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Protein

Endothelin-2

Gene

Edn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Vasoconstrictor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei66 – 672Cleavage; by KELBy similarity

GO - Molecular functioni

  1. hormone activity Source: MGI

GO - Biological processi

  1. artery smooth muscle contraction Source: MGI
  2. calcium-mediated signaling Source: MGI
  3. cytokine-mediated signaling pathway Source: MGI
  4. energy homeostasis Source: MGI
  5. inositol phosphate-mediated signaling Source: MGI
  6. lung alveolus development Source: MGI
  7. macrophage activation Source: MGI
  8. macrophage chemotaxis Source: MGI
  9. neutrophil chemotaxis Source: MGI
  10. positive regulation of cell proliferation Source: MGI
  11. positive regulation of cytosolic calcium ion concentration Source: MGI
  12. positive regulation of heart rate Source: MGI
  13. positive regulation of leukocyte chemotaxis Source: MGI
  14. positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
  15. positive regulation of smooth muscle contraction Source: MGI
  16. prostaglandin biosynthetic process Source: BHF-UCL
  17. regulation of systemic arterial blood pressure by endothelin Source: MGI
  18. regulation of vasoconstriction Source: InterPro
  19. temperature homeostasis Source: MGI
  20. vasoconstriction Source: MGI
  21. vein smooth muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-2
Short name:
ET-2
Alternative name(s):
Preproendothelin-2
Short name:
PPET2
Vasoactive intestinal contractor
Short name:
VIC
Gene namesi
Name:Edn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:95284. Edn2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 4322PRO_0000008099Add
BLAST
Peptidei46 – 6621Endothelin-2PRO_0000008100Add
BLAST
Propeptidei67 – 175109PRO_0000008101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 60By similarity
Disulfide bondi48 ↔ 56By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP22389.

Expressioni

Gene expression databases

BgeeiP22389.
CleanExiMM_EDN2.
GenevestigatoriP22389.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 10816Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43933.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP22389.
KOiK16367.
OMAiPTAWCSV.
OrthoDBiEOG7F7WBX.
PhylomeDBiP22389.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22389-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSAWCSIAL ALLLALHEGK GQAAATLEQP ASAPKGRGPH LRFRRCSCNS
60 70 80 90 100
WLDKECVYFC HLDIIWVNTA GQTAPYGLGN PPRRRRRSLP KRCECSTAGD
110 120 130 140 150
SACATFCHRR HWPEAVVAPS SQAPAAVLKT GKMWTAEGDL LRKLRDISAT
160 170
KLRFARLQPE VTRKAIPAYS RWRKR
Length:175
Mass (Da):19,538
Last modified:April 27, 2001 - v3
Checksum:i6BCDD79CAAA0244A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1522KL → NV in CAA42155. (PubMed:1859843)Curated
Sequence conflicti156 – 17520RLQPE…RWRKR → SYSQR(PubMed:1859843)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59556 mRNA. Translation: CAA42155.1.
AB030303 Genomic DNA. Translation: BAA94208.1.
BC037042 mRNA. Translation: AAH37042.1.
M26498 Genomic DNA. No translation available.
CCDSiCCDS38864.1.
PIRiS17194.
RefSeqiNP_031928.2. NM_007902.2.
UniGeneiMm.284855.

Genome annotation databases

EnsembliENSMUST00000030384; ENSMUSP00000030384; ENSMUSG00000028635.
GeneIDi13615.
KEGGimmu:13615.
UCSCiuc008unb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59556 mRNA. Translation: CAA42155.1.
AB030303 Genomic DNA. Translation: BAA94208.1.
BC037042 mRNA. Translation: AAH37042.1.
M26498 Genomic DNA. No translation available.
CCDSiCCDS38864.1.
PIRiS17194.
RefSeqiNP_031928.2. NM_007902.2.
UniGeneiMm.284855.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP22389.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030384; ENSMUSP00000030384; ENSMUSG00000028635.
GeneIDi13615.
KEGGimmu:13615.
UCSCiuc008unb.1. mouse.

Organism-specific databases

CTDi1907.
MGIiMGI:95284. Edn2.

Phylogenomic databases

eggNOGiNOG43933.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP22389.
KOiK16367.
OMAiPTAWCSV.
OrthoDBiEOG7F7WBX.
PhylomeDBiP22389.
TreeFamiTF333184.

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi284276.
PROiP22389.
SOURCEiSearch...

Gene expression databases

BgeeiP22389.
CleanExiMM_EDN2.
GenevestigatoriP22389.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, sequence analysis and tissue distribution of a precursor for vasoactive intestinal contractor (VIC)."
    Saida K., Mitsui Y.
    Biochim. Biophys. Acta 1089:404-406(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  2. "The prepro vasoactive intestinal contractor (VIC)/endothelin-2 gene (EDN2): structure, evolution, production, and embryonic expression."
    Saida K., Hashimoto M., Mitsui Y., Ishida N., Uchide T.
    Genomics 64:51-61(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  4. "A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity."
    Saida K., Mitsui Y., Ishida N.
    J. Biol. Chem. 264:14613-14616(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-70.

Entry informationi

Entry nameiEDN2_MOUSE
AccessioniPrimary (citable) accession number: P22389
Secondary accession number(s): Q9JME3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 27, 2001
Last modified: February 4, 2015
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.