B, D

The sequence of this isoform differs from the canonical sequence as follows:
     308-324: EDAETDIGYVLVTLTAW → DDLSGDYSYVLQCLASY

Show »
Length:324
Mass (Da):36,074
Checksum:i644D4C01AF54DDB3
GO
Isoform c (identifier: P22464-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     308-324: EDAETDIGYVLVTLTAW → GDTSGDYKRALLAIVGF

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):35,945
Checksum:i66547B16DC2533D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13P → H in AAN71504 (PubMed:12537569).Curated1
Sequence conflicti268M → L in AAG12161 (Ref. 1) Curated1
Sequence conflicti268M → L in AAA28370 (PubMed:2141610).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009664308 – 324EDAET…TLTAW → DDLSGDYSYVLQCLASY in isoform b. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_009665308 – 324EDAET…TLTAW → GDTSGDYKRALLAIVGF in isoform c. 2 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261718 mRNA Translation: AAF69016.1
AY007377 mRNA Translation: AAG12161.1
AE014297 Genomic DNA Translation: AAF55841.1
AE014297 Genomic DNA Translation: AAN13848.1
AE014297 Genomic DNA Translation: AAS65188.1
AE014297 Genomic DNA Translation: AAS65189.1
AY118504 mRNA Translation: AAM49873.1
BT001749 mRNA Translation: AAN71504.1
BT044420 mRNA Translation: ACH92485.1
M34068 mRNA Translation: AAA28370.1
PIRiA42234 LUFF9
RefSeqiNP_001262796.1, NM_001275867.1 [P22464-3]
NP_001262797.1, NM_001275868.1 [P22464-3]
NP_476603.1, NM_057255.3 [P22464-2]
NP_476604.1, NM_057256.4 [P22464-1]
NP_996252.1, NM_206530.2 [P22464-2]
NP_996253.1, NM_206531.2 [P22464-3]
UniGeneiDm.4864

Genome annotation databases

EnsemblMetazoaiFBtr0089517; FBpp0088505; FBgn0000083 [P22464-1]
FBtr0089518; FBpp0088506; FBgn0000083 [P22464-2]
FBtr0089519; FBpp0088986; FBgn0000083 [P22464-3]
FBtr0089520; FBpp0088985; FBgn0000083 [P22464-2]
FBtr0336797; FBpp0307769; FBgn0000083 [P22464-3]
FBtr0336798; FBpp0307770; FBgn0000083 [P22464-3]
GeneIDi42492
KEGGidme:Dmel_CG5730
UCSCiCG5730-RD d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANXB9_DROME
AccessioniPrimary (citable) accession number: P22464
Secondary accession number(s): A4V371
, B5RJE6, Q8IGJ8, Q969D3, Q9NG55, Q9VDF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: December 1, 2000
Last modified: March 28, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health