Reviewed, UniProtKB/Swiss-Prot P22237 (NDUS3_DICDI)

Names and origin

Protein names

Recommended name:
    NADH-ubiquinone oxidoreductase subunit 9
    EC=1.6.5.3
    EC=1.6.99.3

Gene names

Name:	nad9
Synonyms:	ndufs3, noxA
ORF Names:	DDB_G0294032

Encoded on

Mitochondrion

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. NADH + acceptor = NAD+ + reduced acceptor.
Subunit structure	Complex I is composed of about 45 different subunits By similarity.
Subcellular location	Mitochondrion inner membrane By similarity.
Sequence similarities	Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	NADH-ubiquinone oxidoreductase subunit 9		PRO_0000118645

Sequences

	Sequence		Length	Mass (Da)
	P22237-1 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: A22D482B71B38374	FASTA	209	25,033
	10 20 30 40 50 60 MKDYKNELKV KINLGEHLRL SIPGLVKKIM YKTHYLEIQV EKEKMLTVLK YLKEASKYQC 70 80 90 100 110 120 NMLLDIVCVD CLNIEEIKIG RFKLIYVLNS IYNNTRVHLS TYVENNGIIE TTSGLFESSV 130 140 150 160 170 180 WLEREIWDMF GIYFEKHPDL RRILTDYGFV GYPLKKDFPI TGYLEVYYDV NDKKIIYKPI 190 200 ELMQEYRNYN FGAVWGDYER KVYLENIIK

References

[1]	"ORF209 of Dictyostelium discoideum mitochondrial DNA has a homologue in chloroplast DNA." Tanaka Y., Kuroe K., Angata K., Yanagisawa K. Plant Mol. Biol. 15:659-660(1990) [PubMed: 2102381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization." Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y. Mol. Gen. Genet. 263:514-519(2000) [PubMed: 10821186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AX3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X52680 Genomic DNA. Translation: CAA36903.1. AB000109 Genomic DNA. Translation: BAA78066.1.
PIR	S12247.
RefSeq	NP_050084.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2193912.
Organism-specific databases
dictyBase	DDB_G0294032. nad9.
Enzyme and pathway databases
BRENDA	1.6.5.3. 424. 1.6.99.3. 424.
Family and domain databases
InterPro	IPR001268. NADH_UbQ_OxRdtase_30kDa_su. [Graphical view]
Pfam	PF00329. Complex1_30kDa. 1 hit. [Graphical view]
ProDom	PD001581. Complex1_30K. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00542. COMPLEX1_30K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDUS3_DICDI

Accession

Primary (citable) accession number: P22237

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)