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P22289 (QCR9_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b-c1 complex subunit 9
Alternative name(s):
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7.3 kDa protein
Ubiquinol-cytochrome c reductase complex 7.3 kDa protein
Gene names
Name:QCR9
Synonyms:UCR9
Ordered Locus Names:YGR183C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length66 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR9 is required for formation of a fully functional complex.

Subunit structure

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Subcellular location

Mitochondrion inner membrane.

Miscellaneous

Present with 4550 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the UQCR10/QCR9 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ALO1P547831EBI-19947,EBI-2519
PEX11Q124621EBI-19947,EBI-13198

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 6665Cytochrome b-c1 complex subunit 9
PRO_0000193558

Regions

Transmembrane16 – 3722Helical; Potential

Secondary structure

........ 66
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P22289 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 120106C00F3CCED0

FASTA667,476
        10         20         30         40         50         60 
MSFSSLYKTF FKRNAVFVGT IFAGAFVFQT VFDTAITSWY ENHNKGKLWK DVKARIAAGD 


GDDDDE 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of QCR9, a nuclear gene encoding the 7.3-kDa subunit 9 of the Saccharomyces cerevisiae ubiquinol-cytochrome c oxidoreductase complex. An intron-containing gene with a conserved sequence occurring in the intron of COX4."
Phillips J.D., Schmitt M.E., Brown T.A., Beckmann J.D., Trumpower B.L.
J. Biol. Chem. 265:20813-20821(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-10.
Strain: ATCC 64665 / S288c / DC5.
[2]"DNA sequence analysis of a 23,002 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII."
Arroyo J., Garcia-Gonzalez M., Garcia-Saez M.I., Sanchez-Perez M., Nombela C.
Yeast 13:357-363(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment."
Hunte C., Koepke J., Lange C., Rossmanith T., Michel H.
Structure 8:669-684(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
[7]"Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c."
Lange C., Hunte C.
Proc. Natl. Acad. Sci. U.S.A. 99:2800-2805(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.97 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M59797 Genomic DNA. Translation: AAA63575.1.
Z72968 Genomic DNA. Translation: CAA97209.1.
BK006941 Genomic DNA. Translation: DAA08277.1.
PIRA38325.
RefSeqNP_011699.1. NM_001181312.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30I4-58[»]
1KB9X-ray2.30I4-58[»]
1KYOX-ray2.97I/T2-58[»]
1P84X-ray2.50I4-58[»]
2IBZX-ray2.30I1-66[»]
3CX5X-ray1.90I/T2-66[»]
3CXHX-ray2.50I/T2-66[»]
ProteinModelPortalP22289.
SMRP22289. Positions 2-58.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33435. 119 interactions.
IntActP22289. 5 interactions.
MINTMINT-4487623.
STRING4932.YGR183C.

Proteomic databases

MaxQBP22289.
PaxDbP22289.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGR183C; YGR183C; YGR183C.
GeneID853095.
KEGGsce:YGR183C.

Organism-specific databases

SGDS000003415. QCR9.

Phylogenomic databases

eggNOGNOG274563.
HOGENOMHOG000215187.
KOK00419.
OMADANEYLI.
OrthoDBEOG7CG7CQ.

Enzyme and pathway databases

BioCycYEAST:YGR183C-MONOMER.

Gene expression databases

GenevestigatorP22289.

Family and domain databases

Gene3D1.20.5.260. 1 hit.
InterProIPR008027. QCR9.
[Graphical view]
PANTHERPTHR12980. PTHR12980. 1 hit.
PfamPF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]
SUPFAMSSF81514. SSF81514. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP22289.
NextBio973084.
PROP22289.

Entry information

Entry nameQCR9_YEAST
AccessionPrimary (citable) accession number: P22289
Secondary accession number(s): D6VUW6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references