##gff-version 3 P22459 UniProtKB Chain 1 653 . . . ID=PRO_0000053981;Note=Potassium voltage-gated channel subfamily A member 4 P22459 UniProtKB Topological domain 1 304 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Transmembrane 305 326 . . . Note=Helical%3B Name%3DSegment S1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Topological domain 327 370 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Transmembrane 371 392 . . . Note=Helical%3B Name%3DSegment S2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Topological domain 393 403 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Transmembrane 404 424 . . . Note=Helical%3B Name%3DSegment S3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Topological domain 425 439 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Transmembrane 440 460 . . . Note=Helical%3B Voltage-sensor%3B Name%3DSegment S4;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Topological domain 461 475 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Transmembrane 476 497 . . . Note=Helical%3B Name%3DSegment S5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Topological domain 498 511 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Intramembrane 512 523 . . . Note=Helical%3B Name%3DPore helix;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Intramembrane 524 531 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Topological domain 532 538 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Transmembrane 539 567 . . . Note=Helical%3B Name%3DSegment S6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Topological domain 568 653 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Region 24 148 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P22459 UniProtKB Region 462 475 . . . Note=S4-S5 linker;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Region 629 653 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P22459 UniProtKB Motif 524 529 . . . Note=Selectivity filter;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63142 P22459 UniProtKB Motif 651 653 . . . Note=PDZ-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 P22459 UniProtKB Compositional bias 80 94 . . . Note=Basic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P22459 UniProtKB Compositional bias 120 140 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P22459 UniProtKB Modified residue 90 90 . . . Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000255;evidence=ECO:0000255 P22459 UniProtKB Modified residue 122 122 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61423 P22459 UniProtKB Modified residue 599 599 . . . Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000255;evidence=ECO:0000255 P22459 UniProtKB Glycosylation 352 352 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P22459 UniProtKB Natural variant 89 89 . . . ID=VAR_081837;Note=In MCIDDS%3B uncertain significance%3B mildly decreased function in potassium transmembrane transport. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27582084;Dbxref=dbSNP:rs779101828,PMID:27582084 P22459 UniProtKB Sequence conflict 38 38 . . . Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P22459 UniProtKB Sequence conflict 42 42 . . . Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P22459 UniProtKB Sequence conflict 84 88 . . . Note=RRRRQ->EEEAT;Ontology_term=ECO:0000305;evidence=ECO:0000305 P22459 UniProtKB Sequence conflict 304 304 . . . Note=S->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 P22459 UniProtKB Sequence conflict 542 542 . . . Note=S->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P22459 UniProtKB Sequence conflict 631 631 . . . Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305