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P22458 (VTNC_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Vitronectin
Short name=VN
Alternative name(s):
Glycoprotein 66
S-protein
Serum-spreading factor
Gene names
Name:VTN
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

Subunit structure

Interacts with SERPINE1/PAI1 and C1QBP By similarity. Monomer.

Subcellular location

Secreted › extracellular space.

Tissue specificity

Plasma.

Domain

The SMB domain mediates interaction with SERPINE1/PAI1 By similarity.

Post-translational modification

Sulfated on 2 tyrosine residues By similarity.

N- and O-glycosylated. Ref.2

It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

Sequence similarities

Contains 4 hemopexin-like domains.

Contains 1 SMB (somatomedin-B) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.2
Chain20 – 475456Vitronectin
PRO_0000036400

Regions

Domain20 – 6344SMB
Domain161 – 20444Hemopexin-like 1
Domain206 – 25247Hemopexin-like 2
Domain254 – 30451Hemopexin-like 3
Domain422 – 46948Hemopexin-like 4
Region366 – 39227Glycosaminoglycan binding region
Motif64 – 663Cell attachment site

Amino acid modifications

Modified residue691Phosphothreonine By similarity
Modified residue751Sulfotyrosine Potential
Modified residue781Sulfotyrosine Potential
Modified residue801Sulfotyrosine Potential
Modified residue2791Sulfotyrosine Potential
Modified residue2821Sulfotyrosine Potential
Modified residue3121Phosphoserine By similarity
Modified residue3941Phosphoserine By similarity
Glycosylation871N-linked (GlcNAc...) Probable
Glycosylation1691N-linked (GlcNAc...) Probable
Glycosylation2421N-linked (GlcNAc...) Probable
Disulfide bond24 ↔ 40Alternate By similarity
Disulfide bond24 ↔ 28Alternate By similarity
Disulfide bond28 ↔ 58Alternate By similarity
Disulfide bond38 ↔ 51Alternate By similarity
Disulfide bond38 ↔ 40Alternate By similarity
Disulfide bond44 ↔ 50 By similarity
Disulfide bond51 ↔ 58Alternate By similarity

Experimental info

Sequence conflict261D → G AA sequence Ref.2
Sequence conflict34 – 352AN → SD AA sequence Ref.2
Sequence conflict441C → P AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P22458 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: D5D1F31B8C2FA12D

FASTA47553,943
        10         20         30         40         50         60 
MAPLRPIFTL ALLLWVVLAD QESCKDRCTE GFNANRKCQC DELCSYYQSC CADYAAECKP 

        70         80         90        100        110        120 
QVTRGDVFTM PEDEYGPYDY IEQTKDNASV HAQPESPTVG QEPTLSPDLQ TEGGAEPTHE 

       130        140        150        160        170        180 
VPLEPEMETL RPEGEDLQAG TTELGTSASP AEEELCSGKP FDAFTDLKNG SLFAFRGQYC 

       190        200        210        220        230        240 
YELDETAVRP GYPKLIQDVW GIEGPIDAAF TRINCQGKTY LFKGSQYWRF EDGILDPDYP 

       250        260        270        280        290        300 
RNISEGFSGI PDNVDAAFAL PAHSYSGRER VYFFKGDKYW EYQFQQQPSQ EECEGSSLSA 

       310        320        330        340        350        360 
VFEHFAMLHR DSWEDIFKLL FWGRPSGGAR QPQFISRDWH GVPGKVDAAM AGRIYISGLT 

       370        380        390        400        410        420 
PSPSAKKQKS RRRSRKRYRS RYGRGRSQNS RRLSRSISRL WFSSEEVSLG PYNYEDYETS 

       430        440        450        460        470 
WLKPATSEPI QSVYFFSGDK YYRVNLRTQR VDTVNPPYPR SIAQYWLGCP APGGQ

« Hide

References

[1]"Monoclonal antibody EMR1a/212D recognizing site of deposition of extracellular lipid in atherosclerosis. Isolation and characterization of a cDNA clone for the antigen."
Sato R., Komine Y., Imanaka T., Takano T.
J. Biol. Chem. 265:21232-21236(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]"Vitronectin diversity in evolution but uniformity in ligand binding and size of the core polypeptide."
Nakashima N., Miyazaki K., Ishikawa M., Yatohgo T., Ogawa H., Uchibori H., Matsumoto I., Seno N., Hayashi M.
Biochim. Biophys. Acta 1120:1-10(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-44, GLYCOSYLATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M55442 mRNA. Translation: AAA31258.1.
PIRA38340.
RefSeqNP_001075761.1. NM_001082292.1.
UniGeneOcu.1882.

3D structure databases

ProteinModelPortalP22458.
SMRP22458. Positions 20-70.
ModBaseSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000024132.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009128.

Organism-specific databases

CTD7448.

Phylogenomic databases

eggNOGNOG245064.
HOGENOMHOG000133161.
HOVERGENHBG002902.
OrthoDBEOG4JT065.

Family and domain databases

Gene3D2.110.10.10. 3 hits.
InterProIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR020436. Somatomedin_B_chordata.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PfamPF00045. Hemopexin. 4 hits.
PF01033. Somatomedin_B. 1 hit.
[Graphical view]
PRINTSPR00022. SOMATOMEDINB.
SMARTSM00120. HX. 4 hits.
SM00201. SO. 1 hit.
[Graphical view]
SUPFAMSSF50923. Hemopexin. 1 hit.
PROSITEPS00024. HEMOPEXIN. 2 hits.
PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVTNC_RABIT
AccessionPrimary (citable) accession number: P22458
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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