Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P22443

- CP19A_RAT

UniProt

P22443 - CP19A_RAT

Protein

Aromatase

Gene

Cyp19a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi437 – 4371Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: RGD
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: RGD

    GO - Biological processi

    1. adrenal gland development Source: RGD
    2. androgen metabolic process Source: RGD
    3. bile acid metabolic process Source: RGD
    4. biphenyl metabolic process Source: RGD
    5. bone development Source: RGD
    6. C21-steroid hormone metabolic process Source: RGD
    7. cellular response to fibroblast growth factor stimulus Source: RGD
    8. cellular response to follicle-stimulating hormone stimulus Source: RGD
    9. cellular response to glucose stimulus Source: RGD
    10. cellular response to gonadotropin stimulus Source: RGD
    11. cellular response to hydrostatic pressure Source: RGD
    12. dibenzo-p-dioxin metabolic process Source: RGD
    13. estrogen biosynthetic process Source: RGD
    14. granulocyte differentiation Source: RGD
    15. hippocampus development Source: RGD
    16. hypothalamus development Source: RGD
    17. luteinization Source: RGD
    18. male gonad development Source: RGD
    19. melatonin metabolic process Source: RGD
    20. negative regulation of bone resorption Source: RGD
    21. phthalate metabolic process Source: RGD
    22. progesterone metabolic process Source: RGD
    23. regulation of synapse structure and activity Source: RGD
    24. response to cesium ion Source: RGD
    25. response to drug Source: RGD
    26. response to estradiol Source: RGD
    27. response to estrogen Source: RGD
    28. response to herbicide Source: RGD
    29. response to ionizing radiation Source: RGD
    30. response to metal ion Source: RGD
    31. response to morphine Source: RGD
    32. response to organic cyclic compound Source: RGD
    33. response to testosterone Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:Cyp19a1
    Synonyms:Arom, Cyp19
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2457. Cyp19a1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: RGD
    2. cytoplasm Source: RGD
    3. cytosol Source: RGD
    4. dendritic spine Source: RGD
    5. endoplasmic reticulum Source: RGD
    6. membrane Source: UniProtKB-SubCell
    7. neuronal cell body Source: RGD
    8. synapse Source: RGD
    9. synaptic vesicle Source: RGD
    10. terminal bouton Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508AromatasePRO_0000051962Add
    BLAST

    Proteomic databases

    PaxDbiP22443.
    PRIDEiP22443.

    Expressioni

    Gene expression databases

    GenevestigatoriP22443.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000000212.

    Structurei

    3D structure databases

    ProteinModelPortaliP22443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000111912.
    HOVERGENiHBG050750.
    PhylomeDBiP22443.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22443-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLEMLNPMH YNVTIMVPET VPVSAMPLLL IMGLLLLIRN CESSSSIPGP    50
    GYCLGIGPLI SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS 100
    SSMVHVMKHS NYISRFGSKR GLQCIGMHEN GIIFNNNPSL WRTVRPFFMK 150
    ALTGPGLIRM VEVCVESIKQ HLDRLGDVTD NSGYVDVVTL MRHIMLDTSN 200
    TLFLGIPLDE SSIVKKIQGY FNAWQALLIK PNIFFKISWL YRKYERSVKD 250
    LKDEIEILVE KKRQKVSSAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI 300
    LEMLIAAPDT MSVTLYVMLL LIAEYPEVET AILKEIHTVV GDRDIRIGDV 350
    QNLKVVENFI NESLRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR 400
    MHRLEYFPKP NEFTLENFEK NVPYRYFQPF GFGPRSCAGK YIAMVMMKVV 450
    LVTLLKRFHV KTLQKRCIEN MPKNNDLSLH LDEDSPIVEI IFRHIFNTPF 500
    LQCLYISL 508
    Length:508
    Mass (Da):58,412
    Last modified:August 1, 1991 - v1
    Checksum:iC0ADFB0FD80AB352
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 42LE → FQ no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti10 – 101H → Q no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti88 – 881W → C no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti101 – 1011S → L no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti123 – 1297QCIGMHE → VVHGHAR no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti188 – 1881V → L no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti210 – 2101E → G no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti328 – 3314VETA → WKQ no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti342 – 3421D → A no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti364 – 3696LRYQPV → CGISPF no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti422 – 4221V → L no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti425 – 4251R → T no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti449 – 4491V → I no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti466 – 4661R → K no nucleotide entry (PubMed:2340950)Curated
    Sequence conflicti493 – 4975RHIFN → SPRNS no nucleotide entry (PubMed:2340950)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33986 mRNA. Translation: AAA41044.1.
    PIRiA36121.
    UniGeneiRn.21402.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33986 mRNA. Translation: AAA41044.1 .
    PIRi A36121.
    UniGenei Rn.21402.

    3D structure databases

    ProteinModelPortali P22443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000000212.

    Chemistry

    BindingDBi P22443.
    ChEMBLi CHEMBL3859.

    Proteomic databases

    PaxDbi P22443.
    PRIDEi P22443.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2457. Cyp19a1.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000111912.
    HOVERGENi HBG050750.
    PhylomeDBi P22443.

    Miscellaneous databases

    PROi P22443.

    Gene expression databases

    Genevestigatori P22443.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Aromatase cytochrome P450 in rat ovarian granulosa cells before and after luteinization: adenosine 3',5'-monophosphate-dependent and independent regulation. Cloning and sequencing of rat aromatase cDNA and 5' genomic DNA."
      Hickey G.J., Krasnow J.S., Beattie W.G., Richards J.S.
      Mol. Endocrinol. 4:3-12(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. "The structure of cDNA clones encoding the aromatase P-450 isolated from a rat Leydig cell tumor line demonstrates differential processing of aromatase mRNA in rat ovary and a neoplastic cell line."
      Lephart E.D., Peterson K.G., Noble J.F., George F.W., McPhaul M.J.
      Mol. Cell. Endocrinol. 70:31-40(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP19A_RAT
    AccessioniPrimary (citable) accession number: P22443
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3