P22350 (P5CR_METSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase
Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2

Gene names

Name:

proC

Organism

Methanobrevibacter smithii

Taxonomic identifier

2173 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	Pyrroline-5-carboxylate reductase		PRO_0000187313

Sequences

	Sequence		Length	Mass (Da)
	P22350 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: E8B1361C9AF80C65	FASTA	251	27,859
	10 20 30 40 50 60 MNLGIIGYGN IGELLSQNII SHDFCNLNKL YIANRTLSKI NHLKDIDPRI SITDDNIEVA 70 80 90 100 110 120 KTCEKIIISV KTPDLAIVLD PLKPHITKNQ QIIHTCAGTD LEFKDCGLSC VIPTISSTYD 130 140 150 160 170 180 EDNPKKGVSI IMHDENVSGE NREFVEKLFS KFSQIKVVDS PMDLEIATIA ASCMPAFIAL 190 200 210 220 230 240 GVDLFAGELE EKCNLSKEET FKILAETLNS TAYILKEDIY SPDELINKVA TKNGITQKGL 250 DVLDKRPARY L

References

[1]	"Structure of genes and an insertion element in the methane producing archaebacterium Methanobrevibacter smithii." Hamilton P.T., Reeve J.N. Mol. Gen. Genet. 200:47-59(1985) [PubMed: 2993814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X02587 Genomic DNA. Translation: CAA26425.1.
PIR	S28654.
3D structure databases
ProteinModelPortal	P22350.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_METSM

Accession

Primary (citable) accession number: P22350

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program