P22274 (ARF_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADP-ribosylation factor

Gene names

Name:	ARF1
ORF Names:	CaO19.6447, CaO19.13805

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Subcellular location	Golgi apparatus.
Sequence similarities	Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Golgi apparatus
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Myristate
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 179	178	ADP-ribosylation factor		PRO_0000207412
Regions
	Nucleotide binding	24 – 31	8	GTP By similarity
	Nucleotide binding	67 – 71	5	GTP By similarity
	Nucleotide binding	126 – 129	4	GTP By similarity
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine By similarity
Experimental info
	Sequence conflict	149	1	M → R in AAB23053. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P22274 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 3021949760974CF3	FASTA	179	20,233
	10 20 30 40 50 60 MGLTISKLFA SLLGRREMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 70 80 90 100 110 120 ISFTVWDVGG QDKIRPLWRY YFQNTQGIIF VVDSNDRDRI NEAREELQSM LNEDELKDAV 130 140 150 160 170 LLVLANKQDL PNAMNAAEIT EKMGLHSIMN RPWFIQATCA TTGDGLYEGL EWLSNQVGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the gene encoding the ADP-ribosylation factor in Candida albicans." Denich K., Malloy P.J., Feldman D. Gene 110:123-128(1992) [PubMed: 1544569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I." Langner C.A., Lodge J.K., Travis S.J., Caldwell J.E., Lu T., Li Q., Bryant M.L., Devadas B., Gokel G.W., Kobayashi G.S. J. Biol. Chem. 267:17159-17169(1992) [PubMed: 1512254] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M54910 Genomic DNA. Translation: AAA64266.1. S43354 Genomic DNA. Translation: AAB23053.2. AACQ01000073 Genomic DNA. Translation: EAK97201.1. AACQ01000072 Genomic DNA. Translation: EAK97288.1.
PIR	JH0260.
RefSeq	XP_716201.1. XM_711108.1. XP_716284.1. XM_711191.1.
3D structure databases
ProteinModelPortal	P22274.
SMR	P22274. Positions 2-177.
ModBase	Search...
Protein-protein interaction databases
STRING	P22274.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3642130. 3642182.
KEGG	cal:CaO19.13805. cal:CaO19.6447.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR024156. Small_GTPase_ARF. IPR006689. Small_GTPase_ARF/SAR. [Graphical view]
KO	K07977.
PANTHER	PTHR11711. ARF/SAR. 1 hit.
Pfam	PF00025. Arf. 1 hit. [Graphical view]
PRINTS	PR00328. SAR1GTPBP.
SMART	SM00177. ARF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. Small_GTP. 1 hit.
PROSITE	PS51417. ARF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARF_CANAL

Accession

Primary (citable) accession number: P22274
Secondary accession number(s): Q5A316

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 80 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program