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Protein

Cytochrome b-c1 complex subunit 9

Gene

QCR9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR9 is required for formation of a fully functional complex.

GO - Biological processi

  • aerobic respiration Source: SGD
  • hydrogen ion transmembrane transport Source: GOC
  • iron-sulfur cluster assembly Source: SGD
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:YGR183C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 9
Alternative name(s):
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7.3 kDa protein
Ubiquinol-cytochrome c reductase complex 7.3 kDa protein
Gene namesi
Name:QCR9
Synonyms:UCR9
Ordered Locus Names:YGR183C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR183C.
SGDiS000003415. QCR9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3722HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • mitochondrial respiratory chain complex III Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 6665Cytochrome b-c1 complex subunit 9PRO_0000193558Add
BLAST

Proteomic databases

MaxQBiP22289.
PaxDbiP22289.

Interactioni

Subunit structurei

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Protein-protein interaction databases

BioGridi33435. 119 interactions.
IntActiP22289. 5 interactions.
MINTiMINT-4487623.

Structurei

Secondary structure

1
66
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 118Combined sources
Helixi18 – 4326Combined sources
Turni44 – 474Combined sources
Helixi49 – 557Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30I4-58[»]
1KB9X-ray2.30I4-58[»]
1KYOX-ray2.97I/T2-58[»]
1P84X-ray2.50I4-58[»]
2IBZX-ray2.30I1-66[»]
3CX5X-ray1.90I/T2-66[»]
3CXHX-ray2.50I/T2-66[»]
4PD4X-ray3.04I2-58[»]
ProteinModelPortaliP22289.
SMRiP22289. Positions 2-58.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22289.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR10/QCR9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274563.
HOGENOMiHOG000215187.
InParanoidiP22289.
KOiK00419.
OMAiDVKGKFL.
OrthoDBiEOG7CG7CQ.

Family and domain databases

Gene3Di1.20.5.260. 1 hit.
InterProiIPR008027. QCR9.
[Graphical view]
PANTHERiPTHR12980. PTHR12980. 1 hit.
PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]
SUPFAMiSSF81514. SSF81514. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSSLYKTF FKRNAVFVGT IFAGAFVFQT VFDTAITSWY ENHNKGKLWK
60
DVKARIAAGD GDDDDE
Length:66
Mass (Da):7,476
Last modified:January 23, 2007 - v2
Checksum:i120106C00F3CCED0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59797 Genomic DNA. Translation: AAA63575.1.
Z72968 Genomic DNA. Translation: CAA97209.1.
BK006941 Genomic DNA. Translation: DAA08277.1.
PIRiA38325.
RefSeqiNP_011699.1. NM_001181312.1.

Genome annotation databases

EnsemblFungiiYGR183C; YGR183C; YGR183C.
GeneIDi853095.
KEGGisce:YGR183C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59797 Genomic DNA. Translation: AAA63575.1.
Z72968 Genomic DNA. Translation: CAA97209.1.
BK006941 Genomic DNA. Translation: DAA08277.1.
PIRiA38325.
RefSeqiNP_011699.1. NM_001181312.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30I4-58[»]
1KB9X-ray2.30I4-58[»]
1KYOX-ray2.97I/T2-58[»]
1P84X-ray2.50I4-58[»]
2IBZX-ray2.30I1-66[»]
3CX5X-ray1.90I/T2-66[»]
3CXHX-ray2.50I/T2-66[»]
4PD4X-ray3.04I2-58[»]
ProteinModelPortaliP22289.
SMRiP22289. Positions 2-58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33435. 119 interactions.
IntActiP22289. 5 interactions.
MINTiMINT-4487623.

Proteomic databases

MaxQBiP22289.
PaxDbiP22289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR183C; YGR183C; YGR183C.
GeneIDi853095.
KEGGisce:YGR183C.

Organism-specific databases

EuPathDBiFungiDB:YGR183C.
SGDiS000003415. QCR9.

Phylogenomic databases

eggNOGiNOG274563.
HOGENOMiHOG000215187.
InParanoidiP22289.
KOiK00419.
OMAiDVKGKFL.
OrthoDBiEOG7CG7CQ.

Enzyme and pathway databases

BioCyciYEAST:YGR183C-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP22289.
NextBioi973084.
PROiP22289.

Family and domain databases

Gene3Di1.20.5.260. 1 hit.
InterProiIPR008027. QCR9.
[Graphical view]
PANTHERiPTHR12980. PTHR12980. 1 hit.
PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]
SUPFAMiSSF81514. SSF81514. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of QCR9, a nuclear gene encoding the 7.3-kDa subunit 9 of the Saccharomyces cerevisiae ubiquinol-cytochrome c oxidoreductase complex. An intron-containing gene with a conserved sequence occurring in the intron of COX4."
    Phillips J.D., Schmitt M.E., Brown T.A., Beckmann J.D., Trumpower B.L.
    J. Biol. Chem. 265:20813-20821(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-10.
    Strain: ATCC 64665 / S288c / DC5.
  2. "DNA sequence analysis of a 23,002 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII."
    Arroyo J., Garcia-Gonzalez M., Garcia-Saez M.I., Sanchez-Perez M., Nombela C.
    Yeast 13:357-363(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment."
    Hunte C., Koepke J., Lange C., Rossmanith T., Michel H.
    Structure 8:669-684(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
  7. "Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c."
    Lange C., Hunte C.
    Proc. Natl. Acad. Sci. U.S.A. 99:2800-2805(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.97 ANGSTROMS).

Entry informationi

Entry nameiQCR9_YEAST
AccessioniPrimary (citable) accession number: P22289
Secondary accession number(s): D6VUW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4550 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.