ID   NDUS3_DICDI             Reviewed;         209 AA.
AC   P22237;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   24-JAN-2024, entry version 129.
DE   RecName: Full=NADH-ubiquinone oxidoreductase subunit 9;
DE            EC=7.1.1.2;
GN   Name=nad9; Synonyms=ndufs3, noxA; ORFNames=DDB_G0294032;
OS   Dictyostelium discoideum (Social amoeba).
OG   Mitochondrion.
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2102381; DOI=10.1007/bf00017840;
RA   Tanaka Y., Kuroe K., Angata K., Yanagisawa K.;
RT   "ORF209 of Dictyostelium discoideum mitochondrial DNA has a homologue in
RT   chloroplast DNA.";
RL   Plant Mol. Biol. 15:659-660(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX3;
RX   PubMed=10821186; DOI=10.1007/pl00008685;
RA   Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K.,
RA   Morio T., Urushihara H., Yanagisawa K., Tanaka Y.;
RT   "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene
RT   content and genome organization.";
RL   Mol. Gen. Genet. 263:514-519(2000).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Complex I is composed of about 45 different subunits.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I 30 kDa subunit family.
CC       {ECO:0000305}.
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DR   EMBL; X52680; CAA36903.1; -; Genomic_DNA.
DR   EMBL; AB000109; BAA78066.1; -; Genomic_DNA.
DR   PIR; S12247; S12247.
DR   RefSeq; NP_050084.1; NC_000895.1.
DR   AlphaFoldDB; P22237; -.
DR   SMR; P22237; -.
DR   STRING; 44689.P22237; -.
DR   GeneID; 2193912; -.
DR   KEGG; ddi:DidioMp17; -.
DR   dictyBase; DDB_G0294032; nad9.
DR   InParanoid; P22237; -.
DR   PhylomeDB; P22237; -.
DR   Reactome; R-DDI-6799198; Complex I biogenesis.
DR   PRO; PR:P22237; -.
DR   Proteomes; UP000002195; Mitochondrion.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.30.460.80; NADH:ubiquinone oxidoreductase, 30kDa subunit; 1.
DR   HAMAP; MF_01357; NDH1_NuoC; 1.
DR   InterPro; IPR010218; NADH_DH_suC.
DR   InterPro; IPR037232; NADH_quin_OxRdtase_su_C/D-like.
DR   InterPro; IPR001268; NADH_UbQ_OxRdtase_30kDa_su.
DR   InterPro; IPR020396; NADH_UbQ_OxRdtase_CS.
DR   PANTHER; PTHR10884:SF14; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR10884; NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3; 1.
DR   Pfam; PF00329; Complex1_30kDa; 1.
DR   SUPFAM; SSF143243; Nqo5-like; 1.
DR   PROSITE; PS00542; COMPLEX1_30K; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Oxidoreductase; Reference proteome; Respiratory chain; Translocase;
KW   Transport; Ubiquinone.
FT   CHAIN           1..209
FT                   /note="NADH-ubiquinone oxidoreductase subunit 9"
FT                   /id="PRO_0000118645"
SQ   SEQUENCE   209 AA;  25033 MW;  A22D482B71B38374 CRC64;
     MKDYKNELKV KINLGEHLRL SIPGLVKKIM YKTHYLEIQV EKEKMLTVLK YLKEASKYQC
     NMLLDIVCVD CLNIEEIKIG RFKLIYVLNS IYNNTRVHLS TYVENNGIIE TTSGLFESSV
     WLEREIWDMF GIYFEKHPDL RRILTDYGFV GYPLKKDFPI TGYLEVYYDV NDKKIIYKPI
     ELMQEYRNYN FGAVWGDYER KVYLENIIK
//