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Protein

Interleukin-6 receptor subunit alpha

Gene

Il6ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-1059683 Interleukin-6 signaling
R-MMU-110056 MAPK3 (ERK1) activation
R-MMU-112411 MAPK1 (ERK2) activation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6 receptor subunit alpha
Short name:
IL-6 receptor subunit alpha
Short name:
IL-6R subunit alpha
Short name:
IL-6R-alpha
Short name:
IL-6RA
Alternative name(s):
IL-6R 1
CD_antigen: CD126
Gene namesi
Name:Il6ra
Synonyms:Il6r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:105304 Il6ra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 364ExtracellularSequence analysisAdd BLAST345
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 460CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001089620 – 460Interleukin-6 receptor subunit alphaAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 190PROSITE-ProRule annotation
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi47 ↔ 92PROSITE-ProRule annotation
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 128PROSITE-ProRule annotation
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 173PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP22272
PaxDbiP22272
PRIDEiP22272

PTM databases

PhosphoSitePlusiP22272

Expressioni

Gene expression databases

BgeeiENSMUSG00000027947
CleanExiMM_IL6RA
ExpressionAtlasiP22272 baseline and differential
GenevisibleiP22272 MM

Interactioni

Subunit structurei

Hexamer of two molecules each of IL6, IL6R and IL6ST.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP22272, 1 interactor
STRINGi10090.ENSMUSP00000029559

Structurei

3D structure databases

ProteinModelPortaliP22272
SMRiP22272
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 116Ig-like C2-typeAdd BLAST97
Domaini109 – 214Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST106
Domaini215 – 313Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi300 – 304WSXWS motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi404 – 408Poly-Pro5

Domaini

The two fibronectin type-III-like domains contained in the C-terminal part form together a cytokine-binding domain.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5K Eukaryota
ENOG4111XGC LUCA
GeneTreeiENSGT00530000063103
HOGENOMiHOG000036902
HOVERGENiHBG052118
InParanoidiP22272
KOiK05055
OMAiSNRDYFF
OrthoDBiEOG091G07XD
PhylomeDBiP22272
TreeFamiTF331210

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF09240 IL6Ra-bind, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01354 HEMATOPO_REC_L_F3, 1 hit
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22272-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK
60 70 80 90 100
EAAGNVTIHW VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG
110 120 130 140 150
TVPLLVDVPP EEPKLSCFRK NPLVNAICEW RPSSTPSPTT KAVLFAKKIN
160 170 180 190 200
TTNGKSDFQV PCQYSQQLKS FSCQVEILEG DKVYHIVSLC VANSVGSKSS
210 220 230 240 250
HNEAFHSLKM VQPDPPANLV VSAIPGRPRW LKVSWQHPET WDPSYYLLQF
260 270 280 290 300
QLRYRPVWSK EFTVLLLPVA QYQCVIHDAL RGVKHVVQVR GKEELDLGQW
310 320 330 340 350
SEWSPEVTGT PWIAEPRTTP AGILWNPTQV SVEDSANHED QYESSTEATS
360 370 380 390 400
VLAPVQESSS MSLPTFLVAG GSLAFGLLLC VFIILRLKQK WKSEAEKESK
410 420 430 440 450
TTSPPPPPYS LGPLKPTFLL VPLLTPHSSG SDNTVNHSCL GVRDAQSPYD
460
NSNRDYLFPR
Length:460
Mass (Da):50,455
Last modified:August 1, 1992 - v2
Checksum:iF85C5906D08525C4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti374A → R in CAA37810 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51975 mRNA Translation: CAA36237.1
X53802 mRNA Translation: CAA37810.1
CCDSiCCDS38496.1
PIRiJL0144
JL0145
RefSeqiNP_034689.2, NM_010559.3
UniGeneiMm.2856

Genome annotation databases

EnsembliENSMUST00000029559; ENSMUSP00000029559; ENSMUSG00000027947
GeneIDi16194
KEGGimmu:16194
UCSCiuc008qaf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIL6RA_MOUSE
AccessioniPrimary (citable) accession number: P22272
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1992
Last modified: June 20, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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