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P22452

- RL39_HALMA

UniProt

P22452 - RL39_HALMA

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Protein

50S ribosomal protein L39e

Gene

rpl39e

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA. Forms part of the polypeptide exit tunnel.

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-KW
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-2791-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L39e
Alternative name(s):
Hl39e
Hl46e
Gene namesi
Name:rpl39e
Ordered Locus Names:rrnAC3112
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 504950S ribosomal protein L39ePRO_0000127047Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Interacts weakly with protein L23.2 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC3112.

Structurei

Secondary structure

1
50
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1813Combined sources
Helixi24 – 296Combined sources
Turni30 – 323Combined sources
Turni43 – 453Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40Y2-50[»]
1JJ2X-ray2.4012-49[»]
1K73X-ray3.0132-49[»]
1K8AX-ray3.0032-49[»]
1K9MX-ray3.0032-49[»]
1KC8X-ray3.0132-49[»]
1KD1X-ray3.0032-49[»]
1KQSX-ray3.1012-49[»]
1M1KX-ray3.2032-49[»]
1M90X-ray2.8032-49[»]
1N8RX-ray3.0032-49[»]
1NJIX-ray3.0032-49[»]
1Q7YX-ray3.2032-49[»]
1Q81X-ray2.9532-49[»]
1Q82X-ray2.9832-49[»]
1Q86X-ray3.0032-49[»]
1QVFX-ray3.1012-49[»]
1QVGX-ray2.9012-49[»]
1S72X-ray2.4021-50[»]
1VQ4X-ray2.7021-50[»]
1VQ5X-ray2.6021-50[»]
1VQ6X-ray2.7021-50[»]
1VQ7X-ray2.5021-50[»]
1VQ8X-ray2.2021-50[»]
1VQ9X-ray2.4021-50[»]
1VQKX-ray2.3021-50[»]
1VQLX-ray2.3021-50[»]
1VQMX-ray2.3021-50[»]
1VQNX-ray2.4021-50[»]
1VQOX-ray2.2021-50[»]
1VQPX-ray2.2521-50[»]
1W2BX-ray3.5012-49[»]
1YHQX-ray2.4021-50[»]
1YI2X-ray2.6521-50[»]
1YIJX-ray2.6021-50[»]
1YITX-ray2.8021-50[»]
1YJ9X-ray2.9021-50[»]
1YJNX-ray3.0021-50[»]
1YJWX-ray2.9021-50[»]
2OTJX-ray2.9021-50[»]
2OTLX-ray2.7021-50[»]
2QA4X-ray3.0021-50[»]
2QEXX-ray2.9021-50[»]
3CC2X-ray2.4021-50[»]
3CC4X-ray2.7021-50[»]
3CC7X-ray2.7021-50[»]
3CCEX-ray2.7521-50[»]
3CCJX-ray2.7021-50[»]
3CCLX-ray2.9021-50[»]
3CCMX-ray2.5521-50[»]
3CCQX-ray2.9021-50[»]
3CCRX-ray3.0021-50[»]
3CCSX-ray2.9521-50[»]
3CCUX-ray2.8021-50[»]
3CCVX-ray2.9021-50[»]
3CD6X-ray2.7521-50[»]
3CMAX-ray2.8021-50[»]
3CMEX-ray2.9521-50[»]
3CPWX-ray2.7011-50[»]
3CXCX-ray3.0012-50[»]
3G4SX-ray3.2021-50[»]
3G6EX-ray2.7021-50[»]
3G71X-ray2.8521-50[»]
3I55X-ray3.1121-50[»]
3I56X-ray2.9021-50[»]
3OW2X-ray2.7012-50[»]
4ADXelectron microscopy6.6021-50[»]
4HUBX-ray2.4021-50[»]
ProteinModelPortaliP22452.
SMRiP22452. Positions 2-50.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22452.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L39e family.Curated

Phylogenomic databases

eggNOGiCOG2167.
HOGENOMiHOG000230627.
KOiK02924.
OMAiPAWVIMK.

Family and domain databases

Gene3Di1.10.1620.10. 1 hit.
HAMAPiMF_00629. Ribosomal_L39e.
InterProiIPR000077. Ribosomal_L39.
IPR020083. Ribosomal_L39_CS.
IPR023626. Ribosomal_L39e_dom.
[Graphical view]
PANTHERiPTHR19970. PTHR19970. 1 hit.
PfamiPF00832. Ribosomal_L39. 1 hit.
[Graphical view]
SUPFAMiSSF48662. SSF48662. 1 hit.
PROSITEiPS00051. RIBOSOMAL_L39E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22452-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKKSKATKK RLAKLDNQNS RVPAWVMLKT DREVQRNHKR RHWRRNDTDE
Length:50
Mass (Da):6,115
Last modified:January 23, 2007 - v2
Checksum:i4999D410AB7B331A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55007 Genomic DNA. Translation: CAA38750.1.
AY596297 Genomic DNA. Translation: AAV47823.1.
PIRiS13066. R6HS39.
RefSeqiYP_137529.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV47823; AAV47823; rrnAC3112.
GeneIDi3130549.
KEGGihma:rrnAC3112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55007 Genomic DNA. Translation: CAA38750.1 .
AY596297 Genomic DNA. Translation: AAV47823.1 .
PIRi S13066. R6HS39.
RefSeqi YP_137529.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FFK X-ray 2.40 Y 2-50 [» ]
1JJ2 X-ray 2.40 1 2-49 [» ]
1K73 X-ray 3.01 3 2-49 [» ]
1K8A X-ray 3.00 3 2-49 [» ]
1K9M X-ray 3.00 3 2-49 [» ]
1KC8 X-ray 3.01 3 2-49 [» ]
1KD1 X-ray 3.00 3 2-49 [» ]
1KQS X-ray 3.10 1 2-49 [» ]
1M1K X-ray 3.20 3 2-49 [» ]
1M90 X-ray 2.80 3 2-49 [» ]
1N8R X-ray 3.00 3 2-49 [» ]
1NJI X-ray 3.00 3 2-49 [» ]
1Q7Y X-ray 3.20 3 2-49 [» ]
1Q81 X-ray 2.95 3 2-49 [» ]
1Q82 X-ray 2.98 3 2-49 [» ]
1Q86 X-ray 3.00 3 2-49 [» ]
1QVF X-ray 3.10 1 2-49 [» ]
1QVG X-ray 2.90 1 2-49 [» ]
1S72 X-ray 2.40 2 1-50 [» ]
1VQ4 X-ray 2.70 2 1-50 [» ]
1VQ5 X-ray 2.60 2 1-50 [» ]
1VQ6 X-ray 2.70 2 1-50 [» ]
1VQ7 X-ray 2.50 2 1-50 [» ]
1VQ8 X-ray 2.20 2 1-50 [» ]
1VQ9 X-ray 2.40 2 1-50 [» ]
1VQK X-ray 2.30 2 1-50 [» ]
1VQL X-ray 2.30 2 1-50 [» ]
1VQM X-ray 2.30 2 1-50 [» ]
1VQN X-ray 2.40 2 1-50 [» ]
1VQO X-ray 2.20 2 1-50 [» ]
1VQP X-ray 2.25 2 1-50 [» ]
1W2B X-ray 3.50 1 2-49 [» ]
1YHQ X-ray 2.40 2 1-50 [» ]
1YI2 X-ray 2.65 2 1-50 [» ]
1YIJ X-ray 2.60 2 1-50 [» ]
1YIT X-ray 2.80 2 1-50 [» ]
1YJ9 X-ray 2.90 2 1-50 [» ]
1YJN X-ray 3.00 2 1-50 [» ]
1YJW X-ray 2.90 2 1-50 [» ]
2OTJ X-ray 2.90 2 1-50 [» ]
2OTL X-ray 2.70 2 1-50 [» ]
2QA4 X-ray 3.00 2 1-50 [» ]
2QEX X-ray 2.90 2 1-50 [» ]
3CC2 X-ray 2.40 2 1-50 [» ]
3CC4 X-ray 2.70 2 1-50 [» ]
3CC7 X-ray 2.70 2 1-50 [» ]
3CCE X-ray 2.75 2 1-50 [» ]
3CCJ X-ray 2.70 2 1-50 [» ]
3CCL X-ray 2.90 2 1-50 [» ]
3CCM X-ray 2.55 2 1-50 [» ]
3CCQ X-ray 2.90 2 1-50 [» ]
3CCR X-ray 3.00 2 1-50 [» ]
3CCS X-ray 2.95 2 1-50 [» ]
3CCU X-ray 2.80 2 1-50 [» ]
3CCV X-ray 2.90 2 1-50 [» ]
3CD6 X-ray 2.75 2 1-50 [» ]
3CMA X-ray 2.80 2 1-50 [» ]
3CME X-ray 2.95 2 1-50 [» ]
3CPW X-ray 2.70 1 1-50 [» ]
3CXC X-ray 3.00 1 2-50 [» ]
3G4S X-ray 3.20 2 1-50 [» ]
3G6E X-ray 2.70 2 1-50 [» ]
3G71 X-ray 2.85 2 1-50 [» ]
3I55 X-ray 3.11 2 1-50 [» ]
3I56 X-ray 2.90 2 1-50 [» ]
3OW2 X-ray 2.70 1 2-50 [» ]
4ADX electron microscopy 6.60 2 1-50 [» ]
4HUB X-ray 2.40 2 1-50 [» ]
ProteinModelPortali P22452.
SMRi P22452. Positions 2-50.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC3112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV47823 ; AAV47823 ; rrnAC3112 .
GeneIDi 3130549.
KEGGi hma:rrnAC3112.

Phylogenomic databases

eggNOGi COG2167.
HOGENOMi HOG000230627.
KOi K02924.
OMAi PAWVIMK.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-2791-MONOMER.

Miscellaneous databases

EvolutionaryTracei P22452.

Family and domain databases

Gene3Di 1.10.1620.10. 1 hit.
HAMAPi MF_00629. Ribosomal_L39e.
InterProi IPR000077. Ribosomal_L39.
IPR020083. Ribosomal_L39_CS.
IPR023626. Ribosomal_L39e_dom.
[Graphical view ]
PANTHERi PTHR19970. PTHR19970. 1 hit.
Pfami PF00832. Ribosomal_L39. 1 hit.
[Graphical view ]
SUPFAMi SSF48662. SSF48662. 1 hit.
PROSITEi PS00051. RIBOSOMAL_L39E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evidence for an additional archaebacterial gene cluster in Halobacterium marismortui encoding ribosomal proteins HL46e and HL30."
    Bergmann U., Arndt E.
    Biochim. Biophys. Acta 1050:56-60(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-50.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  3. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
    Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
    Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  4. "The structural basis of ribosome activity in peptide bond synthesis."
    Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
    Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  5. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
    Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
    Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  6. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  7. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  9. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  10. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  11. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL39_HALMA
AccessioniPrimary (citable) accession number: P22452
Secondary accession number(s): Q5UY30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3