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P22389

- EDN2_MOUSE

UniProt

P22389 - EDN2_MOUSE

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Protein

Endothelin-2

Gene

Edn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Vasoconstrictor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei66 – 672Cleavage; by KELBy similarity

GO - Biological processi

  1. artery smooth muscle contraction Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cytokine-mediated signaling pathway Source: Ensembl
  4. energy homeostasis Source: MGI
  5. inositol phosphate-mediated signaling Source: Ensembl
  6. lung alveolus development Source: MGI
  7. macrophage activation Source: Ensembl
  8. macrophage chemotaxis Source: Ensembl
  9. neutrophil chemotaxis Source: Ensembl
  10. positive regulation of cell proliferation Source: Ensembl
  11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  12. positive regulation of heart rate Source: Ensembl
  13. positive regulation of leukocyte chemotaxis Source: Ensembl
  14. positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
  15. positive regulation of smooth muscle contraction Source: MGI
  16. prostaglandin biosynthetic process Source: BHF-UCL
  17. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  18. regulation of vasoconstriction Source: InterPro
  19. temperature homeostasis Source: MGI
  20. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-2
Short name:
ET-2
Alternative name(s):
Preproendothelin-2
Short name:
PPET2
Vasoactive intestinal contractor
Short name:
VIC
Gene namesi
Name:Edn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:95284. Edn2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 4322PRO_0000008099Add
BLAST
Peptidei46 – 6621Endothelin-2PRO_0000008100Add
BLAST
Propeptidei67 – 175109PRO_0000008101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 60By similarity
Disulfide bondi48 ↔ 56By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP22389.

Expressioni

Gene expression databases

BgeeiP22389.
CleanExiMM_EDN2.
GenevestigatoriP22389.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 10816Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43933.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP22389.
KOiK16367.
OMAiEQTAPYG.
OrthoDBiEOG7F7WBX.
PhylomeDBiP22389.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22389 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSAWCSIAL ALLLALHEGK GQAAATLEQP ASAPKGRGPH LRFRRCSCNS
60 70 80 90 100
WLDKECVYFC HLDIIWVNTA GQTAPYGLGN PPRRRRRSLP KRCECSTAGD
110 120 130 140 150
SACATFCHRR HWPEAVVAPS SQAPAAVLKT GKMWTAEGDL LRKLRDISAT
160 170
KLRFARLQPE VTRKAIPAYS RWRKR
Length:175
Mass (Da):19,538
Last modified:April 27, 2001 - v3
Checksum:i6BCDD79CAAA0244A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1522KL → NV in CAA42155. (PubMed:1859843)Curated
Sequence conflicti156 – 17520RLQPE…RWRKR → SYSQR(PubMed:1859843)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59556 mRNA. Translation: CAA42155.1.
AB030303 Genomic DNA. Translation: BAA94208.1.
BC037042 mRNA. Translation: AAH37042.1.
M26498 Genomic DNA. No translation available.
CCDSiCCDS38864.1.
PIRiS17194.
RefSeqiNP_031928.2. NM_007902.2.
UniGeneiMm.284855.

Genome annotation databases

EnsembliENSMUST00000030384; ENSMUSP00000030384; ENSMUSG00000028635.
GeneIDi13615.
KEGGimmu:13615.
UCSCiuc008unb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59556 mRNA. Translation: CAA42155.1 .
AB030303 Genomic DNA. Translation: BAA94208.1 .
BC037042 mRNA. Translation: AAH37042.1 .
M26498 Genomic DNA. No translation available.
CCDSi CCDS38864.1.
PIRi S17194.
RefSeqi NP_031928.2. NM_007902.2.
UniGenei Mm.284855.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P22389.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030384 ; ENSMUSP00000030384 ; ENSMUSG00000028635 .
GeneIDi 13615.
KEGGi mmu:13615.
UCSCi uc008unb.1. mouse.

Organism-specific databases

CTDi 1907.
MGIi MGI:95284. Edn2.

Phylogenomic databases

eggNOGi NOG43933.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
InParanoidi P22389.
KOi K16367.
OMAi EQTAPYG.
OrthoDBi EOG7F7WBX.
PhylomeDBi P22389.
TreeFami TF333184.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 284276.
PROi P22389.
SOURCEi Search...

Gene expression databases

Bgeei P22389.
CleanExi MM_EDN2.
Genevestigatori P22389.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view ]
PANTHERi PTHR13874:SF8. PTHR13874:SF8. 1 hit.
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, sequence analysis and tissue distribution of a precursor for vasoactive intestinal contractor (VIC)."
    Saida K., Mitsui Y.
    Biochim. Biophys. Acta 1089:404-406(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  2. "The prepro vasoactive intestinal contractor (VIC)/endothelin-2 gene (EDN2): structure, evolution, production, and embryonic expression."
    Saida K., Hashimoto M., Mitsui Y., Ishida N., Uchide T.
    Genomics 64:51-61(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  4. "A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity."
    Saida K., Mitsui Y., Ishida N.
    J. Biol. Chem. 264:14613-14616(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-70.

Entry informationi

Entry nameiEDN2_MOUSE
AccessioniPrimary (citable) accession number: P22389
Secondary accession number(s): Q9JME3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 27, 2001
Last modified: October 1, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3