Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P22289

- QCR9_YEAST

UniProt

P22289 - QCR9_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome b-c1 complex subunit 9

Gene

QCR9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR9 is required for formation of a fully functional complex.

GO - Biological processi

  1. aerobic respiration Source: SGD
  2. hydrogen ion transmembrane transport Source: GOC
  3. iron-sulfur cluster assembly Source: SGD
  4. mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:YGR183C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 9
Alternative name(s):
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7.3 kDa protein
Ubiquinol-cytochrome c reductase complex 7.3 kDa protein
Gene namesi
Name:QCR9
Synonyms:UCR9
Ordered Locus Names:YGR183C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

SGDiS000003415. QCR9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3722HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. mitochondrial respiratory chain complex III Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 6665Cytochrome b-c1 complex subunit 9PRO_0000193558Add
BLAST

Proteomic databases

MaxQBiP22289.
PaxDbiP22289.

Expressioni

Gene expression databases

GenevestigatoriP22289.

Interactioni

Subunit structurei

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
ALO1P547831EBI-19947,EBI-2519
PEX11Q124621EBI-19947,EBI-13198

Protein-protein interaction databases

BioGridi33435. 119 interactions.
IntActiP22289. 5 interactions.
MINTiMINT-4487623.
STRINGi4932.YGR183C.

Structurei

Secondary structure

1
66
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 118Combined sources
Helixi18 – 4326Combined sources
Turni44 – 474Combined sources
Helixi49 – 557Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30I4-58[»]
1KB9X-ray2.30I4-58[»]
1KYOX-ray2.97I/T2-58[»]
1P84X-ray2.50I4-58[»]
2IBZX-ray2.30I1-66[»]
3CX5X-ray1.90I/T2-66[»]
3CXHX-ray2.50I/T2-66[»]
4PD4X-ray3.04I2-58[»]
ProteinModelPortaliP22289.
SMRiP22289. Positions 2-58.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22289.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR10/QCR9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274563.
HOGENOMiHOG000215187.
InParanoidiP22289.
KOiK00419.
OMAiDANEYLI.
OrthoDBiEOG7CG7CQ.

Family and domain databases

Gene3Di1.20.5.260. 1 hit.
InterProiIPR008027. QCR9.
[Graphical view]
PANTHERiPTHR12980. PTHR12980. 1 hit.
PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]
SUPFAMiSSF81514. SSF81514. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22289-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFSSLYKTF FKRNAVFVGT IFAGAFVFQT VFDTAITSWY ENHNKGKLWK
60
DVKARIAAGD GDDDDE
Length:66
Mass (Da):7,476
Last modified:January 23, 2007 - v2
Checksum:i120106C00F3CCED0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59797 Genomic DNA. Translation: AAA63575.1.
Z72968 Genomic DNA. Translation: CAA97209.1.
BK006941 Genomic DNA. Translation: DAA08277.1.
PIRiA38325.
RefSeqiNP_011699.1. NM_001181312.1.

Genome annotation databases

EnsemblFungiiYGR183C; YGR183C; YGR183C.
GeneIDi853095.
KEGGisce:YGR183C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59797 Genomic DNA. Translation: AAA63575.1 .
Z72968 Genomic DNA. Translation: CAA97209.1 .
BK006941 Genomic DNA. Translation: DAA08277.1 .
PIRi A38325.
RefSeqi NP_011699.1. NM_001181312.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EZV X-ray 2.30 I 4-58 [» ]
1KB9 X-ray 2.30 I 4-58 [» ]
1KYO X-ray 2.97 I/T 2-58 [» ]
1P84 X-ray 2.50 I 4-58 [» ]
2IBZ X-ray 2.30 I 1-66 [» ]
3CX5 X-ray 1.90 I/T 2-66 [» ]
3CXH X-ray 2.50 I/T 2-66 [» ]
4PD4 X-ray 3.04 I 2-58 [» ]
ProteinModelPortali P22289.
SMRi P22289. Positions 2-58.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33435. 119 interactions.
IntActi P22289. 5 interactions.
MINTi MINT-4487623.
STRINGi 4932.YGR183C.

Proteomic databases

MaxQBi P22289.
PaxDbi P22289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR183C ; YGR183C ; YGR183C .
GeneIDi 853095.
KEGGi sce:YGR183C.

Organism-specific databases

SGDi S000003415. QCR9.

Phylogenomic databases

eggNOGi NOG274563.
HOGENOMi HOG000215187.
InParanoidi P22289.
KOi K00419.
OMAi DANEYLI.
OrthoDBi EOG7CG7CQ.

Enzyme and pathway databases

BioCyci YEAST:YGR183C-MONOMER.

Miscellaneous databases

EvolutionaryTracei P22289.
NextBioi 973084.
PROi P22289.

Gene expression databases

Genevestigatori P22289.

Family and domain databases

Gene3Di 1.20.5.260. 1 hit.
InterProi IPR008027. QCR9.
[Graphical view ]
PANTHERi PTHR12980. PTHR12980. 1 hit.
Pfami PF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view ]
SUPFAMi SSF81514. SSF81514. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of QCR9, a nuclear gene encoding the 7.3-kDa subunit 9 of the Saccharomyces cerevisiae ubiquinol-cytochrome c oxidoreductase complex. An intron-containing gene with a conserved sequence occurring in the intron of COX4."
    Phillips J.D., Schmitt M.E., Brown T.A., Beckmann J.D., Trumpower B.L.
    J. Biol. Chem. 265:20813-20821(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-10.
    Strain: ATCC 64665 / S288c / DC5.
  2. "DNA sequence analysis of a 23,002 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII."
    Arroyo J., Garcia-Gonzalez M., Garcia-Saez M.I., Sanchez-Perez M., Nombela C.
    Yeast 13:357-363(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment."
    Hunte C., Koepke J., Lange C., Rossmanith T., Michel H.
    Structure 8:669-684(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
  7. "Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c."
    Lange C., Hunte C.
    Proc. Natl. Acad. Sci. U.S.A. 99:2800-2805(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.97 ANGSTROMS).

Entry informationi

Entry nameiQCR9_YEAST
AccessioniPrimary (citable) accession number: P22289
Secondary accession number(s): D6VUW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4550 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3