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P22389 (EDN2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin-2

Short name=ET-2
Alternative name(s):
Preproendothelin-2
Short name=PPET2
Vasoactive intestinal contractor
Short name=VIC
Gene names
Name:Edn2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length175 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Vasoconstrictor.

Subcellular location

Secreted.

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionVasoactive
Vasoconstrictor
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processartery smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

calcium-mediated signaling

Inferred from electronic annotation. Source: Ensembl

cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

energy homeostasis

Inferred from mutant phenotype PubMed 23676500. Source: MGI

inositol phosphate-mediated signaling

Inferred from electronic annotation. Source: Ensembl

lung alveolus development

Inferred from mutant phenotype PubMed 23676500. Source: MGI

macrophage activation

Inferred from electronic annotation. Source: Ensembl

macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

positive regulation of leukocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of prostaglandin-endoperoxide synthase activity

Inferred from mutant phenotype PubMed 9492062. Source: BHF-UCL

positive regulation of smooth muscle contraction

Inferred from direct assay Ref.4. Source: MGI

prostaglandin biosynthetic process

Inferred from direct assay PubMed 9492062. Source: BHF-UCL

regulation of systemic arterial blood pressure by endothelin

Inferred from electronic annotation. Source: Ensembl

regulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

temperature homeostasis

Inferred from mutant phenotype PubMed 23676500. Source: MGI

vein smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Propeptide22 – 4322
PRO_0000008099
Peptide46 – 6621Endothelin-2
PRO_0000008100
Propeptide67 – 175109
PRO_0000008101

Regions

Region93 – 10816Endothelin-like

Sites

Site66 – 672Cleavage; by KEL By similarity

Amino acid modifications

Disulfide bond46 ↔ 60 By similarity
Disulfide bond48 ↔ 56 By similarity

Experimental info

Sequence conflict151 – 1522KL → NV in CAA42155. Ref.1
Sequence conflict156 – 17520RLQPE…RWRKR → SYSQR Ref.1

Sequences

Sequence LengthMass (Da)Tools
P22389 [UniParc].

Last modified April 27, 2001. Version 3.
Checksum: 6BCDD79CAAA0244A

FASTA17519,538
        10         20         30         40         50         60 
MVSAWCSIAL ALLLALHEGK GQAAATLEQP ASAPKGRGPH LRFRRCSCNS WLDKECVYFC 

        70         80         90        100        110        120 
HLDIIWVNTA GQTAPYGLGN PPRRRRRSLP KRCECSTAGD SACATFCHRR HWPEAVVAPS 

       130        140        150        160        170 
SQAPAAVLKT GKMWTAEGDL LRKLRDISAT KLRFARLQPE VTRKAIPAYS RWRKR 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning, sequence analysis and tissue distribution of a precursor for vasoactive intestinal contractor (VIC)."
Saida K., Mitsui Y.
Biochim. Biophys. Acta 1089:404-406(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
[2]"The prepro vasoactive intestinal contractor (VIC)/endothelin-2 gene (EDN2): structure, evolution, production, and embryonic expression."
Saida K., Hashimoto M., Mitsui Y., Ishida N., Uchide T.
Genomics 64:51-61(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Retina.
[4]"A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity."
Saida K., Mitsui Y., Ishida N.
J. Biol. Chem. 264:14613-14616(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-70.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59556 mRNA. Translation: CAA42155.1.
AB030303 Genomic DNA. Translation: BAA94208.1.
BC037042 mRNA. Translation: AAH37042.1.
M26498 Genomic DNA. No translation available.
PIRS17194.
RefSeqNP_031928.2. NM_007902.2.
UniGeneMm.284855.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP22389.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030384; ENSMUSP00000030384; ENSMUSG00000028635.
GeneID13615.
KEGGmmu:13615.
UCSCuc008unb.1. mouse.

Organism-specific databases

CTD1907.
MGIMGI:95284. Edn2.

Phylogenomic databases

eggNOGNOG43933.
GeneTreeENSGT00530000063310.
HOGENOMHOG000231110.
HOVERGENHBG051441.
InParanoidP22389.
KOK16367.
OMAHLRLRRC.
OrthoDBEOG7F7WBX.
PhylomeDBP22389.
TreeFamTF333184.

Gene expression databases

BgeeP22389.
CleanExMM_EDN2.
GenevestigatorP22389.

Family and domain databases

InterProIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERPTHR13874:SF4. PTHR13874:SF4. 1 hit.
PfamPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSPR00365. ENDOTHELIN.
SMARTSM00272. END. 2 hits.
[Graphical view]
PROSITEPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio284276.
PROP22389.
SOURCESearch...

Entry information

Entry nameEDN2_MOUSE
AccessionPrimary (citable) accession number: P22389
Secondary accession number(s): Q9JME3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 27, 2001
Last modified: April 16, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot