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Protein

Interleukin-6 receptor subunit alpha

Gene

Il6ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

GO - Molecular functioni

  1. ciliary neurotrophic factor binding Source: MGI
  2. enzyme binding Source: MGI
  3. interleukin-6 binding Source: MGI
  4. interleukin-6 receptor activity Source: MGI
  5. protein homodimerization activity Source: MGI

GO - Biological processi

  1. ciliary neurotrophic factor-mediated signaling pathway Source: MGI
  2. cytokine-mediated signaling pathway Source: MGI
  3. endocrine pancreas development Source: MGI
  4. interleukin-6-mediated signaling pathway Source: MGI
  5. negative regulation of collagen biosynthetic process Source: MGI
  6. positive regulation of activation of Janus kinase activity Source: MGI
  7. positive regulation of cell proliferation Source: MGI
  8. positive regulation of chemokine production Source: MGI
  9. positive regulation of interleukin-6 production Source: MGI
  10. positive regulation of MAPK cascade Source: MGI
  11. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  12. positive regulation of smooth muscle cell proliferation Source: MGI
  13. positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
  14. response to cytokine Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_277805. ERK1 activation.
REACT_301070. Interleukin-6 signaling.
REACT_353300. ERK2 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6 receptor subunit alpha
Short name:
IL-6 receptor subunit alpha
Short name:
IL-6R subunit alpha
Short name:
IL-6R-alpha
Short name:
IL-6RA
Alternative name(s):
IL-6R 1
CD_antigen: CD126
Gene namesi
Name:Il6ra
Synonyms:Il6r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:105304. Il6ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 364345ExtracellularSequence AnalysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence AnalysisAdd
BLAST
Topological domaini386 – 46075CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. cell surface Source: MGI
  3. ciliary neurotrophic factor receptor complex Source: MGI
  4. extracellular region Source: MGI
  5. extracellular space Source: MGI
  6. interleukin-6 receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 460441Interleukin-6 receptor subunit alphaPRO_0000010896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 190PROSITE-ProRule annotation
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi47 ↔ 92PROSITE-ProRule annotation
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 128PROSITE-ProRule annotation
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi162 ↔ 173PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP22272.

PTM databases

PhosphoSiteiP22272.

Expressioni

Gene expression databases

BgeeiP22272.
CleanExiMM_IL6RA.
GenevestigatoriP22272.

Interactioni

Subunit structurei

Hexamer of two molecules each of IL6, IL6R and IL6ST.By similarity

Protein-protein interaction databases

IntActiP22272. 1 interaction.
MINTiMINT-1524697.
STRINGi10090.ENSMUSP00000029559.

Structurei

3D structure databases

ProteinModelPortaliP22272.
SMRiP22272. Positions 25-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11697Ig-like C2-typeAdd
BLAST
Domaini109 – 214106Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini215 – 31399Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi300 – 3045WSXWS motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi404 – 4085Poly-Pro

Domaini

The two fibronectin type-III-like domains contained in the C-terminal part form together a cytokine-binding domain.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47227.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000036902.
HOVERGENiHBG052118.
InParanoidiP22272.
KOiK05055.
OMAiCQLAVPE.
OrthoDBiEOG71CFM2.
PhylomeDBiP22272.
TreeFamiTF331210.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015321. IL-6_rcpt_alpha-bd.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22272-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK
60 70 80 90 100
EAAGNVTIHW VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG
110 120 130 140 150
TVPLLVDVPP EEPKLSCFRK NPLVNAICEW RPSSTPSPTT KAVLFAKKIN
160 170 180 190 200
TTNGKSDFQV PCQYSQQLKS FSCQVEILEG DKVYHIVSLC VANSVGSKSS
210 220 230 240 250
HNEAFHSLKM VQPDPPANLV VSAIPGRPRW LKVSWQHPET WDPSYYLLQF
260 270 280 290 300
QLRYRPVWSK EFTVLLLPVA QYQCVIHDAL RGVKHVVQVR GKEELDLGQW
310 320 330 340 350
SEWSPEVTGT PWIAEPRTTP AGILWNPTQV SVEDSANHED QYESSTEATS
360 370 380 390 400
VLAPVQESSS MSLPTFLVAG GSLAFGLLLC VFIILRLKQK WKSEAEKESK
410 420 430 440 450
TTSPPPPPYS LGPLKPTFLL VPLLTPHSSG SDNTVNHSCL GVRDAQSPYD
460
NSNRDYLFPR
Length:460
Mass (Da):50,455
Last modified:August 1, 1992 - v2
Checksum:iF85C5906D08525C4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti374 – 3741A → R in CAA37810 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51975 mRNA. Translation: CAA36237.1.
X53802 mRNA. Translation: CAA37810.1.
CCDSiCCDS38496.1.
PIRiJL0144.
JL0145.
RefSeqiNP_034689.2. NM_010559.2.
UniGeneiMm.2856.

Genome annotation databases

EnsembliENSMUST00000029559; ENSMUSP00000029559; ENSMUSG00000027947.
GeneIDi16194.
KEGGimmu:16194.
UCSCiuc008qaf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51975 mRNA. Translation: CAA36237.1.
X53802 mRNA. Translation: CAA37810.1.
CCDSiCCDS38496.1.
PIRiJL0144.
JL0145.
RefSeqiNP_034689.2. NM_010559.2.
UniGeneiMm.2856.

3D structure databases

ProteinModelPortaliP22272.
SMRiP22272. Positions 25-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP22272. 1 interaction.
MINTiMINT-1524697.
STRINGi10090.ENSMUSP00000029559.

PTM databases

PhosphoSiteiP22272.

Proteomic databases

PRIDEiP22272.

Protocols and materials databases

DNASUi16194.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029559; ENSMUSP00000029559; ENSMUSG00000027947.
GeneIDi16194.
KEGGimmu:16194.
UCSCiuc008qaf.1. mouse.

Organism-specific databases

CTDi16194.
MGIiMGI:105304. Il6ra.

Phylogenomic databases

eggNOGiNOG47227.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000036902.
HOVERGENiHBG052118.
InParanoidiP22272.
KOiK05055.
OMAiCQLAVPE.
OrthoDBiEOG71CFM2.
PhylomeDBiP22272.
TreeFamiTF331210.

Enzyme and pathway databases

ReactomeiREACT_277805. ERK1 activation.
REACT_301070. Interleukin-6 signaling.
REACT_353300. ERK2 activation.

Miscellaneous databases

NextBioi289113.
PROiP22272.
SOURCEiSearch...

Gene expression databases

BgeeiP22272.
CleanExiMM_IL6RA.
GenevestigatoriP22272.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015321. IL-6_rcpt_alpha-bd.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis."
    Sugita T., Totsuka T., Saito M., Yamasaki K., Taga T., Hirano T., Kishimoto T.
    J. Exp. Med. 171:2001-2009(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Spleen.
  2. Fiorillo M.T., Ciliberto G., Dente L.
    Submitted (JUN-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H.
    Tissue: Liver.

Entry informationi

Entry nameiIL6RA_MOUSE
AccessioniPrimary (citable) accession number: P22272
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1992
Last modified: April 1, 2015
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.