ID   CCL1_HUMAN              Reviewed;          96 AA.
AC   P22362; B2R5G9; Q2M309;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   24-JAN-2024, entry version 198.
DE   RecName: Full=C-C motif chemokine 1;
DE   AltName: Full=Small-inducible cytokine A1;
DE   AltName: Full=T lymphocyte-secreted protein I-309;
DE   Flags: Precursor;
GN   Name=CCL1; Synonyms=SCYA1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2809212;
RA   Miller M.D., Hata S., Waal Malefyt R., Krangel M.S.;
RT   "A novel polypeptide secreted by activated human T lymphocytes.";
RL   J. Immunol. 143:2907-2916(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2212659;
RA   Miller M.D., Wilson S.D., Dorf M.E., Seuanez H.N., O'Brien S.J.,
RA   Krangel M.S.;
RT   "Sequence and chromosomal location of the I-309 gene. Relationship to genes
RT   encoding a family of inflammatory cytokines.";
RL   J. Immunol. 145:2737-2744(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 24-38.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally verified
RT   cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [7]
RP   FUNCTION, AND SIGNAL SEQUENCE CLEAVAGE SITE.
RX   PubMed=1557400; DOI=10.1073/pnas.89.7.2950;
RA   Miller M.D., Krangel M.S.;
RT   "The human cytokine I-309 is a monocyte chemoattractant.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:2950-2954(1992).
RN   [8]
RP   STRUCTURE BY NMR OF 23-96.
RX   PubMed=10821677; DOI=10.1021/bi000089l;
RA   Keizer D.W., Crump M.P., Lee T.W., Slupsky C.M., Clark-Lewis I.,
RA   Sykes B.D.;
RT   "Human CC chemokine I-309, structural consequences of the additional
RT   disulfide bond.";
RL   Biochemistry 39:6053-6059(2000).
CC   -!- FUNCTION: Cytokine that is chemotactic for monocytes but not for
CC       neutrophils. Binds to CCR8. {ECO:0000269|PubMed:1557400}.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: By phorbol myristate acetate (PMA).
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=CCL1 entry;
CC       URL="https://en.wikipedia.org/wiki/CCL1";
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DR   EMBL; M57502; AAA61196.1; -; mRNA.
DR   EMBL; M57506; AAA52705.1; -; Genomic_DNA.
DR   EMBL; AK312183; BAG35116.1; -; mRNA.
DR   EMBL; CH471147; EAW80204.1; -; Genomic_DNA.
DR   EMBL; BC105073; AAI05074.1; -; mRNA.
DR   EMBL; BC105075; AAI05076.1; -; mRNA.
DR   CCDS; CCDS11282.1; -.
DR   PIR; A37236; A37236.
DR   RefSeq; NP_002972.1; NM_002981.2.
DR   PDB; 1EL0; NMR; -; A=23-96.
DR   PDB; 4OIJ; X-ray; 2.00 A; A/B=23-96.
DR   PDB; 4OIK; X-ray; 2.10 A; A/B=23-96.
DR   PDBsum; 1EL0; -.
DR   PDBsum; 4OIJ; -.
DR   PDBsum; 4OIK; -.
DR   AlphaFoldDB; P22362; -.
DR   BMRB; P22362; -.
DR   SMR; P22362; -.
DR   BioGRID; 112250; 5.
DR   DIP; DIP-5835N; -.
DR   IntAct; P22362; 1.
DR   STRING; 9606.ENSP00000225842; -.
DR   GlyCosmos; P22362; 1 site, No reported glycans.
DR   GlyGen; P22362; 1 site.
DR   BioMuta; CCL1; -.
DR   DMDM; 123950; -.
DR   MassIVE; P22362; -.
DR   PaxDb; 9606-ENSP00000225842; -.
DR   PeptideAtlas; P22362; -.
DR   Antibodypedia; 15502; 374 antibodies from 31 providers.
DR   DNASU; 6346; -.
DR   Ensembl; ENST00000225842.4; ENSP00000225842.3; ENSG00000108702.4.
DR   GeneID; 6346; -.
DR   KEGG; hsa:6346; -.
DR   MANE-Select; ENST00000225842.4; ENSP00000225842.3; NM_002981.2; NP_002972.1.
DR   UCSC; uc002hid.3; human.
DR   AGR; HGNC:10609; -.
DR   CTD; 6346; -.
DR   DisGeNET; 6346; -.
DR   GeneCards; CCL1; -.
DR   HGNC; HGNC:10609; CCL1.
DR   HPA; ENSG00000108702; Group enriched (intestine, lymphoid tissue).
DR   MIM; 182281; gene.
DR   neXtProt; NX_P22362; -.
DR   OpenTargets; ENSG00000108702; -.
DR   PharmGKB; PA35542; -.
DR   VEuPathDB; HostDB:ENSG00000108702; -.
DR   eggNOG; ENOG502SZRS; Eukaryota.
DR   GeneTree; ENSGT01100000263482; -.
DR   HOGENOM; CLU_141716_5_0_1; -.
DR   InParanoid; P22362; -.
DR   OMA; MHVSSSN; -.
DR   OrthoDB; 4558017at2759; -.
DR   PhylomeDB; P22362; -.
DR   TreeFam; TF334888; -.
DR   PathwayCommons; P22362; -.
DR   Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   SignaLink; P22362; -.
DR   SIGNOR; P22362; -.
DR   BioGRID-ORCS; 6346; 14 hits in 1138 CRISPR screens.
DR   EvolutionaryTrace; P22362; -.
DR   GenomeRNAi; 6346; -.
DR   Pharos; P22362; Tbio.
DR   PRO; PR:P22362; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P22362; Protein.
DR   Bgee; ENSG00000108702; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 48 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IDA:CAFA.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IDA:CAFA.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; TAS:ProtInc.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0006874; P:intracellular calcium ion homeostasis; TAS:ProtInc.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:CAFA.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IDA:BHF-UCL.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IDA:BHF-UCL.
DR   GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:CAFA.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   GO; GO:0016032; P:viral process; TAS:ProtInc.
DR   CDD; cd00272; Chemokine_CC; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF5; C-C MOTIF CHEMOKINE 1; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
DR   Genevisible; P22362; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Chemotaxis; Cytokine; Direct protein sequencing;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:15340161,
FT                   ECO:0000269|PubMed:1557400"
FT   CHAIN           24..96
FT                   /note="C-C motif chemokine 1"
FT                   /id="PRO_0000005141"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        33..57
FT   DISULFID        34..73
FT   DISULFID        49..91
FT   STRAND          28..30
FT                   /evidence="ECO:0007829|PDB:1EL0"
FT   STRAND          31..33
FT                   /evidence="ECO:0007829|PDB:4OIJ"
FT   HELIX           44..46
FT                   /evidence="ECO:0007829|PDB:4OIJ"
FT   STRAND          47..52
FT                   /evidence="ECO:0007829|PDB:4OIJ"
FT   HELIX           55..57
FT                   /evidence="ECO:0007829|PDB:4OIJ"
FT   STRAND          61..67
FT                   /evidence="ECO:0007829|PDB:4OIJ"
FT   STRAND          71..75
FT                   /evidence="ECO:0007829|PDB:4OIJ"
FT   HELIX           79..86
FT                   /evidence="ECO:0007829|PDB:4OIJ"
SQ   SEQUENCE   96 AA;  10992 MW;  7E67F1F82892F3C7 CRC64;
     MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY RNTSSICSNE
     GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK
//