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P22390

- BLAC_CITKO

UniProt

P22390 - BLAC_CITKO

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Protein
Beta-lactamase
Gene
N/A
Organism
Citrobacter koseri (Citrobacter diversus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Acyl-ester intermediate
Active sitei174 – 1741Proton acceptor By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

SABIO-RKP22390.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
OrganismiCitrobacter koseri (Citrobacter diversus)
Taxonomic identifieri545 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 Publication
Add
BLAST
Chaini28 – 294267Beta-lactamase
PRO_0000016977Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP22390.
SMRiP22390. Positions 35-293.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni240 – 2423Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22390-1 [UniParc]FASTAAdd to Basket

« Hide

MFKKRGRQTV LIAAVLAFFT ASSPLLARTQ GEPTQVQQKL AALEKQSGGR    50
LGVALINTAD RSQILYRGDE RFAMCSTSKT MVAAAVLKQS ETQHDILQQK 100
MVIKKADLTN WNPVTEKYVD KEMTLAELSA ATLQYSDNTA MNKLLEHLGG 150
TSNVTAFARS IGDTTFRLDR KEPELNTAIP GDERDTTCPL AMAKSLHKLT 200
LGDALAGAQR AQLVEWLKGN TTGGQSIRAG LPEGWVVGDK TGAGDYGTTN 250
DIAVIWPEDR APLILVTYFT QPQQDAKGRK DILAAAAKIV TEGL 294
Length:294
Mass (Da):31,862
Last modified:December 1, 1992 - v2
Checksum:iBF075822858C54BB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281R → G AA sequence 1 Publication
Sequence conflicti61 – 611R → S AA sequence 1 Publication
Sequence conflicti80 – 834TMVA → AMAT AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62610 Genomic DNA. Translation: CAA44485.1.
PIRiS19006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62610 Genomic DNA. Translation: CAA44485.1 .
PIRi S19006.

3D structure databases

ProteinModelPortali P22390.
SMRi P22390. Positions 35-293.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P22390.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and nucleotide sequencing of the gene encoding the beta-lactamase from Citrobacter diversus."
    Perilli M., Franceschini N., Segatore B., Amicosante G., Oratore A., Duez C., Joris B., Frere J.-M.
    FEMS Microbiol. Lett. 67:79-84(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ULA-27.
  2. "Proteolytic interconversion and N-terminal sequences of the Citrobacter diversus major beta-lactamases."
    Franceschini N., Amicosante G., Perilli M., Maccarrone M., Oratore A., van Beeumen J., Frere J.-M.
    Biochem. J. 275:629-633(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-83.
    Strain: ULA-27.
  3. "Chromosome-encoded beta-lactamases of Citrobacter diversus. Interaction with beta-iodopenicillanate and labelling of the active site."
    Amicosante G., Oratore A., Joris B., Galleni M., Frere J.-M., van Beeumen J.
    Biochem. J. 254:891-893(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 72-79.

Entry informationi

Entry nameiBLAC_CITKO
AccessioniPrimary (citable) accession number: P22390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: December 1, 1992
Last modified: December 11, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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