Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C motif chemokine 1

Gene

CCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.1 Publication

GO - Molecular functioni

  1. chemokine activity Source: ProtInc

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. cellular calcium ion homeostasis Source: ProtInc
  3. chemotaxis Source: ProtInc
  4. immune response Source: InterPro
  5. signal transduction Source: ProtInc
  6. viral process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 1
Alternative name(s):
Small-inducible cytokine A1
T lymphocyte-secreted protein I-309
Gene namesi
Name:CCL1
Synonyms:SCYA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10609. CCL1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23232 PublicationsAdd
BLAST
Chaini24 – 9673C-C motif chemokine 1PRO_0000005141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57
Disulfide bondi34 ↔ 73
Disulfide bondi49 ↔ 91
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP22362.

Expressioni

Inductioni

By phorbol myristate acetate (PMA).

Gene expression databases

BgeeiP22362.
CleanExiHS_CCL1.
ExpressionAtlasiP22362. differential.
GenevestigatoriP22362.

Organism-specific databases

HPAiHPA049861.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

DIPiDIP-5835N.
MINTiMINT-1533384.
STRINGi9606.ENSP00000225842.

Structurei

Secondary structure

1
96
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 303Combined sources
Beta strandi31 – 333Combined sources
Helixi44 – 463Combined sources
Beta strandi47 – 526Combined sources
Helixi55 – 573Combined sources
Beta strandi61 – 677Combined sources
Beta strandi71 – 755Combined sources
Helixi79 – 868Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EL0NMR-A23-96[»]
4OIJX-ray2.00A/B23-96[»]
4OIKX-ray2.10A/B23-96[»]
DisProtiDP00644.
ProteinModelPortaliP22362.
SMRiP22362. Positions 26-96.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22362.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG68213.
GeneTreeiENSGT00530000064270.
HOGENOMiHOG000036686.
HOVERGENiHBG098128.
InParanoidiP22362.
KOiK05514.
OMAiLAGMWPE.
OrthoDBiEOG7K9K59.
PhylomeDBiP22362.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY
60 70 80 90
RNTSSICSNE GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK
Length:96
Mass (Da):10,992
Last modified:July 31, 1991 - v1
Checksum:i7E67F1F82892F3C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57502 mRNA. Translation: AAA61196.1.
M57506 Genomic DNA. Translation: AAA52705.1.
AK312183 mRNA. Translation: BAG35116.1.
CH471147 Genomic DNA. Translation: EAW80204.1.
BC105073 mRNA. Translation: AAI05074.1.
BC105075 mRNA. Translation: AAI05076.1.
CCDSiCCDS11282.1.
PIRiA37236.
RefSeqiNP_002972.1. NM_002981.2.
UniGeneiHs.72918.

Genome annotation databases

EnsembliENST00000225842; ENSP00000225842; ENSG00000108702.
GeneIDi6346.
KEGGihsa:6346.
UCSCiuc002hid.1. human.

Polymorphism databases

DMDMi123950.

Cross-referencesi

Web resourcesi

Wikipedia

CCL1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57502 mRNA. Translation: AAA61196.1.
M57506 Genomic DNA. Translation: AAA52705.1.
AK312183 mRNA. Translation: BAG35116.1.
CH471147 Genomic DNA. Translation: EAW80204.1.
BC105073 mRNA. Translation: AAI05074.1.
BC105075 mRNA. Translation: AAI05076.1.
CCDSiCCDS11282.1.
PIRiA37236.
RefSeqiNP_002972.1. NM_002981.2.
UniGeneiHs.72918.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EL0NMR-A23-96[»]
4OIJX-ray2.00A/B23-96[»]
4OIKX-ray2.10A/B23-96[»]
DisProtiDP00644.
ProteinModelPortaliP22362.
SMRiP22362. Positions 26-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5835N.
MINTiMINT-1533384.
STRINGi9606.ENSP00000225842.

Polymorphism databases

DMDMi123950.

Proteomic databases

PRIDEiP22362.

Protocols and materials databases

DNASUi6346.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225842; ENSP00000225842; ENSG00000108702.
GeneIDi6346.
KEGGihsa:6346.
UCSCiuc002hid.1. human.

Organism-specific databases

CTDi6346.
GeneCardsiGC17M032687.
HGNCiHGNC:10609. CCL1.
HPAiHPA049861.
MIMi182281. gene.
neXtProtiNX_P22362.
PharmGKBiPA35542.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG68213.
GeneTreeiENSGT00530000064270.
HOGENOMiHOG000036686.
HOVERGENiHBG098128.
InParanoidiP22362.
KOiK05514.
OMAiLAGMWPE.
OrthoDBiEOG7K9K59.
PhylomeDBiP22362.
TreeFamiTF334888.

Miscellaneous databases

EvolutionaryTraceiP22362.
GenomeRNAii6346.
NextBioi24656.
PROiP22362.
SOURCEiSearch...

Gene expression databases

BgeeiP22362.
CleanExiHS_CCL1.
ExpressionAtlasiP22362. differential.
GenevestigatoriP22362.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel polypeptide secreted by activated human T lymphocytes."
    Miller M.D., Hata S., Waal Malefyt R., Krangel M.S.
    J. Immunol. 143:2907-2916(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines."
    Miller M.D., Wilson S.D., Dorf M.E., Seuanez H.N., O'Brien S.J., Krangel M.S.
    J. Immunol. 145:2737-2744(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-38.
  7. "The human cytokine I-309 is a monocyte chemoattractant."
    Miller M.D., Krangel M.S.
    Proc. Natl. Acad. Sci. U.S.A. 89:2950-2954(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SIGNAL SEQUENCE CLEAVAGE SITE.
  8. "Human CC chemokine I-309, structural consequences of the additional disulfide bond."
    Keizer D.W., Crump M.P., Lee T.W., Slupsky C.M., Clark-Lewis I., Sykes B.D.
    Biochemistry 39:6053-6059(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 23-96.

Entry informationi

Entry nameiCCL1_HUMAN
AccessioniPrimary (citable) accession number: P22362
Secondary accession number(s): B2R5G9, Q2M309
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 31, 1991
Last sequence update: July 31, 1991
Last modified: January 6, 2015
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.