Reviewed, UniProtKB/Swiss-Prot P22246 (ADH1_DROMT)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1

Gene names

Name:

Adh1

Organism

Drosophila mettleri (Fruit fly)

Taxonomic identifier

7228 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	alcohol metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 254	253	Alcohol dehydrogenase 1		PRO_0000054480
Regions
	Nucleotide binding	10 – 33	24	NAD By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	138	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P22246-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: BB0D26CB95649D86	FASTA	254	27,539
	10 20 30 40 50 60 MAIANKNIIF VAGLGGIGLD TSREIVKSGP KNLVILDRVE NPTAIAELKA INPKVTITFY 70 80 90 100 110 120 PYDVTVSVAE STKLLKTIFD KLKTVDLLIN GAGILDDYQI ERTIAVNFAG TVNTTTAIMA 130 140 150 160 170 180 FWDKRKGGPG GVIANICSVT GFNSIYQVPV YSASKAAAIS FTNSLAKLAP ITGVTAYSIN 190 200 210 220 230 240 PGITKTPLVH KFNSWLDVEP RVAELLLEHP TQTTLQCAQN FVKAIEANKN GAIWKLDLGR 250 LDAIEWTQHW DSHI

References

[1]	"The structure of the Adh locus of Drosophila mettleri: an intermediate in the evolution of the Adh locus in the repleta group of Drosophila." Yum J., Starmer W.T., Sullivan D.T. Mol. Biol. Evol. 8:857-867(1991) [PubMed: 1775067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M57300 Genomic DNA. Translation: AAA28364.1.
PIR	A40553.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
SMR	P22246. Positions 1-254.
ModBase	Search...
Organism-specific databases
FlyBase	FBgn0012533. Dmet\Adh1.
Enzyme and pathway databases
BRENDA	1.1.1.1. 294208.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002425. Insect_ADH. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1_DROMT

Accession

Primary (citable) accession number: P22246

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	January 23, 2007
Last modified:	September 22, 2009
This is version 54 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project