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Reviewed, UniProtKB/Swiss-Prot P22281 (ALDHX_YEAST)

Last modified June 16, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Aldehyde dehydrogenase 1, mitochondrial
    EC=1.2.1.3
Gene names
Name: ALD1
Synonyms: ALDH, ALDH1
OrganismSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length533 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = an acid + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Subunit structure

Homotetramer.

Subcellular location

Mitochondrion matrix.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Caution

Is not present in yeast genome.

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Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2121Mitochondrion
Chain22 – 533512Aldehyde dehydrogenase 1, mitochondrial
PRO_0000007163

Regions

Nucleotide binding266 – 2716NAD By similarity

Sites

Active site2891 By similarity
Active site3231 By similarity

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Sequences

Sequence LengthMass (Da)Tools
P22281-1 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: B5718E2328A21A0B

FASTA53359,507
        10         20         30         40         50         60 
MLATRNLVPI IRASIKWRIK LSALHYCMSD AETSEALLED NSAYINNEKH NLFLEKIFSD 

        70         80         90        100        110        120 
YQPFKHDNRT QVSCSQHMRD YRPLLTLSSA TRSVLFSLLA SDMSIILSIS PNTGILLCIG 

       130        140        150        160        170        180 
HLLASDIEDV VIVLSRGSPL VDLASTRIFK LAQNGTLRFA IKRTTFQELR FLRKSKDENV 

       190        200        210        220        230        240 
MEAATRGIIT IRQLYYENKV LPLRFTGNVA THIEENLEFE EQITWRTHVD SSIFPNTRCA 

       250        260        270        280        290        300 
YPSGYGPSAK IPCLSHKPND ILAYTGSTLV GRVVSKLAPE QVMKKVTLES GGKSTMAVFI 

       310        320        330        340        350        360 
QHDVTWAVEN TQFGVFDRQG QCCIAQSGYT VHRSTLSQIV ENNLEKDPSY VLHVDTESDI 

       370        380        390        400        410        420 
RGPFILKIHF ESIPRRINSA KAENSKVLCG GPRENSVYLY PTLSATLTDE CRIMKEEVFA 

       430        440        450        460        470        480 
PIITILCVKT VDEAIQRGNN SKFGLAAYVT KENVHGIILS TALKTVKLFI ICVHLASYQI 

       490        500        510        520        530 
PFGGNKNSGM GAELGKRALE NYTEGNHVLP VSLVKETLAP NTETASPARW PIH

« Hide

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References

[1]"Molecular cloning of the mitochondrial aldehyde dehydrogenase gene of Saccharomyces cerevisiae by genetic complementation."
Saigal D., Cunningham S.J., Farres J., Weiner H.
J. Bacteriol. 173:3199-3208(1991) [PubMed: 2022618] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

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Cross-references

Sequence databases

M57887 Genomic DNA. Translation: AAA34419.1.
PIRA39410.

3D structure databases

HSSPHSSP built from PDB template 1BXS based on UniProtKB P51977.
ModBaseSearch...

Organism-specific databases

SGDS000029651. ALD1.

Enzyme and pathway databases

BRENDA1.2.1.3. 250.

Family and domain databases

InterProIPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameALDHX_YEAST
AccessionPrimary (citable) accession number: P22281
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents