P22362 (CCL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 1

Alternative name(s):
Small-inducible cytokine A1
T lymphocyte-secreted protein I-309

Gene names

Name:	CCL1
Synonyms:	SCYA1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	96 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Ref.7
Subunit structure	Monomer.
Subcellular location	Secreted.
Induction	By phorbol myristate acetate (PMA).
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular calcium ion homeostasis Traceable author statement PubMed 9417093. Source: ProtInc chemotaxis Traceable author statement PubMed 9417093. Source: ProtInc immune response Inferred from electronic annotation. Source: InterPro signal transduction Traceable author statement PubMed 9417093. Source: ProtInc viral reproduction Traceable author statement PubMed 9417093. Source: ProtInc
Cellular_component	extracellular space Traceable author statement Ref.2. Source: ProtInc
Molecular_function	chemokine activity Traceable author statement PubMed 9417093. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Ref.6

Chain

24 – 96

73

C-C motif chemokine 1

PRO_0000005141

Amino acid modifications

Glycosylation

52

1

N-linked (GlcNAc...) Potential

Disulfide bond

33 ↔ 57

Disulfide bond

34 ↔ 73

Disulfide bond

49 ↔ 91

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

96

Helix Strand Turn

Details...

Beta strand

28 – 30

3

Turn

44 – 46

3

Beta strand

47 – 52

6

Helix

55 – 57

3

Beta strand

62 – 74

13

Helix

80 – 87

8

Sequences

	Sequence		Length	Mass (Da)
	P22362 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 7E67F1F82892F3C7	FASTA	96	10,992
	10 20 30 40 50 60 MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY RNTSSICSNE 70 80 90 GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel polypeptide secreted by activated human T lymphocytes." Miller M.D., Hata S., Waal Malefyt R., Krangel M.S. J. Immunol. 143:2907-2916(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines." Miller M.D., Wilson S.D., Dorf M.E., Seuanez H.N., O'Brien S.J., Krangel M.S. J. Immunol. 145:2737-2744(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-38.
[7]	"The human cytokine I-309 is a monocyte chemoattractant." Miller M.D., Krangel M.S. Proc. Natl. Acad. Sci. U.S.A. 89:2950-2954(1992) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SIGNAL SEQUENCE CLEAVAGE SITE.
[8]	"Human CC chemokine I-309, structural consequences of the additional disulfide bond." Keizer D.W., Crump M.P., Lee T.W., Slupsky C.M., Clark-Lewis I., Sykes B.D. Biochemistry 39:6053-6059(2000) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 23-96.
+	Additional computationally mapped references.

Web resources

Wikipedia

CCL1 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M57502 mRNA. Translation: AAA61196.1.
M57506 Genomic DNA. Translation: AAA52705.1.
AK312183 mRNA. Translation: BAG35116.1.
CH471147 Genomic DNA. Translation: EAW80204.1.
BC105073 mRNA. Translation: AAI05074.1.
BC105075 mRNA. Translation: AAI05076.1.

IPI

IPI00026221.

PIR

A37236.

RefSeq

NP_002972.1. NM_002981.1.

UniGene

Hs.72918.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EL0	NMR	-	A	23-96	[»]

ProteinModelPortal

P22362.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5835N.

STRING

9606.ENSP00000225842.

Polymorphism databases

DMDM

123950.

Proteomic databases

PRIDE

P22362.

Protocols and materials databases

DNASU

6346.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000225842; ENSP00000225842; ENSG00000108702.

GeneID

6346.

KEGG

hsa:6346.

UCSC

uc002hid.1. human.

Organism-specific databases

CTD

6346.

GeneCards

GC17M032687.

HGNC

HGNC:10609. CCL1.

HPA

HPA049861.

MIM

182281. gene.

neXtProt

NX_P22362.

PharmGKB

PA35542.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG68213.

HOGENOM

HOG000036686.

HOVERGEN

HBG098128.

InParanoid

P22362.

KO

K05514.

OMA

SSICSNE.

OrthoDB

EOG4J119T.

PhylomeDB

P22362.

Gene expression databases

ArrayExpress

P22362.

Bgee

P22362.

CleanEx

HS_CCL1.

Genevestigator

P22362.

GermOnline

ENSG00000108702. Homo sapiens.

Family and domain databases

InterPro

IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]

Pfam

PF00048. IL8. 1 hit.
[Graphical view]

SMART

SM00199. SCY. 1 hit.
[Graphical view]

SUPFAM

SSF54117. Chemokine_IL8. 1 hit.

PROSITE

PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P22362.

GenomeRNAi

6346.

NextBio

24656.

SOURCE

Search...

Entry information

Entry name

CCL1_HUMAN

Accession

Primary (citable) accession number: P22362
Secondary accession number(s): B2R5G9, Q2M309

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	May 1, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.