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P22388

- EDN1_RAT

UniProt

P22388 - EDN1_RAT

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Protein

Endothelin-1

Gene

Edn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KELBy similarity

GO - Molecular functioni

  1. endothelin A receptor binding Source: RGD
  2. endothelin B receptor binding Source: RGD

GO - Biological processi

  1. artery smooth muscle contraction Source: RGD
  2. body fluid secretion Source: Ensembl
  3. calcium-mediated signaling Source: Ensembl
  4. cartilage development Source: Ensembl
  5. cell growth Source: RGD
  6. cellular response to calcium ion Source: RGD
  7. cellular response to drug Source: RGD
  8. cellular response to fatty acid Source: RGD
  9. cellular response to glucocorticoid stimulus Source: RGD
  10. cellular response to hypoxia Source: RGD
  11. cellular response to interferon-gamma Source: RGD
  12. cellular response to interleukin-1 Source: RGD
  13. cellular response to mineralocorticoid stimulus Source: RGD
  14. cellular response to peptide hormone stimulus Source: RGD
  15. cellular response to transforming growth factor beta stimulus Source: RGD
  16. cellular response to tumor necrosis factor Source: RGD
  17. dorsal/ventral pattern formation Source: Ensembl
  18. epithelial fluid transport Source: RGD
  19. glucose transport Source: Ensembl
  20. heart development Source: Ensembl
  21. histamine secretion Source: RGD
  22. inositol phosphate-mediated signaling Source: Ensembl
  23. intracellular signal transduction Source: RGD
  24. in utero embryonic development Source: Ensembl
  25. maternal process involved in parturition Source: RGD
  26. membrane depolarization Source: RGD
  27. middle ear morphogenesis Source: Ensembl
  28. multicellular organismal aging Source: RGD
  29. negative regulation of cAMP biosynthetic process Source: Ensembl
  30. negative regulation of cellular protein metabolic process Source: Ensembl
  31. negative regulation of hormone secretion Source: RGD
  32. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  33. negative regulation of smooth muscle cell apoptotic process Source: RGD
  34. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  35. neural crest cell development Source: Ensembl
  36. nitric oxide transport Source: Ensembl
  37. patterning of blood vessels Source: Ensembl
  38. peptide hormone secretion Source: Ensembl
  39. phosphatidylinositol 3-kinase signaling Source: Ensembl
  40. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
  41. positive regulation of cardiac muscle hypertrophy Source: Ensembl
  42. positive regulation of cell proliferation Source: RGD
  43. positive regulation of cell size Source: Ensembl
  44. positive regulation of cytosolic calcium ion concentration Source: RGD
  45. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  46. positive regulation of heart rate Source: Ensembl
  47. positive regulation of hormone secretion Source: Ensembl
  48. positive regulation of JUN kinase activity Source: Ensembl
  49. positive regulation of mitosis Source: Ensembl
  50. positive regulation of neutrophil chemotaxis Source: RGD
  51. positive regulation of odontogenesis Source: RGD
  52. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
  53. positive regulation of prostaglandin secretion Source: RGD
  54. positive regulation of receptor biosynthetic process Source: Ensembl
  55. positive regulation of renal sodium excretion Source: Ensembl
  56. positive regulation of sarcomere organization Source: Ensembl
  57. positive regulation of smooth muscle cell proliferation Source: Ensembl
  58. positive regulation of smooth muscle contraction Source: RGD
  59. positive regulation of transcription from RNA polymerase II promoter Source: RGD
  60. positive regulation of urine volume Source: Ensembl
  61. prostaglandin biosynthetic process Source: Ensembl
  62. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  63. protein kinase C deactivation Source: Ensembl
  64. regulation of blood pressure Source: RGD
  65. regulation of pH Source: Ensembl
  66. regulation of sensory perception of pain Source: RGD
  67. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  68. regulation of vasoconstriction Source: InterPro
  69. respiratory gaseous exchange Source: Ensembl
  70. response to activity Source: RGD
  71. response to amino acid Source: RGD
  72. response to dexamethasone Source: RGD
  73. response to drug Source: RGD
  74. response to hypoxia Source: RGD
  75. response to leptin Source: RGD
  76. response to lipopolysaccharide Source: RGD
  77. response to muscle stretch Source: RGD
  78. response to nicotine Source: RGD
  79. response to ozone Source: RGD
  80. response to prostaglandin F Source: RGD
  81. response to salt Source: RGD
  82. response to testosterone Source: RGD
  83. response to transforming growth factor beta Source: RGD
  84. rhythmic excitation Source: Ensembl
  85. sensory perception of pain Source: RGD
  86. superoxide anion generation Source: RGD
  87. vasoconstriction Source: RGD
  88. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_250028. Peptide ligand-binding receptors.
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Gene namesi
Name:Edn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi2532. Edn1.

Subcellular locationi

GO - Cellular componenti

  1. basal part of cell Source: RGD
  2. extracellular space Source: RGD
  3. rough endoplasmic reticulum lumen Source: RGD
  4. Weibel-Palade body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 5025PRO_0000008072Add
BLAST
Peptidei53 – 7321Endothelin-1PRO_0000008073Add
BLAST
Propeptidei74 – 202129PRO_0000008074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP22388.

Expressioni

Gene expression databases

ExpressionAtlasiP22388. baseline and differential.
GenevestigatoriP22388.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019361.

Structurei

Secondary structure

1
202
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi54 – 574Combined sources
Helixi61 – 699Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CMHNMR-A60-73[»]
6CMHNMR-A53-73[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22388.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12415Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP22388.
KOiK16366.
OMAiMDYFPMI.
OrthoDBiEOG7PS1H7.
PhylomeDBiP22388.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22388-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYFPVIFSL LFVAFQGAPE TAVLGAELSP RAEKEVQSPP PSTSWRPRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPERV VPYGLGSPSR SKRSLKDLLP
110 120 130 140 150
TKTTDQGNRC QCAHQKDKKC WNFCQADKEL RAQSTMQKGV KDFKKGKPCP
160 170 180 190 200
KLGKKCIYQQ LVEGRKLRRL EAISNSIKTS FRVAKLKAEL YRDQKLIHNR

AH
Length:202
Mass (Da):23,135
Last modified:November 1, 1991 - v2
Checksum:i701886BAFD09AC4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64711 mRNA. Translation: AAA41129.1.
PIRiJN0125.
RefSeqiNP_036680.1. NM_012548.2.
UniGeneiRn.10918.

Genome annotation databases

EnsembliENSRNOT00000019361; ENSRNOP00000019361; ENSRNOG00000014361.
GeneIDi24323.
KEGGirno:24323.
UCSCiRGD:2532. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64711 mRNA. Translation: AAA41129.1 .
PIRi JN0125.
RefSeqi NP_036680.1. NM_012548.2.
UniGenei Rn.10918.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CMH NMR - A 60-73 [» ]
6CMH NMR - A 53-73 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000019361.

Proteomic databases

PRIDEi P22388.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000019361 ; ENSRNOP00000019361 ; ENSRNOG00000014361 .
GeneIDi 24323.
KEGGi rno:24323.
UCSCi RGD:2532. rat.

Organism-specific databases

CTDi 1906.
RGDi 2532. Edn1.

Phylogenomic databases

eggNOGi NOG46593.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
InParanoidi P22388.
KOi K16366.
OMAi MDYFPMI.
OrthoDBi EOG7PS1H7.
PhylomeDBi P22388.
TreeFami TF333184.

Enzyme and pathway databases

Reactomei REACT_250028. Peptide ligand-binding receptors.
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTracei P22388.
NextBioi 602983.
PROi P22388.

Gene expression databases

ExpressionAtlasi P22388. baseline and differential.
Genevestigatori P22388.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA."
    Sakurai T., Yanagisawa M., Inoue A., Ryan U.S., Kimura S., Mitsui Y., Goto K., Masaki T.
    Biochem. Biophys. Res. Commun. 175:44-47(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Endothelin-1 mRNA expression in the rat kidney."
    Nunez D.J.R., Taylor E.A., Oh V.M.S., Schofield J.P., Brown M.J.
    Biochem. J. 275:817-819(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-77.
    Strain: Wistar.
    Tissue: Kidney.

Entry informationi

Entry nameiEDN1_RAT
AccessioniPrimary (citable) accession number: P22388
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1991
Last modified: November 26, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3