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P22388

- EDN1_RAT

UniProt

P22388 - EDN1_RAT

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Protein

Endothelin-1

Gene
Edn1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KEL By similarity

GO - Molecular functioni

  1. endothelin A receptor binding Source: RGD
  2. endothelin B receptor binding Source: RGD

GO - Biological processi

  1. body fluid secretion Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cartilage development Source: Ensembl
  4. cell growth Source: RGD
  5. cellular response to interleukin-1 Source: RGD
  6. cellular response to tumor necrosis factor Source: RGD
  7. dorsal/ventral pattern formation Source: Ensembl
  8. epithelial fluid transport Source: RGD
  9. glucose transport Source: Ensembl
  10. heart development Source: Ensembl
  11. histamine secretion Source: RGD
  12. inositol phosphate-mediated signaling Source: Ensembl
  13. intracellular signal transduction Source: RGD
  14. in utero embryonic development Source: Ensembl
  15. maternal process involved in parturition Source: RGD
  16. membrane depolarization Source: RGD
  17. middle ear morphogenesis Source: Ensembl
  18. multicellular organismal aging Source: RGD
  19. negative regulation of cAMP biosynthetic process Source: Ensembl
  20. negative regulation of cellular protein metabolic process Source: Ensembl
  21. negative regulation of hormone secretion Source: RGD
  22. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  23. negative regulation of smooth muscle cell apoptotic process Source: RGD
  24. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  25. neural crest cell development Source: Ensembl
  26. nitric oxide transport Source: Ensembl
  27. patterning of blood vessels Source: Ensembl
  28. peptide hormone secretion Source: Ensembl
  29. phosphatidylinositol 3-kinase signaling Source: Ensembl
  30. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
  31. positive regulation of cardiac muscle hypertrophy Source: Ensembl
  32. positive regulation of cell proliferation Source: RGD
  33. positive regulation of cell size Source: Ensembl
  34. positive regulation of cytosolic calcium ion concentration Source: RGD
  35. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  36. positive regulation of heart rate Source: Ensembl
  37. positive regulation of hormone secretion Source: Ensembl
  38. positive regulation of JUN kinase activity Source: Ensembl
  39. positive regulation of mitosis Source: Ensembl
  40. positive regulation of neutrophil chemotaxis Source: RGD
  41. positive regulation of odontogenesis Source: RGD
  42. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
  43. positive regulation of receptor biosynthetic process Source: Ensembl
  44. positive regulation of renal sodium excretion Source: Ensembl
  45. positive regulation of sarcomere organization Source: Ensembl
  46. positive regulation of smooth muscle cell proliferation Source: Ensembl
  47. positive regulation of smooth muscle contraction Source: RGD
  48. positive regulation of urine volume Source: Ensembl
  49. prostaglandin biosynthetic process Source: Ensembl
  50. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  51. protein kinase C deactivation Source: Ensembl
  52. regulation of blood pressure Source: RGD
  53. regulation of pH Source: Ensembl
  54. regulation of sensory perception of pain Source: RGD
  55. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  56. regulation of vasoconstriction Source: InterPro
  57. respiratory gaseous exchange Source: Ensembl
  58. response to amino acid Source: RGD
  59. response to drug Source: RGD
  60. response to hypoxia Source: RGD
  61. response to lipopolysaccharide Source: RGD
  62. response to nicotine Source: RGD
  63. response to testosterone Source: RGD
  64. rhythmic excitation Source: Ensembl
  65. sensory perception of pain Source: RGD
  66. superoxide anion generation Source: RGD
  67. vasoconstriction Source: RGD
  68. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Gene namesi
Name:Edn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi2532. Edn1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Propeptidei26 – 5025PRO_0000008072Add
BLAST
Peptidei53 – 7321Endothelin-1PRO_0000008073Add
BLAST
Propeptidei74 – 202129PRO_0000008074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67 By similarity
Disulfide bondi55 ↔ 63 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP22388.

Expressioni

Gene expression databases

ArrayExpressiP22388.
GenevestigatoriP22388.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019361.

Structurei

Secondary structure

1
202
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi54 – 574
Helixi61 – 699

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CMHNMR-A60-73[»]
6CMHNMR-A53-73[»]

Miscellaneous databases

EvolutionaryTraceiP22388.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12415Endothelin-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP22388.
KOiK16366.
OMAiMDYFPMI.
OrthoDBiEOG7PS1H7.
PhylomeDBiP22388.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22388-1 [UniParc]FASTAAdd to Basket

« Hide

MDYFPVIFSL LFVAFQGAPE TAVLGAELSP RAEKEVQSPP PSTSWRPRRS    50
KRCSCSSLMD KECVYFCHLD IIWVNTPERV VPYGLGSPSR SKRSLKDLLP 100
TKTTDQGNRC QCAHQKDKKC WNFCQADKEL RAQSTMQKGV KDFKKGKPCP 150
KLGKKCIYQQ LVEGRKLRRL EAISNSIKTS FRVAKLKAEL YRDQKLIHNR 200
AH 202
Length:202
Mass (Da):23,135
Last modified:November 1, 1991 - v2
Checksum:i701886BAFD09AC4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64711 mRNA. Translation: AAA41129.1.
PIRiJN0125.
RefSeqiNP_036680.1. NM_012548.2.
XP_006253847.1. XM_006253785.1.
UniGeneiRn.10918.

Genome annotation databases

EnsembliENSRNOT00000019361; ENSRNOP00000019361; ENSRNOG00000014361.
GeneIDi24323.
KEGGirno:24323.
UCSCiRGD:2532. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64711 mRNA. Translation: AAA41129.1 .
PIRi JN0125.
RefSeqi NP_036680.1. NM_012548.2.
XP_006253847.1. XM_006253785.1.
UniGenei Rn.10918.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CMH NMR - A 60-73 [» ]
6CMH NMR - A 53-73 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000019361.

Proteomic databases

PRIDEi P22388.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000019361 ; ENSRNOP00000019361 ; ENSRNOG00000014361 .
GeneIDi 24323.
KEGGi rno:24323.
UCSCi RGD:2532. rat.

Organism-specific databases

CTDi 1906.
RGDi 2532. Edn1.

Phylogenomic databases

eggNOGi NOG46593.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
InParanoidi P22388.
KOi K16366.
OMAi MDYFPMI.
OrthoDBi EOG7PS1H7.
PhylomeDBi P22388.
TreeFami TF333184.

Miscellaneous databases

EvolutionaryTracei P22388.
NextBioi 602983.
PROi P22388.

Gene expression databases

ArrayExpressi P22388.
Genevestigatori P22388.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA."
    Sakurai T., Yanagisawa M., Inoue A., Ryan U.S., Kimura S., Mitsui Y., Goto K., Masaki T.
    Biochem. Biophys. Res. Commun. 175:44-47(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Endothelin-1 mRNA expression in the rat kidney."
    Nunez D.J.R., Taylor E.A., Oh V.M.S., Schofield J.P., Brown M.J.
    Biochem. J. 275:817-819(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-77.
    Strain: Wistar.
    Tissue: Kidney.

Entry informationi

Entry nameiEDN1_RAT
AccessioniPrimary (citable) accession number: P22388
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1991
Last modified: May 14, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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