Reviewed,
UniProtKB/Swiss-Prot P22366 (MYD88_MOUSE)
Last modified
June 16, 2009.
Version 88.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Myeloid differentiation primary response protein MyD88 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 296 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. May be involved in myeloid differentiation. Ref.5 |
| Subunit structure | Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1 and IRAK2 via their respective TIR domains. Interacts with IL1RL1 By similarity. |
| Subcellular location | Cytoplasm Probable. |
| Tissue specificity | Ubiquitous. Ref.1 |
| Induction | By interleukin-6. |
| Sequence similarities | Contains 1 death domain. Contains 1 TIR domain. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Il1rl1 | P14719 | 1 | EBI-525108,EBI-525078 | |
| Irak1 | Q62406 | 1 | EBI-525108,EBI-448533 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 296 | 296 | Myeloid differentiation primary response protein MyD88 | PRO_0000096667 | |||||
Regions | |||||||||
| Domain | 54 – 109 | 56 | Death | ||||||
| Domain | 159 – 296 | 138 | TIR | ||||||
Experimental info | |||||||||
| Mutagenesis | 56 | 1 | F → N: Prevents dimerization of death domains and activation of JNK and NF-kappa-B. Ref.5 | ||||||
| Sequence conflict | 51 | 1 | A → P Ref.1 | ||||||
| Sequence conflict | 51 | 1 | A → P Ref.4 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family." Bonnert T.P., Garka K.E., Parnet P., Sonoda G., Testa J.R., Sims J.E. FEBS Lett. 402:81-84(1997) [PubMed: 9013863] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [2] | "Genetic structure and chromosomal mapping of MyD88." Hardiman G., Jenkins N.A., Copeland N.G., Gilbert D.J., Garcia D.K., Naylor S.L., Kastelein R.A., Bazan J.F. Genomics 45:332-339(1997) [PubMed: 9344657] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Myeloid leukemia cell. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland and Olfactory epithelium. |
| [4] | "Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6." Lord K.A., Hoffman-Liebermann B., Liebermann D.A. Oncogene 5:1095-1097(1990) [PubMed: 2374694] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-296. |
| [5] | "MyD88, an adapter protein involved in interleukin-1 signaling." Burns K., Martinon F., Esslinger C., Pahl H., Schneider P., Bodmer J.-L., Di Marco F., French L., Tschopp J. J. Biol. Chem. 273:12203-12209(1998) [PubMed: 9575168] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF PHE-56. Tissue: Bone marrow. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U89023 Genomic DNA. Translation: AAB83958.1. U84409 mRNA. Translation: AAC53013.1. BC005591 mRNA. Translation: AAH05591.1. BC058787 mRNA. Translation: AAH58787.1. X51397 mRNA. Translation: CAA35762.1. | |
| IPI | IPI00127375. |
| PIR | S11226. |
| RefSeq | NP_034981.1. |
| UniGene | Mm.213003 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P22366. 6 interactions. |
PTM databases | |
| PhosphoSite | P22366. |
Proteomic databases | |
| PRIDE | P22366. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000032508. Mus musculus. [Contig view] |
| GeneID | 17874. |
| KEGG | mmu:17874. |
Organism-specific databases | |
| MGI | MGI:108005. Myd88. |
Phylogenomic databases | |
| HOGENOM | P22366. |
| HOVERGEN | P22366. |
| OMA | P22366. GFEYLEI. |
Gene expression databases | |
| ArrayExpress | P22366. |
| Bgee | P22366. |
| CleanEx | MM_MYD88. |
| GermOnline | ENSMUSG00000032508. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000488. Death. IPR011029. DEATH-like. IPR017281. Myelin_different_resp_MyD88. IPR000157. Toll-Interleukin_rcpt. [Graphical view] |
| Gene3D | G3DSA:1.10.533.10. DEATH_like. 1 hit. |
| Pfam | PF00531. Death. 1 hit. PF01582. TIR. 1 hit. [Graphical view] |
| PIRSF | PIRSF037756. MyD88. 1 hit. |
| SMART | SM00005. DEATH. 1 hit. SM00255. TIR. 1 hit. [Graphical view] |
| PROSITE | PS50017. DEATH_DOMAIN. 1 hit. PS50104. TIR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 292657. |
| SOURCE | Search... |
Entry information
| Entry name | MYD88_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P22366 Secondary accession number(s): O35916 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


