P22348 (PURE_METSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable N5-carboxyaminoimidazole ribonucleotide mutase
Short name=N5-CAIR mutase
EC=5.4.99.18

Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutase

Gene names

Name:

purE

Organism

Methanobrevibacter smithii

Taxonomic identifier

2173 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity.
Catalytic activity	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	5-(carboxyamino)imidazole ribonucleotide mutase activity Inferred from electronic annotation. Source: EC phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Probable N5-carboxyaminoimidazole ribonucleotide mutase		PRO_0000074991
Sites
	Binding site	11	1	Substrate By similarity
	Binding site	14	1	Substrate By similarity
	Binding site	41	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P22348 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: EB94F7CF79EC9FD2	FASTA	339	36,694
	10 20 30 40 50 60 MTPKVMIILG SGSDIAIAEK SMKILEKLEI PYSLKIASAH RTPDLVRELV VQGTNAGIKV 70 80 90 100 110 120 FIGIAGLAAH LPGAIAAYTH KPVIGVPVDV KVSGLDALYS SVQMPYPSPV ATVGIDRGDN 130 140 150 160 170 180 GAILAARILG LYDEEIRKKV LESKEGYRQK VIKNNEEIVQ KIDNPHITND FLRIKNLELN 190 200 210 220 230 240 ETTEEFNGSY INKNAEVVII VGRHTDLITG KKVSVTLDRL KIPHDMQVIC PIRSGKKFRA 250 260 270 280 290 300 YVNTMKNAKI FIGINSNSSQ VSGGLVGLTE KPVIGVPCEN ELGNNYLLST VNMPPGVPVA 310 320 330 TVGVNNGRNA AVLSGEILSI NNPVLLELLE KLKNKKINI

References

[1]	"Structure of genes and an insertion element in the methane producing archaebacterium Methanobrevibacter smithii." Hamilton P.T., Reeve J.N. Mol. Gen. Genet. 200:47-59(1985) [PubMed: 2993814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X02586 Genomic DNA. Translation: CAA26422.1.
PIR	S28656.
3D structure databases
ProteinModelPortal	P22348.
SMR	P22348. Positions 5-162.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000031. N5-CAIR_Mutase_PurE_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 2 hits.
Pfam	PF00731. AIRC. 2 hits. [Graphical view]
SMART	SM01001. AIRC. 2 hits. [Graphical view]
SUPFAM	SSF52255. AIR_carboxyl. 2 hits.
TIGRFAMs	TIGR01162. PurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PURE_METSM

Accession

Primary (citable) accession number: P22348

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program