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Protein

Coagulation factor VII

Gene

F7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

Catalytic activityi

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei93Important for S-92 for O-xylosylationBy similarity1
Active sitei233Charge relay systemBy similarity1
Active sitei282Charge relay systemBy similarity1
Binding sitei378SubstrateBy similarity1
Active sitei384Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processBlood coagulation, Hemostasis
LigandCalcium

Enzyme and pathway databases

ReactomeiR-BTA-140834 Extrinsic Pathway of Fibrin Clot Formation
R-BTA-159740 Gamma-carboxylation of protein precursors
R-BTA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-BTA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins

Protein family/group databases

MEROPSiS01.215

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor VII (EC:3.4.21.21)
Alternative name(s):
Serum prothrombin conversion accelerator
Cleaved into the following 2 chains:
Gene namesi
Name:F7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:28689 F7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000024012624 – 401 PublicationAdd BLAST17
ChainiPRO_000002772741 – 192Factor VII light chain1 PublicationAdd BLAST152
ChainiPRO_0000027728193 – 447Factor VII heavy chain1 PublicationAdd BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei464-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Modified residuei474-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Modified residuei544-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Modified residuei564-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Disulfide bondi57 ↔ 62By similarity
Modified residuei594-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Modified residuei604-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Modified residuei654-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Modified residuei664-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Modified residuei694-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Modified residuei744-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Modified residuei754-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Disulfide bondi90 ↔ 101By similarity
Glycosylationi92O-linked (Glc...) serine2 Publications1
Glycosylationi92O-linked (Glc...) serine; alternateBy similarity2 Publications1
Glycosylationi92O-linked (Xyl...) serine; alternateBy similarity2 Publications1
Disulfide bondi95 ↔ 110By similarity
Glycosylationi100O-linked (Fuc) serineBy similarity1
Disulfide bondi112 ↔ 121By similarity
Disulfide bondi131 ↔ 142By similarity
Disulfide bondi138 ↔ 152By similarity
Disulfide bondi154 ↔ 167By similarity
Disulfide bondi175 ↔ 302By similarity
Glycosylationi185N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi199 ↔ 204By similarity
Disulfide bondi218 ↔ 234By similarity
Glycosylationi243N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi350 ↔ 369By similarity
Disulfide bondi380 ↔ 408By similarity

Post-translational modificationi

The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
O-glycosylated. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines.By similarity
Can be either O-glucosylated or O-xylosylated at Ser-92 by POGLUT1.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei192 – 193Cleavage; by factor Xa, factor XIIa, factor IXa, or thrombin2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP22457
PRIDEiP22457

PTM databases

iPTMnetiP22457

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSBTAG00000007411

Interactioni

Subunit structurei

Heterodimer of a light chain and a heavy chain linked by a disulfide bond.

Protein-protein interaction databases

ELMiP22457
STRINGi9913.ENSBTAP00000009746

Structurei

3D structure databases

ProteinModelPortaliP22457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 85GlaPROSITE-ProRule annotationAdd BLAST45
Domaini86 – 122EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini127 – 168EGF-like 2PROSITE-ProRule annotationAdd BLAST42
Domaini193 – 432Peptidase S1PROSITE-ProRule annotationAdd BLAST240

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIMB Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118890
HOGENOMiHOG000251821
HOVERGENiHBG013304
InParanoidiP22457
KOiK01320
OMAiCEQYCSD
OrthoDBiEOG091G0AH5
TreeFamiTF327329

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di4.10.740.10, 1 hit
InterProiView protein in InterPro
IPR017857 Coagulation_fac-like_Gla_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR033190 F7
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR012224 Pept_S1A_FX
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PANTHERiPTHR44064:SF1 PTHR44064:SF1, 1 hit
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00594 Gla, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001143 Factor_X, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
PR00001 GLABLOOD
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
SM00069 GLA, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSQAWALAL LCFLLSLWGS LPAVFLPQEQ ALSILHRPRR ANGFLEELLP
60 70 80 90 100
GSLERECREE LCSFEEAHEI FRNEERTRQF WVSYNDGDQC ASSPCQNGGS
110 120 130 140 150
CEDQLRSYIC FCPDGFEGRN CETDKQSQLI CANDNGGCEQ YCGADPGAGR
160 170 180 190 200
FCWCHEGYAL QADGVSCAPT VEYPCGKIPV LEKRNGSKPQ GRIVGGHVCP
210 220 230 240 250
KGECPWQAML KLNGALLCGG TLVGPAWVVS AAHCFERLRS RGNLTAVLGE
260 270 280 290 300
HDLSRVEGPE QERRVAQIIV PKQYVPGQTD HDVALLQLAQ PVALGDHVAP
310 320 330 340 350
LCLPDPDFAD QTLAFVRFSA VSGWGQLLER GVTARKLMVV LVPRLLTQDC
360 370 380 390 400
LQQSRQRPGG PVVTDNMFCA GYSDGSKDAC KGDSGGPHAT RFRGTWFLTG
410 420 430 440
VVSWGEGCAA AGHFGIYTRV SRYTAWLRQL MGHPPSRQGF FQVPLLP
Length:447
Mass (Da):48,961
Last modified:June 13, 2006 - v2
Checksum:i6FE6CA805E84B871
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021584 mRNA Translation: AAX46431.1
BC146045 mRNA Translation: AAI46046.1
PIRiA31979 KFBO7
RefSeqiNP_001029978.1, NM_001034806.1
UniGeneiBt.37397

Genome annotation databases

EnsembliENSBTAT00000009746; ENSBTAP00000009746; ENSBTAG00000007411
GeneIDi617960
KEGGibta:617960

Similar proteinsi

Entry informationi

Entry nameiFA7_BOVIN
AccessioniPrimary (citable) accession number: P22457
Secondary accession number(s): A6H6Y5, Q58DL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 13, 2006
Last modified: June 20, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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