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P22389

- EDN2_MOUSE

UniProt

P22389 - EDN2_MOUSE

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Protein

Endothelin-2

Gene
Edn2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Vasoconstrictor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei66 – 672Cleavage; by KEL By similarity

GO - Biological processi

  1. artery smooth muscle contraction Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cytokine-mediated signaling pathway Source: Ensembl
  4. energy homeostasis Source: MGI
  5. inositol phosphate-mediated signaling Source: Ensembl
  6. lung alveolus development Source: MGI
  7. macrophage activation Source: Ensembl
  8. macrophage chemotaxis Source: Ensembl
  9. neutrophil chemotaxis Source: Ensembl
  10. positive regulation of cell proliferation Source: Ensembl
  11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  12. positive regulation of heart rate Source: Ensembl
  13. positive regulation of leukocyte chemotaxis Source: Ensembl
  14. positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
  15. positive regulation of smooth muscle contraction Source: MGI
  16. prostaglandin biosynthetic process Source: BHF-UCL
  17. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  18. regulation of vasoconstriction Source: InterPro
  19. temperature homeostasis Source: MGI
  20. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-2
Short name:
ET-2
Alternative name(s):
Preproendothelin-2
Short name:
PPET2
Vasoactive intestinal contractor
Short name:
VIC
Gene namesi
Name:Edn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:95284. Edn2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Propeptidei22 – 4322PRO_0000008099Add
BLAST
Peptidei46 – 6621Endothelin-2PRO_0000008100Add
BLAST
Propeptidei67 – 175109PRO_0000008101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 60 By similarity
Disulfide bondi48 ↔ 56 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP22389.

Expressioni

Gene expression databases

BgeeiP22389.
CleanExiMM_EDN2.
GenevestigatoriP22389.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 10816Endothelin-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43933.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP22389.
KOiK16367.
OMAiEQTAPYG.
OrthoDBiEOG7F7WBX.
PhylomeDBiP22389.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22389-1 [UniParc]FASTAAdd to Basket

« Hide

MVSAWCSIAL ALLLALHEGK GQAAATLEQP ASAPKGRGPH LRFRRCSCNS    50
WLDKECVYFC HLDIIWVNTA GQTAPYGLGN PPRRRRRSLP KRCECSTAGD 100
SACATFCHRR HWPEAVVAPS SQAPAAVLKT GKMWTAEGDL LRKLRDISAT 150
KLRFARLQPE VTRKAIPAYS RWRKR 175
Length:175
Mass (Da):19,538
Last modified:April 27, 2001 - v3
Checksum:i6BCDD79CAAA0244A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1522KL → NV in CAA42155. 1 Publication
Sequence conflicti156 – 17520RLQPE…RWRKR → SYSQR1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59556 mRNA. Translation: CAA42155.1.
AB030303 Genomic DNA. Translation: BAA94208.1.
BC037042 mRNA. Translation: AAH37042.1.
M26498 Genomic DNA. No translation available.
CCDSiCCDS38864.1.
PIRiS17194.
RefSeqiNP_031928.2. NM_007902.2.
UniGeneiMm.284855.

Genome annotation databases

EnsembliENSMUST00000030384; ENSMUSP00000030384; ENSMUSG00000028635.
GeneIDi13615.
KEGGimmu:13615.
UCSCiuc008unb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59556 mRNA. Translation: CAA42155.1 .
AB030303 Genomic DNA. Translation: BAA94208.1 .
BC037042 mRNA. Translation: AAH37042.1 .
M26498 Genomic DNA. No translation available.
CCDSi CCDS38864.1.
PIRi S17194.
RefSeqi NP_031928.2. NM_007902.2.
UniGenei Mm.284855.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P22389.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030384 ; ENSMUSP00000030384 ; ENSMUSG00000028635 .
GeneIDi 13615.
KEGGi mmu:13615.
UCSCi uc008unb.1. mouse.

Organism-specific databases

CTDi 1907.
MGIi MGI:95284. Edn2.

Phylogenomic databases

eggNOGi NOG43933.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
InParanoidi P22389.
KOi K16367.
OMAi EQTAPYG.
OrthoDBi EOG7F7WBX.
PhylomeDBi P22389.
TreeFami TF333184.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 284276.
PROi P22389.
SOURCEi Search...

Gene expression databases

Bgeei P22389.
CleanExi MM_EDN2.
Genevestigatori P22389.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view ]
PANTHERi PTHR13874:SF8. PTHR13874:SF8. 1 hit.
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, sequence analysis and tissue distribution of a precursor for vasoactive intestinal contractor (VIC)."
    Saida K., Mitsui Y.
    Biochim. Biophys. Acta 1089:404-406(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  2. "The prepro vasoactive intestinal contractor (VIC)/endothelin-2 gene (EDN2): structure, evolution, production, and embryonic expression."
    Saida K., Hashimoto M., Mitsui Y., Ishida N., Uchide T.
    Genomics 64:51-61(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  4. "A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity."
    Saida K., Mitsui Y., Ishida N.
    J. Biol. Chem. 264:14613-14616(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-70.

Entry informationi

Entry nameiEDN2_MOUSE
AccessioniPrimary (citable) accession number: P22389
Secondary accession number(s): Q9JME3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 27, 2001
Last modified: September 3, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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