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Protein

Aromatase

Gene

Cyp19a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)

GO - Molecular functioni

GO - Biological processi

  • adrenal gland development Source: RGD
  • androgen metabolic process Source: RGD
  • bile acid metabolic process Source: RGD
  • biphenyl metabolic process Source: RGD
  • bone development Source: RGD
  • C21-steroid hormone metabolic process Source: RGD
  • cellular response to fibroblast growth factor stimulus Source: RGD
  • cellular response to follicle-stimulating hormone stimulus Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to gonadotropin stimulus Source: RGD
  • cellular response to hydrostatic pressure Source: RGD
  • dibenzo-p-dioxin metabolic process Source: RGD
  • estrogen biosynthetic process Source: RGD
  • granulocyte differentiation Source: RGD
  • hippocampus development Source: RGD
  • hypothalamus development Source: RGD
  • luteinization Source: RGD
  • male gonad development Source: RGD
  • melatonin metabolic process Source: RGD
  • negative regulation of bone resorption Source: RGD
  • phthalate metabolic process Source: RGD
  • progesterone metabolic process Source: RGD
  • regulation of synapse structure or activity Source: RGD
  • response to cesium ion Source: RGD
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to estrogen Source: RGD
  • response to herbicide Source: RGD
  • response to ionizing radiation Source: RGD
  • response to metal ion Source: RGD
  • response to morphine Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to testosterone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:Cyp19a1
Synonyms:Arom, Cyp19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2457. Cyp19a1.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • cytoplasm Source: RGD
  • cytosol Source: RGD
  • dendritic spine Source: RGD
  • endoplasmic reticulum Source: RGD
  • membrane Source: UniProtKB-SubCell
  • neuronal cell body Source: RGD
  • synapse Source: RGD
  • synaptic vesicle Source: RGD
  • terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508AromatasePRO_0000051962Add
BLAST

Proteomic databases

PaxDbiP22443.
PRIDEiP22443.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000212.

Structurei

3D structure databases

ProteinModelPortaliP22443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP22443.
PhylomeDBiP22443.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLEMLNPMH YNVTIMVPET VPVSAMPLLL IMGLLLLIRN CESSSSIPGP
60 70 80 90 100
GYCLGIGPLI SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS
110 120 130 140 150
SSMVHVMKHS NYISRFGSKR GLQCIGMHEN GIIFNNNPSL WRTVRPFFMK
160 170 180 190 200
ALTGPGLIRM VEVCVESIKQ HLDRLGDVTD NSGYVDVVTL MRHIMLDTSN
210 220 230 240 250
TLFLGIPLDE SSIVKKIQGY FNAWQALLIK PNIFFKISWL YRKYERSVKD
260 270 280 290 300
LKDEIEILVE KKRQKVSSAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVTLYVMLL LIAEYPEVET AILKEIHTVV GDRDIRIGDV
360 370 380 390 400
QNLKVVENFI NESLRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEYFPKP NEFTLENFEK NVPYRYFQPF GFGPRSCAGK YIAMVMMKVV
460 470 480 490 500
LVTLLKRFHV KTLQKRCIEN MPKNNDLSLH LDEDSPIVEI IFRHIFNTPF

LQCLYISL
Length:508
Mass (Da):58,412
Last modified:August 1, 1991 - v1
Checksum:iC0ADFB0FD80AB352
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 42LE → FQ no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti10 – 101H → Q no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti88 – 881W → C no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti101 – 1011S → L no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti123 – 1297QCIGMHE → VVHGHAR no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti188 – 1881V → L no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti210 – 2101E → G no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti328 – 3314VETA → WKQ no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti342 – 3421D → A no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti364 – 3696LRYQPV → CGISPF no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti422 – 4221V → L no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti425 – 4251R → T no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti449 – 4491V → I no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti466 – 4661R → K no nucleotide entry (PubMed:2340950).Curated
Sequence conflicti493 – 4975RHIFN → SPRNS no nucleotide entry (PubMed:2340950).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33986 mRNA. Translation: AAA41044.1.
PIRiA36121.
UniGeneiRn.21402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33986 mRNA. Translation: AAA41044.1.
PIRiA36121.
UniGeneiRn.21402.

3D structure databases

ProteinModelPortaliP22443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000212.

Chemistry

BindingDBiP22443.
ChEMBLiCHEMBL3859.

Proteomic databases

PaxDbiP22443.
PRIDEiP22443.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi2457. Cyp19a1.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP22443.
PhylomeDBiP22443.

Miscellaneous databases

PROiP22443.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Aromatase cytochrome P450 in rat ovarian granulosa cells before and after luteinization: adenosine 3',5'-monophosphate-dependent and independent regulation. Cloning and sequencing of rat aromatase cDNA and 5' genomic DNA."
    Hickey G.J., Krasnow J.S., Beattie W.G., Richards J.S.
    Mol. Endocrinol. 4:3-12(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "The structure of cDNA clones encoding the aromatase P-450 isolated from a rat Leydig cell tumor line demonstrates differential processing of aromatase mRNA in rat ovary and a neoplastic cell line."
    Lephart E.D., Peterson K.G., Noble J.F., George F.W., McPhaul M.J.
    Mol. Cell. Endocrinol. 70:31-40(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP19A_RAT
AccessioniPrimary (citable) accession number: P22443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: June 24, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.