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Protein

Dipeptidase 1

Gene

DPEP1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi38Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi141Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi141Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei168SubstratePROSITE-ProRule annotation1
Metal bindingi214Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi235Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei246SubstratePROSITE-ProRule annotation1
Binding sitei304SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-9981.

Protein family/group databases

MEROPSiM19.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 1 (EC:3.4.13.19)
Alternative name(s):
Microsomal dipeptidase
Renal dipeptidase
Gene namesi
Name:DPEP1
Synonyms:RDP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • apical part of cell Source: UniProtKB
  • apical plasma membrane Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: UniProtKB
  • extracellular space Source: UniProtKB
  • microvillus membrane Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000001865617 – 384Dipeptidase 1Add BLAST368
PropeptideiPRO_0000018657385 – 409Removed in mature formBy similarityAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)1 Publication1
Disulfide bondi87 ↔ 170PROSITE-ProRule annotation
Disulfide bondi242 ↔ 274PROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi377Interchain
Lipidationi384GPI-anchor amidated serine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP22412.
PeptideAtlasiP22412.
PRIDEiP22412.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000019823.

Chemistry databases

BindingDBiP22412.

Structurei

3D structure databases

ProteinModelPortaliP22412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
HOVERGENiHBG002339.
InParanoidiP22412.
KOiK01273.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR000180. Dipep_AS.
IPR028536. Dpep1.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF17. PTHR10443:SF17. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTSWWLWPL VAVCAADQFR DLAVRIMQDT PVIDGHNDLP WQLLNLFNNQ
60 70 80 90 100
LQDPGANLSS LAHTHTNIPK LKAGFVGGQF WSAYVPCDTQ NRDAVKRTLE
110 120 130 140 150
QIDVIQRMCQ AYPETFACVT SSTGIRQAFR EGKVASLVGV EGGHSIDSSL
160 170 180 190 200
GVLRALYHLG MRYMTLTHSC NTPWADNWLV DTGDDKAQSQ GLSHFGQSVV
210 220 230 240 250
KEMNRLGVMI DLAHVSVATM RAALKLSQAP VIFSHSSAYS LCPHRRNVPD
260 270 280 290 300
DVLQLVKETG SLVMVNFYND YVSCSAKANL SQVADHLDHI KKVAGAAAVG
310 320 330 340 350
FGGDYDGVSR VPSGLEDVSK YPDLVAELLR RQWTEAEVRG ALADNLLRVF
360 370 380 390 400
EAVEQASNHA QVPGEEPIPL GQLEASCRTN YGYSAAPSLH LPPGSLLASL

VPLLLLSLP
Length:409
Mass (Da):44,700
Last modified:August 1, 1991 - v1
Checksum:i926B7F0044FA055F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53730 mRNA. Translation: CAA37762.1.
D13142 mRNA. Translation: BAA02433.1.
PIRiJS0759.
RefSeqiNP_999273.1. NM_214108.1.
UniGeneiSsc.315.

Genome annotation databases

GeneIDi397196.
KEGGissc:397196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53730 mRNA. Translation: CAA37762.1.
D13142 mRNA. Translation: BAA02433.1.
PIRiJS0759.
RefSeqiNP_999273.1. NM_214108.1.
UniGeneiSsc.315.

3D structure databases

ProteinModelPortaliP22412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000019823.

Chemistry databases

BindingDBiP22412.
ChEMBLiCHEMBL2626.

Protein family/group databases

MEROPSiM19.001.

Proteomic databases

PaxDbiP22412.
PeptideAtlasiP22412.
PRIDEiP22412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397196.
KEGGissc:397196.

Organism-specific databases

CTDi1800.

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
HOVERGENiHBG002339.
InParanoidiP22412.
KOiK01273.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-9981.

Miscellaneous databases

PROiP22412.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR000180. Dipep_AS.
IPR028536. Dpep1.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF17. PTHR10443:SF17. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPEP1_PIG
AccessioniPrimary (citable) accession number: P22412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.