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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1010-MONOMER.
BRENDAi6.3.4.21. 5542.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:STM1004
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 400399Nicotinate phosphoribosyltransferasePRO_0000205846Add
BLAST

Proteomic databases

PRIDEiP22253.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1004.

Structurei

3D structure databases

ProteinModelPortaliP22253.
SMRiP22253. Positions 2-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000284928.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.
PhylomeDBiP22253.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQFASPVLH SLLDTDAYKL HMQQAVFHHY YDVQVAAEFR CRGDDLLGIY
60 70 80 90 100
ADAIREQVDA MQHLRLLEDE FQWLSGLPFF KPDYLNWLRE FRYNPAQVCV
110 120 130 140 150
TNDNGKLNIR LTGPWREVIM WEVPLLAVIS ELVHHYRSPN AGVDQALDAL
160 170 180 190 200
ESKLVDFTAL TANLDMSRFH LMDFGTRRRF SREVQQAIVK RLQQESWFVG
210 220 230 240 250
TSNYDLARRL ALTPMGTQAH EWFQAHQQIS PDLATSQRAA LAAWLNEYPD
260 270 280 290 300
QLGIALTDCI TMDAFLRDFG IEFASRYQGL RHDSGDPVAW GEKAIAHYEK
310 320 330 340 350
LGIDPLTKTL VFSDNLDLPK AVELYRHFAS RVQLSFGIGT RLTCDIPQVK
360 370 380 390 400
PLNIVIKLVE CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPQVRKAS
Length:400
Mass (Da):45,661
Last modified:January 22, 2007 - v2
Checksum:iBA76FF5EF0D02F3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55986 Genomic DNA. Translation: AAA27190.1.
AE006468 Genomic DNA. Translation: AAL19938.1.
PIRiA39130.
RefSeqiNP_459979.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19938; AAL19938; STM1004.
GeneIDi1252522.
KEGGistm:STM1004.
PATRICi32380429. VBISalEnt20916_1061.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55986 Genomic DNA. Translation: AAA27190.1.
AE006468 Genomic DNA. Translation: AAL19938.1.
PIRiA39130.
RefSeqiNP_459979.1. NC_003197.1.

3D structure databases

ProteinModelPortaliP22253.
SMRiP22253. Positions 2-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1004.

Proteomic databases

PRIDEiP22253.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL19938; AAL19938; STM1004.
GeneIDi1252522.
KEGGistm:STM1004.
PATRICi32380429. VBISalEnt20916_1061.

Phylogenomic databases

HOGENOMiHOG000284928.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.
PhylomeDBiP22253.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.
BioCyciSENT99287:GCTI-1010-MONOMER.
BRENDAi6.3.4.21. 5542.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and nucleic acid sequence of the Salmonella typhimurium pncB gene and structure of nicotinate phosphoribosyltransferase."
    Vinitsky A., Teng H., Grubmeyer C.T.
    J. Bacteriol. 173:536-540(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiPNCB_SALTY
AccessioniPrimary (citable) accession number: P22253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 31, 1991
Last sequence update: January 22, 2007
Last modified: March 31, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.