P22272 (IL6RA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-6 receptor subunit alpha
Short name=IL-6 receptor subunit alpha
Short name=IL-6R subunit alpha
Short name=IL-6R-alpha
Short name=IL-6RA

Alternative name(s):
IL-6R 1
CD_antigen=CD126

Gene names

Name:	Il6ra
Synonyms:	Il6r

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
Subunit structure	Hexamer of two molecules each of IL6, IL6R and IL6ST By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Domain	The two fibronectin type-III-like domains contained in the C-terminal part form together a cytokine-binding domain. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 3 subfamily. Contains 1 fibronectin type-III domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to Gram-negative bacterium Inferred from electronic annotation. Source: Compara defense response to Gram-positive bacterium Inferred from electronic annotation. Source: Compara negative regulation of collagen biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of interleukin-8 production Inferred from electronic annotation. Source: Compara positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of activation of Janus kinase activity Inferred from electronic annotation. Source: Compara positive regulation of chemokine production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of tyrosine phosphorylation of Stat3 protein Inferred from electronic annotation. Source: Compara
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara cell surface Inferred from direct assay PubMed 1312474. Source: MGI extracellular region Inferred from electronic annotation. Source: Compara interleukin-6 receptor complex Inferred from electronic annotation. Source: Compara
Molecular_function	ciliary neurotrophic factor receptor activity Inferred from electronic annotation. Source: Compara interleukin-6 binding Inferred from direct assay PubMed 1312474. Source: MGI interleukin-6 receptor activity Inferred from direct assay PubMed 1312474. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 460	441	Interleukin-6 receptor subunit alpha		PRO_0000010896
Regions
	Topological domain	20 – 364	345	Extracellular Potential
	Transmembrane	365 – 385	21	Helical; Potential
	Topological domain	386 – 460	75	Cytoplasmic Potential
	Domain	20 – 116	97	Ig-like C2-type
	Domain	213 – 308	96	Fibronectin type-III
	Motif	300 – 304	5	WSXWS motif
	Compositional bias	404 – 408	5	Poly-Pro
Amino acid modifications
	Glycosylation	32	1	N-linked (GlcNAc...) Potential
	Glycosylation	55	1	N-linked (GlcNAc...) Potential
	Glycosylation	150	1	N-linked (GlcNAc...) Potential
	Disulfide bond	25 ↔ 190		By similarity
	Disulfide bond	47 ↔ 92		By similarity
	Disulfide bond	117 ↔ 128		By similarity
	Disulfide bond	162 ↔ 173		By similarity
Experimental info
	Sequence conflict	374	1	A → R in CAA37810. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P22272 [UniParc]. Last modified August 1, 1992. Version 2. Checksum: F85C5906D08525C4	FASTA	460	50,455
	10 20 30 40 50 60 MLTVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK EAAGNVTIHW 70 80 90 100 110 120 VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG TVPLLVDVPP EEPKLSCFRK 130 140 150 160 170 180 NPLVNAICEW RPSSTPSPTT KAVLFAKKIN TTNGKSDFQV PCQYSQQLKS FSCQVEILEG 190 200 210 220 230 240 DKVYHIVSLC VANSVGSKSS HNEAFHSLKM VQPDPPANLV VSAIPGRPRW LKVSWQHPET 250 260 270 280 290 300 WDPSYYLLQF QLRYRPVWSK EFTVLLLPVA QYQCVIHDAL RGVKHVVQVR GKEELDLGQW 310 320 330 340 350 360 SEWSPEVTGT PWIAEPRTTP AGILWNPTQV SVEDSANHED QYESSTEATS VLAPVQESSS 370 380 390 400 410 420 MSLPTFLVAG GSLAFGLLLC VFIILRLKQK WKSEAEKESK TTSPPPPPYS LGPLKPTFLL 430 440 450 460 VPLLTPHSSG SDNTVNHSCL GVRDAQSPYD NSNRDYLFPR

References

[1]	"Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis." Sugita T., Totsuka T., Saito M., Yamasaki K., Taga T., Hirano T., Kishimoto T. J. Exp. Med. 171:2001-2009(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Spleen.
[2]	Fiorillo M.T., Ciliberto G., Dente L. Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C3H. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X51975 mRNA. Translation: CAA36237.1. X53802 mRNA. Translation: CAA37810.1.
IPI	IPI00126188.
PIR	JL0144. JL0145.
RefSeq	NP_034689.2. NM_010559.2.
UniGene	Mm.2856.
3D structure databases
ProteinModelPortal	P22272.
SMR	P22272. Positions 25-312.
ModBase	Search...
Protein-protein interaction databases
IntAct	P22272. 1 interaction.
STRING	10090.ENSMUSP00000029559.
PTM databases
PhosphoSite	P22272.
Proteomic databases
PRIDE	P22272.
Protocols and materials databases
DNASU	16194.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000029559; ENSMUSP00000029559; ENSMUSG00000027947.
GeneID	16194.
KEGG	mmu:16194.
UCSC	uc008qaf.1. mouse.
Organism-specific databases
CTD	16194.
MGI	MGI:105304. Il6ra.
Phylogenomic databases
eggNOG	NOG47227.
GeneTree	ENSGT00530000063103.
HOGENOM	HOG000036902.
HOVERGEN	HBG052118.
InParanoid	P22272.
KO	K05055.
OMA	CQLAVPE.
OrthoDB	EOG4TTGHS.
Gene expression databases
Bgee	P22272.
CleanEx	MM_IL6RA.
Genevestigator	P22272.
GermOnline	ENSMUSG00000027947. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR003961. Fibronectin_type3. IPR003530. Hematopoietin_rcpt_L_F3_CS. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. IPR015321. IL6_recept-bd. IPR013151. Immunoglobulin. [Graphical view]
Pfam	PF00047. ig. 1 hit. PF09240. IL6Ra-bind. 1 hit. [Graphical view]
SMART	SM00060. FN3. 1 hit. SM00408. IGc2. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits.
PROSITE	PS50853. FN3. 1 hit. PS01354. HEMATOPO_REC_L_F3. 1 hit. PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	289113.
SOURCE	Search...

Entry information

Entry name

IL6RA_MOUSE

Accession

Primary (citable) accession number: P22272

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1992
Last modified:	May 1, 2013
This is version 131 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program