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Protein

Growth arrest and DNA damage-inducible protein GADD45 beta

Gene

Gadd45b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 beta
Alternative name(s):
Myeloid differentiation primary response protein MyD118
Negative growth regulatory protein MyD118
Gene namesi
Name:Gadd45b
Synonyms:Myd118
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107776 Gadd45b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483351 – 160Growth arrest and DNA damage-inducible protein GADD45 betaAdd BLAST160

Proteomic databases

PaxDbiP22339
PRIDEiP22339

PTM databases

PhosphoSitePlusiP22339

Expressioni

Tissue specificityi

In myeloid precursor enriched BM cells.

Inductioni

By cytokines.

Gene expression databases

BgeeiENSMUSG00000015312
CleanExiMM_GADD45B
ExpressionAtlasiP22339 baseline and differential
GenevisibleiP22339 MM

Interactioni

Subunit structurei

Interacts with GADD45GIP1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GADD45GIP1Q8TAE83EBI-2266938,EBI-372506From Homo sapiens.

Protein-protein interaction databases

BioGridi201638, 8 interactors
IntActiP22339, 2 interactors
STRINGi10090.ENSMUSP00000015456

Structurei

3D structure databases

ProteinModelPortaliP22339
SMRiP22339
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GADD45 family.Curated

Phylogenomic databases

eggNOGiENOG410IH6M Eukaryota
ENOG4111K8B LUCA
GeneTreeiENSGT00390000016506
HOGENOMiHOG000013221
HOVERGENiHBG051684
InParanoidiP22339
KOiK04402
OMAiAQRQDCL
OrthoDBiEOG091G0RHU
PhylomeDBiP22339
TreeFamiTF300196

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR024824 GADD45
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
PANTHERiPTHR10411 PTHR10411, 1 hit
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit

Sequencei

Sequence statusi: Complete.

P22339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEELVASD NAVQKMQAVT AAVEQLLVAA QRQDRLTVGV YEAAKLMNVD
60 70 80 90 100
PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDIDIV RVSGMQRLAQ
110 120 130 140 150
LLGEPAETLG TTEARDLHCL LVTNCHTDSW KSQGLVEVAS YCEESRGNNQ
160
WVPYISLEER
Length:160
Mass (Da):17,783
Last modified:August 1, 1991 - v1
Checksum:iAD297587576532C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54149 mRNA Translation: CAA38088.1
AF176045 Genomic DNA Translation: AAD51080.2
AF441860 Genomic DNA Translation: AAN23034.1
AK010420 mRNA Translation: BAB26923.1
AK149895 mRNA Translation: BAE29151.1
AK154952 mRNA Translation: BAE32947.1
BC023815 mRNA Translation: AAH23815.1
CCDSiCCDS24038.1
PIRiA43813
RefSeqiNP_032681.1, NM_008655.1
UniGeneiMm.1360

Genome annotation databases

EnsembliENSMUST00000015456; ENSMUSP00000015456; ENSMUSG00000015312
GeneIDi17873
KEGGimmu:17873
UCSCiuc007gfl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGA45B_MOUSE
AccessioniPrimary (citable) accession number: P22339
Secondary accession number(s): Q3U342, Q9R106
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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