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P22289

- QCR9_YEAST

UniProt

P22289 - QCR9_YEAST

Protein

Cytochrome b-c1 complex subunit 9

Gene

QCR9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR9 is required for formation of a fully functional complex.

    GO - Biological processi

    1. aerobic respiration Source: SGD
    2. hydrogen ion transmembrane transport Source: GOC
    3. iron-sulfur cluster assembly Source: SGD
    4. mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Enzyme and pathway databases

    BioCyciYEAST:YGR183C-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 9
    Alternative name(s):
    Complex III subunit 9
    Complex III subunit X
    Cytochrome c1 non-heme 7.3 kDa protein
    Ubiquinol-cytochrome c reductase complex 7.3 kDa protein
    Gene namesi
    Name:QCR9
    Synonyms:UCR9
    Ordered Locus Names:YGR183C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    SGDiS000003415. QCR9.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex III Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 6665Cytochrome b-c1 complex subunit 9PRO_0000193558Add
    BLAST

    Proteomic databases

    MaxQBiP22289.
    PaxDbiP22289.

    Expressioni

    Gene expression databases

    GenevestigatoriP22289.

    Interactioni

    Subunit structurei

    Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ALO1P547831EBI-19947,EBI-2519
    PEX11Q124621EBI-19947,EBI-13198

    Protein-protein interaction databases

    BioGridi33435. 119 interactions.
    IntActiP22289. 5 interactions.
    MINTiMINT-4487623.
    STRINGi4932.YGR183C.

    Structurei

    Secondary structure

    1
    66
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 118
    Helixi18 – 4326
    Turni44 – 474
    Helixi49 – 557

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EZVX-ray2.30I4-58[»]
    1KB9X-ray2.30I4-58[»]
    1KYOX-ray2.97I/T2-58[»]
    1P84X-ray2.50I4-58[»]
    2IBZX-ray2.30I1-66[»]
    3CX5X-ray1.90I/T2-66[»]
    3CXHX-ray2.50I/T2-66[»]
    4PD4X-ray3.04I2-58[»]
    ProteinModelPortaliP22289.
    SMRiP22289. Positions 2-58.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP22289.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3722HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UQCR10/QCR9 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274563.
    HOGENOMiHOG000215187.
    KOiK00419.
    OMAiDANEYLI.
    OrthoDBiEOG7CG7CQ.

    Family and domain databases

    Gene3Di1.20.5.260. 1 hit.
    InterProiIPR008027. QCR9.
    [Graphical view]
    PANTHERiPTHR12980. PTHR12980. 1 hit.
    PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
    [Graphical view]
    SUPFAMiSSF81514. SSF81514. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22289-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFSSLYKTF FKRNAVFVGT IFAGAFVFQT VFDTAITSWY ENHNKGKLWK   50
    DVKARIAAGD GDDDDE 66
    Length:66
    Mass (Da):7,476
    Last modified:January 23, 2007 - v2
    Checksum:i120106C00F3CCED0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59797 Genomic DNA. Translation: AAA63575.1.
    Z72968 Genomic DNA. Translation: CAA97209.1.
    BK006941 Genomic DNA. Translation: DAA08277.1.
    PIRiA38325.
    RefSeqiNP_011699.1. NM_001181312.1.

    Genome annotation databases

    EnsemblFungiiYGR183C; YGR183C; YGR183C.
    GeneIDi853095.
    KEGGisce:YGR183C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59797 Genomic DNA. Translation: AAA63575.1 .
    Z72968 Genomic DNA. Translation: CAA97209.1 .
    BK006941 Genomic DNA. Translation: DAA08277.1 .
    PIRi A38325.
    RefSeqi NP_011699.1. NM_001181312.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EZV X-ray 2.30 I 4-58 [» ]
    1KB9 X-ray 2.30 I 4-58 [» ]
    1KYO X-ray 2.97 I/T 2-58 [» ]
    1P84 X-ray 2.50 I 4-58 [» ]
    2IBZ X-ray 2.30 I 1-66 [» ]
    3CX5 X-ray 1.90 I/T 2-66 [» ]
    3CXH X-ray 2.50 I/T 2-66 [» ]
    4PD4 X-ray 3.04 I 2-58 [» ]
    ProteinModelPortali P22289.
    SMRi P22289. Positions 2-58.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33435. 119 interactions.
    IntActi P22289. 5 interactions.
    MINTi MINT-4487623.
    STRINGi 4932.YGR183C.

    Proteomic databases

    MaxQBi P22289.
    PaxDbi P22289.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR183C ; YGR183C ; YGR183C .
    GeneIDi 853095.
    KEGGi sce:YGR183C.

    Organism-specific databases

    SGDi S000003415. QCR9.

    Phylogenomic databases

    eggNOGi NOG274563.
    HOGENOMi HOG000215187.
    KOi K00419.
    OMAi DANEYLI.
    OrthoDBi EOG7CG7CQ.

    Enzyme and pathway databases

    BioCyci YEAST:YGR183C-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P22289.
    NextBioi 973084.
    PROi P22289.

    Gene expression databases

    Genevestigatori P22289.

    Family and domain databases

    Gene3Di 1.20.5.260. 1 hit.
    InterProi IPR008027. QCR9.
    [Graphical view ]
    PANTHERi PTHR12980. PTHR12980. 1 hit.
    Pfami PF05365. UCR_UQCRX_QCR9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81514. SSF81514. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of QCR9, a nuclear gene encoding the 7.3-kDa subunit 9 of the Saccharomyces cerevisiae ubiquinol-cytochrome c oxidoreductase complex. An intron-containing gene with a conserved sequence occurring in the intron of COX4."
      Phillips J.D., Schmitt M.E., Brown T.A., Beckmann J.D., Trumpower B.L.
      J. Biol. Chem. 265:20813-20821(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-10.
      Strain: ATCC 64665 / S288c / DC5.
    2. "DNA sequence analysis of a 23,002 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII."
      Arroyo J., Garcia-Gonzalez M., Garcia-Saez M.I., Sanchez-Perez M., Nombela C.
      Yeast 13:357-363(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment."
      Hunte C., Koepke J., Lange C., Rossmanith T., Michel H.
      Structure 8:669-684(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
    7. "Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c."
      Lange C., Hunte C.
      Proc. Natl. Acad. Sci. U.S.A. 99:2800-2805(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.97 ANGSTROMS).

    Entry informationi

    Entry nameiQCR9_YEAST
    AccessioniPrimary (citable) accession number: P22289
    Secondary accession number(s): D6VUW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 4550 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3