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Protein

Growth arrest and DNA damage-inducible protein GADD45 beta

Gene

Gadd45b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Apoptosis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 beta
Alternative name(s):
Myeloid differentiation primary response protein MyD118
Negative growth regulatory protein MyD118
Gene namesi
Name:Gadd45b
Synonyms:Myd118
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107776. Gadd45b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483351 – 160Growth arrest and DNA damage-inducible protein GADD45 betaAdd BLAST160

Proteomic databases

PaxDbiP22339.
PRIDEiP22339.

PTM databases

PhosphoSitePlusiP22339.

Expressioni

Tissue specificityi

In myeloid precursor enriched BM cells.

Inductioni

By cytokines.

Gene expression databases

BgeeiENSMUSG00000015312.
CleanExiMM_GADD45B.
GenevisibleiP22339. MM.

Interactioni

Subunit structurei

Interacts with GADD45GIP1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GADD45GIP1Q8TAE83EBI-2266938,EBI-372506From a different organism.

Protein-protein interaction databases

BioGridi201638. 8 interactors.
IntActiP22339. 2 interactors.
STRINGi10090.ENSMUSP00000015456.

Structurei

3D structure databases

ProteinModelPortaliP22339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GADD45 family.Curated

Phylogenomic databases

eggNOGiENOG410IH6M. Eukaryota.
ENOG4111K8B. LUCA.
GeneTreeiENSGT00390000016506.
HOGENOMiHOG000013221.
HOVERGENiHBG051684.
InParanoidiP22339.
KOiK04402.
OMAiHTDSWKS.
OrthoDBiEOG091G0RHU.
PhylomeDBiP22339.
TreeFamiTF300196.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PANTHERiPTHR10411. PTHR10411. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.

Sequencei

Sequence statusi: Complete.

P22339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEELVASD NAVQKMQAVT AAVEQLLVAA QRQDRLTVGV YEAAKLMNVD
60 70 80 90 100
PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDIDIV RVSGMQRLAQ
110 120 130 140 150
LLGEPAETLG TTEARDLHCL LVTNCHTDSW KSQGLVEVAS YCEESRGNNQ
160
WVPYISLEER
Length:160
Mass (Da):17,783
Last modified:August 1, 1991 - v1
Checksum:iAD297587576532C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54149 mRNA. Translation: CAA38088.1.
AF176045 Genomic DNA. Translation: AAD51080.2.
AF441860 Genomic DNA. Translation: AAN23034.1.
AK010420 mRNA. Translation: BAB26923.1.
AK149895 mRNA. Translation: BAE29151.1.
AK154952 mRNA. Translation: BAE32947.1.
BC023815 mRNA. Translation: AAH23815.1.
CCDSiCCDS24038.1.
PIRiA43813.
RefSeqiNP_032681.1. NM_008655.1.
UniGeneiMm.1360.

Genome annotation databases

EnsembliENSMUST00000015456; ENSMUSP00000015456; ENSMUSG00000015312.
GeneIDi17873.
KEGGimmu:17873.
UCSCiuc007gfl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54149 mRNA. Translation: CAA38088.1.
AF176045 Genomic DNA. Translation: AAD51080.2.
AF441860 Genomic DNA. Translation: AAN23034.1.
AK010420 mRNA. Translation: BAB26923.1.
AK149895 mRNA. Translation: BAE29151.1.
AK154952 mRNA. Translation: BAE32947.1.
BC023815 mRNA. Translation: AAH23815.1.
CCDSiCCDS24038.1.
PIRiA43813.
RefSeqiNP_032681.1. NM_008655.1.
UniGeneiMm.1360.

3D structure databases

ProteinModelPortaliP22339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201638. 8 interactors.
IntActiP22339. 2 interactors.
STRINGi10090.ENSMUSP00000015456.

PTM databases

PhosphoSitePlusiP22339.

Proteomic databases

PaxDbiP22339.
PRIDEiP22339.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015456; ENSMUSP00000015456; ENSMUSG00000015312.
GeneIDi17873.
KEGGimmu:17873.
UCSCiuc007gfl.1. mouse.

Organism-specific databases

CTDi4616.
MGIiMGI:107776. Gadd45b.

Phylogenomic databases

eggNOGiENOG410IH6M. Eukaryota.
ENOG4111K8B. LUCA.
GeneTreeiENSGT00390000016506.
HOGENOMiHOG000013221.
HOVERGENiHBG051684.
InParanoidiP22339.
KOiK04402.
OMAiHTDSWKS.
OrthoDBiEOG091G0RHU.
PhylomeDBiP22339.
TreeFamiTF300196.

Miscellaneous databases

PROiP22339.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015312.
CleanExiMM_GADD45B.
GenevisibleiP22339. MM.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PANTHERiPTHR10411. PTHR10411. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGA45B_MOUSE
AccessioniPrimary (citable) accession number: P22339
Secondary accession number(s): Q3U342, Q9R106
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.