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P22388

- EDN1_RAT

UniProt

P22388 - EDN1_RAT

Protein

Endothelin-1

Gene

Edn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Endothelins are endothelium-derived vasoconstrictor peptides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei73 – 742Cleavage; by KELBy similarity

    GO - Molecular functioni

    1. endothelin A receptor binding Source: RGD
    2. endothelin B receptor binding Source: RGD

    GO - Biological processi

    1. artery smooth muscle contraction Source: RGD
    2. body fluid secretion Source: Ensembl
    3. calcium-mediated signaling Source: Ensembl
    4. cartilage development Source: Ensembl
    5. cell growth Source: RGD
    6. cellular response to calcium ion Source: RGD
    7. cellular response to drug Source: RGD
    8. cellular response to fatty acid Source: RGD
    9. cellular response to glucocorticoid stimulus Source: RGD
    10. cellular response to hypoxia Source: RGD
    11. cellular response to interferon-gamma Source: RGD
    12. cellular response to interleukin-1 Source: RGD
    13. cellular response to mineralocorticoid stimulus Source: RGD
    14. cellular response to peptide hormone stimulus Source: RGD
    15. cellular response to transforming growth factor beta stimulus Source: RGD
    16. cellular response to tumor necrosis factor Source: RGD
    17. dorsal/ventral pattern formation Source: Ensembl
    18. epithelial fluid transport Source: RGD
    19. glucose transport Source: Ensembl
    20. heart development Source: Ensembl
    21. histamine secretion Source: RGD
    22. inositol phosphate-mediated signaling Source: Ensembl
    23. intracellular signal transduction Source: RGD
    24. in utero embryonic development Source: Ensembl
    25. maternal process involved in parturition Source: RGD
    26. membrane depolarization Source: RGD
    27. middle ear morphogenesis Source: Ensembl
    28. multicellular organismal aging Source: RGD
    29. negative regulation of cAMP biosynthetic process Source: Ensembl
    30. negative regulation of cellular protein metabolic process Source: Ensembl
    31. negative regulation of hormone secretion Source: RGD
    32. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    33. negative regulation of smooth muscle cell apoptotic process Source: RGD
    34. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    35. neural crest cell development Source: Ensembl
    36. nitric oxide transport Source: Ensembl
    37. patterning of blood vessels Source: Ensembl
    38. peptide hormone secretion Source: Ensembl
    39. phosphatidylinositol 3-kinase signaling Source: Ensembl
    40. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
    41. positive regulation of cardiac muscle hypertrophy Source: Ensembl
    42. positive regulation of cell proliferation Source: RGD
    43. positive regulation of cell size Source: Ensembl
    44. positive regulation of cytosolic calcium ion concentration Source: RGD
    45. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    46. positive regulation of heart rate Source: Ensembl
    47. positive regulation of hormone secretion Source: Ensembl
    48. positive regulation of JUN kinase activity Source: Ensembl
    49. positive regulation of mitosis Source: Ensembl
    50. positive regulation of neutrophil chemotaxis Source: RGD
    51. positive regulation of odontogenesis Source: RGD
    52. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
    53. positive regulation of prostaglandin secretion Source: RGD
    54. positive regulation of receptor biosynthetic process Source: Ensembl
    55. positive regulation of renal sodium excretion Source: Ensembl
    56. positive regulation of sarcomere organization Source: Ensembl
    57. positive regulation of smooth muscle cell proliferation Source: Ensembl
    58. positive regulation of smooth muscle contraction Source: RGD
    59. positive regulation of transcription from RNA polymerase II promoter Source: RGD
    60. positive regulation of urine volume Source: Ensembl
    61. prostaglandin biosynthetic process Source: Ensembl
    62. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    63. protein kinase C deactivation Source: Ensembl
    64. regulation of blood pressure Source: RGD
    65. regulation of pH Source: Ensembl
    66. regulation of sensory perception of pain Source: RGD
    67. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
    68. regulation of vasoconstriction Source: InterPro
    69. respiratory gaseous exchange Source: Ensembl
    70. response to activity Source: RGD
    71. response to amino acid Source: RGD
    72. response to dexamethasone Source: RGD
    73. response to drug Source: RGD
    74. response to hypoxia Source: RGD
    75. response to leptin Source: RGD
    76. response to lipopolysaccharide Source: RGD
    77. response to muscle stretch Source: RGD
    78. response to nicotine Source: RGD
    79. response to ozone Source: RGD
    80. response to prostaglandin F Source: RGD
    81. response to salt Source: RGD
    82. response to testosterone Source: RGD
    83. response to transforming growth factor beta Source: RGD
    84. rhythmic excitation Source: Ensembl
    85. sensory perception of pain Source: RGD
    86. superoxide anion generation Source: RGD
    87. vasoconstriction Source: RGD
    88. vein smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-1
    Short name:
    ET-1
    Alternative name(s):
    Preproendothelin-1
    Short name:
    PPET1
    Gene namesi
    Name:Edn1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi2532. Edn1.

    Subcellular locationi

    GO - Cellular componenti

    1. basal part of cell Source: RGD
    2. extracellular space Source: RGD
    3. rough endoplasmic reticulum lumen Source: RGD
    4. Weibel-Palade body Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 5025PRO_0000008072Add
    BLAST
    Peptidei53 – 7321Endothelin-1PRO_0000008073Add
    BLAST
    Propeptidei74 – 202129PRO_0000008074Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 67By similarity
    Disulfide bondi55 ↔ 63By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP22388.

    Expressioni

    Gene expression databases

    ArrayExpressiP22388.
    GenevestigatoriP22388.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000019361.

    Structurei

    Secondary structure

    1
    202
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi54 – 574
    Helixi61 – 699

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CMHNMR-A60-73[»]
    6CMHNMR-A53-73[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP22388.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 12415Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46593.
    GeneTreeiENSGT00530000063310.
    HOGENOMiHOG000231110.
    HOVERGENiHBG051441.
    InParanoidiP22388.
    KOiK16366.
    OMAiMDYFPMI.
    OrthoDBiEOG7PS1H7.
    PhylomeDBiP22388.
    TreeFamiTF333184.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22388-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYFPVIFSL LFVAFQGAPE TAVLGAELSP RAEKEVQSPP PSTSWRPRRS    50
    KRCSCSSLMD KECVYFCHLD IIWVNTPERV VPYGLGSPSR SKRSLKDLLP 100
    TKTTDQGNRC QCAHQKDKKC WNFCQADKEL RAQSTMQKGV KDFKKGKPCP 150
    KLGKKCIYQQ LVEGRKLRRL EAISNSIKTS FRVAKLKAEL YRDQKLIHNR 200
    AH 202
    Length:202
    Mass (Da):23,135
    Last modified:November 1, 1991 - v2
    Checksum:i701886BAFD09AC4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64711 mRNA. Translation: AAA41129.1.
    PIRiJN0125.
    RefSeqiNP_036680.1. NM_012548.2.
    XP_006253847.1. XM_006253785.1.
    UniGeneiRn.10918.

    Genome annotation databases

    EnsembliENSRNOT00000019361; ENSRNOP00000019361; ENSRNOG00000014361.
    GeneIDi24323.
    KEGGirno:24323.
    UCSCiRGD:2532. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64711 mRNA. Translation: AAA41129.1 .
    PIRi JN0125.
    RefSeqi NP_036680.1. NM_012548.2.
    XP_006253847.1. XM_006253785.1.
    UniGenei Rn.10918.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CMH NMR - A 60-73 [» ]
    6CMH NMR - A 53-73 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000019361.

    Proteomic databases

    PRIDEi P22388.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000019361 ; ENSRNOP00000019361 ; ENSRNOG00000014361 .
    GeneIDi 24323.
    KEGGi rno:24323.
    UCSCi RGD:2532. rat.

    Organism-specific databases

    CTDi 1906.
    RGDi 2532. Edn1.

    Phylogenomic databases

    eggNOGi NOG46593.
    GeneTreei ENSGT00530000063310.
    HOGENOMi HOG000231110.
    HOVERGENi HBG051441.
    InParanoidi P22388.
    KOi K16366.
    OMAi MDYFPMI.
    OrthoDBi EOG7PS1H7.
    PhylomeDBi P22388.
    TreeFami TF333184.

    Miscellaneous databases

    EvolutionaryTracei P22388.
    NextBioi 602983.
    PROi P22388.

    Gene expression databases

    ArrayExpressi P22388.
    Genevestigatori P22388.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA."
      Sakurai T., Yanagisawa M., Inoue A., Ryan U.S., Kimura S., Mitsui Y., Goto K., Masaki T.
      Biochem. Biophys. Res. Commun. 175:44-47(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Endothelin-1 mRNA expression in the rat kidney."
      Nunez D.J.R., Taylor E.A., Oh V.M.S., Schofield J.P., Brown M.J.
      Biochem. J. 275:817-819(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-77.
      Strain: Wistar.
      Tissue: Kidney.

    Entry informationi

    Entry nameiEDN1_RAT
    AccessioniPrimary (citable) accession number: P22388
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3