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Protein

54S ribosomal protein L8, mitochondrial

Gene

MRPL8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial genome maintenance Source: GO_Central
  • mitochondrial translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31525-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L8, mitochondrial
Alternative name(s):
YmL8
Gene namesi
Name:MRPL8
Ordered Locus Names:YJL063C
ORF Names:HRD238, J1125
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL063C.
SGDiS000003599. MRPL8.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 23823754S ribosomal protein L8, mitochondrialPRO_0000175550Add
BLAST

Proteomic databases

MaxQBiP22353.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).1 Publication

Protein-protein interaction databases

BioGridi33690. 20 interactions.
DIPiDIP-5672N.
IntActiP22353. 8 interactions.
MINTiMINT-497599.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20L1-238[»]
ProteinModelPortaliP22353.
SMRiP22353. Positions 6-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L17P family.Curated

Phylogenomic databases

HOGENOMiHOG000141790.
InParanoidiP22353.
OMAiSTHAKCK.
OrthoDBiEOG092C4R3Y.

Family and domain databases

Gene3Di3.90.1030.10. 1 hit.
InterProiIPR000456. Ribosomal_L17.
[Graphical view]
PANTHERiPTHR14413. PTHR14413. 1 hit.
PfamiPF01196. Ribosomal_L17. 1 hit.
[Graphical view]
SUPFAMiSSF64263. SSF64263. 1 hit.
TIGRFAMsiTIGR00059. L17. 1 hit.
PROSITEiPS01167. RIBOSOMAL_L17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVGIARKLS RDKAHRDALL KNLACQLFQH ESIVSTHAKC KEASRVAERI
60 70 80 90 100
ITWTKRAITT SNSVAQAELK SQIQSQLFLA GDNRKLMKRL FSEIAPRYLE
110 120 130 140 150
RPGGYTRVLR LEPRANDSAP QSVLELVDSP VMSESHTVNR GNLKMWLLVK
160 170 180 190 200
SVINDDANQL PHNPLTLQNL HKVAKFKAEA QLHGEIMLIK QVLLKEMSLP
210 220 230
YDEALENERT QALLKEVYSS SLPKKTKKPS SYVMVPRP
Length:238
Mass (Da):26,945
Last modified:January 23, 2007 - v4
Checksum:iA130EFD95E8719BA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21T → G AA sequence (PubMed:2183197).Curated
Sequence conflicti82 – 821D → G in CAA37834 (PubMed:2183197).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53841 Genomic DNA. Translation: CAA37834.1.
Z34288 Genomic DNA. Translation: CAA84060.1.
Z49338 Genomic DNA. Translation: CAA89354.1.
AY558249 Genomic DNA. Translation: AAS56575.1.
BK006943 Genomic DNA. Translation: DAA08734.1.
PIRiS50809.
RefSeqiNP_012472.1. NM_001181496.1.

Genome annotation databases

EnsemblFungiiYJL063C; YJL063C; YJL063C.
GeneIDi853382.
KEGGisce:YJL063C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53841 Genomic DNA. Translation: CAA37834.1.
Z34288 Genomic DNA. Translation: CAA84060.1.
Z49338 Genomic DNA. Translation: CAA89354.1.
AY558249 Genomic DNA. Translation: AAS56575.1.
BK006943 Genomic DNA. Translation: DAA08734.1.
PIRiS50809.
RefSeqiNP_012472.1. NM_001181496.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20L1-238[»]
ProteinModelPortaliP22353.
SMRiP22353. Positions 6-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33690. 20 interactions.
DIPiDIP-5672N.
IntActiP22353. 8 interactions.
MINTiMINT-497599.

Proteomic databases

MaxQBiP22353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL063C; YJL063C; YJL063C.
GeneIDi853382.
KEGGisce:YJL063C.

Organism-specific databases

EuPathDBiFungiDB:YJL063C.
SGDiS000003599. MRPL8.

Phylogenomic databases

HOGENOMiHOG000141790.
InParanoidiP22353.
OMAiSTHAKCK.
OrthoDBiEOG092C4R3Y.

Enzyme and pathway databases

BioCyciYEAST:G3O-31525-MONOMER.

Miscellaneous databases

PROiP22353.

Family and domain databases

Gene3Di3.90.1030.10. 1 hit.
InterProiIPR000456. Ribosomal_L17.
[Graphical view]
PANTHERiPTHR14413. PTHR14413. 1 hit.
PfamiPF01196. Ribosomal_L17. 1 hit.
[Graphical view]
SUPFAMiSSF64263. SSF64263. 1 hit.
TIGRFAMsiTIGR00059. L17. 1 hit.
PROSITEiPS01167. RIBOSOMAL_L17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRM08_YEAST
AccessioniPrimary (citable) accession number: P22353
Secondary accession number(s): D6VWB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 146 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Although this protein has evidently no mitochondrial targeting pre-sequence, it is efficiently transported into mitochondria.
Present with 3000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.