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Protein

Aldehyde dehydrogenase 1, mitochondrial

Gene

ALD1

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase 1, mitochondrial (ALD1), Aldehyde dehydrogenase 2, mitochondrial (ALD2)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei289 – 2891By similarity
Active sitei323 – 3231By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi266 – 2716NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase 1, mitochondrial (EC:1.2.1.3)
Gene namesi
Name:ALD1
Synonyms:ALDH, ALDH1
OrganismiSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifieri4932 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Organism-specific databases

SGDiS000029651. ALD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionAdd
BLAST
Chaini22 – 533512Aldehyde dehydrogenase 1, mitochondrialPRO_0000007163Add
BLAST

Proteomic databases

PaxDbiP22281.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi4932.YKR096W.

Structurei

3D structure databases

ProteinModelPortaliP22281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG46869.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22281-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLATRNLVPI IRASIKWRIK LSALHYCMSD AETSEALLED NSAYINNEKH
60 70 80 90 100
NLFLEKIFSD YQPFKHDNRT QVSCSQHMRD YRPLLTLSSA TRSVLFSLLA
110 120 130 140 150
SDMSIILSIS PNTGILLCIG HLLASDIEDV VIVLSRGSPL VDLASTRIFK
160 170 180 190 200
LAQNGTLRFA IKRTTFQELR FLRKSKDENV MEAATRGIIT IRQLYYENKV
210 220 230 240 250
LPLRFTGNVA THIEENLEFE EQITWRTHVD SSIFPNTRCA YPSGYGPSAK
260 270 280 290 300
IPCLSHKPND ILAYTGSTLV GRVVSKLAPE QVMKKVTLES GGKSTMAVFI
310 320 330 340 350
QHDVTWAVEN TQFGVFDRQG QCCIAQSGYT VHRSTLSQIV ENNLEKDPSY
360 370 380 390 400
VLHVDTESDI RGPFILKIHF ESIPRRINSA KAENSKVLCG GPRENSVYLY
410 420 430 440 450
PTLSATLTDE CRIMKEEVFA PIITILCVKT VDEAIQRGNN SKFGLAAYVT
460 470 480 490 500
KENVHGIILS TALKTVKLFI ICVHLASYQI PFGGNKNSGM GAELGKRALE
510 520 530
NYTEGNHVLP VSLVKETLAP NTETASPARW PIH
Length:533
Mass (Da):59,507
Last modified:August 1, 1991 - v1
Checksum:iB5718E2328A21A0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57887 Genomic DNA. Translation: AAA34419.1.
PIRiA39410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57887 Genomic DNA. Translation: AAA34419.1.
PIRiA39410.

3D structure databases

ProteinModelPortaliP22281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4932.YKR096W.

Chemistry

BindingDBiP22281.
ChEMBLiCHEMBL5923.

Proteomic databases

PaxDbiP22281.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

SGDiS000029651. ALD1.

Phylogenomic databases

eggNOGiNOG46869.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of the mitochondrial aldehyde dehydrogenase gene of Saccharomyces cerevisiae by genetic complementation."
    Saigal D., Cunningham S.J., Farres J., Weiner H.
    J. Bacteriol. 173:3199-3208(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiALDHX_YEASX
AccessioniPrimary (citable) accession number: P22281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Is not present in yeast genome.Curated

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.