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P22450 (RL14_HALMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L14
Alternative name(s):
Hl27
Hmal14
Gene names
Name:rpl14
Ordered Locus Names:rrnAC1602
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula

Protein attributes

Sequence length132 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Forms part of two intersubunit bridges in the 70S ribosome By similarity. Binds to 23S rRNA. HAMAP-Rule MF_01367

Subunit structure

The L3/L14/L24e cluster may contact the 16S rRNA in 2 intersubunit bridges By similarity. Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e. Ref.3 Ref.4 Ref.5 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12

Sequence similarities

Belongs to the ribosomal protein L14P family.

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13213250S ribosomal protein L14 HAMAP-Rule MF_01367
PRO_0000128571

Secondary structure

........................... 132
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P22450 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 536F9C4461B7EA87

FASTA13214,193
        10         20         30         40         50         60 
MEALGADVTQ GLEKGSLITC ADNTGARELK VISVHGYSGT KNRHPKAGLG DKITVSVTKG 

        70         80         90        100        110        120 
TPEMRRQVLE AVVVRQRKPI RRPDGTRVKF EDNAAVIVDE NEDPRGTELK GPIAREVAQR 

       130 
FGSVASAATM IV 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of four genes encoding ribosomal proteins from the 'S10 and spectinomycin' operon equivalent region in the archaebacterium Halobacterium marismortui."
Arndt E.
FEBS Lett. 267:193-198(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[3]"The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[4]"The structural basis of ribosome activity in peptide bond synthesis."
Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[5]"A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[6]"Placement of protein and RNA structures into a 5 A-resolution map of the 50S ribosomal subunit."
Ban N., Nissen P., Hansen J., Capel M., Moore P.B., Steitz T.A.
Nature 400:841-847(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING.
[7]"The kink-turn: a new RNA secondary structure motif."
Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[8]"The structures of four macrolide antibiotics bound to the large ribosomal subunit."
Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[9]"Structural insights into peptide bond formation."
Hansen J.L., Schmeing T.M., Moore P.B., Steitz T.A.
Proc. Natl. Acad. Sci. U.S.A. 99:11670-11675(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[10]"Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
Hansen J.L., Moore P.B., Steitz T.A.
J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[11]"Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
Schmeing T.M., Moore P.B., Steitz T.A.
RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
[12]"Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
Gabdulkhakov A., Nikonov S., Garber M.
Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55311 Genomic DNA. Translation: CAA39018.1.
AY596297 Genomic DNA. Translation: AAV46519.1.
PIRR5HS14. S10734.
RefSeqYP_136225.1. NC_006396.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1C04X-ray5.00D31-107[»]
1FFKX-ray2.40H1-132[»]
1JJ2X-ray2.40J1-132[»]
1K73X-ray3.01L1-132[»]
1K8AX-ray3.00L1-132[»]
1K9MX-ray3.00L1-132[»]
1KC8X-ray3.01L1-132[»]
1KD1X-ray3.00L1-132[»]
1KQSX-ray3.10J1-132[»]
1M1KX-ray3.20L1-132[»]
1M90X-ray2.80L1-132[»]
1N8RX-ray3.00L1-132[»]
1NJIX-ray3.00L1-132[»]
1Q7YX-ray3.20L1-132[»]
1Q81X-ray2.95L1-132[»]
1Q82X-ray2.98L1-132[»]
1Q86X-ray3.00L1-132[»]
1QVFX-ray3.10J1-132[»]
1QVGX-ray2.90J1-132[»]
1S72X-ray2.40K1-132[»]
1VQ4X-ray2.70K1-132[»]
1VQ5X-ray2.60K1-132[»]
1VQ6X-ray2.70K1-132[»]
1VQ7X-ray2.50K1-132[»]
1VQ8X-ray2.20K1-132[»]
1VQ9X-ray2.40K1-132[»]
1VQKX-ray2.30K1-132[»]
1VQLX-ray2.30K1-132[»]
1VQMX-ray2.30K1-132[»]
1VQNX-ray2.40K1-132[»]
1VQOX-ray2.20K1-132[»]
1VQPX-ray2.25K1-132[»]
1W2BX-ray3.50J1-132[»]
1YHQX-ray2.40K1-132[»]
1YI2X-ray2.65K1-132[»]
1YIJX-ray2.60K1-132[»]
1YITX-ray2.80K1-132[»]
1YJ9X-ray2.90K1-132[»]
1YJNX-ray3.00K1-132[»]
1YJWX-ray2.90K1-132[»]
2OTJX-ray2.90K1-132[»]
2OTLX-ray2.70K1-132[»]
2QA4X-ray3.00K1-132[»]
2QEXX-ray2.90K1-132[»]
3CC2X-ray2.40K1-132[»]
3CC4X-ray2.70K1-132[»]
3CC7X-ray2.70K1-132[»]
3CCEX-ray2.75K1-132[»]
3CCJX-ray2.70K1-132[»]
3CCLX-ray2.90K1-132[»]
3CCMX-ray2.55K1-132[»]
3CCQX-ray2.90K1-132[»]
3CCRX-ray3.00K1-132[»]
3CCSX-ray2.95K1-132[»]
3CCUX-ray2.80K1-132[»]
3CCVX-ray2.90K1-132[»]
3CD6X-ray2.75K1-132[»]
3CMAX-ray2.80K1-132[»]
3CMEX-ray2.95K1-132[»]
3CPWX-ray2.70J1-132[»]
3CXCX-ray3.00J1-132[»]
3G4SX-ray3.20K1-132[»]
3G6EX-ray2.70K1-132[»]
3G71X-ray2.85K1-132[»]
3I55X-ray3.11K1-132[»]
3I56X-ray2.90K1-132[»]
3OW2X-ray2.70J1-132[»]
4HUBX-ray2.40K1-132[»]
ProteinModelPortalP22450.
SMRP22450. Positions 1-132.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272569.rrnAC1602.

Proteomic databases

PRIDEP22450.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV46519; AAV46519; rrnAC1602.
GeneID3128380.
KEGGhma:rrnAC1602.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0093.
HOGENOMHOG000183703.
KOK02874.
OMAELRKKTM.
ProtClustDBPRK08571.

Enzyme and pathway databases

BioCycHMAR272569:GJDH-1458-MONOMER.

Family and domain databases

Gene3D2.40.150.20. 1 hit.
HAMAPMF_01367. Ribosomal_L14.
InterProIPR019972. Ribosomal_L14_CS.
IPR023571. Ribosomal_L14_dom.
IPR000218. Ribosomal_L14b/L23e.
IPR019971. Ribosomal_L14P_arc.
[Graphical view]
PANTHERPTHR11761. PTHR11761. 1 hit.
PfamPF00238. Ribosomal_L14. 1 hit.
[Graphical view]
SUPFAMSSF50193. SSF50193. 1 hit.
TIGRFAMsTIGR03673. rpl14p_arch. 1 hit.
PROSITEPS00049. RIBOSOMAL_L14. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP22450.

Entry information

Entry nameRL14_HALMA
AccessionPrimary (citable) accession number: P22450
Secondary accession number(s): Q5V1T3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: February 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references