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P22272

- IL6RA_MOUSE

UniProt

P22272 - IL6RA_MOUSE

Protein

Interleukin-6 receptor subunit alpha

Gene

Il6ra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

    GO - Molecular functioni

    1. ciliary neurotrophic factor receptor activity Source: Ensembl
    2. interleukin-6 binding Source: MGI
    3. interleukin-6 receptor activity Source: MGI

    GO - Biological processi

    1. defense response to Gram-negative bacterium Source: Ensembl
    2. defense response to Gram-positive bacterium Source: Ensembl
    3. interleukin-6-mediated signaling pathway Source: MGI
    4. negative regulation of collagen biosynthetic process Source: Ensembl
    5. negative regulation of interleukin-8 production Source: Ensembl
    6. positive regulation of activation of Janus kinase activity Source: Ensembl
    7. positive regulation of chemokine production Source: Ensembl
    8. positive regulation of interleukin-6 production Source: Ensembl
    9. positive regulation of MAPK cascade Source: Ensembl
    10. positive regulation of smooth muscle cell proliferation Source: Ensembl
    11. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_199118. Interleukin-6 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-6 receptor subunit alpha
    Short name:
    IL-6 receptor subunit alpha
    Short name:
    IL-6R subunit alpha
    Short name:
    IL-6R-alpha
    Short name:
    IL-6RA
    Alternative name(s):
    IL-6R 1
    CD_antigen: CD126
    Gene namesi
    Name:Il6ra
    Synonyms:Il6r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:105304. Il6ra.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cell surface Source: MGI
    3. extracellular space Source: Ensembl
    4. interleukin-6 receptor complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 460441Interleukin-6 receptor subunit alphaPRO_0000010896Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 190PROSITE-ProRule annotation
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi47 ↔ 92PROSITE-ProRule annotation
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 128PROSITE-ProRule annotation
    Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi162 ↔ 173PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP22272.

    PTM databases

    PhosphoSiteiP22272.

    Expressioni

    Gene expression databases

    BgeeiP22272.
    CleanExiMM_IL6RA.
    GenevestigatoriP22272.

    Interactioni

    Subunit structurei

    Hexamer of two molecules each of IL6, IL6R and IL6ST.By similarity

    Protein-protein interaction databases

    IntActiP22272. 1 interaction.
    MINTiMINT-1524697.
    STRINGi10090.ENSMUSP00000029559.

    Structurei

    3D structure databases

    ProteinModelPortaliP22272.
    SMRiP22272. Positions 25-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 364345ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini386 – 46075CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei365 – 38521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 11697Ig-like C2-typeAdd
    BLAST
    Domaini109 – 214106Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini215 – 31399Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi300 – 3045WSXWS motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi404 – 4085Poly-Pro

    Domaini

    The two fibronectin type-III-like domains contained in the C-terminal part form together a cytokine-binding domain.
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

    Sequence similaritiesi

    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47227.
    GeneTreeiENSGT00530000063103.
    HOGENOMiHOG000036902.
    HOVERGENiHBG052118.
    InParanoidiP22272.
    KOiK05055.
    OMAiCQLAVPE.
    OrthoDBiEOG71CFM2.
    PhylomeDBiP22272.
    TreeFamiTF331210.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR003530. Hematopoietin_rcpt_L_F3_CS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR015321. IL-6_rcpt_alpha-bd.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF00047. ig. 1 hit.
    PF09240. IL6Ra-bind. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 1 hit.
    PS01354. HEMATOPO_REC_L_F3. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22272-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK    50
    EAAGNVTIHW VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG 100
    TVPLLVDVPP EEPKLSCFRK NPLVNAICEW RPSSTPSPTT KAVLFAKKIN 150
    TTNGKSDFQV PCQYSQQLKS FSCQVEILEG DKVYHIVSLC VANSVGSKSS 200
    HNEAFHSLKM VQPDPPANLV VSAIPGRPRW LKVSWQHPET WDPSYYLLQF 250
    QLRYRPVWSK EFTVLLLPVA QYQCVIHDAL RGVKHVVQVR GKEELDLGQW 300
    SEWSPEVTGT PWIAEPRTTP AGILWNPTQV SVEDSANHED QYESSTEATS 350
    VLAPVQESSS MSLPTFLVAG GSLAFGLLLC VFIILRLKQK WKSEAEKESK 400
    TTSPPPPPYS LGPLKPTFLL VPLLTPHSSG SDNTVNHSCL GVRDAQSPYD 450
    NSNRDYLFPR 460
    Length:460
    Mass (Da):50,455
    Last modified:August 1, 1992 - v2
    Checksum:iF85C5906D08525C4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti374 – 3741A → R in CAA37810. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51975 mRNA. Translation: CAA36237.1.
    X53802 mRNA. Translation: CAA37810.1.
    CCDSiCCDS38496.1.
    PIRiJL0144.
    JL0145.
    RefSeqiNP_034689.2. NM_010559.2.
    UniGeneiMm.2856.

    Genome annotation databases

    EnsembliENSMUST00000029559; ENSMUSP00000029559; ENSMUSG00000027947.
    GeneIDi16194.
    KEGGimmu:16194.
    UCSCiuc008qaf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51975 mRNA. Translation: CAA36237.1 .
    X53802 mRNA. Translation: CAA37810.1 .
    CCDSi CCDS38496.1.
    PIRi JL0144.
    JL0145.
    RefSeqi NP_034689.2. NM_010559.2.
    UniGenei Mm.2856.

    3D structure databases

    ProteinModelPortali P22272.
    SMRi P22272. Positions 25-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P22272. 1 interaction.
    MINTi MINT-1524697.
    STRINGi 10090.ENSMUSP00000029559.

    PTM databases

    PhosphoSitei P22272.

    Proteomic databases

    PRIDEi P22272.

    Protocols and materials databases

    DNASUi 16194.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029559 ; ENSMUSP00000029559 ; ENSMUSG00000027947 .
    GeneIDi 16194.
    KEGGi mmu:16194.
    UCSCi uc008qaf.1. mouse.

    Organism-specific databases

    CTDi 16194.
    MGIi MGI:105304. Il6ra.

    Phylogenomic databases

    eggNOGi NOG47227.
    GeneTreei ENSGT00530000063103.
    HOGENOMi HOG000036902.
    HOVERGENi HBG052118.
    InParanoidi P22272.
    KOi K05055.
    OMAi CQLAVPE.
    OrthoDBi EOG71CFM2.
    PhylomeDBi P22272.
    TreeFami TF331210.

    Enzyme and pathway databases

    Reactomei REACT_199118. Interleukin-6 signaling.

    Miscellaneous databases

    NextBioi 289113.
    PROi P22272.
    SOURCEi Search...

    Gene expression databases

    Bgeei P22272.
    CleanExi MM_IL6RA.
    Genevestigatori P22272.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR003530. Hematopoietin_rcpt_L_F3_CS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR015321. IL-6_rcpt_alpha-bd.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF00047. ig. 1 hit.
    PF09240. IL6Ra-bind. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 1 hit.
    PS01354. HEMATOPO_REC_L_F3. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis."
      Sugita T., Totsuka T., Saito M., Yamasaki K., Taga T., Hirano T., Kishimoto T.
      J. Exp. Med. 171:2001-2009(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Spleen.
    2. Fiorillo M.T., Ciliberto G., Dente L.
      Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H.
      Tissue: Liver.

    Entry informationi

    Entry nameiIL6RA_MOUSE
    AccessioniPrimary (citable) accession number: P22272
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3