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P22460

- KCNA5_HUMAN

UniProt

P22460 - KCNA5_HUMAN

Protein

Potassium voltage-gated channel subfamily A member 5

Gene

KCNA5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 4 (01 May 2007)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.2 Publications

    GO - Molecular functioni

    1. alpha-actinin binding Source: BHF-UCL
    2. delayed rectifier potassium channel activity Source: BHF-UCL
    3. outward rectifier potassium channel activity Source: BHF-UCL
    4. potassium channel inhibitor activity Source: Ensembl
    5. protein binding Source: IntAct
    6. protein kinase binding Source: BHF-UCL
    7. scaffold protein binding Source: BHF-UCL
    8. voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Source: BHF-UCL

    GO - Biological processi

    1. atrial cardiac muscle cell action potential Source: BHF-UCL
    2. membrane hyperpolarization Source: BHF-UCL
    3. negative regulation of cytosolic calcium ion concentration Source: Ensembl
    4. negative regulation of potassium ion transport Source: Ensembl
    5. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    6. positive regulation of myoblast proliferation Source: Ensembl
    7. potassium ion export Source: BHF-UCL
    8. potassium ion homeostasis Source: Ensembl
    9. potassium ion transport Source: MGI
    10. protein homooligomerization Source: InterPro
    11. regulation of atrial cardiac muscle cell membrane repolarization Source: BHF-UCL
    12. regulation of heart rate by cardiac conduction Source: BHF-UCL
    13. regulation of insulin secretion Source: BHF-UCL
    14. regulation of membrane potential Source: BHF-UCL
    15. regulation of potassium ion transport Source: BHF-UCL
    16. regulation of vasoconstriction Source: Ensembl
    17. response to hypoxia Source: Ensembl
    18. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Protein family/group databases

    TCDBi1.A.1.2.4. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily A member 5
    Alternative name(s):
    HPCN1
    Voltage-gated potassium channel HK2
    Voltage-gated potassium channel subunit Kv1.5
    Gene namesi
    Name:KCNA5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6224. KCNA5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. Golgi apparatus Source: UniProtKB
    3. intercalated disc Source: BHF-UCL
    4. intracellular canaliculus Source: Ensembl
    5. membrane raft Source: BHF-UCL
    6. perinuclear region of cytoplasm Source: Ensembl
    7. plasma membrane Source: UniProtKB
    8. voltage-gated potassium channel complex Source: BHF-UCL
    9. Z disc Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Atrial fibrillation, familial, 7 (ATFB7) [MIM:612240]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi15 – 151T → A: Loss of DLG1 effect on channel current. 1 Publication
    Mutagenesisi220 – 2201I → N: Reduces sumoylation; when associated with N-535. 1 Publication
    Mutagenesisi221 – 2211K → R: Abolishes sumoylation; when associated with R-536. 1 Publication
    Mutagenesisi535 – 5351L → N: Reduces sumoylation; when associated with N-220. 1 Publication
    Mutagenesisi536 – 5361K → R: Abolishes sumoylation; when associated with R-221. 1 Publication

    Keywords - Diseasei

    Atrial fibrillation

    Organism-specific databases

    MIMi612240. phenotype.
    Orphaneti334. Familial atrial fibrillation.
    PharmGKBiPA208.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 613613Potassium voltage-gated channel subfamily A member 5PRO_0000053985Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Cross-linki221 – 221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
    Lipidationi346 – 3461S-palmitoyl cysteineSequence Analysis
    Cross-linki536 – 536Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
    Modified residuei557 – 5571Phosphoserine; by PKASequence Analysis

    Post-translational modificationi

    Sumoylated on Lys-221, and Lys-536, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel.1 Publication

    Keywords - PTMi

    Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP22460.
    PRIDEiP22460.

    PTM databases

    PhosphoSiteiP22460.

    Expressioni

    Tissue specificityi

    Pancreatic islets and insulinoma.

    Gene expression databases

    BgeeiP22460.
    CleanExiHS_KCNA5.
    GenevestigatoriP22460.

    Organism-specific databases

    HPAiCAB022562.
    HPA021516.

    Interactioni

    Subunit structurei

    Heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 By similarity. Interacts with UBE2I.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ACTN2P356096EBI-6426121,EBI-77797

    Protein-protein interaction databases

    BioGridi109943. 27 interactions.
    DIPiDIP-42010N.
    IntActiP22460. 2 interactions.
    MINTiMINT-200758.
    STRINGi9606.ENSP00000252321.

    Structurei

    3D structure databases

    ProteinModelPortaliP22460.
    SMRiP22460. Positions 120-527.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei251 – 26919Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei325 – 34521Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei356 – 37722Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei398 – 41922Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei434 – 45522Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei495 – 51622Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati61 – 71111Add
    BLAST
    Repeati72 – 82112Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni61 – 82222 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-PAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi480 – 4856Selectivity filterBy similarity
    Motifi611 – 6133PDZ-bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi94 – 996Poly-Glu
    Compositional biasi382 – 3876Poly-Gly

    Domaini

    The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231015.
    HOVERGENiHBG052230.
    InParanoidiP22460.
    KOiK04878.
    OMAiGGELQCP.
    OrthoDBiEOG7M0NRD.
    PhylomeDBiP22460.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR004052. K_chnl_volt-dep_Kv1.5.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PTHR11537:SF25. PTHR11537:SF25. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01512. KV15CHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P22460-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEIALVPLEN GGAMTVRGGD EARAGCGQAT GGELQCPPTA GLSDGPKEPA    50
    PKGRGAQRDA DSGVRPLPPL PDPGVRPLPP LPEELPRPRR PPPEDEEEEG 100
    DPGLGTVEDQ ALGTASLHHQ RVHINISGLR FETQLGTLAQ FPNTLLGDPA 150
    KRLRYFDPLR NEYFFDRNRP SFDGILYYYQ SGGRLRRPVN VSLDVFADEI 200
    RFYQLGDEAM ERFREDEGFI KEEEKPLPRN EFQRQVWLIF EYPESSGSAR 250
    AIAIVSVLVI LISIITFCLE TLPEFRDERE LLRHPPAPHQ PPAPAPGANG 300
    SGVMAPPSGP TVAPLLPRTL ADPFFIVETT CVIWFTFELL VRFFACPSKA 350
    GFSRNIMNII DVVAIFPYFI TLGTELAEQQ PGGGGGGQNG QQAMSLAILR 400
    VIRLVRVFRI FKLSRHSKGL QILGKTLQAS MRELGLLIFF LFIGVILFSS 450
    AVYFAEADNQ GTHFSSIPDA FWWAVVTMTT VGYGDMRPIT VGGKIVGSLC 500
    AIAGVLTIAL PVPVIVSNFN YFYHRETDHE EPAVLKEEQG TQSQGPGLDR 550
    GVQRKVSGSR GSFCKAGGTL ENADSARRGS CPLEKCNVKA KSNVDLRRSL 600
    YALCLDTSRE TDL 613
    Length:613
    Mass (Da):67,228
    Last modified:May 1, 2007 - v4
    Checksum:iA5B02B27F8396E3D
    GO
    Isoform 2 (identifier: P22460-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         1-209: Missing.

    Show »
    Length:404
    Mass (Da):44,427
    Checksum:i75826108B430EAC1
    GO

    Sequence cautioni

    The sequence AAA60146.1 differs from that shown. Reason: Frameshift at position 579.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551Missing in AAA61276. (PubMed:2001794)Curated
    Sequence conflicti138 – 1381L → Q in AAA36422. (PubMed:1986382)Curated
    Sequence conflicti154 – 1541R → P in AAA61276. (PubMed:2001794)Curated
    Sequence conflicti154 – 1541R → P in AAA36422. (PubMed:1986382)Curated
    Sequence conflicti187 – 1882RP → G in AAA61276. (PubMed:2001794)Curated
    Sequence conflicti214 – 2141R → G in AAA36422. (PubMed:1986382)Curated
    Sequence conflicti228 – 2281P → V in AAA36422. (PubMed:1986382)Curated
    Sequence conflicti282 – 2821L → V in AAA60146. (PubMed:1349297)Curated
    Sequence conflicti307 – 3071P → A in AAA61276. (PubMed:2001794)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti228 – 2281P → S.
    Corresponds to variant rs1056464 [ dbSNP | Ensembl ].
    VAR_053856
    Natural varianti300 – 3001G → S in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035770
    Natural varianti578 – 5781R → K.
    Corresponds to variant rs12720445 [ dbSNP | Ensembl ].
    VAR_054786

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 209209Missing in isoform 2. CuratedVSP_037110Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60451 mRNA. Translation: AAA61276.1.
    M55513 mRNA. Translation: AAA36422.1.
    M83254 mRNA. Translation: AAA60146.1. Frameshift.
    BC096357 mRNA. Translation: AAH96357.1.
    BC096358 mRNA. Translation: AAH96358.3.
    BC099665 mRNA. Translation: AAH99665.3.
    BC099666 mRNA. Translation: AAH99666.3.
    CCDSiCCDS8536.1. [P22460-1]
    PIRiA56031.
    RefSeqiNP_002225.2. NM_002234.3. [P22460-1]
    UniGeneiHs.150208.
    Hs.741439.

    Genome annotation databases

    EnsembliENST00000252321; ENSP00000252321; ENSG00000130037. [P22460-1]
    GeneIDi3741.
    KEGGihsa:3741.
    UCSCiuc001qni.4. human. [P22460-1]

    Polymorphism databases

    DMDMi146345443.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60451 mRNA. Translation: AAA61276.1 .
    M55513 mRNA. Translation: AAA36422.1 .
    M83254 mRNA. Translation: AAA60146.1 . Frameshift.
    BC096357 mRNA. Translation: AAH96357.1 .
    BC096358 mRNA. Translation: AAH96358.3 .
    BC099665 mRNA. Translation: AAH99665.3 .
    BC099666 mRNA. Translation: AAH99666.3 .
    CCDSi CCDS8536.1. [P22460-1 ]
    PIRi A56031.
    RefSeqi NP_002225.2. NM_002234.3. [P22460-1 ]
    UniGenei Hs.150208.
    Hs.741439.

    3D structure databases

    ProteinModelPortali P22460.
    SMRi P22460. Positions 120-527.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109943. 27 interactions.
    DIPi DIP-42010N.
    IntActi P22460. 2 interactions.
    MINTi MINT-200758.
    STRINGi 9606.ENSP00000252321.

    Chemistry

    BindingDBi P22460.
    ChEMBLi CHEMBL2362996.
    GuidetoPHARMACOLOGYi 542.

    Protein family/group databases

    TCDBi 1.A.1.2.4. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei P22460.

    Polymorphism databases

    DMDMi 146345443.

    Proteomic databases

    PaxDbi P22460.
    PRIDEi P22460.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252321 ; ENSP00000252321 ; ENSG00000130037 . [P22460-1 ]
    GeneIDi 3741.
    KEGGi hsa:3741.
    UCSCi uc001qni.4. human. [P22460-1 ]

    Organism-specific databases

    CTDi 3741.
    GeneCardsi GC12P005153.
    HGNCi HGNC:6224. KCNA5.
    HPAi CAB022562.
    HPA021516.
    MIMi 176267. gene.
    612240. phenotype.
    neXtProti NX_P22460.
    Orphaneti 334. Familial atrial fibrillation.
    PharmGKBi PA208.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231015.
    HOVERGENi HBG052230.
    InParanoidi P22460.
    KOi K04878.
    OMAi GGELQCP.
    OrthoDBi EOG7M0NRD.
    PhylomeDBi P22460.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNA5.
    GenomeRNAii 3741.
    NextBioi 14639.
    PROi P22460.
    SOURCEi Search...

    Gene expression databases

    Bgeei P22460.
    CleanExi HS_KCNA5.
    Genevestigatori P22460.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR004052. K_chnl_volt-dep_Kv1.5.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    PTHR11537:SF25. PTHR11537:SF25. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01512. KV15CHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle."
      Tamkun M.M., Knoth K.M., Walbridge J.A., Kroemer H., Roden D.M., Glover D.M.
      FASEB J. 5:331-337(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    2. "Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel."
      Philipson L.H., Hice R.E., Schaefer K., Lamendola J., Bell G.I., Nelson D.J., Steiner D.F.
      Proc. Natl. Acad. Sci. U.S.A. 88:53-57(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Insulinoma.
    3. "Molecular cloning, characterization, and genomic localization of a human potassium channel gene."
      Curran M.E., Landes G.M., Keating M.T.
      Genomics 12:729-737(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression."
      Snyders D.J., Tamkun M.M., Bennett P.B.
      J. Gen. Physiol. 101:513-543(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Altered state dependence of c-type inactivation in the long and short forms of human Kv1.5."
      Kurata H.T., Soon G.S., Fedida D.
      J. Gen. Physiol. 118:315-332(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
    7. "A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97."
      Mathur R., Choi W.S., Eldstrom J., Wang Z., Kim J., Steele D.F., Fedida D.
      Biochem. Biophys. Res. Commun. 342:1-8(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DLG1, MUTAGENESIS OF THR-15.
    8. "Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation."
      Olson T.M., Alekseev A.E., Liu X.K., Park S., Zingman L.V., Bienengraeber M., Sattiraju S., Ballew J.D., Jahangir A., Terzic A.
      Hum. Mol. Genet. 15:2185-2191(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN ATFB7.
    9. Cited for: SUMOYLATION AT LYS-221 AND LYS-536, INTERACTION WITH UBE2I, MUTAGENESIS OF ILE-220; LYS-221; LEU-535 AND LYS-536.
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-300.

    Entry informationi

    Entry nameiKCNA5_HUMAN
    AccessioniPrimary (citable) accession number: P22460
    Secondary accession number(s): Q4KKT8
    , Q4VAJ1, Q4VAJ2, Q9UDA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 145 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3