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Protein

Vitronectin

Gene

VTN

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vitronectin
Short name:
VN
Alternative name(s):
Glycoprotein 66
S-protein
Serum-spreading factor
Gene namesi
Name:VTN
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000003640020 – 475VitronectinAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 40PROSITE-ProRule annotation
Disulfide bondi24 ↔ 28AlternatePROSITE-ProRule annotation
Disulfide bondi28 ↔ 58PROSITE-ProRule annotation
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi38 ↔ 40PROSITE-ProRule annotation
Disulfide bondi44 ↔ 50PROSITE-ProRule annotation
Disulfide bondi51 ↔ 58PROSITE-ProRule annotation
Modified residuei69PhosphothreonineBy similarity1
Modified residuei75SulfotyrosineSequence analysis1
Modified residuei78SulfotyrosineSequence analysis1
Modified residuei80SulfotyrosineSequence analysis1
Glycosylationi87N-linked (GlcNAc...)1 Publication1
Glycosylationi169N-linked (GlcNAc...)1 Publication1
Glycosylationi242N-linked (GlcNAc...)1 Publication1
Modified residuei279SulfotyrosineSequence analysis1
Modified residuei282SulfotyrosineSequence analysis1
Modified residuei312PhosphoserineBy similarity1
Modified residuei394PhosphoserineBy similarity1

Post-translational modificationi

Sulfated on 2 tyrosine residues.By similarity
N- and O-glycosylated.1 Publication
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PRIDEiP22458.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Subunit structurei

Interacts with SERPINE1/PAI1 and C1QBP (By similarity). Monomer.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000024132.

Structurei

3D structure databases

ProteinModelPortaliP22458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 63SMBPROSITE-ProRule annotationAdd BLAST44
Repeati158 – 202Hemopexin 1Add BLAST45
Repeati203 – 250Hemopexin 2Add BLAST48
Repeati251 – 305Hemopexin 3Add BLAST55
Repeati419 – 469Hemopexin 4Add BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni366 – 392Glycosaminoglycan binding regionAdd BLAST27

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 66Cell attachment site3

Domaini

The SMB domain mediates interaction with SERPINE1/PAI1.By similarity

Sequence similaritiesi

Contains 4 hemopexin repeats.Curated
Contains 1 SMB (somatomedin-B) domain.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
HOGENOMiHOG000133161.
HOVERGENiHBG002902.
InParanoidiP22458.
KOiK06251.

Family and domain databases

CDDicd00094. HX. 1 hit.
Gene3Di2.110.10.10. 3 hits.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR020436. Somatomedin_B_chordata.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PfamiPF00045. Hemopexin. 4 hits.
PF01033. Somatomedin_B. 1 hit.
[Graphical view]
PRINTSiPR00022. SOMATOMEDINB.
SMARTiSM00120. HX. 4 hits.
SM00201. SO. 1 hit.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 3 hits.
SSF90188. SSF90188. 1 hit.
PROSITEiPS00024. HEMOPEXIN. 2 hits.
PS51642. HEMOPEXIN_2. 4 hits.
PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLRPIFTL ALLLWVVLAD QESCKDRCTE GFNANRKCQC DELCSYYQSC
60 70 80 90 100
CADYAAECKP QVTRGDVFTM PEDEYGPYDY IEQTKDNASV HAQPESPTVG
110 120 130 140 150
QEPTLSPDLQ TEGGAEPTHE VPLEPEMETL RPEGEDLQAG TTELGTSASP
160 170 180 190 200
AEEELCSGKP FDAFTDLKNG SLFAFRGQYC YELDETAVRP GYPKLIQDVW
210 220 230 240 250
GIEGPIDAAF TRINCQGKTY LFKGSQYWRF EDGILDPDYP RNISEGFSGI
260 270 280 290 300
PDNVDAAFAL PAHSYSGRER VYFFKGDKYW EYQFQQQPSQ EECEGSSLSA
310 320 330 340 350
VFEHFAMLHR DSWEDIFKLL FWGRPSGGAR QPQFISRDWH GVPGKVDAAM
360 370 380 390 400
AGRIYISGLT PSPSAKKQKS RRRSRKRYRS RYGRGRSQNS RRLSRSISRL
410 420 430 440 450
WFSSEEVSLG PYNYEDYETS WLKPATSEPI QSVYFFSGDK YYRVNLRTQR
460 470
VDTVNPPYPR SIAQYWLGCP APGGQ
Length:475
Mass (Da):53,943
Last modified:August 1, 1991 - v1
Checksum:iD5D1F31B8C2FA12D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26D → G AA sequence (PubMed:1372829).Curated1
Sequence conflicti34 – 35AN → SD AA sequence (PubMed:1372829).Curated2
Sequence conflicti44C → P AA sequence (PubMed:1372829).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55442 mRNA. Translation: AAA31258.1.
PIRiA38340.
RefSeqiNP_001075761.1. NM_001082292.1.
UniGeneiOcu.1882.

Genome annotation databases

GeneIDi100009128.
KEGGiocu:100009128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55442 mRNA. Translation: AAA31258.1.
PIRiA38340.
RefSeqiNP_001075761.1. NM_001082292.1.
UniGeneiOcu.1882.

3D structure databases

ProteinModelPortaliP22458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000024132.

Proteomic databases

PRIDEiP22458.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009128.
KEGGiocu:100009128.

Organism-specific databases

CTDi7448.

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
HOGENOMiHOG000133161.
HOVERGENiHBG002902.
InParanoidiP22458.
KOiK06251.

Family and domain databases

CDDicd00094. HX. 1 hit.
Gene3Di2.110.10.10. 3 hits.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR020436. Somatomedin_B_chordata.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PfamiPF00045. Hemopexin. 4 hits.
PF01033. Somatomedin_B. 1 hit.
[Graphical view]
PRINTSiPR00022. SOMATOMEDINB.
SMARTiSM00120. HX. 4 hits.
SM00201. SO. 1 hit.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 3 hits.
SSF90188. SSF90188. 1 hit.
PROSITEiPS00024. HEMOPEXIN. 2 hits.
PS51642. HEMOPEXIN_2. 4 hits.
PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVTNC_RABIT
AccessioniPrimary (citable) accession number: P22458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.