Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-6 receptor subunit alpha

Gene

Il6r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

GO - Molecular functioni

GO - Biological processi

  • cell growth Source: RGD
  • ciliary neurotrophic factor-mediated signaling pathway Source: RGD
  • cytokine-mediated signaling pathway Source: RGD
  • developmental growth Source: RGD
  • endocrine pancreas development Source: RGD
  • interleukin-6-mediated signaling pathway Source: RGD
  • negative regulation of collagen biosynthetic process Source: RGD
  • positive regulation of activation of Janus kinase activity Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of chemokine production Source: RGD
  • positive regulation of interleukin-6 production Source: RGD
  • positive regulation of JAK-STAT cascade Source: RGD
  • positive regulation of MAPK cascade Source: RGD
  • positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
  • response to cAMP Source: RGD
  • response to cytokine Source: RGD
  • response to ethanol Source: RGD
  • response to gamma radiation Source: RGD
  • response to glucocorticoid Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to peptide hormone Source: RGD

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6 receptor subunit alpha
Short name:
IL-6 receptor subunit alpha
Short name:
IL-6R subunit alpha
Short name:
IL-6R-alpha
Short name:
IL-6RA
Alternative name(s):
IL-6R 1
CD_antigen: CD126
Gene namesi
Name:Il6r
Synonyms:Il6ra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2902. Il6r.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 364ExtracellularSequence analysisAdd BLAST345
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 462CytoplasmicSequence analysisAdd BLAST77

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4289.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001089820 – 462Interleukin-6 receptor subunit alphaAdd BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 190PROSITE-ProRule annotation
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi47 ↔ 92PROSITE-ProRule annotation
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 128PROSITE-ProRule annotation
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 173PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22273.
PRIDEiP22273.

Interactioni

Subunit structurei

Hexamer of two molecules each of IL6, IL6R and IL6ST.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028234.

Chemistry databases

BindingDBiP22273.

Structurei

3D structure databases

ProteinModelPortaliP22273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 108Ig-like C2-typeAdd BLAST89
Domaini215 – 313Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST99

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi300 – 304WSXWS motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi404 – 408Poly-Pro5

Domaini

The two fibronectin type-III-like domains contained in the C-terminal part form together a cytokine-binding domain.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5K. Eukaryota.
ENOG4111XGC. LUCA.
HOGENOMiHOG000036902.
HOVERGENiHBG052118.
InParanoidiP22273.
PhylomeDBiP22273.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR015321. TypeI_recpt_CBD.
PfamiView protein in Pfam
PF00047. ig. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiView protein in PROSITE
PS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK
60 70 80 90 100
EAAGNATIHW VYSGSQSREW TTTGNTLVLR AVQVNDTGHY LCFLDDHLVG
110 120 130 140 150
TVPLLVDVPP EEPKLSCFRK NPLVNAFCEW HPSSTPSPTT KAVMFAKKIN
160 170 180 190 200
TTNGKSDFQV PCQYSQQLKS FSCEVEILEG DKVYHIVSLC VANSVGSRSS
210 220 230 240 250
HNVVFQSLKM VQPDPPANLV VSAIPGXPRW LKVSWQDPES WDPSYYLLQF
260 270 280 290 300
ELRYRPVWSK XFTVWPLQVA QHQCVIHDAL RGVKHVVQVR GKEEFDIGQW
310 320 330 340 350
SKWSPEVTGT PWLAEPRTTP AGIPGNPTQV SVEDYDNHED QYGSSTEATS
360 370 380 390 400
VLAPVQGSSP IPLPTFLVAG GSLAFGLLLC VFIILRLKKK WKSQAEKESK
410 420 430 440 450
TTSPPPYPLG PLKPTFLLVP LLTPSGSHNS SGTDNTGSHS CLGVRDPQCP
460
NDNSNRDYLF PR
Length:462
Mass (Da):50,401
Last modified:February 1, 1995 - v2
Checksum:iA4D6064CEDC0537D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227 – 261XPRWL…VWSKX → SLVGSKSVGKTLSPGTQVTT CCNSSFDTDLYGQRT in AAA41431 (PubMed:2174054).CuratedAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58587 mRNA. Translation: AAA41431.1.
PIRiA37986.
UniGeneiRn.1716.

Genome annotation databases

UCSCiRGD:2902. rat.

Similar proteinsi

Entry informationi

Entry nameiIL6RA_RAT
AccessioniPrimary (citable) accession number: P22273
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families