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Protein

Cytochrome b-c1 complex subunit 9

Gene

QCR9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR9 is required for formation of a fully functional complex.

Miscellaneous

Present with 4550 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • aerobic respiration Source: SGD
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
  • mitochondrial respiratory chain complex III assembly Source: SGD

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:YGR183C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 9
Alternative name(s):
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7.3 kDa protein
Ubiquinol-cytochrome c reductase complex 7.3 kDa protein
Gene namesi
Name:QCR9
Synonyms:UCR9
Ordered Locus Names:YGR183C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR183C
SGDiS000003415 QCR9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 37HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001935582 – 66Cytochrome b-c1 complex subunit 9Add BLAST65

Proteomic databases

MaxQBiP22289
PaxDbiP22289
PRIDEiP22289
TopDownProteomicsiP22289

Interactioni

Subunit structurei

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Protein-protein interaction databases

BioGridi33435, 315 interactors
IntActiP22289, 5 interactors
MINTiP22289
STRINGi4932.YGR183C

Structurei

Secondary structure

166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 11Combined sources8
Helixi18 – 43Combined sources26
Turni44 – 47Combined sources4
Helixi49 – 55Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30I4-58[»]
1KB9X-ray2.30I4-58[»]
1KYOX-ray2.97I/T2-58[»]
1P84X-ray2.50I4-58[»]
2IBZX-ray2.30I1-66[»]
3CX5X-ray1.90I/T2-66[»]
3CXHX-ray2.50I/T2-66[»]
4PD4X-ray3.04I2-58[»]
ProteinModelPortaliP22289
SMRiP22289
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22289

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR10/QCR9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000215187
InParanoidiP22289
KOiK00419
OMAiNRGKLWK
OrthoDBiEOG092C5W3D

Family and domain databases

Gene3Di1.20.5.260, 1 hit
InterProiView protein in InterPro
IPR008027 QCR9
IPR036656 QCR9_sf
PANTHERiPTHR12980 PTHR12980, 1 hit
PfamiView protein in Pfam
PF05365 UCR_UQCRX_QCR9, 1 hit
SUPFAMiSSF81514 SSF81514, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSSLYKTF FKRNAVFVGT IFAGAFVFQT VFDTAITSWY ENHNKGKLWK
60
DVKARIAAGD GDDDDE
Length:66
Mass (Da):7,476
Last modified:January 23, 2007 - v2
Checksum:i120106C00F3CCED0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59797 Genomic DNA Translation: AAA63575.1
Z72968 Genomic DNA Translation: CAA97209.1
BK006941 Genomic DNA Translation: DAA08277.1
PIRiA38325
RefSeqiNP_011699.1, NM_001181312.1

Genome annotation databases

EnsemblFungiiYGR183C; YGR183C; YGR183C
GeneIDi853095
KEGGisce:YGR183C

Similar proteinsi

Entry informationi

Entry nameiQCR9_YEAST
AccessioniPrimary (citable) accession number: P22289
Secondary accession number(s): D6VUW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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