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P22460

- KCNA5_HUMAN

UniProt

P22460 - KCNA5_HUMAN

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Protein
Potassium voltage-gated channel subfamily A member 5
Gene
KCNA5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.2 Publications

GO - Molecular functioni

  1. alpha-actinin binding Source: BHF-UCL
  2. delayed rectifier potassium channel activity Source: BHF-UCL
  3. outward rectifier potassium channel activity Source: BHF-UCL
  4. potassium channel inhibitor activity Source: Ensembl
  5. protein binding Source: IntAct
  6. protein kinase binding Source: BHF-UCL
  7. scaffold protein binding Source: BHF-UCL
  8. voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Source: BHF-UCL

GO - Biological processi

  1. atrial cardiac muscle cell action potential Source: BHF-UCL
  2. membrane hyperpolarization Source: BHF-UCL
  3. negative regulation of cytosolic calcium ion concentration Source: Ensembl
  4. negative regulation of potassium ion transport Source: Ensembl
  5. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  6. positive regulation of myoblast proliferation Source: Ensembl
  7. potassium ion export Source: BHF-UCL
  8. potassium ion homeostasis Source: Ensembl
  9. potassium ion transport Source: MGI
  10. protein homooligomerization Source: InterPro
  11. regulation of atrial cardiac muscle cell membrane repolarization Source: BHF-UCL
  12. regulation of heart rate by cardiac conduction Source: BHF-UCL
  13. regulation of insulin secretion Source: BHF-UCL
  14. regulation of membrane potential Source: BHF-UCL
  15. regulation of potassium ion transport Source: BHF-UCL
  16. regulation of vasoconstriction Source: Ensembl
  17. response to hypoxia Source: Ensembl
  18. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.2.4. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 5
Alternative name(s):
HPCN1
Voltage-gated potassium channel HK2
Voltage-gated potassium channel subunit Kv1.5
Gene namesi
Name:KCNA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6224. KCNA5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei251 – 26919Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Transmembranei325 – 34521Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Transmembranei356 – 37722Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Transmembranei398 – 41922Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Transmembranei434 – 45522Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Transmembranei495 – 51622Helical; Name=Segment S6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Z disc Source: Ensembl
  3. endoplasmic reticulum Source: Ensembl
  4. intercalated disc Source: BHF-UCL
  5. intracellular canaliculus Source: Ensembl
  6. membrane raft Source: BHF-UCL
  7. perinuclear region of cytoplasm Source: Ensembl
  8. plasma membrane Source: UniProtKB
  9. voltage-gated potassium channel complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Atrial fibrillation, familial, 7 (ATFB7) [MIM:612240]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi15 – 151T → A: Loss of DLG1 effect on channel current. 1 Publication
Mutagenesisi220 – 2201I → N: Reduces sumoylation; when associated with N-535. 1 Publication
Mutagenesisi221 – 2211K → R: Abolishes sumoylation; when associated with R-536. 1 Publication
Mutagenesisi535 – 5351L → N: Reduces sumoylation; when associated with N-220. 1 Publication
Mutagenesisi536 – 5361K → R: Abolishes sumoylation; when associated with R-221. 1 Publication

Keywords - Diseasei

Atrial fibrillation

Organism-specific databases

MIMi612240. phenotype.
Orphaneti334. Familial atrial fibrillation.
PharmGKBiPA208.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613Potassium voltage-gated channel subfamily A member 5
PRO_0000053985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Cross-linki221 – 221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Lipidationi346 – 3461S-palmitoyl cysteine Reviewed prediction
Cross-linki536 – 536Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei557 – 5571Phosphoserine; by PKA Reviewed prediction

Post-translational modificationi

Sumoylated on Lys-221, and Lys-536, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel.1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP22460.
PRIDEiP22460.

PTM databases

PhosphoSiteiP22460.

Expressioni

Tissue specificityi

Pancreatic islets and insulinoma.

Gene expression databases

BgeeiP22460.
CleanExiHS_KCNA5.
GenevestigatoriP22460.

Organism-specific databases

HPAiCAB022562.
HPA021516.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 By similarity. Interacts with UBE2I.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN2P356096EBI-6426121,EBI-77797

Protein-protein interaction databases

BioGridi109943. 27 interactions.
DIPiDIP-42010N.
IntActiP22460. 2 interactions.
MINTiMINT-200758.
STRINGi9606.ENSP00000252321.

Structurei

3D structure databases

ProteinModelPortaliP22460.
SMRiP22460. Positions 120-527.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati61 – 71111
Add
BLAST
Repeati72 – 82112
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 82222 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-P
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi480 – 4856Selectivity filter By similarity
Motifi611 – 6133PDZ-binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi94 – 996Poly-Glu
Compositional biasi382 – 3876Poly-Gly

Domaini

The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiP22460.
KOiK04878.
OMAiGGELQCP.
OrthoDBiEOG7M0NRD.
PhylomeDBiP22460.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004052. K_chnl_volt-dep_Kv1.5.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF25. PTHR11537:SF25. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01512. KV15CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P22460-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEIALVPLEN GGAMTVRGGD EARAGCGQAT GGELQCPPTA GLSDGPKEPA    50
PKGRGAQRDA DSGVRPLPPL PDPGVRPLPP LPEELPRPRR PPPEDEEEEG 100
DPGLGTVEDQ ALGTASLHHQ RVHINISGLR FETQLGTLAQ FPNTLLGDPA 150
KRLRYFDPLR NEYFFDRNRP SFDGILYYYQ SGGRLRRPVN VSLDVFADEI 200
RFYQLGDEAM ERFREDEGFI KEEEKPLPRN EFQRQVWLIF EYPESSGSAR 250
AIAIVSVLVI LISIITFCLE TLPEFRDERE LLRHPPAPHQ PPAPAPGANG 300
SGVMAPPSGP TVAPLLPRTL ADPFFIVETT CVIWFTFELL VRFFACPSKA 350
GFSRNIMNII DVVAIFPYFI TLGTELAEQQ PGGGGGGQNG QQAMSLAILR 400
VIRLVRVFRI FKLSRHSKGL QILGKTLQAS MRELGLLIFF LFIGVILFSS 450
AVYFAEADNQ GTHFSSIPDA FWWAVVTMTT VGYGDMRPIT VGGKIVGSLC 500
AIAGVLTIAL PVPVIVSNFN YFYHRETDHE EPAVLKEEQG TQSQGPGLDR 550
GVQRKVSGSR GSFCKAGGTL ENADSARRGS CPLEKCNVKA KSNVDLRRSL 600
YALCLDTSRE TDL 613
Length:613
Mass (Da):67,228
Last modified:May 1, 2007 - v4
Checksum:iA5B02B27F8396E3D
GO
Isoform 2 (identifier: P22460-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Show »
Length:404
Mass (Da):44,427
Checksum:i75826108B430EAC1
GO

Sequence cautioni

The sequence AAA60146.1 differs from that shown. Reason: Frameshift at position 579.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti228 – 2281P → S.
Corresponds to variant rs1056464 [ dbSNP | Ensembl ].
VAR_053856
Natural varianti300 – 3001G → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_035770
Natural varianti578 – 5781R → K.
Corresponds to variant rs12720445 [ dbSNP | Ensembl ].
VAR_054786

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 209209Missing in isoform 2.
VSP_037110Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551Missing in AAA61276. 1 Publication
Sequence conflicti138 – 1381L → Q in AAA36422. 1 Publication
Sequence conflicti154 – 1541R → P in AAA61276. 1 Publication
Sequence conflicti154 – 1541R → P in AAA36422. 1 Publication
Sequence conflicti187 – 1882RP → G in AAA61276. 1 Publication
Sequence conflicti214 – 2141R → G in AAA36422. 1 Publication
Sequence conflicti228 – 2281P → V in AAA36422. 1 Publication
Sequence conflicti282 – 2821L → V in AAA60146. 1 Publication
Sequence conflicti307 – 3071P → A in AAA61276. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60451 mRNA. Translation: AAA61276.1.
M55513 mRNA. Translation: AAA36422.1.
M83254 mRNA. Translation: AAA60146.1. Frameshift.
BC096357 mRNA. Translation: AAH96357.1.
BC096358 mRNA. Translation: AAH96358.3.
BC099665 mRNA. Translation: AAH99665.3.
BC099666 mRNA. Translation: AAH99666.3.
CCDSiCCDS8536.1. [P22460-1]
PIRiA56031.
RefSeqiNP_002225.2. NM_002234.3. [P22460-1]
UniGeneiHs.150208.
Hs.741439.

Genome annotation databases

EnsembliENST00000252321; ENSP00000252321; ENSG00000130037. [P22460-1]
GeneIDi3741.
KEGGihsa:3741.
UCSCiuc001qni.4. human. [P22460-1]

Polymorphism databases

DMDMi146345443.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60451 mRNA. Translation: AAA61276.1 .
M55513 mRNA. Translation: AAA36422.1 .
M83254 mRNA. Translation: AAA60146.1 . Frameshift.
BC096357 mRNA. Translation: AAH96357.1 .
BC096358 mRNA. Translation: AAH96358.3 .
BC099665 mRNA. Translation: AAH99665.3 .
BC099666 mRNA. Translation: AAH99666.3 .
CCDSi CCDS8536.1. [P22460-1 ]
PIRi A56031.
RefSeqi NP_002225.2. NM_002234.3. [P22460-1 ]
UniGenei Hs.150208.
Hs.741439.

3D structure databases

ProteinModelPortali P22460.
SMRi P22460. Positions 120-527.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109943. 27 interactions.
DIPi DIP-42010N.
IntActi P22460. 2 interactions.
MINTi MINT-200758.
STRINGi 9606.ENSP00000252321.

Chemistry

BindingDBi P22460.
ChEMBLi CHEMBL2362996.
GuidetoPHARMACOLOGYi 542.

Protein family/group databases

TCDBi 1.A.1.2.4. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei P22460.

Polymorphism databases

DMDMi 146345443.

Proteomic databases

PaxDbi P22460.
PRIDEi P22460.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252321 ; ENSP00000252321 ; ENSG00000130037 . [P22460-1 ]
GeneIDi 3741.
KEGGi hsa:3741.
UCSCi uc001qni.4. human. [P22460-1 ]

Organism-specific databases

CTDi 3741.
GeneCardsi GC12P005153.
HGNCi HGNC:6224. KCNA5.
HPAi CAB022562.
HPA021516.
MIMi 176267. gene.
612240. phenotype.
neXtProti NX_P22460.
Orphaneti 334. Familial atrial fibrillation.
PharmGKBi PA208.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231015.
HOVERGENi HBG052230.
InParanoidi P22460.
KOi K04878.
OMAi GGELQCP.
OrthoDBi EOG7M0NRD.
PhylomeDBi P22460.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNA5.
GenomeRNAii 3741.
NextBioi 14639.
PROi P22460.
SOURCEi Search...

Gene expression databases

Bgeei P22460.
CleanExi HS_KCNA5.
Genevestigatori P22460.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004052. K_chnl_volt-dep_Kv1.5.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
PTHR11537:SF25. PTHR11537:SF25. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01512. KV15CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle."
    Tamkun M.M., Knoth K.M., Walbridge J.A., Kroemer H., Roden D.M., Glover D.M.
    FASEB J. 5:331-337(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel."
    Philipson L.H., Hice R.E., Schaefer K., Lamendola J., Bell G.I., Nelson D.J., Steiner D.F.
    Proc. Natl. Acad. Sci. U.S.A. 88:53-57(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Insulinoma.
  3. "Molecular cloning, characterization, and genomic localization of a human potassium channel gene."
    Curran M.E., Landes G.M., Keating M.T.
    Genomics 12:729-737(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression."
    Snyders D.J., Tamkun M.M., Bennett P.B.
    J. Gen. Physiol. 101:513-543(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Altered state dependence of c-type inactivation in the long and short forms of human Kv1.5."
    Kurata H.T., Soon G.S., Fedida D.
    J. Gen. Physiol. 118:315-332(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
  7. "A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97."
    Mathur R., Choi W.S., Eldstrom J., Wang Z., Kim J., Steele D.F., Fedida D.
    Biochem. Biophys. Res. Commun. 342:1-8(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DLG1, MUTAGENESIS OF THR-15.
  8. "Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation."
    Olson T.M., Alekseev A.E., Liu X.K., Park S., Zingman L.V., Bienengraeber M., Sattiraju S., Ballew J.D., Jahangir A., Terzic A.
    Hum. Mol. Genet. 15:2185-2191(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ATFB7.
  9. Cited for: SUMOYLATION AT LYS-221 AND LYS-536, INTERACTION WITH UBE2I, MUTAGENESIS OF ILE-220; LYS-221; LEU-535 AND LYS-536.
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-300.

Entry informationi

Entry nameiKCNA5_HUMAN
AccessioniPrimary (citable) accession number: P22460
Secondary accession number(s): Q4KKT8
, Q4VAJ1, Q4VAJ2, Q9UDA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 144 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi