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P22362

- CCL1_HUMAN

UniProt

P22362 - CCL1_HUMAN

Protein

C-C motif chemokine 1

Gene

CCL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.1 Publication

    GO - Molecular functioni

    1. chemokine activity Source: ProtInc

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. cellular calcium ion homeostasis Source: ProtInc
    3. chemotaxis Source: ProtInc
    4. immune response Source: InterPro
    5. signal transduction Source: ProtInc
    6. viral process Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 1
    Alternative name(s):
    Small-inducible cytokine A1
    T lymphocyte-secreted protein I-309
    Gene namesi
    Name:CCL1
    Synonyms:SCYA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10609. CCL1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35542.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23232 PublicationsAdd
    BLAST
    Chaini24 – 9673C-C motif chemokine 1PRO_0000005141Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57
    Disulfide bondi34 ↔ 73
    Disulfide bondi49 ↔ 91
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP22362.

    Expressioni

    Inductioni

    By phorbol myristate acetate (PMA).

    Gene expression databases

    ArrayExpressiP22362.
    BgeeiP22362.
    CleanExiHS_CCL1.
    GenevestigatoriP22362.

    Organism-specific databases

    HPAiHPA049861.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    DIPiDIP-5835N.
    MINTiMINT-1533384.
    STRINGi9606.ENSP00000225842.

    Structurei

    Secondary structure

    1
    96
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 303
    Beta strandi31 – 333
    Helixi44 – 463
    Beta strandi47 – 526
    Helixi55 – 573
    Beta strandi61 – 677
    Beta strandi71 – 755
    Helixi79 – 868

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EL0NMR-A23-96[»]
    4OIJX-ray2.00A/B23-96[»]
    4OIKX-ray2.10A/B23-96[»]
    DisProtiDP00644.
    ProteinModelPortaliP22362.
    SMRiP22362. Positions 23-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP22362.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG68213.
    HOGENOMiHOG000036686.
    HOVERGENiHBG098128.
    InParanoidiP22362.
    KOiK05514.
    OMAiDSKSMHV.
    OrthoDBiEOG7K9K59.
    PhylomeDBiP22362.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22362-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY   50
    RNTSSICSNE GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK 96
    Length:96
    Mass (Da):10,992
    Last modified:August 1, 1991 - v1
    Checksum:i7E67F1F82892F3C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57502 mRNA. Translation: AAA61196.1.
    M57506 Genomic DNA. Translation: AAA52705.1.
    AK312183 mRNA. Translation: BAG35116.1.
    CH471147 Genomic DNA. Translation: EAW80204.1.
    BC105073 mRNA. Translation: AAI05074.1.
    BC105075 mRNA. Translation: AAI05076.1.
    CCDSiCCDS11282.1.
    PIRiA37236.
    RefSeqiNP_002972.1. NM_002981.2.
    UniGeneiHs.72918.

    Genome annotation databases

    EnsembliENST00000225842; ENSP00000225842; ENSG00000108702.
    GeneIDi6346.
    KEGGihsa:6346.
    UCSCiuc002hid.1. human.

    Polymorphism databases

    DMDMi123950.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL1 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57502 mRNA. Translation: AAA61196.1 .
    M57506 Genomic DNA. Translation: AAA52705.1 .
    AK312183 mRNA. Translation: BAG35116.1 .
    CH471147 Genomic DNA. Translation: EAW80204.1 .
    BC105073 mRNA. Translation: AAI05074.1 .
    BC105075 mRNA. Translation: AAI05076.1 .
    CCDSi CCDS11282.1.
    PIRi A37236.
    RefSeqi NP_002972.1. NM_002981.2.
    UniGenei Hs.72918.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EL0 NMR - A 23-96 [» ]
    4OIJ X-ray 2.00 A/B 23-96 [» ]
    4OIK X-ray 2.10 A/B 23-96 [» ]
    DisProti DP00644.
    ProteinModelPortali P22362.
    SMRi P22362. Positions 23-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5835N.
    MINTi MINT-1533384.
    STRINGi 9606.ENSP00000225842.

    Polymorphism databases

    DMDMi 123950.

    Proteomic databases

    PRIDEi P22362.

    Protocols and materials databases

    DNASUi 6346.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225842 ; ENSP00000225842 ; ENSG00000108702 .
    GeneIDi 6346.
    KEGGi hsa:6346.
    UCSCi uc002hid.1. human.

    Organism-specific databases

    CTDi 6346.
    GeneCardsi GC17M032687.
    HGNCi HGNC:10609. CCL1.
    HPAi HPA049861.
    MIMi 182281. gene.
    neXtProti NX_P22362.
    PharmGKBi PA35542.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68213.
    HOGENOMi HOG000036686.
    HOVERGENi HBG098128.
    InParanoidi P22362.
    KOi K05514.
    OMAi DSKSMHV.
    OrthoDBi EOG7K9K59.
    PhylomeDBi P22362.
    TreeFami TF334888.

    Miscellaneous databases

    EvolutionaryTracei P22362.
    GenomeRNAii 6346.
    NextBioi 24656.
    PROi P22362.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P22362.
    Bgeei P22362.
    CleanExi HS_CCL1.
    Genevestigatori P22362.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel polypeptide secreted by activated human T lymphocytes."
      Miller M.D., Hata S., Waal Malefyt R., Krangel M.S.
      J. Immunol. 143:2907-2916(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines."
      Miller M.D., Wilson S.D., Dorf M.E., Seuanez H.N., O'Brien S.J., Krangel M.S.
      J. Immunol. 145:2737-2744(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-38.
    7. "The human cytokine I-309 is a monocyte chemoattractant."
      Miller M.D., Krangel M.S.
      Proc. Natl. Acad. Sci. U.S.A. 89:2950-2954(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SIGNAL SEQUENCE CLEAVAGE SITE.
    8. "Human CC chemokine I-309, structural consequences of the additional disulfide bond."
      Keizer D.W., Crump M.P., Lee T.W., Slupsky C.M., Clark-Lewis I., Sykes B.D.
      Biochemistry 39:6053-6059(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 23-96.

    Entry informationi

    Entry nameiCCL1_HUMAN
    AccessioniPrimary (citable) accession number: P22362
    Secondary accession number(s): B2R5G9, Q2M309
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3