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P22389

- EDN2_MOUSE

UniProt

P22389 - EDN2_MOUSE

Protein

Endothelin-2

Gene

Edn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Vasoconstrictor.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei66 – 672Cleavage; by KELBy similarity

    GO - Biological processi

    1. artery smooth muscle contraction Source: Ensembl
    2. calcium-mediated signaling Source: Ensembl
    3. cytokine-mediated signaling pathway Source: Ensembl
    4. energy homeostasis Source: MGI
    5. inositol phosphate-mediated signaling Source: Ensembl
    6. lung alveolus development Source: MGI
    7. macrophage activation Source: Ensembl
    8. macrophage chemotaxis Source: Ensembl
    9. neutrophil chemotaxis Source: Ensembl
    10. positive regulation of cell proliferation Source: Ensembl
    11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    12. positive regulation of heart rate Source: Ensembl
    13. positive regulation of leukocyte chemotaxis Source: Ensembl
    14. positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
    15. positive regulation of smooth muscle contraction Source: MGI
    16. prostaglandin biosynthetic process Source: BHF-UCL
    17. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
    18. regulation of vasoconstriction Source: InterPro
    19. temperature homeostasis Source: MGI
    20. vein smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-2
    Short name:
    ET-2
    Alternative name(s):
    Preproendothelin-2
    Short name:
    PPET2
    Vasoactive intestinal contractor
    Short name:
    VIC
    Gene namesi
    Name:Edn2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:95284. Edn2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 4322PRO_0000008099Add
    BLAST
    Peptidei46 – 6621Endothelin-2PRO_0000008100Add
    BLAST
    Propeptidei67 – 175109PRO_0000008101Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 60By similarity
    Disulfide bondi48 ↔ 56By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP22389.

    Expressioni

    Gene expression databases

    BgeeiP22389.
    CleanExiMM_EDN2.
    GenevestigatoriP22389.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 10816Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43933.
    GeneTreeiENSGT00530000063310.
    HOGENOMiHOG000231110.
    HOVERGENiHBG051441.
    InParanoidiP22389.
    KOiK16367.
    OMAiEQTAPYG.
    OrthoDBiEOG7F7WBX.
    PhylomeDBiP22389.
    TreeFamiTF333184.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    IPR015658. ET-2.
    [Graphical view]
    PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22389-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSAWCSIAL ALLLALHEGK GQAAATLEQP ASAPKGRGPH LRFRRCSCNS    50
    WLDKECVYFC HLDIIWVNTA GQTAPYGLGN PPRRRRRSLP KRCECSTAGD 100
    SACATFCHRR HWPEAVVAPS SQAPAAVLKT GKMWTAEGDL LRKLRDISAT 150
    KLRFARLQPE VTRKAIPAYS RWRKR 175
    Length:175
    Mass (Da):19,538
    Last modified:April 27, 2001 - v3
    Checksum:i6BCDD79CAAA0244A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1522KL → NV in CAA42155. (PubMed:1859843)Curated
    Sequence conflicti156 – 17520RLQPE…RWRKR → SYSQR(PubMed:1859843)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59556 mRNA. Translation: CAA42155.1.
    AB030303 Genomic DNA. Translation: BAA94208.1.
    BC037042 mRNA. Translation: AAH37042.1.
    M26498 Genomic DNA. No translation available.
    CCDSiCCDS38864.1.
    PIRiS17194.
    RefSeqiNP_031928.2. NM_007902.2.
    UniGeneiMm.284855.

    Genome annotation databases

    EnsembliENSMUST00000030384; ENSMUSP00000030384; ENSMUSG00000028635.
    GeneIDi13615.
    KEGGimmu:13615.
    UCSCiuc008unb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59556 mRNA. Translation: CAA42155.1 .
    AB030303 Genomic DNA. Translation: BAA94208.1 .
    BC037042 mRNA. Translation: AAH37042.1 .
    M26498 Genomic DNA. No translation available.
    CCDSi CCDS38864.1.
    PIRi S17194.
    RefSeqi NP_031928.2. NM_007902.2.
    UniGenei Mm.284855.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P22389.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030384 ; ENSMUSP00000030384 ; ENSMUSG00000028635 .
    GeneIDi 13615.
    KEGGi mmu:13615.
    UCSCi uc008unb.1. mouse.

    Organism-specific databases

    CTDi 1907.
    MGIi MGI:95284. Edn2.

    Phylogenomic databases

    eggNOGi NOG43933.
    GeneTreei ENSGT00530000063310.
    HOGENOMi HOG000231110.
    HOVERGENi HBG051441.
    InParanoidi P22389.
    KOi K16367.
    OMAi EQTAPYG.
    OrthoDBi EOG7F7WBX.
    PhylomeDBi P22389.
    TreeFami TF333184.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 284276.
    PROi P22389.
    SOURCEi Search...

    Gene expression databases

    Bgeei P22389.
    CleanExi MM_EDN2.
    Genevestigatori P22389.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    IPR015658. ET-2.
    [Graphical view ]
    PANTHERi PTHR13874:SF8. PTHR13874:SF8. 1 hit.
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning, sequence analysis and tissue distribution of a precursor for vasoactive intestinal contractor (VIC)."
      Saida K., Mitsui Y.
      Biochim. Biophys. Acta 1089:404-406(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
    2. "The prepro vasoactive intestinal contractor (VIC)/endothelin-2 gene (EDN2): structure, evolution, production, and embryonic expression."
      Saida K., Hashimoto M., Mitsui Y., Ishida N., Uchide T.
      Genomics 64:51-61(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.
    4. "A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity."
      Saida K., Mitsui Y., Ishida N.
      J. Biol. Chem. 264:14613-14616(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-70.

    Entry informationi

    Entry nameiEDN2_MOUSE
    AccessioniPrimary (citable) accession number: P22389
    Secondary accession number(s): Q9JME3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3