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P22362

- CCL1_HUMAN

UniProt

P22362 - CCL1_HUMAN

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Protein
C-C motif chemokine 1
Gene
CCL1, SCYA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.1 Publication

GO - Molecular functioni

  1. chemokine activity Source: ProtInc

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. cellular calcium ion homeostasis Source: ProtInc
  3. chemotaxis Source: ProtInc
  4. immune response Source: InterPro
  5. signal transduction Source: ProtInc
  6. viral process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 1
Alternative name(s):
Small-inducible cytokine A1
T lymphocyte-secreted protein I-309
Gene namesi
Name:CCL1
Synonyms:SCYA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10609. CCL1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 Publication
Add
BLAST
Chaini24 – 9673C-C motif chemokine 1
PRO_0000005141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57
Disulfide bondi34 ↔ 73
Disulfide bondi49 ↔ 91
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP22362.

Expressioni

Inductioni

By phorbol myristate acetate (PMA).

Gene expression databases

ArrayExpressiP22362.
BgeeiP22362.
CleanExiHS_CCL1.
GenevestigatoriP22362.

Organism-specific databases

HPAiHPA049861.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

DIPiDIP-5835N.
MINTiMINT-1533384.
STRINGi9606.ENSP00000225842.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 303
Beta strandi31 – 333
Helixi44 – 463
Beta strandi47 – 526
Helixi55 – 573
Beta strandi61 – 677
Beta strandi71 – 755
Helixi79 – 868

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EL0NMR-A23-96[»]
4OIJX-ray2.00A/B23-96[»]
4OIKX-ray2.10A/B23-96[»]
DisProtiDP00644.
ProteinModelPortaliP22362.
SMRiP22362. Positions 23-96.

Miscellaneous databases

EvolutionaryTraceiP22362.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG68213.
HOGENOMiHOG000036686.
HOVERGENiHBG098128.
InParanoidiP22362.
KOiK05514.
OMAiDSKSMHV.
OrthoDBiEOG7K9K59.
PhylomeDBiP22362.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22362-1 [UniParc]FASTAAdd to Basket

« Hide

MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY   50
RNTSSICSNE GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK 96
Length:96
Mass (Da):10,992
Last modified:August 1, 1991 - v1
Checksum:i7E67F1F82892F3C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57502 mRNA. Translation: AAA61196.1.
M57506 Genomic DNA. Translation: AAA52705.1.
AK312183 mRNA. Translation: BAG35116.1.
CH471147 Genomic DNA. Translation: EAW80204.1.
BC105073 mRNA. Translation: AAI05074.1.
BC105075 mRNA. Translation: AAI05076.1.
CCDSiCCDS11282.1.
PIRiA37236.
RefSeqiNP_002972.1. NM_002981.2.
UniGeneiHs.72918.

Genome annotation databases

EnsembliENST00000225842; ENSP00000225842; ENSG00000108702.
GeneIDi6346.
KEGGihsa:6346.
UCSCiuc002hid.1. human.

Polymorphism databases

DMDMi123950.

Cross-referencesi

Web resourcesi

Wikipedia

CCL1 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57502 mRNA. Translation: AAA61196.1 .
M57506 Genomic DNA. Translation: AAA52705.1 .
AK312183 mRNA. Translation: BAG35116.1 .
CH471147 Genomic DNA. Translation: EAW80204.1 .
BC105073 mRNA. Translation: AAI05074.1 .
BC105075 mRNA. Translation: AAI05076.1 .
CCDSi CCDS11282.1.
PIRi A37236.
RefSeqi NP_002972.1. NM_002981.2.
UniGenei Hs.72918.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EL0 NMR - A 23-96 [» ]
4OIJ X-ray 2.00 A/B 23-96 [» ]
4OIK X-ray 2.10 A/B 23-96 [» ]
DisProti DP00644.
ProteinModelPortali P22362.
SMRi P22362. Positions 23-96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5835N.
MINTi MINT-1533384.
STRINGi 9606.ENSP00000225842.

Polymorphism databases

DMDMi 123950.

Proteomic databases

PRIDEi P22362.

Protocols and materials databases

DNASUi 6346.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225842 ; ENSP00000225842 ; ENSG00000108702 .
GeneIDi 6346.
KEGGi hsa:6346.
UCSCi uc002hid.1. human.

Organism-specific databases

CTDi 6346.
GeneCardsi GC17M032687.
HGNCi HGNC:10609. CCL1.
HPAi HPA049861.
MIMi 182281. gene.
neXtProti NX_P22362.
PharmGKBi PA35542.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68213.
HOGENOMi HOG000036686.
HOVERGENi HBG098128.
InParanoidi P22362.
KOi K05514.
OMAi DSKSMHV.
OrthoDBi EOG7K9K59.
PhylomeDBi P22362.
TreeFami TF334888.

Miscellaneous databases

EvolutionaryTracei P22362.
GenomeRNAii 6346.
NextBioi 24656.
PROi P22362.
SOURCEi Search...

Gene expression databases

ArrayExpressi P22362.
Bgeei P22362.
CleanExi HS_CCL1.
Genevestigatori P22362.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel polypeptide secreted by activated human T lymphocytes."
    Miller M.D., Hata S., Waal Malefyt R., Krangel M.S.
    J. Immunol. 143:2907-2916(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines."
    Miller M.D., Wilson S.D., Dorf M.E., Seuanez H.N., O'Brien S.J., Krangel M.S.
    J. Immunol. 145:2737-2744(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-38.
  7. "The human cytokine I-309 is a monocyte chemoattractant."
    Miller M.D., Krangel M.S.
    Proc. Natl. Acad. Sci. U.S.A. 89:2950-2954(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SIGNAL SEQUENCE CLEAVAGE SITE.
  8. "Human CC chemokine I-309, structural consequences of the additional disulfide bond."
    Keizer D.W., Crump M.P., Lee T.W., Slupsky C.M., Clark-Lewis I., Sykes B.D.
    Biochemistry 39:6053-6059(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 23-96.

Entry informationi

Entry nameiCCL1_HUMAN
AccessioniPrimary (citable) accession number: P22362
Secondary accession number(s): B2R5G9, Q2M309
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: September 3, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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