Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial 2-oxoglutarate/malate carrier protein

Gene

SLC25A11

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-BTA-70263. Gluconeogenesis.
R-BTA-70326. Glucose metabolism.

Protein family/group databases

TCDBi2.A.29.2.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxoglutarate/malate carrier protein
Short name:
OGCP
Alternative name(s):
Solute carrier family 25 member 11
Gene namesi
Name:SLC25A11
Synonyms:SLC20A4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4219Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei83 – 10119Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei119 – 14022Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei183 – 20220Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei222 – 24019Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei281 – 30020Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 314313Mitochondrial 2-oxoglutarate/malate carrier proteinPRO_0000090624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei57 – 571N6-succinyllysineBy similarity
Modified residuei102 – 1021PhosphotyrosineBy similarity
Modified residuei256 – 2561N6-acetyllysineBy similarity

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP22292.
PRIDEiP22292.

Expressioni

Tissue specificityi

Heart, liver and brain.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035103.

Structurei

3D structure databases

ProteinModelPortaliP22292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 10886Solcar 1Add
BLAST
Repeati117 – 20892Solcar 2Add
BLAST
Repeati217 – 30690Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiP22292.
KOiK15104.
OMAiNDDILCH.
OrthoDBiEOG793B7Z.
TreeFamiTF354262.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATASPGAS GMDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ
60 70 80 90 100
LSGEGAKTRE YKTSFHALIS ILRAEGLRGI YTGLSAGLLR QATYTTTRLG
110 120 130 140 150
IYTVLFERLT GADGTPPGFL LKAVIGMTAG ATGAFVGTPA EVALIRMTAD
160 170 180 190 200
GRLPVDQRRG YKNVFNALFR IVQEEGVPTL WRGCIPTMAR AVVVNAAQLA
210 220 230 240 250
SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV DIVKTRIQNM
260 270 280 290 300
RMIDGKPEYK NGLDVLVKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL
310
EQMNKAYKRL FLSG
Length:314
Mass (Da):34,172
Last modified:January 23, 2007 - v3
Checksum:i1FF22D1A0B3D36E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66115 Genomic DNA. Translation: CAA46906.1.
M58703 mRNA. Translation: AAA30671.1.
M60662 mRNA. Translation: AAA30672.1.
BT020806 mRNA. Translation: AAX08823.1.
BC142283 mRNA. Translation: AAI42284.1.
BC146129 mRNA. Translation: AAI46130.1.
PIRiA36305.
RefSeqiNP_777096.1. NM_174671.2.
UniGeneiBt.27871.

Genome annotation databases

EnsembliENSBTAT00000035225; ENSBTAP00000035103; ENSBTAG00000004910.
GeneIDi282523.
KEGGibta:282523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66115 Genomic DNA. Translation: CAA46906.1.
M58703 mRNA. Translation: AAA30671.1.
M60662 mRNA. Translation: AAA30672.1.
BT020806 mRNA. Translation: AAX08823.1.
BC142283 mRNA. Translation: AAI42284.1.
BC146129 mRNA. Translation: AAI46130.1.
PIRiA36305.
RefSeqiNP_777096.1. NM_174671.2.
UniGeneiBt.27871.

3D structure databases

ProteinModelPortaliP22292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035103.

Protein family/group databases

TCDBi2.A.29.2.1. the mitochondrial carrier (mc) family.

Proteomic databases

PaxDbiP22292.
PRIDEiP22292.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000035225; ENSBTAP00000035103; ENSBTAG00000004910.
GeneIDi282523.
KEGGibta:282523.

Organism-specific databases

CTDi8402.

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiP22292.
KOiK15104.
OMAiNDDILCH.
OrthoDBiEOG793B7Z.
TreeFamiTF354262.

Enzyme and pathway databases

ReactomeiR-BTA-70263. Gluconeogenesis.
R-BTA-70326. Glucose metabolism.

Miscellaneous databases

NextBioi20806271.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier."
    Iacobazzi V., Palmieri F., Runswick M.J., Walker J.E.
    DNA Seq. 3:79-88(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence of the bovine 2-oxoglutarate/malate carrier protein: structural relationship to other mitochondrial transport proteins."
    Runswick M.J., Walker J.E., Bisaccia F., Iacobazzi V., Palmieri F.
    Biochemistry 29:11033-11040(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons and Hypothalamus.

Entry informationi

Entry nameiM2OM_BOVIN
AccessioniPrimary (citable) accession number: P22292
Secondary accession number(s): A5PJY2, Q5E9W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: February 17, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.