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Protein

Esterase

Gene

estA

Organism
Streptomyces scabiei
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Esterase (EC:3.1.1.-)
Gene namesi
Name:estA
OrganismiStreptomyces scabiei
Taxonomic identifieri1930 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 391 PublicationAdd BLAST39
ChainiPRO_000002120840 – 345EsteraseAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi73 ↔ 103
Disulfide bondi156 ↔ 180
Disulfide bondi236 ↔ 294

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

By zinc.

Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi44 – 49Combined sources6
Helixi53 – 56Combined sources4
Turni57 – 59Combined sources3
Beta strandi61 – 63Combined sources3
Turni64 – 67Combined sources4
Helixi69 – 73Combined sources5
Helixi80 – 89Combined sources10
Turni90 – 92Combined sources3
Beta strandi94 – 100Combined sources7
Helixi108 – 111Combined sources4
Beta strandi115 – 117Combined sources3
Helixi118 – 120Combined sources3
Beta strandi122 – 124Combined sources3
Helixi127 – 130Combined sources4
Beta strandi137 – 140Combined sources4
Helixi144 – 147Combined sources4
Helixi149 – 155Combined sources7
Turni158 – 161Combined sources4
Beta strandi171 – 175Combined sources5
Helixi177 – 179Combined sources3
Helixi180 – 183Combined sources4
Turni184 – 186Combined sources3
Helixi188 – 214Combined sources27
Beta strandi219 – 223Combined sources5
Helixi233 – 237Combined sources5
Turni247 – 250Combined sources4
Turni253 – 255Combined sources3
Helixi256 – 275Combined sources20
Turni276 – 278Combined sources3
Beta strandi280 – 282Combined sources3
Helixi285 – 287Combined sources3
Beta strandi304 – 314Combined sources11
Beta strandi316 – 318Combined sources3
Helixi325 – 342Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ESCX-ray2.10A40-345[»]
1ESDX-ray2.30A40-345[»]
1ESEX-ray2.40A40-345[»]
ProteinModelPortaliP22266.
SMRiP22266.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22266.

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAMRKTTN SPVVRRLTAA AVALGSCLAL AGPAGSAGAA PADPVPTVFF
60 70 80 90 100
GDSYTANFGI APVTNQDSER GWCFQAKENY PAVATRSLAD KGITLDVQAD
110 120 130 140 150
VSCGGALIHH FWEKQELPFG AGELPPQQDA LKQDTQLTVG SLGGNTLGFN
160 170 180 190 200
RILKQCSDEL RKPSLLPGDP VDGDEPAAKC GEFFGTGDGK QWLDDQFERV
210 220 230 240 250
GAELEELLDR IGYFAPDAKR VLVGYPRLVP EDTTKCLTAA PGQTQLPFAD
260 270 280 290 300
IPQDALPVLD QIQKRLNDAM KKAAADGGAD FVDLYAGTGA NTACDGADRG
310 320 330 340
IGGLLEDSQL ELLGTKIPWY AHPNDKGRDI QAKQVADKIE EILNR
Length:345
Mass (Da):36,670
Last modified:August 1, 1991 - v1
Checksum:i237DC28EE185B00E
GO

Sequence cautioni

The sequence AAA26744 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57297 Genomic DNA. Translation: AAA26743.1.
M57297 Genomic DNA. Translation: AAA26744.1. Different initiation.
PIRiA37845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57297 Genomic DNA. Translation: AAA26743.1.
M57297 Genomic DNA. Translation: AAA26744.1. Different initiation.
PIRiA37845.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ESCX-ray2.10A40-345[»]
1ESDX-ray2.30A40-345[»]
1ESEX-ray2.40A40-345[»]
ProteinModelPortaliP22266.
SMRiP22266.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP22266.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiESTA_STRSC
AccessioniPrimary (citable) accession number: P22266
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.