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P22266

- ESTA_STRSC

UniProt

P22266 - ESTA_STRSC

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Protein
Esterase
Gene
estA
Organism
Streptomyces scabiei
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Esterase (EC:3.1.1.-)
Gene namesi
Name:estA
OrganismiStreptomyces scabiei
Taxonomic identifieri1930 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 39391 Publication
Add
BLAST
Chaini40 – 345306Esterase
PRO_0000021208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi73 ↔ 103
Disulfide bondi156 ↔ 180
Disulfide bondi236 ↔ 294

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

By zinc.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi44 – 496
Helixi53 – 564
Turni57 – 593
Beta strandi61 – 633
Turni64 – 674
Helixi69 – 735
Helixi80 – 8910
Turni90 – 923
Beta strandi94 – 1007
Helixi108 – 1114
Beta strandi115 – 1173
Helixi118 – 1203
Beta strandi122 – 1243
Helixi127 – 1304
Beta strandi137 – 1404
Helixi144 – 1474
Helixi149 – 1557
Turni158 – 1614
Beta strandi171 – 1755
Helixi177 – 1793
Helixi180 – 1834
Turni184 – 1863
Helixi188 – 21427
Beta strandi219 – 2235
Helixi233 – 2375
Turni247 – 2504
Turni253 – 2553
Helixi256 – 27520
Turni276 – 2783
Beta strandi280 – 2823
Helixi285 – 2873
Beta strandi304 – 31411
Beta strandi316 – 3183
Helixi325 – 34218

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ESCX-ray2.10A40-345[»]
1ESDX-ray2.30A40-345[»]
1ESEX-ray2.40A40-345[»]
ProteinModelPortaliP22266.
SMRiP22266. Positions 43-344.

Miscellaneous databases

EvolutionaryTraceiP22266.

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22266-1 [UniParc]FASTAAdd to Basket

« Hide

MSSAMRKTTN SPVVRRLTAA AVALGSCLAL AGPAGSAGAA PADPVPTVFF    50
GDSYTANFGI APVTNQDSER GWCFQAKENY PAVATRSLAD KGITLDVQAD 100
VSCGGALIHH FWEKQELPFG AGELPPQQDA LKQDTQLTVG SLGGNTLGFN 150
RILKQCSDEL RKPSLLPGDP VDGDEPAAKC GEFFGTGDGK QWLDDQFERV 200
GAELEELLDR IGYFAPDAKR VLVGYPRLVP EDTTKCLTAA PGQTQLPFAD 250
IPQDALPVLD QIQKRLNDAM KKAAADGGAD FVDLYAGTGA NTACDGADRG 300
IGGLLEDSQL ELLGTKIPWY AHPNDKGRDI QAKQVADKIE EILNR 345
Length:345
Mass (Da):36,670
Last modified:August 1, 1991 - v1
Checksum:i237DC28EE185B00E
GO

Sequence cautioni

The sequence AAA26744.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57297 Genomic DNA. Translation: AAA26743.1.
M57297 Genomic DNA. Translation: AAA26744.1. Different initiation.
PIRiA37845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57297 Genomic DNA. Translation: AAA26743.1 .
M57297 Genomic DNA. Translation: AAA26744.1 . Different initiation.
PIRi A37845.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ESC X-ray 2.10 A 40-345 [» ]
1ESD X-ray 2.30 A 40-345 [» ]
1ESE X-ray 2.40 A 40-345 [» ]
ProteinModelPortali P22266.
SMRi P22266. Positions 43-344.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P22266.

Family and domain databases

Gene3Di 3.40.50.1110. 1 hit.
InterProi IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing, and regulation of expression of an extracellular esterase gene from the plant pathogen Streptomyces scabies."
    Raymer G., Willard J.M.A., Schottel J.L.
    J. Bacteriol. 172:7020-7026(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 40-69.
    Strain: FL1.
  2. "Regulation and secretion of an extracellular esterase from Streptomyces scabies."
    Schottel J.L., Hale V., Babcock M.J.
    Gene 115:27-31(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "A novel variant of the catalytic triad in the Streptomyces scabies esterase."
    Wei Y., Schottel J.L., Derewenda U., Swenson L., Patkar S., Derewenda Z.S.
    Nat. Struct. Biol. 2:218-223(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).

Entry informationi

Entry nameiESTA_STRSC
AccessioniPrimary (citable) accession number: P22266
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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