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P22281

- ALDHX_YEASX

UniProt

P22281 - ALDHX_YEASX

Protein

Aldehyde dehydrogenase 1, mitochondrial

Gene

ALD1

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei289 – 2891By similarity
    Active sitei323 – 3231By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi266 – 2716NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase 1, mitochondrial (EC:1.2.1.3)
    Gene namesi
    Name:ALD1
    Synonyms:ALDH, ALDH1
    OrganismiSaccharomyces cerevisiae (Baker's yeast)
    Taxonomic identifieri4932 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

    Organism-specific databases

    SGDiS000029651. ALD1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121MitochondrionAdd
    BLAST
    Chaini22 – 533512Aldehyde dehydrogenase 1, mitochondrialPRO_0000007163Add
    BLAST

    Proteomic databases

    PaxDbiP22281.

    Expressioni

    Gene expression databases

    GenevestigatoriP22281.

    Interactioni

    Subunit structurei

    Homotetramer.

    Structurei

    3D structure databases

    ProteinModelPortaliP22281.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG46869.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view]
    PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22281-1 [UniParc]FASTAAdd to Basket

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    MLATRNLVPI IRASIKWRIK LSALHYCMSD AETSEALLED NSAYINNEKH    50
    NLFLEKIFSD YQPFKHDNRT QVSCSQHMRD YRPLLTLSSA TRSVLFSLLA 100
    SDMSIILSIS PNTGILLCIG HLLASDIEDV VIVLSRGSPL VDLASTRIFK 150
    LAQNGTLRFA IKRTTFQELR FLRKSKDENV MEAATRGIIT IRQLYYENKV 200
    LPLRFTGNVA THIEENLEFE EQITWRTHVD SSIFPNTRCA YPSGYGPSAK 250
    IPCLSHKPND ILAYTGSTLV GRVVSKLAPE QVMKKVTLES GGKSTMAVFI 300
    QHDVTWAVEN TQFGVFDRQG QCCIAQSGYT VHRSTLSQIV ENNLEKDPSY 350
    VLHVDTESDI RGPFILKIHF ESIPRRINSA KAENSKVLCG GPRENSVYLY 400
    PTLSATLTDE CRIMKEEVFA PIITILCVKT VDEAIQRGNN SKFGLAAYVT 450
    KENVHGIILS TALKTVKLFI ICVHLASYQI PFGGNKNSGM GAELGKRALE 500
    NYTEGNHVLP VSLVKETLAP NTETASPARW PIH 533
    Length:533
    Mass (Da):59,507
    Last modified:August 1, 1991 - v1
    Checksum:iB5718E2328A21A0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57887 Genomic DNA. Translation: AAA34419.1.
    PIRiA39410.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57887 Genomic DNA. Translation: AAA34419.1 .
    PIRi A39410.

    3D structure databases

    ProteinModelPortali P22281.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P22281.
    ChEMBLi CHEMBL5923.

    Proteomic databases

    PaxDbi P22281.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    SGDi S000029651. ALD1.

    Phylogenomic databases

    eggNOGi NOG46869.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Gene expression databases

    Genevestigatori P22281.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view ]
    PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the mitochondrial aldehyde dehydrogenase gene of Saccharomyces cerevisiae by genetic complementation."
      Saigal D., Cunningham S.J., Farres J., Weiner H.
      J. Bacteriol. 173:3199-3208(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiALDHX_YEASX
    AccessioniPrimary (citable) accession number: P22281
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    Is not present in yeast genome.Curated

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3