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P22272

- IL6RA_MOUSE

UniProt

P22272 - IL6RA_MOUSE

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Protein
Interleukin-6 receptor subunit alpha
Gene
Il6ra, Il6r
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

GO - Molecular functioni

  1. ciliary neurotrophic factor receptor activity Source: Ensembl
  2. interleukin-6 binding Source: MGI
  3. interleukin-6 receptor activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. defense response to Gram-negative bacterium Source: Ensembl
  2. defense response to Gram-positive bacterium Source: Ensembl
  3. interleukin-6-mediated signaling pathway Source: MGI
  4. negative regulation of collagen biosynthetic process Source: Ensembl
  5. negative regulation of interleukin-8 production Source: Ensembl
  6. positive regulation of MAPK cascade Source: Ensembl
  7. positive regulation of activation of Janus kinase activity Source: Ensembl
  8. positive regulation of chemokine production Source: Ensembl
  9. positive regulation of interleukin-6 production Source: Ensembl
  10. positive regulation of smooth muscle cell proliferation Source: Ensembl
  11. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_199118. Interleukin-6 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6 receptor subunit alpha
Short name:
IL-6 receptor subunit alpha
Short name:
IL-6R subunit alpha
Short name:
IL-6R-alpha
Short name:
IL-6RA
Alternative name(s):
IL-6R 1
CD_antigen: CD126
Gene namesi
Name:Il6ra
Synonyms:Il6r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:105304. Il6ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 364345Extracellular Reviewed prediction
Add
BLAST
Transmembranei365 – 38521Helical; Reviewed prediction
Add
BLAST
Topological domaini386 – 46075Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cell surface Source: MGI
  3. extracellular space Source: Ensembl
  4. interleukin-6 receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919
Add
BLAST
Chaini20 – 460441Interleukin-6 receptor subunit alpha
PRO_0000010896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 190 By similarity
Glycosylationi32 – 321N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi47 ↔ 92 By similarity
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi117 ↔ 128 By similarity
Glycosylationi150 – 1501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi162 ↔ 173 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP22272.

PTM databases

PhosphoSiteiP22272.

Expressioni

Gene expression databases

BgeeiP22272.
CleanExiMM_IL6RA.
GenevestigatoriP22272.

Interactioni

Subunit structurei

Hexamer of two molecules each of IL6, IL6R and IL6ST By similarity.

Protein-protein interaction databases

IntActiP22272. 1 interaction.
MINTiMINT-1524697.
STRINGi10090.ENSMUSP00000029559.

Structurei

3D structure databases

ProteinModelPortaliP22272.
SMRiP22272. Positions 25-312.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11697Ig-like C2-type
Add
BLAST
Domaini109 – 214106Fibronectin type-III 1
Add
BLAST
Domaini215 – 31399Fibronectin type-III 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi300 – 3045WSXWS motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi404 – 4085Poly-Pro

Domaini

The two fibronectin type-III-like domains contained in the C-terminal part form together a cytokine-binding domain.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47227.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000036902.
HOVERGENiHBG052118.
InParanoidiP22272.
KOiK05055.
OMAiCQLAVPE.
OrthoDBiEOG71CFM2.
PhylomeDBiP22272.
TreeFamiTF331210.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. Fibronectin_type3.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015321. IL-6_rcpt_alpha-bd.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22272-1 [UniParc]FASTAAdd to Basket

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MLTVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK    50
EAAGNVTIHW VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG 100
TVPLLVDVPP EEPKLSCFRK NPLVNAICEW RPSSTPSPTT KAVLFAKKIN 150
TTNGKSDFQV PCQYSQQLKS FSCQVEILEG DKVYHIVSLC VANSVGSKSS 200
HNEAFHSLKM VQPDPPANLV VSAIPGRPRW LKVSWQHPET WDPSYYLLQF 250
QLRYRPVWSK EFTVLLLPVA QYQCVIHDAL RGVKHVVQVR GKEELDLGQW 300
SEWSPEVTGT PWIAEPRTTP AGILWNPTQV SVEDSANHED QYESSTEATS 350
VLAPVQESSS MSLPTFLVAG GSLAFGLLLC VFIILRLKQK WKSEAEKESK 400
TTSPPPPPYS LGPLKPTFLL VPLLTPHSSG SDNTVNHSCL GVRDAQSPYD 450
NSNRDYLFPR 460
Length:460
Mass (Da):50,455
Last modified:August 1, 1992 - v2
Checksum:iF85C5906D08525C4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti374 – 3741A → R in CAA37810. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51975 mRNA. Translation: CAA36237.1.
X53802 mRNA. Translation: CAA37810.1.
CCDSiCCDS38496.1.
PIRiJL0144.
JL0145.
RefSeqiNP_034689.2. NM_010559.2.
UniGeneiMm.2856.

Genome annotation databases

EnsembliENSMUST00000029559; ENSMUSP00000029559; ENSMUSG00000027947.
GeneIDi16194.
KEGGimmu:16194.
UCSCiuc008qaf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51975 mRNA. Translation: CAA36237.1 .
X53802 mRNA. Translation: CAA37810.1 .
CCDSi CCDS38496.1.
PIRi JL0144.
JL0145.
RefSeqi NP_034689.2. NM_010559.2.
UniGenei Mm.2856.

3D structure databases

ProteinModelPortali P22272.
SMRi P22272. Positions 25-312.
ModBasei Search...

Protein-protein interaction databases

IntActi P22272. 1 interaction.
MINTi MINT-1524697.
STRINGi 10090.ENSMUSP00000029559.

PTM databases

PhosphoSitei P22272.

Proteomic databases

PRIDEi P22272.

Protocols and materials databases

DNASUi 16194.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029559 ; ENSMUSP00000029559 ; ENSMUSG00000027947 .
GeneIDi 16194.
KEGGi mmu:16194.
UCSCi uc008qaf.1. mouse.

Organism-specific databases

CTDi 16194.
MGIi MGI:105304. Il6ra.

Phylogenomic databases

eggNOGi NOG47227.
GeneTreei ENSGT00530000063103.
HOGENOMi HOG000036902.
HOVERGENi HBG052118.
InParanoidi P22272.
KOi K05055.
OMAi CQLAVPE.
OrthoDBi EOG71CFM2.
PhylomeDBi P22272.
TreeFami TF331210.

Enzyme and pathway databases

Reactomei REACT_199118. Interleukin-6 signaling.

Miscellaneous databases

NextBioi 289113.
PROi P22272.
SOURCEi Search...

Gene expression databases

Bgeei P22272.
CleanExi MM_IL6RA.
Genevestigatori P22272.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR003961. Fibronectin_type3.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015321. IL-6_rcpt_alpha-bd.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF00047. ig. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis."
    Sugita T., Totsuka T., Saito M., Yamasaki K., Taga T., Hirano T., Kishimoto T.
    J. Exp. Med. 171:2001-2009(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Spleen.
  2. Fiorillo M.T., Ciliberto G., Dente L.
    Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H.
    Tissue: Liver.

Entry informationi

Entry nameiIL6RA_MOUSE
AccessioniPrimary (citable) accession number: P22272
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1992
Last modified: September 3, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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