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Protein

Cystatin-related protein 2

Gene

Crp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-related protein 2
Alternative name(s):
Prostatic 22 kDa glycoprotein P22K15
Gene namesi
Name:Crp2
Synonyms:P22k15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727814. P22k15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000000667327 – 30Sequence analysis4
ChainiPRO_000000667431 – 176Cystatin-related protein 2Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi129 ↔ 139By similarity
Disulfide bondi153 ↔ 173By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP22283.

Expressioni

Tissue specificityi

Prostate.

Inductioni

By androgens.

Family & Domainsi

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000033690.
HOVERGENiHBG000007.
InParanoidiP22283.
PhylomeDBiP22283.
TreeFamiTF340321.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiView protein in InterPro
IPR027214. Cystatin.
IPR000010. Cystatin_dom.
PANTHERiPTHR11413. PTHR11413. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKTLCGTQL LLAIFVLFLN FSHATAKGTR GPMEIFKKNF MEKNKLNDVY
60 70 80 90 100
DIFKFLYNKF SHDTYLSNIK NQSFTMNTWG FGEIEVVKTK CRKIDSDFYK
110 120 130 140 150
CSFQWEFCNI KRTPGVTIYY ITLPGSVRCR KLLSKLVNCP FEEQTEQLKR
160 170
EICYFQLYPD YIEQNIRSVR FNCYTK
Length:176
Mass (Da):21,013
Last modified:August 1, 1991 - v1
Checksum:i1B8F4FAEBA06B461
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149 – 176KREIC…NCYTK → IERNMLLSTVS in CAA78385 (PubMed:8462870).CuratedAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58169 mRNA. Translation: AAA63499.1.
Z13994 Genomic DNA. Translation: CAA78385.1.
BC100632 mRNA. Translation: AAI00633.1.
PIRiJT0616.
RefSeqiNP_954887.1. NM_199266.2.
UniGeneiRn.43503.

Genome annotation databases

GeneIDi296229.
KEGGirno:296229.
UCSCiRGD:727814. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58169 mRNA. Translation: AAA63499.1.
Z13994 Genomic DNA. Translation: CAA78385.1.
BC100632 mRNA. Translation: AAI00633.1.
PIRiJT0616.
RefSeqiNP_954887.1. NM_199266.2.
UniGeneiRn.43503.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP22283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi296229.
KEGGirno:296229.
UCSCiRGD:727814. rat.

Organism-specific databases

CTDi296229.
RGDi727814. P22k15.

Phylogenomic databases

HOGENOMiHOG000033690.
HOVERGENiHBG000007.
InParanoidiP22283.
PhylomeDBiP22283.
TreeFamiTF340321.

Miscellaneous databases

PROiPR:P22283.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiView protein in InterPro
IPR027214. Cystatin.
IPR000010. Cystatin_dom.
PANTHERiPTHR11413. PTHR11413. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei22P2_RAT
AccessioniPrimary (citable) accession number: P22283
Secondary accession number(s): Q497B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 10, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.