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P22362 (CCL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 1
Alternative name(s):
Small-inducible cytokine A1
T lymphocyte-secreted protein I-309
Gene names
Name:CCL1
Synonyms:SCYA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length96 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Ref.7

Subunit structure

Monomer.

Subcellular location

Secreted.

Induction

By phorbol myristate acetate (PMA).

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.6
Chain24 – 9673C-C motif chemokine 1
PRO_0000005141

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential
Disulfide bond33 ↔ 57
Disulfide bond34 ↔ 73
Disulfide bond49 ↔ 91

Secondary structure

............ 96
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P22362 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 7E67F1F82892F3C7

FASTA9610,992
        10         20         30         40         50         60 
MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY RNTSSICSNE 

        70         80         90 
GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK 

« Hide

References

« Hide 'large scale' references
[1]"A novel polypeptide secreted by activated human T lymphocytes."
Miller M.D., Hata S., Waal Malefyt R., Krangel M.S.
J. Immunol. 143:2907-2916(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines."
Miller M.D., Wilson S.D., Dorf M.E., Seuanez H.N., O'Brien S.J., Krangel M.S.
J. Immunol. 145:2737-2744(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-38.
[7]"The human cytokine I-309 is a monocyte chemoattractant."
Miller M.D., Krangel M.S.
Proc. Natl. Acad. Sci. U.S.A. 89:2950-2954(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SIGNAL SEQUENCE CLEAVAGE SITE.
[8]"Human CC chemokine I-309, structural consequences of the additional disulfide bond."
Keizer D.W., Crump M.P., Lee T.W., Slupsky C.M., Clark-Lewis I., Sykes B.D.
Biochemistry 39:6053-6059(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 23-96.
+Additional computationally mapped references.

Web resources

Wikipedia

CCL1 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M57502 mRNA. Translation: AAA61196.1.
M57506 Genomic DNA. Translation: AAA52705.1.
AK312183 mRNA. Translation: BAG35116.1.
CH471147 Genomic DNA. Translation: EAW80204.1.
BC105073 mRNA. Translation: AAI05074.1.
BC105075 mRNA. Translation: AAI05076.1.
PIRA37236.
RefSeqNP_002972.1. NM_002981.2.
UniGeneHs.72918.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EL0NMR-A23-96[»]
DisProtDP00644.
ProteinModelPortalP22362.
SMRP22362. Positions 23-96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5835N.
MINTMINT-1533384.
STRING9606.ENSP00000225842.

Polymorphism databases

DMDM123950.

Proteomic databases

PRIDEP22362.

Protocols and materials databases

DNASU6346.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000225842; ENSP00000225842; ENSG00000108702.
GeneID6346.
KEGGhsa:6346.
UCSCuc002hid.1. human.

Organism-specific databases

CTD6346.
GeneCardsGC17M032687.
HGNCHGNC:10609. CCL1.
HPAHPA049861.
MIM182281. gene.
neXtProtNX_P22362.
PharmGKBPA35542.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68213.
HOGENOMHOG000036686.
HOVERGENHBG098128.
InParanoidP22362.
KOK05514.
OMASSICSNE.
OrthoDBEOG7K9K59.
PhylomeDBP22362.
TreeFamTF334888.

Gene expression databases

ArrayExpressP22362.
BgeeP22362.
CleanExHS_CCL1.
GenevestigatorP22362.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP22362.
GenomeRNAi6346.
NextBio24656.
PROP22362.
SOURCESearch...

Entry information

Entry nameCCL1_HUMAN
AccessionPrimary (citable) accession number: P22362
Secondary accession number(s): B2R5G9, Q2M309
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: April 16, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM