Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P22452 (RL39_HALMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L39e
Alternative name(s):
Hl39e
Hl46e
Gene names
Name:rpl39e
Ordered Locus Names:rrnAC3112
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula

Protein attributes

Sequence length50 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the 23S rRNA. Forms part of the polypeptide exit tunnel. HAMAP-Rule MF_00629

Subunit structure

Part of the 50S ribosomal subunit. Interacts weakly with protein L23. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11

Sequence similarities

Belongs to the ribosomal protein L39e family.

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 504950S ribosomal protein L39e HAMAP-Rule MF_00629
PRO_0000127047

Secondary structure

........ 50
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P22452 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 4999D410AB7B331A

FASTA506,115
        10         20         30         40         50 
MGKKSKATKK RLAKLDNQNS RVPAWVMLKT DREVQRNHKR RHWRRNDTDE 

« Hide

References

« Hide 'large scale' references
[1]"Evidence for an additional archaebacterial gene cluster in Halobacterium marismortui encoding ribosomal proteins HL46e and HL30."
Bergmann U., Arndt E.
Biochim. Biophys. Acta 1050:56-60(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-50.
[2]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[3]"The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[4]"The structural basis of ribosome activity in peptide bond synthesis."
Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[5]"A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[6]"The kink-turn: a new RNA secondary structure motif."
Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[7]"The structures of four macrolide antibiotics bound to the large ribosomal subunit."
Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[8]"Structural insights into peptide bond formation."
Hansen J.L., Schmeing T.M., Moore P.B., Steitz T.A.
Proc. Natl. Acad. Sci. U.S.A. 99:11670-11675(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[9]"Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
Hansen J.L., Moore P.B., Steitz T.A.
J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[10]"Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
Schmeing T.M., Moore P.B., Steitz T.A.
RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
[11]"Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
Gabdulkhakov A., Nikonov S., Garber M.
Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55007 Genomic DNA. Translation: CAA38750.1.
AY596297 Genomic DNA. Translation: AAV47823.1.
PIRR6HS39. S13066.
RefSeqYP_137529.1. NC_006396.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40Y2-50[»]
1JJ2X-ray2.4012-50[»]
1K73X-ray3.0132-50[»]
1K8AX-ray3.0032-50[»]
1K9MX-ray3.0032-50[»]
1KC8X-ray3.0132-50[»]
1KD1X-ray3.0032-50[»]
1KQSX-ray3.1012-50[»]
1M1KX-ray3.2032-50[»]
1M90X-ray2.8032-50[»]
1N8RX-ray3.0032-50[»]
1NJIX-ray3.0032-50[»]
1Q7YX-ray3.2032-50[»]
1Q81X-ray2.9532-50[»]
1Q82X-ray2.9832-50[»]
1Q86X-ray3.0032-50[»]
1QVFX-ray3.1012-50[»]
1QVGX-ray2.9012-50[»]
1S72X-ray2.4021-50[»]
1VQ4X-ray2.7021-50[»]
1VQ5X-ray2.6021-50[»]
1VQ6X-ray2.7021-50[»]
1VQ7X-ray2.5021-50[»]
1VQ8X-ray2.2021-50[»]
1VQ9X-ray2.4021-50[»]
1VQKX-ray2.3021-50[»]
1VQLX-ray2.3021-50[»]
1VQMX-ray2.3021-50[»]
1VQNX-ray2.4021-50[»]
1VQOX-ray2.2021-50[»]
1VQPX-ray2.2521-50[»]
1W2BX-ray3.5012-49[»]
1YHQX-ray2.4021-50[»]
1YI2X-ray2.6521-50[»]
1YIJX-ray2.6021-50[»]
1YITX-ray2.8021-50[»]
1YJ9X-ray2.9021-50[»]
1YJNX-ray3.0021-50[»]
1YJWX-ray2.9021-50[»]
2OTJX-ray2.9021-50[»]
2OTLX-ray2.7021-50[»]
2QA4X-ray3.0021-50[»]
2QEXX-ray2.9021-50[»]
3CC2X-ray2.4021-50[»]
3CC4X-ray2.7021-50[»]
3CC7X-ray2.7021-50[»]
3CCEX-ray2.7521-50[»]
3CCJX-ray2.7021-50[»]
3CCLX-ray2.9021-50[»]
3CCMX-ray2.5521-50[»]
3CCQX-ray2.9021-50[»]
3CCRX-ray3.0021-50[»]
3CCSX-ray2.9521-50[»]
3CCUX-ray2.8021-50[»]
3CCVX-ray2.9021-50[»]
3CD6X-ray2.7521-50[»]
3CMAX-ray2.8021-50[»]
3CMEX-ray2.9521-50[»]
3CPWX-ray2.7011-50[»]
3CXCX-ray3.0012-49[»]
3G4SX-ray3.2021-50[»]
3G6EX-ray2.7021-50[»]
3G71X-ray2.8521-50[»]
3I55X-ray3.1121-50[»]
3I56X-ray2.9021-50[»]
3OW2X-ray2.7012-50[»]
4HUBX-ray2.4021-50[»]
ProteinModelPortalP22452.
SMRP22452. Positions 2-50.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272569.rrnAC3112.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV47823; AAV47823; rrnAC3112.
GeneID3130549.
KEGGhma:rrnAC3112.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2167.
HOGENOMHOG000230627.
KOK02924.
OMAPAWVIMK.
ProtClustDBPRK01242.

Enzyme and pathway databases

BioCycHMAR272569:GJDH-2791-MONOMER.

Family and domain databases

Gene3D1.10.1620.10. 1 hit.
HAMAPMF_00629. Ribosomal_L39e.
InterProIPR000077. Ribosomal_L39.
IPR020083. Ribosomal_L39_CS.
IPR023626. Ribosomal_L39e_dom.
[Graphical view]
PANTHERPTHR19970. PTHR19970. 1 hit.
PfamPF00832. Ribosomal_L39. 1 hit.
[Graphical view]
SUPFAMSSF48662. SSF48662. 1 hit.
PROSITEPS00051. RIBOSOMAL_L39E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP22452.

Entry information

Entry nameRL39_HALMA
AccessionPrimary (citable) accession number: P22452
Secondary accession number(s): Q5UY30
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references