Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P22434

- PDE1_YEAST

UniProt

P22434 - PDE1_YEAST

Protein

3',5'-cyclic-nucleotide phosphodiesterase 1

Gene

PDE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Controls the level of cAMP in yeast cells, together with the high-affinity cAMP phosphodiesterase (PDE2).

    Catalytic activityi

    Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: SGD

    GO - Biological processi

    1. cAMP catabolic process Source: InterPro
    2. cAMP-mediated signaling Source: SGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP

    Enzyme and pathway databases

    BioCyciYEAST:YGL248W-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic-nucleotide phosphodiesterase 1 (EC:3.1.4.17)
    Short name:
    PDEase 1
    Alternative name(s):
    3':5'-CNP
    Low-affinity cAMP phosphodiesterase
    Gene namesi
    Name:PDE1
    Ordered Locus Names:YGL248W
    ORF Names:NRB369
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL248w.
    SGDiS000003217. PDE1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3693693',5'-cyclic-nucleotide phosphodiesterase 1PRO_0000206791Add
    BLAST

    Proteomic databases

    MaxQBiP22434.
    PaxDbiP22434.

    Expressioni

    Gene expression databases

    GenevestigatoriP22434.

    Interactioni

    Protein-protein interaction databases

    BioGridi33031. 26 interactions.
    STRINGi4932.YGL248W.

    Structurei

    3D structure databases

    ProteinModelPortaliP22434.
    SMRiP22434. Positions 120-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5212.
    HOGENOMiHOG000248334.
    KOiK01120.
    OMAiFESANTM.
    OrthoDBiEOG7X6MB3.

    Family and domain databases

    Gene3Di3.60.15.10. 2 hits.
    InterProiIPR001279. Beta-lactamas-like.
    IPR024225. cAMP-PdiesteraseII_CS.
    IPR000396. Pdiesterase2.
    [Graphical view]
    PfamiPF02112. PDEase_II. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000962. Cyc_nuc_PDEase. 1 hit.
    PRINTSiPR00388. PDIESTERASE2.
    SUPFAMiSSF56281. SSF56281. 1 hit.
    PROSITEiPS00607. PDEASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22434-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVFEITILG ANGGPTEYGT QCFILKPART EDPELIAVDG GAGMYQLREM    50
    LVQGRNENEG DDELVPSFYE HDREPIEFFI DSKLNIQKGL SKSLLQSLKR 100
    QGEHFESANT MKKTYEVFQG ITDYYITHPH LDHISGLVVN SPSIYEQENS 150
    KKKTIWGLPH TIDVLQKHVF NDLIWPDLTA ERSRKLKLKC LNPKEVQKCT 200
    IFPWDVIPFK VHHGIGVKTG APVYSTFYIF RDRKSKDCII VCGDVEQDRR 250
    ESEESLLEEF WSYVAENIPL VHLKGILVEC SCPLSSKPEQ LYGHLSPIYL 300
    INELSNLNTL YNSSKGLSGL NVIVTHVKST PAKRDPRLTI LEELRFLAEE 350
    RNLGDLRISI ALEGHTLFL 369
    Length:369
    Mass (Da):42,016
    Last modified:October 1, 1996 - v2
    Checksum:i47B752477E99BA88
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941L → F in AAA34896. (PubMed:2824992)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17781 Genomic DNA. Translation: AAA34896.1.
    X94357 Genomic DNA. Translation: CAA64139.1.
    Z72770 Genomic DNA. Translation: CAA96968.1.
    BK006941 Genomic DNA. Translation: DAA07871.1.
    PIRiS61613. ESBYPC.
    RefSeqiNP_011266.1. NM_001181114.1.

    Genome annotation databases

    EnsemblFungiiYGL248W; YGL248W; YGL248W.
    GeneIDi852644.
    KEGGisce:YGL248W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17781 Genomic DNA. Translation: AAA34896.1 .
    X94357 Genomic DNA. Translation: CAA64139.1 .
    Z72770 Genomic DNA. Translation: CAA96968.1 .
    BK006941 Genomic DNA. Translation: DAA07871.1 .
    PIRi S61613. ESBYPC.
    RefSeqi NP_011266.1. NM_001181114.1.

    3D structure databases

    ProteinModelPortali P22434.
    SMRi P22434. Positions 120-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33031. 26 interactions.
    STRINGi 4932.YGL248W.

    Proteomic databases

    MaxQBi P22434.
    PaxDbi P22434.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL248W ; YGL248W ; YGL248W .
    GeneIDi 852644.
    KEGGi sce:YGL248W.

    Organism-specific databases

    CYGDi YGL248w.
    SGDi S000003217. PDE1.

    Phylogenomic databases

    eggNOGi COG5212.
    HOGENOMi HOG000248334.
    KOi K01120.
    OMAi FESANTM.
    OrthoDBi EOG7X6MB3.

    Enzyme and pathway databases

    BioCyci YEAST:YGL248W-MONOMER.

    Miscellaneous databases

    NextBioi 971903.

    Gene expression databases

    Genevestigatori P22434.

    Family and domain databases

    Gene3Di 3.60.15.10. 2 hits.
    InterProi IPR001279. Beta-lactamas-like.
    IPR024225. cAMP-PdiesteraseII_CS.
    IPR000396. Pdiesterase2.
    [Graphical view ]
    Pfami PF02112. PDEase_II. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000962. Cyc_nuc_PDEase. 1 hit.
    PRINTSi PR00388. PDIESTERASE2.
    SUPFAMi SSF56281. SSF56281. 1 hit.
    PROSITEi PS00607. PDEASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae."
      Nikawa J., Sass P., Wigler M.
      Mol. Cell. Biol. 7:3629-3636(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae."
      Coissac E., Maillier E., Robineau S., Netter P.
      Yeast 12:1555-1562(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPDE1_YEAST
    AccessioniPrimary (citable) accession number: P22434
    Secondary accession number(s): D6VV87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1400 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3