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P22450

- RL14_HALMA

UniProt

P22450 - RL14_HALMA

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Protein

50S ribosomal protein L14

Gene

rpl14

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Forms part of two intersubunit bridges in the 70S ribosome (By similarity). Binds to 23S rRNA.By similarity

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1458-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L14UniRule annotation
Alternative name(s):
Hl27
Hmal14
Gene namesi
Name:rpl14UniRule annotation
Ordered Locus Names:rrnAC1602
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13213250S ribosomal protein L14PRO_0000128571Add
BLAST

Proteomic databases

PRIDEiP22450.

Interactioni

Subunit structurei

The L3/L14/L24e cluster may contact the 16S rRNA in 2 intersubunit bridges (By similarity). Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e.By similarity2 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC1602.

Structurei

Secondary structure

1
132
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84
Beta strandi17 – 204
Beta strandi22 – 3413
Beta strandi52 – 609
Turni62 – 665
Beta strandi68 – 758
Beta strandi87 – 926
Beta strandi94 – 985
Beta strandi100 – 1023
Beta strandi104 – 1074
Beta strandi111 – 1144
Helixi115 – 1206
Helixi122 – 1254
Beta strandi129 – 1324

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1C04X-ray5.00D71-85[»]
1FFKX-ray2.40H1-132[»]
1JJ2X-ray2.40J1-132[»]
1K73X-ray3.01L1-132[»]
1K8AX-ray3.00L1-132[»]
1K9MX-ray3.00L1-132[»]
1KC8X-ray3.01L1-132[»]
1KD1X-ray3.00L1-132[»]
1KQSX-ray3.10J1-132[»]
1M1KX-ray3.20L1-132[»]
1M90X-ray2.80L1-132[»]
1N8RX-ray3.00L1-132[»]
1NJIX-ray3.00L1-132[»]
1Q7YX-ray3.20L1-132[»]
1Q81X-ray2.95L1-132[»]
1Q82X-ray2.98L1-132[»]
1Q86X-ray3.00L1-132[»]
1QVFX-ray3.10J1-132[»]
1QVGX-ray2.90J1-132[»]
1S72X-ray2.40K1-132[»]
1VQ4X-ray2.70K1-132[»]
1VQ5X-ray2.60K1-132[»]
1VQ6X-ray2.70K1-132[»]
1VQ7X-ray2.50K1-132[»]
1VQ8X-ray2.20K1-132[»]
1VQ9X-ray2.40K1-132[»]
1VQKX-ray2.30K1-132[»]
1VQLX-ray2.30K1-132[»]
1VQMX-ray2.30K1-132[»]
1VQNX-ray2.40K1-132[»]
1VQOX-ray2.20K1-132[»]
1VQPX-ray2.25K1-132[»]
1W2BX-ray3.50J1-132[»]
1YHQX-ray2.40K1-132[»]
1YI2X-ray2.65K1-132[»]
1YIJX-ray2.60K1-132[»]
1YITX-ray2.80K1-132[»]
1YJ9X-ray2.90K1-132[»]
1YJNX-ray3.00K1-132[»]
1YJWX-ray2.90K1-132[»]
2OTJX-ray2.90K1-132[»]
2OTLX-ray2.70K1-132[»]
2QA4X-ray3.00K1-132[»]
2QEXX-ray2.90K1-132[»]
3CC2X-ray2.40K1-132[»]
3CC4X-ray2.70K1-132[»]
3CC7X-ray2.70K1-132[»]
3CCEX-ray2.75K1-132[»]
3CCJX-ray2.70K1-132[»]
3CCLX-ray2.90K1-132[»]
3CCMX-ray2.55K1-132[»]
3CCQX-ray2.90K1-132[»]
3CCRX-ray3.00K1-132[»]
3CCSX-ray2.95K1-132[»]
3CCUX-ray2.80K1-132[»]
3CCVX-ray2.90K1-132[»]
3CD6X-ray2.75K1-132[»]
3CMAX-ray2.80K1-132[»]
3CMEX-ray2.95K1-132[»]
3CPWX-ray2.70J1-132[»]
3CXCX-ray3.00J1-132[»]
3G4SX-ray3.20K1-132[»]
3G6EX-ray2.70K1-132[»]
3G71X-ray2.85K1-132[»]
3I55X-ray3.11K1-132[»]
3I56X-ray2.90K1-132[»]
3OW2X-ray2.70J1-132[»]
4ADXelectron microscopy6.60K1-132[»]
4HUBX-ray2.40K1-132[»]
ProteinModelPortaliP22450.
SMRiP22450. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22450.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L14P family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0093.
HOGENOMiHOG000183703.
KOiK02874.
OMAiGFPKGTD.

Family and domain databases

Gene3Di2.40.150.20. 1 hit.
HAMAPiMF_01367. Ribosomal_L14.
InterProiIPR019972. Ribosomal_L14_CS.
IPR023571. Ribosomal_L14_dom.
IPR000218. Ribosomal_L14b/L23e.
IPR019971. Ribosomal_L14P_arc.
[Graphical view]
PANTHERiPTHR11761. PTHR11761. 1 hit.
PfamiPF00238. Ribosomal_L14. 1 hit.
[Graphical view]
SUPFAMiSSF50193. SSF50193. 1 hit.
TIGRFAMsiTIGR03673. rpl14p_arch. 1 hit.
PROSITEiPS00049. RIBOSOMAL_L14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22450-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEALGADVTQ GLEKGSLITC ADNTGARELK VISVHGYSGT KNRHPKAGLG
60 70 80 90 100
DKITVSVTKG TPEMRRQVLE AVVVRQRKPI RRPDGTRVKF EDNAAVIVDE
110 120 130
NEDPRGTELK GPIAREVAQR FGSVASAATM IV
Length:132
Mass (Da):14,193
Last modified:August 1, 1991 - v1
Checksum:i536F9C4461B7EA87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55311 Genomic DNA. Translation: CAA39018.1.
AY596297 Genomic DNA. Translation: AAV46519.1.
PIRiS10734. R5HS14.
RefSeqiYP_136225.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV46519; AAV46519; rrnAC1602.
GeneIDi3128380.
KEGGihma:rrnAC1602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55311 Genomic DNA. Translation: CAA39018.1 .
AY596297 Genomic DNA. Translation: AAV46519.1 .
PIRi S10734. R5HS14.
RefSeqi YP_136225.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1C04 X-ray 5.00 D 71-85 [» ]
1FFK X-ray 2.40 H 1-132 [» ]
1JJ2 X-ray 2.40 J 1-132 [» ]
1K73 X-ray 3.01 L 1-132 [» ]
1K8A X-ray 3.00 L 1-132 [» ]
1K9M X-ray 3.00 L 1-132 [» ]
1KC8 X-ray 3.01 L 1-132 [» ]
1KD1 X-ray 3.00 L 1-132 [» ]
1KQS X-ray 3.10 J 1-132 [» ]
1M1K X-ray 3.20 L 1-132 [» ]
1M90 X-ray 2.80 L 1-132 [» ]
1N8R X-ray 3.00 L 1-132 [» ]
1NJI X-ray 3.00 L 1-132 [» ]
1Q7Y X-ray 3.20 L 1-132 [» ]
1Q81 X-ray 2.95 L 1-132 [» ]
1Q82 X-ray 2.98 L 1-132 [» ]
1Q86 X-ray 3.00 L 1-132 [» ]
1QVF X-ray 3.10 J 1-132 [» ]
1QVG X-ray 2.90 J 1-132 [» ]
1S72 X-ray 2.40 K 1-132 [» ]
1VQ4 X-ray 2.70 K 1-132 [» ]
1VQ5 X-ray 2.60 K 1-132 [» ]
1VQ6 X-ray 2.70 K 1-132 [» ]
1VQ7 X-ray 2.50 K 1-132 [» ]
1VQ8 X-ray 2.20 K 1-132 [» ]
1VQ9 X-ray 2.40 K 1-132 [» ]
1VQK X-ray 2.30 K 1-132 [» ]
1VQL X-ray 2.30 K 1-132 [» ]
1VQM X-ray 2.30 K 1-132 [» ]
1VQN X-ray 2.40 K 1-132 [» ]
1VQO X-ray 2.20 K 1-132 [» ]
1VQP X-ray 2.25 K 1-132 [» ]
1W2B X-ray 3.50 J 1-132 [» ]
1YHQ X-ray 2.40 K 1-132 [» ]
1YI2 X-ray 2.65 K 1-132 [» ]
1YIJ X-ray 2.60 K 1-132 [» ]
1YIT X-ray 2.80 K 1-132 [» ]
1YJ9 X-ray 2.90 K 1-132 [» ]
1YJN X-ray 3.00 K 1-132 [» ]
1YJW X-ray 2.90 K 1-132 [» ]
2OTJ X-ray 2.90 K 1-132 [» ]
2OTL X-ray 2.70 K 1-132 [» ]
2QA4 X-ray 3.00 K 1-132 [» ]
2QEX X-ray 2.90 K 1-132 [» ]
3CC2 X-ray 2.40 K 1-132 [» ]
3CC4 X-ray 2.70 K 1-132 [» ]
3CC7 X-ray 2.70 K 1-132 [» ]
3CCE X-ray 2.75 K 1-132 [» ]
3CCJ X-ray 2.70 K 1-132 [» ]
3CCL X-ray 2.90 K 1-132 [» ]
3CCM X-ray 2.55 K 1-132 [» ]
3CCQ X-ray 2.90 K 1-132 [» ]
3CCR X-ray 3.00 K 1-132 [» ]
3CCS X-ray 2.95 K 1-132 [» ]
3CCU X-ray 2.80 K 1-132 [» ]
3CCV X-ray 2.90 K 1-132 [» ]
3CD6 X-ray 2.75 K 1-132 [» ]
3CMA X-ray 2.80 K 1-132 [» ]
3CME X-ray 2.95 K 1-132 [» ]
3CPW X-ray 2.70 J 1-132 [» ]
3CXC X-ray 3.00 J 1-132 [» ]
3G4S X-ray 3.20 K 1-132 [» ]
3G6E X-ray 2.70 K 1-132 [» ]
3G71 X-ray 2.85 K 1-132 [» ]
3I55 X-ray 3.11 K 1-132 [» ]
3I56 X-ray 2.90 K 1-132 [» ]
3OW2 X-ray 2.70 J 1-132 [» ]
4ADX electron microscopy 6.60 K 1-132 [» ]
4HUB X-ray 2.40 K 1-132 [» ]
ProteinModelPortali P22450.
SMRi P22450. Positions 1-132.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC1602.

Proteomic databases

PRIDEi P22450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV46519 ; AAV46519 ; rrnAC1602 .
GeneIDi 3128380.
KEGGi hma:rrnAC1602.

Phylogenomic databases

eggNOGi COG0093.
HOGENOMi HOG000183703.
KOi K02874.
OMAi GFPKGTD.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-1458-MONOMER.

Miscellaneous databases

EvolutionaryTracei P22450.

Family and domain databases

Gene3Di 2.40.150.20. 1 hit.
HAMAPi MF_01367. Ribosomal_L14.
InterProi IPR019972. Ribosomal_L14_CS.
IPR023571. Ribosomal_L14_dom.
IPR000218. Ribosomal_L14b/L23e.
IPR019971. Ribosomal_L14P_arc.
[Graphical view ]
PANTHERi PTHR11761. PTHR11761. 1 hit.
Pfami PF00238. Ribosomal_L14. 1 hit.
[Graphical view ]
SUPFAMi SSF50193. SSF50193. 1 hit.
TIGRFAMsi TIGR03673. rpl14p_arch. 1 hit.
PROSITEi PS00049. RIBOSOMAL_L14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of four genes encoding ribosomal proteins from the 'S10 and spectinomycin' operon equivalent region in the archaebacterium Halobacterium marismortui."
    Arndt E.
    FEBS Lett. 267:193-198(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  3. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
    Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
    Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  4. "The structural basis of ribosome activity in peptide bond synthesis."
    Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
    Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  5. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
    Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
    Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  6. "Placement of protein and RNA structures into a 5 A-resolution map of the 50S ribosomal subunit."
    Ban N., Nissen P., Hansen J., Capel M., Moore P.B., Steitz T.A.
    Nature 400:841-847(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.
  7. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  8. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  9. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  10. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  11. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  12. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL14_HALMA
AccessioniPrimary (citable) accession number: P22450
Secondary accession number(s): Q5V1T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 1, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3