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Protein

Interleukin-6 receptor subunit alpha

Gene

Il6r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

GO - Molecular functioni

  • interleukin-6 receptor activity Source: RGD

GO - Biological processi

  • cell growth Source: RGD
  • developmental growth Source: RGD
  • interleukin-6-mediated signaling pathway Source: GOC
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of JAK-STAT cascade Source: RGD
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: RGD
  • response to cAMP Source: RGD
  • response to ethanol Source: RGD
  • response to gamma radiation Source: RGD
  • response to glucocorticoid Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6 receptor subunit alpha
Short name:
IL-6 receptor subunit alpha
Short name:
IL-6R subunit alpha
Short name:
IL-6R-alpha
Short name:
IL-6RA
Alternative name(s):
IL-6R 1
CD_antigen: CD126
Gene namesi
Name:Il6r
Synonyms:Il6ra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2902. Il6r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 364345ExtracellularSequence analysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence analysisAdd
BLAST
Topological domaini386 – 46277CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular space Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4289.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 462443Interleukin-6 receptor subunit alphaPRO_0000010898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 190PROSITE-ProRule annotation
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence analysis
Disulfide bondi47 ↔ 92PROSITE-ProRule annotation
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence analysis
Disulfide bondi117 ↔ 128PROSITE-ProRule annotation
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence analysis
Disulfide bondi162 ↔ 173PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22273.
PRIDEiP22273.

Interactioni

Subunit structurei

Hexamer of two molecules each of IL6, IL6R and IL6ST.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028234.

Structurei

3D structure databases

ProteinModelPortaliP22273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 10889Ig-like C2-typeAdd
BLAST
Domaini215 – 31399Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi300 – 3045WSXWS motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi404 – 4085Poly-Pro

Domaini

The two fibronectin type-III-like domains contained in the C-terminal part form together a cytokine-binding domain.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5K. Eukaryota.
ENOG4111XGC. LUCA.
HOGENOMiHOG000036902.
HOVERGENiHBG052118.
InParanoidiP22273.
PhylomeDBiP22273.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK
60 70 80 90 100
EAAGNATIHW VYSGSQSREW TTTGNTLVLR AVQVNDTGHY LCFLDDHLVG
110 120 130 140 150
TVPLLVDVPP EEPKLSCFRK NPLVNAFCEW HPSSTPSPTT KAVMFAKKIN
160 170 180 190 200
TTNGKSDFQV PCQYSQQLKS FSCEVEILEG DKVYHIVSLC VANSVGSRSS
210 220 230 240 250
HNVVFQSLKM VQPDPPANLV VSAIPGXPRW LKVSWQDPES WDPSYYLLQF
260 270 280 290 300
ELRYRPVWSK XFTVWPLQVA QHQCVIHDAL RGVKHVVQVR GKEEFDIGQW
310 320 330 340 350
SKWSPEVTGT PWLAEPRTTP AGIPGNPTQV SVEDYDNHED QYGSSTEATS
360 370 380 390 400
VLAPVQGSSP IPLPTFLVAG GSLAFGLLLC VFIILRLKKK WKSQAEKESK
410 420 430 440 450
TTSPPPYPLG PLKPTFLLVP LLTPSGSHNS SGTDNTGSHS CLGVRDPQCP
460
NDNSNRDYLF PR
Length:462
Mass (Da):50,401
Last modified:February 1, 1995 - v2
Checksum:iA4D6064CEDC0537D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 26135XPRWL…VWSKX → SLVGSKSVGKTLSPGTQVTT CCNSSFDTDLYGQRT in AAA41431 (PubMed:2174054).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58587 mRNA. Translation: AAA41431.1.
PIRiA37986.
UniGeneiRn.1716.

Genome annotation databases

UCSCiRGD:2902. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58587 mRNA. Translation: AAA41431.1.
PIRiA37986.
UniGeneiRn.1716.

3D structure databases

ProteinModelPortaliP22273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028234.

Chemistry

ChEMBLiCHEMBL4289.

Proteomic databases

PaxDbiP22273.
PRIDEiP22273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2902. rat.

Organism-specific databases

RGDi2902. Il6r.

Phylogenomic databases

eggNOGiENOG410II5K. Eukaryota.
ENOG4111XGC. LUCA.
HOGENOMiHOG000036902.
HOVERGENiHBG052118.
InParanoidiP22273.
PhylomeDBiP22273.

Miscellaneous databases

PROiP22273.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, characterization and functional expression of the rat liver interleukin 6 receptor."
    Baumann M., Baumann H., Fey G.H.
    J. Biol. Chem. 265:19853-19862(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer 344.
    Tissue: Liver.
  2. Gibson T.
    Unpublished observations (FEB-1995)
    Cited for: IDENTIFICATION OF PROBABLE FRAMESHIFT IN 227-261.

Entry informationi

Entry nameiIL6RA_RAT
AccessioniPrimary (citable) accession number: P22273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: February 1, 1995
Last modified: May 11, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.