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Protein

Cytochrome b-c1 complex subunit 9

Gene

QCR9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR9 is required for formation of a fully functional complex.

GO - Biological processi

  • aerobic respiration Source: SGD
  • hydrogen ion transmembrane transport Source: GOC
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
  • mitochondrial respiratory chain complex III assembly Source: SGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:YGR183C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 9
Alternative name(s):
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7.3 kDa protein
Ubiquinol-cytochrome c reductase complex 7.3 kDa protein
Gene namesi
Name:QCR9
Synonyms:UCR9
Ordered Locus Names:YGR183C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR183C.
SGDiS000003415. QCR9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 37HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • mitochondrial respiratory chain complex III Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001935582 – 66Cytochrome b-c1 complex subunit 9Add BLAST65

Proteomic databases

MaxQBiP22289.
PRIDEiP22289.
TopDownProteomicsiP22289.

Interactioni

Subunit structurei

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Protein-protein interaction databases

BioGridi33435. 119 interactors.
IntActiP22289. 5 interactors.
MINTiMINT-4487623.

Structurei

Secondary structure

166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 11Combined sources8
Helixi18 – 43Combined sources26
Turni44 – 47Combined sources4
Helixi49 – 55Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30I4-58[»]
1KB9X-ray2.30I4-58[»]
1KYOX-ray2.97I/T2-58[»]
1P84X-ray2.50I4-58[»]
2IBZX-ray2.30I1-66[»]
3CX5X-ray1.90I/T2-66[»]
3CXHX-ray2.50I/T2-66[»]
4PD4X-ray3.04I2-58[»]
ProteinModelPortaliP22289.
SMRiP22289.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22289.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR10/QCR9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000215187.
InParanoidiP22289.
KOiK00419.
OMAiDVKGKFL.
OrthoDBiEOG092C5W3D.

Family and domain databases

Gene3Di1.20.5.260. 1 hit.
InterProiIPR008027. QCR9.
[Graphical view]
PANTHERiPTHR12980. PTHR12980. 1 hit.
PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]
SUPFAMiSSF81514. SSF81514. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSSLYKTF FKRNAVFVGT IFAGAFVFQT VFDTAITSWY ENHNKGKLWK
60
DVKARIAAGD GDDDDE
Length:66
Mass (Da):7,476
Last modified:January 23, 2007 - v2
Checksum:i120106C00F3CCED0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59797 Genomic DNA. Translation: AAA63575.1.
Z72968 Genomic DNA. Translation: CAA97209.1.
BK006941 Genomic DNA. Translation: DAA08277.1.
PIRiA38325.
RefSeqiNP_011699.1. NM_001181312.1.

Genome annotation databases

EnsemblFungiiYGR183C; YGR183C; YGR183C.
GeneIDi853095.
KEGGisce:YGR183C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59797 Genomic DNA. Translation: AAA63575.1.
Z72968 Genomic DNA. Translation: CAA97209.1.
BK006941 Genomic DNA. Translation: DAA08277.1.
PIRiA38325.
RefSeqiNP_011699.1. NM_001181312.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30I4-58[»]
1KB9X-ray2.30I4-58[»]
1KYOX-ray2.97I/T2-58[»]
1P84X-ray2.50I4-58[»]
2IBZX-ray2.30I1-66[»]
3CX5X-ray1.90I/T2-66[»]
3CXHX-ray2.50I/T2-66[»]
4PD4X-ray3.04I2-58[»]
ProteinModelPortaliP22289.
SMRiP22289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33435. 119 interactors.
IntActiP22289. 5 interactors.
MINTiMINT-4487623.

Proteomic databases

MaxQBiP22289.
PRIDEiP22289.
TopDownProteomicsiP22289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR183C; YGR183C; YGR183C.
GeneIDi853095.
KEGGisce:YGR183C.

Organism-specific databases

EuPathDBiFungiDB:YGR183C.
SGDiS000003415. QCR9.

Phylogenomic databases

HOGENOMiHOG000215187.
InParanoidiP22289.
KOiK00419.
OMAiDVKGKFL.
OrthoDBiEOG092C5W3D.

Enzyme and pathway databases

BioCyciYEAST:YGR183C-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP22289.
PROiP22289.

Family and domain databases

Gene3Di1.20.5.260. 1 hit.
InterProiIPR008027. QCR9.
[Graphical view]
PANTHERiPTHR12980. PTHR12980. 1 hit.
PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]
SUPFAMiSSF81514. SSF81514. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQCR9_YEAST
AccessioniPrimary (citable) accession number: P22289
Secondary accession number(s): D6VUW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4550 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.