Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium voltage-gated channel subfamily A member 5

Gene

KCNA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).3 Publications

GO - Molecular functioni

  • alpha-actinin binding Source: BHF-UCL
  • delayed rectifier potassium channel activity Source: UniProtKB
  • outward rectifier potassium channel activity Source: BHF-UCL
  • potassium channel inhibitor activity Source: Ensembl
  • protein kinase binding Source: BHF-UCL
  • scaffold protein binding Source: BHF-UCL
  • voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Source: BHF-UCL
  • voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization Source: BHF-UCL
  • voltage-gated potassium channel activity involved in SA node cell action potential repolarization Source: BHF-UCL

GO - Biological processi

  • atrial cardiac muscle cell action potential Source: BHF-UCL
  • membrane hyperpolarization Source: BHF-UCL
  • membrane repolarization during bundle of His cell action potential Source: BHF-UCL
  • membrane repolarization during SA node cell action potential Source: BHF-UCL
  • negative regulation of cytosolic calcium ion concentration Source: Ensembl
  • negative regulation of potassium ion transport Source: Ensembl
  • positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  • positive regulation of myoblast proliferation Source: Ensembl
  • potassium ion export Source: BHF-UCL
  • potassium ion homeostasis Source: Ensembl
  • potassium ion transmembrane transport Source: UniProtKB
  • potassium ion transport Source: MGI
  • protein homooligomerization Source: InterPro
  • regulation of atrial cardiac muscle cell membrane repolarization Source: BHF-UCL
  • regulation of heart rate by cardiac conduction Source: BHF-UCL
  • regulation of insulin secretion Source: BHF-UCL
  • regulation of membrane potential Source: BHF-UCL
  • regulation of potassium ion transport Source: BHF-UCL
  • regulation of vasoconstriction Source: Ensembl
  • response to hydrogen peroxide Source: Ensembl
  • response to hyperoxia Source: Ensembl
  • response to hypoxia Source: Ensembl
  • response to mechanical stimulus Source: Ensembl
  • response to organic substance Source: Ensembl
  • synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.2.4. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 5
Alternative name(s):
HPCN1
Voltage-gated potassium channel HK2
Voltage-gated potassium channel subunit Kv1.5
Gene namesi
Name:KCNA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6224. KCNA5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 247247CytoplasmicBy similarityAdd
BLAST
Transmembranei248 – 26922Helical; Name=Segment S1By similarityAdd
BLAST
Topological domaini270 – 32354ExtracellularBy similarityAdd
BLAST
Transmembranei324 – 34522Helical; Name=Segment S2By similarityAdd
BLAST
Topological domaini346 – 35611CytoplasmicBy similarityAdd
BLAST
Transmembranei357 – 37721Helical; Name=Segment S3By similarityAdd
BLAST
Topological domaini378 – 39518ExtracellularBy similarityAdd
BLAST
Transmembranei396 – 41621Helical; Voltage-sensor; Name=Segment S4By similarityAdd
BLAST
Topological domaini417 – 43115CytoplasmicBy similarityAdd
BLAST
Transmembranei432 – 45322Helical; Name=Segment S5By similarityAdd
BLAST
Topological domaini454 – 46714ExtracellularBy similarityAdd
BLAST
Intramembranei468 – 47912Helical; Name=Pore helixBy similarityAdd
BLAST
Intramembranei480 – 4878By similarity
Topological domaini488 – 4947ExtracellularBy similarity
Transmembranei495 – 52329Helical; Name=Segment S6By similarityAdd
BLAST
Topological domaini524 – 61390CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • cytosol Source: GOC
  • endoplasmic reticulum Source: Ensembl
  • Golgi apparatus Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • intercalated disc Source: BHF-UCL
  • intracellular canaliculus Source: Ensembl
  • membrane raft Source: BHF-UCL
  • perinuclear region of cytoplasm Source: Ensembl
  • plasma membrane Source: UniProtKB
  • potassium channel complex Source: UniProtKB
  • voltage-gated potassium channel complex Source: BHF-UCL
  • Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Atrial fibrillation, familial, 7 (ATFB7)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

See also OMIM:612240

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi15 – 151T → A: Loss of DLG1 effect on channel current. 1 Publication
Mutagenesisi220 – 2201I → N: Reduces sumoylation; when associated with N-535. 1 Publication
Mutagenesisi221 – 2211K → R: Abolishes sumoylation; when associated with R-536. 1 Publication
Mutagenesisi535 – 5351L → N: Reduces sumoylation; when associated with N-220. 1 Publication
Mutagenesisi536 – 5361K → R: Abolishes sumoylation; when associated with R-221. 1 Publication

Keywords - Diseasei

Atrial fibrillation

Organism-specific databases

MIMi612240. phenotype.
Orphaneti334. Familial atrial fibrillation.
PharmGKBiPA208.

Chemistry

DrugBankiDB06637. Dalfampridine.

Polymorphism and mutation databases

BioMutaiKCNA5.
DMDMi146345443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613Potassium voltage-gated channel subfamily A member 5PRO_0000053985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki221 – 221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Lipidationi346 – 3461S-palmitoyl cysteineSequence Analysis
Cross-linki536 – 536Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Modified residuei557 – 5571Phosphoserine; by PKASequence Analysis

Post-translational modificationi

Sumoylated on Lys-221, and Lys-536, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel.1 Publication

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP22460.
PRIDEiP22460.

PTM databases

PhosphoSiteiP22460.

Expressioni

Tissue specificityi

Pancreatic islets and insulinoma.

Gene expression databases

BgeeiP22460.
CleanExiHS_KCNA5.
GenevisibleiP22460. HS.

Organism-specific databases

HPAiCAB022562.
HPA021516.

Interactioni

Subunit structurei

Homotetramer and heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 (By similarity). Interacts with KCNAB1 (PubMed:12130714). Interacts with UBE2I (PubMed:17261810).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN2P356096EBI-6426121,EBI-77797

Protein-protein interaction databases

BioGridi109943. 63 interactions.
DIPiDIP-42010N.
IntActiP22460. 2 interactions.
MINTiMINT-200758.
STRINGi9606.ENSP00000252321.

Structurei

3D structure databases

ProteinModelPortaliP22460.
SMRiP22460. Positions 120-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati61 – 71111Add
BLAST
Repeati72 – 82112Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 82222 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-PAdd
BLAST
Regioni418 – 43114S4-S5 linkerBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi480 – 4856Selectivity filterBy similarity
Motifi611 – 6133PDZ-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi94 – 996Poly-Glu
Compositional biasi382 – 3876Poly-Gly

Domaini

The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiP22460.
KOiK04878.
OMAiGGELQCP.
OrthoDBiEOG7M0NRD.
PhylomeDBiP22460.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004052. K_chnl_volt-dep_Kv1.5.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF25. PTHR11537:SF25. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01512. KV15CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P22460-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIALVPLEN GGAMTVRGGD EARAGCGQAT GGELQCPPTA GLSDGPKEPA
60 70 80 90 100
PKGRGAQRDA DSGVRPLPPL PDPGVRPLPP LPEELPRPRR PPPEDEEEEG
110 120 130 140 150
DPGLGTVEDQ ALGTASLHHQ RVHINISGLR FETQLGTLAQ FPNTLLGDPA
160 170 180 190 200
KRLRYFDPLR NEYFFDRNRP SFDGILYYYQ SGGRLRRPVN VSLDVFADEI
210 220 230 240 250
RFYQLGDEAM ERFREDEGFI KEEEKPLPRN EFQRQVWLIF EYPESSGSAR
260 270 280 290 300
AIAIVSVLVI LISIITFCLE TLPEFRDERE LLRHPPAPHQ PPAPAPGANG
310 320 330 340 350
SGVMAPPSGP TVAPLLPRTL ADPFFIVETT CVIWFTFELL VRFFACPSKA
360 370 380 390 400
GFSRNIMNII DVVAIFPYFI TLGTELAEQQ PGGGGGGQNG QQAMSLAILR
410 420 430 440 450
VIRLVRVFRI FKLSRHSKGL QILGKTLQAS MRELGLLIFF LFIGVILFSS
460 470 480 490 500
AVYFAEADNQ GTHFSSIPDA FWWAVVTMTT VGYGDMRPIT VGGKIVGSLC
510 520 530 540 550
AIAGVLTIAL PVPVIVSNFN YFYHRETDHE EPAVLKEEQG TQSQGPGLDR
560 570 580 590 600
GVQRKVSGSR GSFCKAGGTL ENADSARRGS CPLEKCNVKA KSNVDLRRSL
610
YALCLDTSRE TDL
Length:613
Mass (Da):67,228
Last modified:May 1, 2007 - v4
Checksum:iA5B02B27F8396E3D
GO
Isoform 2 (identifier: P22460-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Show »
Length:404
Mass (Da):44,427
Checksum:i75826108B430EAC1
GO

Sequence cautioni

The sequence AAA60146.1 differs from that shown. Reason: Frameshift at position 579. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551Missing in AAA61276 (PubMed:2001794).Curated
Sequence conflicti138 – 1381L → Q in AAA36422 (PubMed:1986382).Curated
Sequence conflicti154 – 1541R → P in AAA61276 (PubMed:2001794).Curated
Sequence conflicti154 – 1541R → P in AAA36422 (PubMed:1986382).Curated
Sequence conflicti187 – 1882RP → G in AAA61276 (PubMed:2001794).Curated
Sequence conflicti214 – 2141R → G in AAA36422 (PubMed:1986382).Curated
Sequence conflicti228 – 2281P → V in AAA36422 (PubMed:1986382).Curated
Sequence conflicti282 – 2821L → V in AAA60146 (PubMed:1349297).Curated
Sequence conflicti307 – 3071P → A in AAA61276 (PubMed:2001794).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti228 – 2281P → S.
Corresponds to variant rs1056464 [ dbSNP | Ensembl ].
VAR_053856
Natural varianti300 – 3001G → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_035770
Natural varianti578 – 5781R → K.
Corresponds to variant rs12720445 [ dbSNP | Ensembl ].
VAR_054786

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 209209Missing in isoform 2. CuratedVSP_037110Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60451 mRNA. Translation: AAA61276.1.
M55513 mRNA. Translation: AAA36422.1.
M83254 mRNA. Translation: AAA60146.1. Frameshift.
BC096357 mRNA. Translation: AAH96357.1.
BC096358 mRNA. Translation: AAH96358.3.
BC099665 mRNA. Translation: AAH99665.3.
BC099666 mRNA. Translation: AAH99666.3.
CCDSiCCDS8536.1. [P22460-1]
PIRiA56031.
RefSeqiNP_002225.2. NM_002234.3. [P22460-1]
UniGeneiHs.150208.
Hs.741439.

Genome annotation databases

EnsembliENST00000252321; ENSP00000252321; ENSG00000130037.
GeneIDi3741.
KEGGihsa:3741.
UCSCiuc001qni.4. human. [P22460-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60451 mRNA. Translation: AAA61276.1.
M55513 mRNA. Translation: AAA36422.1.
M83254 mRNA. Translation: AAA60146.1. Frameshift.
BC096357 mRNA. Translation: AAH96357.1.
BC096358 mRNA. Translation: AAH96358.3.
BC099665 mRNA. Translation: AAH99665.3.
BC099666 mRNA. Translation: AAH99666.3.
CCDSiCCDS8536.1. [P22460-1]
PIRiA56031.
RefSeqiNP_002225.2. NM_002234.3. [P22460-1]
UniGeneiHs.150208.
Hs.741439.

3D structure databases

ProteinModelPortaliP22460.
SMRiP22460. Positions 120-527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109943. 63 interactions.
DIPiDIP-42010N.
IntActiP22460. 2 interactions.
MINTiMINT-200758.
STRINGi9606.ENSP00000252321.

Chemistry

BindingDBiP22460.
ChEMBLiCHEMBL2362996.
DrugBankiDB06637. Dalfampridine.
GuidetoPHARMACOLOGYi542.

Protein family/group databases

TCDBi1.A.1.2.4. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteiP22460.

Polymorphism and mutation databases

BioMutaiKCNA5.
DMDMi146345443.

Proteomic databases

PaxDbiP22460.
PRIDEiP22460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252321; ENSP00000252321; ENSG00000130037.
GeneIDi3741.
KEGGihsa:3741.
UCSCiuc001qni.4. human. [P22460-1]

Organism-specific databases

CTDi3741.
GeneCardsiGC12P005153.
HGNCiHGNC:6224. KCNA5.
HPAiCAB022562.
HPA021516.
MIMi176267. gene.
612240. phenotype.
neXtProtiNX_P22460.
Orphaneti334. Familial atrial fibrillation.
PharmGKBiPA208.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiP22460.
KOiK04878.
OMAiGGELQCP.
OrthoDBiEOG7M0NRD.
PhylomeDBiP22460.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNA5.
GenomeRNAii3741.
NextBioi14639.
PROiP22460.
SOURCEiSearch...

Gene expression databases

BgeeiP22460.
CleanExiHS_KCNA5.
GenevisibleiP22460. HS.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004052. K_chnl_volt-dep_Kv1.5.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF25. PTHR11537:SF25. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01512. KV15CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle."
    Tamkun M.M., Knoth K.M., Walbridge J.A., Kroemer H., Roden D.M., Glover D.M.
    FASEB J. 5:331-337(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel."
    Philipson L.H., Hice R.E., Schaefer K., Lamendola J., Bell G.I., Nelson D.J., Steiner D.F.
    Proc. Natl. Acad. Sci. U.S.A. 88:53-57(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Insulinoma.
  3. "Molecular cloning, characterization, and genomic localization of a human potassium channel gene."
    Curran M.E., Landes G.M., Keating M.T.
    Genomics 12:729-737(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression."
    Snyders D.J., Tamkun M.M., Bennett P.B.
    J. Gen. Physiol. 101:513-543(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Altered state dependence of c-type inactivation in the long and short forms of human Kv1.5."
    Kurata H.T., Soon G.S., Fedida D.
    J. Gen. Physiol. 118:315-332(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
  7. "Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit."
    Williams C.P., Hu N., Shen W., Mashburn A.B., Murray K.T.
    J. Pharmacol. Exp. Ther. 302:545-550(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KCNAB1.
  8. "A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97."
    Mathur R., Choi W.S., Eldstrom J., Wang Z., Kim J., Steele D.F., Fedida D.
    Biochem. Biophys. Res. Commun. 342:1-8(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DLG1, MUTAGENESIS OF THR-15.
  9. "Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation."
    Olson T.M., Alekseev A.E., Liu X.K., Park S., Zingman L.V., Bienengraeber M., Sattiraju S., Ballew J.D., Jahangir A., Terzic A.
    Hum. Mol. Genet. 15:2185-2191(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ATFB7.
  10. Cited for: SUMOYLATION AT LYS-221 AND LYS-536, INTERACTION WITH UBE2I, MUTAGENESIS OF ILE-220; LYS-221; LEU-535 AND LYS-536.
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-300.

Entry informationi

Entry nameiKCNA5_HUMAN
AccessioniPrimary (citable) accession number: P22460
Secondary accession number(s): Q4KKT8
, Q4VAJ1, Q4VAJ2, Q9UDA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 1, 2007
Last modified: July 22, 2015
This is version 153 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.