Reviewed, UniProtKB/Swiss-Prot P22358 (DNAK2_SYNY3)

Names and origin

Protein names

Recommended name:
    Chaperone protein dnaK2
Alternative name(s):
    Heat shock protein 70-2
    Heat shock 70 kDa protein 2
    HSP70-2

Gene names

Name:	dnaK2
Synonyms:	dnaK
Ordered Locus Names:	sll0170

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	636 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts as a chaperone By similarity.
Induction	By stress conditions e.g. heat shock. HAMAP MF_00332
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 636	636	Chaperone protein dnaK2 HAMAP MF_00332		PRO_0000078569
Amino acid modifications
	Modified residue	198	1	Phosphothreonine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	P22358-1 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 33AE4CECBA28F40A	FASTA	636	67,614
	10 20 30 40 50 60 MGKVVGIDLG TTNSCVAVME GGKPTVIANA EGFRTTPSVV GYAKNGDRLV GQIAKRQAVM 70 80 90 100 110 120 NPGNTFYSVK RFIGRKFDEI TNEATEVAYS VVKDGNGNVK LDCPAQGKQF APEEISAQVL 130 140 150 160 170 180 RKLVDDASKY LGETVTQAVI TVPAYFNDSQ RQATKDAGKI AGIEVLRIIN EPTAASLAYG 190 200 210 220 230 240 LDKKDNETIL VFDLGGGTFD VSILEVGEGV FEVLATSGDT HLGGDDFDKK IVDFLAGEFQ 250 260 270 280 290 300 KAEGIDLRKD KQALQRLTEA AEKAKIELSG VSQTEINLPF ITATQDGPKH LDTTLSRAKF 310 320 330 340 350 360 EEICSDLIDR CGIPVENAIR DAKIDKSALD EIVLVGGSTR IPAVQEVVKK ILGKDPNQGV 370 380 390 400 410 420 NPDEVVAVGA AIQGGVLSGE VKDILLLDVS PLSLGVETLG GVMTKIIPRN TTIPTKKSET 430 440 450 460 470 480 FSTAVDGQSN VEIHVLQGER EMANDNKSLG TFRLDGIPPA PRGVPQIEVT FDIDANGILN 490 500 510 520 530 540 VTAKDRGTGK EQSISITGAS TLPDTEVDRM VKEAESNAAA DKERREKIDR KNQADSLVYQ 550 560 570 580 590 600 AEKQITELGD KVPAADKIKA EGLIKDLKEA VAQEDDAKIQ TVMPELQQVL YSIGSNMYQQ 610 620 630 AGAEAGVGAP GAGPEAGTSS GGGDDVIDAE FSEPEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the genes encoding two chaperone proteins of the cyanobacterium Synechocystis sp. PCC 6803." Chitnis P.R., Nelson N. J. Biol. Chem. 266:58-65(1991) [PubMed: 1670771] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M57518 Genomic DNA. Translation: AAA27287.1. BA000022 Genomic DNA. Translation: BAA10059.1.
PIR	C39025.
RefSeq	NP_441989.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P22358. 1 interaction.
STRING	P22358.
Genome annotation databases
GeneID	952783.
GenomeReviews	Gene locus sll0170 in contig BA000022_GR.
KEGG	syn:sll0170.
NMPDR	fig|1148.1.peg.2090.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P22358.
OMA	EVSYSVE
Enzyme and pathway databases
BioCyc	SSP1148:SLL0170-MON.
Family and domain databases
HAMAP	MF_00332. [Tree]
InterPro	IPR012725. Chaperone_DnaK. IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view]
PANTHER	PTHR19375. Hsp70. 1 hit.
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
TIGRFAMs	TIGR02350. prok_dnaK. 1 hit.
PROSITE	PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAK2_SYNY3

Accession

Primary (citable) accession number: P22358

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	November 24, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)