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P22272 (IL6RA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-6 receptor subunit alpha

Short name=IL-6 receptor subunit alpha
Short name=IL-6R subunit alpha
Short name=IL-6R-alpha
Short name=IL-6RA
Alternative name(s):
IL-6R 1
CD_antigen=CD126
Gene names
Name:Il6ra
Synonyms:Il6r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

Subunit structure

Hexamer of two molecules each of IL6, IL6R and IL6ST By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Domain

The two fibronectin type-III-like domains contained in the C-terminal part form together a cytokine-binding domain.

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 3 subfamily.

Contains 2 fibronectin type-III domains.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to Gram-negative bacterium

Inferred from electronic annotation. Source: Ensembl

defense response to Gram-positive bacterium

Inferred from electronic annotation. Source: Ensembl

interleukin-6-mediated signaling pathway

Inferred from direct assay PubMed 1312474. Source: MGI

negative regulation of collagen biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-8 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of activation of Janus kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of chemokine production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

cell surface

Inferred from direct assay PubMed 1312474. Source: MGI

extracellular space

Inferred from electronic annotation. Source: Ensembl

interleukin-6 receptor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionciliary neurotrophic factor receptor activity

Inferred from electronic annotation. Source: Ensembl

interleukin-6 binding

Inferred from direct assay PubMed 1312474. Source: MGI

interleukin-6 receptor activity

Inferred from direct assay PubMed 1312474. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 460441Interleukin-6 receptor subunit alpha
PRO_0000010896

Regions

Topological domain20 – 364345Extracellular Potential
Transmembrane365 – 38521Helical; Potential
Topological domain386 – 46075Cytoplasmic Potential
Domain20 – 11697Ig-like C2-type
Domain109 – 214106Fibronectin type-III 1
Domain215 – 31399Fibronectin type-III 2
Motif300 – 3045WSXWS motif
Compositional bias404 – 4085Poly-Pro

Amino acid modifications

Glycosylation321N-linked (GlcNAc...) Potential
Glycosylation551N-linked (GlcNAc...) Potential
Glycosylation1501N-linked (GlcNAc...) Potential
Disulfide bond25 ↔ 190 By similarity
Disulfide bond47 ↔ 92 By similarity
Disulfide bond117 ↔ 128 By similarity
Disulfide bond162 ↔ 173 By similarity

Experimental info

Sequence conflict3741A → R in CAA37810. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P22272 [UniParc].

Last modified August 1, 1992. Version 2.
Checksum: F85C5906D08525C4

FASTA46050,455
        10         20         30         40         50         60 
MLTVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK EAAGNVTIHW 

        70         80         90        100        110        120 
VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG TVPLLVDVPP EEPKLSCFRK 

       130        140        150        160        170        180 
NPLVNAICEW RPSSTPSPTT KAVLFAKKIN TTNGKSDFQV PCQYSQQLKS FSCQVEILEG 

       190        200        210        220        230        240 
DKVYHIVSLC VANSVGSKSS HNEAFHSLKM VQPDPPANLV VSAIPGRPRW LKVSWQHPET 

       250        260        270        280        290        300 
WDPSYYLLQF QLRYRPVWSK EFTVLLLPVA QYQCVIHDAL RGVKHVVQVR GKEELDLGQW 

       310        320        330        340        350        360 
SEWSPEVTGT PWIAEPRTTP AGILWNPTQV SVEDSANHED QYESSTEATS VLAPVQESSS 

       370        380        390        400        410        420 
MSLPTFLVAG GSLAFGLLLC VFIILRLKQK WKSEAEKESK TTSPPPPPYS LGPLKPTFLL 

       430        440        450        460 
VPLLTPHSSG SDNTVNHSCL GVRDAQSPYD NSNRDYLFPR 

« Hide

References

[1]"Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis."
Sugita T., Totsuka T., Saito M., Yamasaki K., Taga T., Hirano T., Kishimoto T.
J. Exp. Med. 171:2001-2009(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Spleen.
[2]Fiorillo M.T., Ciliberto G., Dente L.
Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C3H.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X51975 mRNA. Translation: CAA36237.1.
X53802 mRNA. Translation: CAA37810.1.
CCDSCCDS38496.1.
PIRJL0144.
JL0145.
RefSeqNP_034689.2. NM_010559.2.
UniGeneMm.2856.

3D structure databases

ProteinModelPortalP22272.
SMRP22272. Positions 25-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP22272. 1 interaction.
MINTMINT-1524697.
STRING10090.ENSMUSP00000029559.

PTM databases

PhosphoSiteP22272.

Proteomic databases

PRIDEP22272.

Protocols and materials databases

DNASU16194.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029559; ENSMUSP00000029559; ENSMUSG00000027947.
GeneID16194.
KEGGmmu:16194.
UCSCuc008qaf.1. mouse.

Organism-specific databases

CTD16194.
MGIMGI:105304. Il6ra.

Phylogenomic databases

eggNOGNOG47227.
GeneTreeENSGT00530000063103.
HOGENOMHOG000036902.
HOVERGENHBG052118.
InParanoidP22272.
KOK05055.
OMACQLAVPE.
OrthoDBEOG71CFM2.
PhylomeDBP22272.
TreeFamTF331210.

Gene expression databases

BgeeP22272.
CleanExMM_IL6RA.
GenevestigatorP22272.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR003961. Fibronectin_type3.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015321. IL-6_rcpt_alpha-bd.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF00047. ig. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289113.
PROP22272.
SOURCESearch...

Entry information

Entry nameIL6RA_MOUSE
AccessionPrimary (citable) accession number: P22272
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1992
Last modified: July 9, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot