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P22434

- PDE1_YEAST

UniProt

P22434 - PDE1_YEAST

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Protein

3',5'-cyclic-nucleotide phosphodiesterase 1

Gene
PDE1, YGL248W, NRB369
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Controls the level of cAMP in yeast cells, together with the high-affinity cAMP phosphodiesterase (PDE2).

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: SGD

GO - Biological processi

  1. cAMP catabolic process Source: InterPro
  2. cAMP-mediated signaling Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP

Enzyme and pathway databases

BioCyciYEAST:YGL248W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic-nucleotide phosphodiesterase 1 (EC:3.1.4.17)
Short name:
PDEase 1
Alternative name(s):
3':5'-CNP
Low-affinity cAMP phosphodiesterase
Gene namesi
Name:PDE1
Ordered Locus Names:YGL248W
ORF Names:NRB369
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL248w.
SGDiS000003217. PDE1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3693693',5'-cyclic-nucleotide phosphodiesterase 1PRO_0000206791Add
BLAST

Proteomic databases

MaxQBiP22434.
PaxDbiP22434.

Expressioni

Gene expression databases

GenevestigatoriP22434.

Interactioni

Protein-protein interaction databases

BioGridi33031. 26 interactions.
STRINGi4932.YGL248W.

Structurei

3D structure databases

ProteinModelPortaliP22434.
SMRiP22434. Positions 120-164.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5212.
HOGENOMiHOG000248334.
KOiK01120.
OMAiFESANTM.
OrthoDBiEOG7X6MB3.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
InterProiIPR001279. Beta-lactamas-like.
IPR024225. cAMP-PdiesteraseII_CS.
IPR000396. Pdiesterase2.
[Graphical view]
PfamiPF02112. PDEase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTSiPR00388. PDIESTERASE2.
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00607. PDEASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22434-1 [UniParc]FASTAAdd to Basket

« Hide

MVVFEITILG ANGGPTEYGT QCFILKPART EDPELIAVDG GAGMYQLREM    50
LVQGRNENEG DDELVPSFYE HDREPIEFFI DSKLNIQKGL SKSLLQSLKR 100
QGEHFESANT MKKTYEVFQG ITDYYITHPH LDHISGLVVN SPSIYEQENS 150
KKKTIWGLPH TIDVLQKHVF NDLIWPDLTA ERSRKLKLKC LNPKEVQKCT 200
IFPWDVIPFK VHHGIGVKTG APVYSTFYIF RDRKSKDCII VCGDVEQDRR 250
ESEESLLEEF WSYVAENIPL VHLKGILVEC SCPLSSKPEQ LYGHLSPIYL 300
INELSNLNTL YNSSKGLSGL NVIVTHVKST PAKRDPRLTI LEELRFLAEE 350
RNLGDLRISI ALEGHTLFL 369
Length:369
Mass (Da):42,016
Last modified:October 1, 1996 - v2
Checksum:i47B752477E99BA88
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941L → F in AAA34896. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17781 Genomic DNA. Translation: AAA34896.1.
X94357 Genomic DNA. Translation: CAA64139.1.
Z72770 Genomic DNA. Translation: CAA96968.1.
BK006941 Genomic DNA. Translation: DAA07871.1.
PIRiS61613. ESBYPC.
RefSeqiNP_011266.1. NM_001181114.1.

Genome annotation databases

EnsemblFungiiYGL248W; YGL248W; YGL248W.
GeneIDi852644.
KEGGisce:YGL248W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17781 Genomic DNA. Translation: AAA34896.1 .
X94357 Genomic DNA. Translation: CAA64139.1 .
Z72770 Genomic DNA. Translation: CAA96968.1 .
BK006941 Genomic DNA. Translation: DAA07871.1 .
PIRi S61613. ESBYPC.
RefSeqi NP_011266.1. NM_001181114.1.

3D structure databases

ProteinModelPortali P22434.
SMRi P22434. Positions 120-164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33031. 26 interactions.
STRINGi 4932.YGL248W.

Proteomic databases

MaxQBi P22434.
PaxDbi P22434.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL248W ; YGL248W ; YGL248W .
GeneIDi 852644.
KEGGi sce:YGL248W.

Organism-specific databases

CYGDi YGL248w.
SGDi S000003217. PDE1.

Phylogenomic databases

eggNOGi COG5212.
HOGENOMi HOG000248334.
KOi K01120.
OMAi FESANTM.
OrthoDBi EOG7X6MB3.

Enzyme and pathway databases

BioCyci YEAST:YGL248W-MONOMER.

Miscellaneous databases

NextBioi 971903.

Gene expression databases

Genevestigatori P22434.

Family and domain databases

Gene3Di 3.60.15.10. 2 hits.
InterProi IPR001279. Beta-lactamas-like.
IPR024225. cAMP-PdiesteraseII_CS.
IPR000396. Pdiesterase2.
[Graphical view ]
Pfami PF02112. PDEase_II. 1 hit.
[Graphical view ]
PIRSFi PIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTSi PR00388. PDIESTERASE2.
SUPFAMi SSF56281. SSF56281. 1 hit.
PROSITEi PS00607. PDEASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae."
    Nikawa J., Sass P., Wigler M.
    Mol. Cell. Biol. 7:3629-3636(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae."
    Coissac E., Maillier E., Robineau S., Netter P.
    Yeast 12:1555-1562(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPDE1_YEAST
AccessioniPrimary (citable) accession number: P22434
Secondary accession number(s): D6VV87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1400 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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