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P22458

- VTNC_RABIT

UniProt

P22458 - VTNC_RABIT

Protein

Vitronectin

Gene

VTN

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. polysaccharide binding Source: InterPro
    3. scavenger receptor activity Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. immune response Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vitronectin
    Short name:
    VN
    Alternative name(s):
    Glycoprotein 66
    S-protein
    Serum-spreading factor
    Gene namesi
    Name:VTN
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 475456VitronectinPRO_0000036400Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 40Alternate; alternatePROSITE-ProRule annotation
    Disulfide bondi24 ↔ 28Alternate; alternatePROSITE-ProRule annotation
    Disulfide bondi28 ↔ 58Alternate; alternatePROSITE-ProRule annotation
    Disulfide bondi38 ↔ 51Alternate; alternatePROSITE-ProRule annotation
    Disulfide bondi38 ↔ 40Alternate; alternatePROSITE-ProRule annotation
    Disulfide bondi44 ↔ 50PROSITE-ProRule annotation
    Disulfide bondi51 ↔ 58Alternate; alternatePROSITE-ProRule annotation
    Modified residuei69 – 691PhosphothreonineBy similarity
    Modified residuei75 – 751SulfotyrosineSequence Analysis
    Modified residuei78 – 781SulfotyrosineSequence Analysis
    Modified residuei80 – 801SulfotyrosineSequence Analysis
    Glycosylationi87 – 871N-linked (GlcNAc...)1 Publication
    Glycosylationi169 – 1691N-linked (GlcNAc...)1 Publication
    Glycosylationi242 – 2421N-linked (GlcNAc...)1 Publication
    Modified residuei279 – 2791SulfotyrosineSequence Analysis
    Modified residuei282 – 2821SulfotyrosineSequence Analysis
    Modified residuei312 – 3121PhosphoserineBy similarity
    Modified residuei394 – 3941PhosphoserineBy similarity

    Post-translational modificationi

    Sulfated on 2 tyrosine residues.By similarity
    N- and O-glycosylated.1 Publication
    It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

    Expressioni

    Tissue specificityi

    Plasma.

    Interactioni

    Subunit structurei

    Interacts with SERPINE1/PAI1 and C1QBP By similarity. Monomer.By similarity

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000024132.

    Structurei

    3D structure databases

    ProteinModelPortaliP22458.
    SMRiP22458. Positions 20-70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 6344SMBPROSITE-ProRule annotationAdd
    BLAST
    Repeati158 – 20245Hemopexin 1Add
    BLAST
    Repeati203 – 25048Hemopexin 2Add
    BLAST
    Repeati251 – 30555Hemopexin 3Add
    BLAST
    Repeati419 – 46951Hemopexin 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni366 – 39227Glycosaminoglycan binding regionAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi64 – 663Cell attachment site

    Domaini

    The SMB domain mediates interaction with SERPINE1/PAI1.By similarity

    Sequence similaritiesi

    Contains 4 hemopexin repeats.Curated
    Contains 1 SMB (somatomedin-B) domain.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG245064.
    HOGENOMiHOG000133161.
    HOVERGENiHBG002902.

    Family and domain databases

    Gene3Di2.110.10.10. 3 hits.
    InterProiIPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR018486. Hemopexin_CS.
    IPR020436. Somatomedin_B_chordata.
    IPR001212. Somatomedin_B_dom.
    [Graphical view]
    PfamiPF00045. Hemopexin. 4 hits.
    PF01033. Somatomedin_B. 1 hit.
    [Graphical view]
    PRINTSiPR00022. SOMATOMEDINB.
    SMARTiSM00120. HX. 4 hits.
    SM00201. SO. 1 hit.
    [Graphical view]
    SUPFAMiSSF50923. SSF50923. 3 hits.
    PROSITEiPS00024. HEMOPEXIN. 2 hits.
    PS51642. HEMOPEXIN_2. 4 hits.
    PS00524. SMB_1. 1 hit.
    PS50958. SMB_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22458-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLRPIFTL ALLLWVVLAD QESCKDRCTE GFNANRKCQC DELCSYYQSC    50
    CADYAAECKP QVTRGDVFTM PEDEYGPYDY IEQTKDNASV HAQPESPTVG 100
    QEPTLSPDLQ TEGGAEPTHE VPLEPEMETL RPEGEDLQAG TTELGTSASP 150
    AEEELCSGKP FDAFTDLKNG SLFAFRGQYC YELDETAVRP GYPKLIQDVW 200
    GIEGPIDAAF TRINCQGKTY LFKGSQYWRF EDGILDPDYP RNISEGFSGI 250
    PDNVDAAFAL PAHSYSGRER VYFFKGDKYW EYQFQQQPSQ EECEGSSLSA 300
    VFEHFAMLHR DSWEDIFKLL FWGRPSGGAR QPQFISRDWH GVPGKVDAAM 350
    AGRIYISGLT PSPSAKKQKS RRRSRKRYRS RYGRGRSQNS RRLSRSISRL 400
    WFSSEEVSLG PYNYEDYETS WLKPATSEPI QSVYFFSGDK YYRVNLRTQR 450
    VDTVNPPYPR SIAQYWLGCP APGGQ 475
    Length:475
    Mass (Da):53,943
    Last modified:August 1, 1991 - v1
    Checksum:iD5D1F31B8C2FA12D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261D → G AA sequence (PubMed:1372829)Curated
    Sequence conflicti34 – 352AN → SD AA sequence (PubMed:1372829)Curated
    Sequence conflicti44 – 441C → P AA sequence (PubMed:1372829)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55442 mRNA. Translation: AAA31258.1.
    PIRiA38340.
    RefSeqiNP_001075761.1. NM_001082292.1.
    UniGeneiOcu.1882.

    Genome annotation databases

    GeneIDi100009128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55442 mRNA. Translation: AAA31258.1 .
    PIRi A38340.
    RefSeqi NP_001075761.1. NM_001082292.1.
    UniGenei Ocu.1882.

    3D structure databases

    ProteinModelPortali P22458.
    SMRi P22458. Positions 20-70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000024132.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100009128.

    Organism-specific databases

    CTDi 7448.

    Phylogenomic databases

    eggNOGi NOG245064.
    HOGENOMi HOG000133161.
    HOVERGENi HBG002902.

    Family and domain databases

    Gene3Di 2.110.10.10. 3 hits.
    InterProi IPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR018486. Hemopexin_CS.
    IPR020436. Somatomedin_B_chordata.
    IPR001212. Somatomedin_B_dom.
    [Graphical view ]
    Pfami PF00045. Hemopexin. 4 hits.
    PF01033. Somatomedin_B. 1 hit.
    [Graphical view ]
    PRINTSi PR00022. SOMATOMEDINB.
    SMARTi SM00120. HX. 4 hits.
    SM00201. SO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50923. SSF50923. 3 hits.
    PROSITEi PS00024. HEMOPEXIN. 2 hits.
    PS51642. HEMOPEXIN_2. 4 hits.
    PS00524. SMB_1. 1 hit.
    PS50958. SMB_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Monoclonal antibody EMR1a/212D recognizing site of deposition of extracellular lipid in atherosclerosis. Isolation and characterization of a cDNA clone for the antigen."
      Sato R., Komine Y., Imanaka T., Takano T.
      J. Biol. Chem. 265:21232-21236(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    2. "Vitronectin diversity in evolution but uniformity in ligand binding and size of the core polypeptide."
      Nakashima N., Miyazaki K., Ishikawa M., Yatohgo T., Ogawa H., Uchibori H., Matsumoto I., Seno N., Hayashi M.
      Biochim. Biophys. Acta 1120:1-10(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-44, GLYCOSYLATION.

    Entry informationi

    Entry nameiVTNC_RABIT
    AccessioniPrimary (citable) accession number: P22458
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3