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P22443

- CP19A_RAT

UniProt

P22443 - CP19A_RAT

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Protein

Aromatase

Gene

Cyp19a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: RGD
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: RGD

GO - Biological processi

  1. adrenal gland development Source: RGD
  2. androgen metabolic process Source: RGD
  3. bile acid metabolic process Source: RGD
  4. biphenyl metabolic process Source: RGD
  5. bone development Source: RGD
  6. C21-steroid hormone metabolic process Source: RGD
  7. cellular response to fibroblast growth factor stimulus Source: RGD
  8. cellular response to follicle-stimulating hormone stimulus Source: RGD
  9. cellular response to glucose stimulus Source: RGD
  10. cellular response to gonadotropin stimulus Source: RGD
  11. cellular response to hydrostatic pressure Source: RGD
  12. dibenzo-p-dioxin metabolic process Source: RGD
  13. estrogen biosynthetic process Source: RGD
  14. granulocyte differentiation Source: RGD
  15. hippocampus development Source: RGD
  16. hypothalamus development Source: RGD
  17. luteinization Source: RGD
  18. male gonad development Source: RGD
  19. melatonin metabolic process Source: RGD
  20. negative regulation of bone resorption Source: RGD
  21. phthalate metabolic process Source: RGD
  22. progesterone metabolic process Source: RGD
  23. regulation of synapse structure and activity Source: RGD
  24. response to cesium ion Source: RGD
  25. response to drug Source: RGD
  26. response to estradiol Source: RGD
  27. response to estrogen Source: RGD
  28. response to herbicide Source: RGD
  29. response to ionizing radiation Source: RGD
  30. response to metal ion Source: RGD
  31. response to morphine Source: RGD
  32. response to organic cyclic compound Source: RGD
  33. response to testosterone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:Cyp19a1
Synonyms:Arom, Cyp19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2457. Cyp19a1.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: RGD
  2. cytoplasm Source: RGD
  3. cytosol Source: RGD
  4. dendritic spine Source: RGD
  5. endoplasmic reticulum Source: RGD
  6. membrane Source: UniProtKB-KW
  7. neuronal cell body Source: RGD
  8. synapse Source: RGD
  9. synaptic vesicle Source: RGD
  10. terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508AromatasePRO_0000051962Add
BLAST

Proteomic databases

PaxDbiP22443.
PRIDEiP22443.

Expressioni

Gene expression databases

GenevestigatoriP22443.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000212.

Structurei

3D structure databases

ProteinModelPortaliP22443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP22443.
PhylomeDBiP22443.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22443-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLEMLNPMH YNVTIMVPET VPVSAMPLLL IMGLLLLIRN CESSSSIPGP
60 70 80 90 100
GYCLGIGPLI SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS
110 120 130 140 150
SSMVHVMKHS NYISRFGSKR GLQCIGMHEN GIIFNNNPSL WRTVRPFFMK
160 170 180 190 200
ALTGPGLIRM VEVCVESIKQ HLDRLGDVTD NSGYVDVVTL MRHIMLDTSN
210 220 230 240 250
TLFLGIPLDE SSIVKKIQGY FNAWQALLIK PNIFFKISWL YRKYERSVKD
260 270 280 290 300
LKDEIEILVE KKRQKVSSAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVTLYVMLL LIAEYPEVET AILKEIHTVV GDRDIRIGDV
360 370 380 390 400
QNLKVVENFI NESLRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEYFPKP NEFTLENFEK NVPYRYFQPF GFGPRSCAGK YIAMVMMKVV
460 470 480 490 500
LVTLLKRFHV KTLQKRCIEN MPKNNDLSLH LDEDSPIVEI IFRHIFNTPF

LQCLYISL
Length:508
Mass (Da):58,412
Last modified:August 1, 1991 - v1
Checksum:iC0ADFB0FD80AB352
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 42LE → FQ no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti10 – 101H → Q no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti88 – 881W → C no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti101 – 1011S → L no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti123 – 1297QCIGMHE → VVHGHAR no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti188 – 1881V → L no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti210 – 2101E → G no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti328 – 3314VETA → WKQ no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti342 – 3421D → A no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti364 – 3696LRYQPV → CGISPF no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti422 – 4221V → L no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti425 – 4251R → T no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti449 – 4491V → I no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti466 – 4661R → K no nucleotide entry (PubMed:2340950)Curated
Sequence conflicti493 – 4975RHIFN → SPRNS no nucleotide entry (PubMed:2340950)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33986 mRNA. Translation: AAA41044.1.
PIRiA36121.
UniGeneiRn.21402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33986 mRNA. Translation: AAA41044.1 .
PIRi A36121.
UniGenei Rn.21402.

3D structure databases

ProteinModelPortali P22443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000212.

Chemistry

BindingDBi P22443.
ChEMBLi CHEMBL3859.

Proteomic databases

PaxDbi P22443.
PRIDEi P22443.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 2457. Cyp19a1.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000111912.
HOVERGENi HBG050750.
InParanoidi P22443.
PhylomeDBi P22443.

Miscellaneous databases

PROi P22443.

Gene expression databases

Genevestigatori P22443.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Aromatase cytochrome P450 in rat ovarian granulosa cells before and after luteinization: adenosine 3',5'-monophosphate-dependent and independent regulation. Cloning and sequencing of rat aromatase cDNA and 5' genomic DNA."
    Hickey G.J., Krasnow J.S., Beattie W.G., Richards J.S.
    Mol. Endocrinol. 4:3-12(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "The structure of cDNA clones encoding the aromatase P-450 isolated from a rat Leydig cell tumor line demonstrates differential processing of aromatase mRNA in rat ovary and a neoplastic cell line."
    Lephart E.D., Peterson K.G., Noble J.F., George F.W., McPhaul M.J.
    Mol. Cell. Endocrinol. 70:31-40(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP19A_RAT
AccessioniPrimary (citable) accession number: P22443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3