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P22223

- CADH3_HUMAN

UniProt

P22223 - CADH3_HUMAN

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Protein

Cadherin-3

Gene

CDH3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. adherens junction organization Source: Reactome
  2. canonical Wnt signaling pathway Source: UniProt
  3. cell adhesion Source: ProtInc
  4. cell-cell junction organization Source: Reactome
  5. cell junction assembly Source: Reactome
  6. hair cycle process Source: UniProt
  7. homophilic cell adhesion Source: InterPro
  8. keratinization Source: UniProt
  9. negative regulation of catagen Source: UniProt
  10. negative regulation of transforming growth factor beta2 production Source: UniProt
  11. positive regulation of gene expression Source: UniProt
  12. positive regulation of insulin-like growth factor receptor signaling pathway Source: UniProt
  13. positive regulation of keratinocyte proliferation Source: UniProt
  14. positive regulation of melanin biosynthetic process Source: UniProt
  15. positive regulation of melanosome transport Source: UniProt
  16. positive regulation of monophenol monooxygenase activity Source: UniProt
  17. regulation of hair cycle by canonical Wnt signaling pathway Source: UniProt
  18. response to drug Source: Ensembl
  19. retina homeostasis Source: UniProt
  20. single organismal cell-cell adhesion Source: Ensembl
  21. visual perception Source: UniProtKB-KW
  22. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Sensory transduction, Vision

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-3
Alternative name(s):
Placental cadherin
Short name:
P-cadherin
Gene namesi
Name:CDH3
Synonyms:CDHP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:1762. CDH3.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell adherens junction Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hypotrichosis congenital with juvenile macular dystrophy (HJMD) [MIM:601553]: A disorder characterized by congenital hypotrichosis, early hair loss, and severe degenerative changes of the retinal macula that culminate in blindness during the second to third decade of life.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti503 – 5031R → H in HJMD. 1 Publication
VAR_015422
Ectodermal dysplasia, with ectrodactyly and macular dystrophy (EEM) [MIM:225280]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti322 – 3221N → I in EEM. 1 Publication
VAR_033010

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia, Hypotrichosis

Organism-specific databases

MIMi225280. phenotype.
601553. phenotype.
Orphaneti1897. EEM syndrome.
1573. Hypotrichosis with juvenile macular degeneration.
PharmGKBiPA26299.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 10783PRO_0000003745Add
BLAST
Chaini108 – 829722Cadherin-3PRO_0000003746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP22223.
PaxDbiP22223.
PRIDEiP22223.

PTM databases

PhosphoSiteiP22223.

Expressioni

Tissue specificityi

Expressed in some normal epithelial tissues and in some carcinoma cell lines.1 Publication

Gene expression databases

BgeeiP22223.
CleanExiHS_CDH3.
ExpressionAtlasiP22223. baseline and differential.
GenevestigatoriP22223.

Organism-specific databases

HPAiCAB002487.
HPA001767.

Interactioni

Subunit structurei

Interacts with CDCP1 and CTNNB1.2 Publications

Protein-protein interaction databases

BioGridi107436. 7 interactions.
IntActiP22223. 5 interactions.
STRINGi9606.ENSP00000264012.

Structurei

3D structure databases

ProteinModelPortaliP22223.
SMRiP22223. Positions 108-647, 729-822.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini108 – 654547ExtracellularSequence AnalysisAdd
BLAST
Topological domaini678 – 829152CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei655 – 67723HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 215108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini216 – 328113Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini329 – 440112Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini441 – 546106Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini547 – 650104Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi785 – 80016Ser-richAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG328838.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP22223.
KOiK06796.
OMAiKQDTYDV.
OrthoDBiEOG7PS1DS.
PhylomeDBiP22223.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P22223-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLPRGPLAS LLLLQVCWLQ CAASEPCRAV FREAEVTLEA GGAEQEPGQA
60 70 80 90 100
LGKVFMGCPG QEPALFSTDN DDFTVRNGET VQERRSLKER NPLKIFPSKR
110 120 130 140 150
ILRRHKRDWV VAPISVPENG KGPFPQRLNQ LKSNKDRDTK IFYSITGPGA
160 170 180 190 200
DSPPEGVFAV EKETGWLLLN KPLDREEIAK YELFGHAVSE NGASVEDPMN
210 220 230 240 250
ISIIVTDQND HKPKFTQDTF RGSVLEGVLP GTSVMQVTAT DEDDAIYTYN
260 270 280 290 300
GVVAYSIHSQ EPKDPHDLMF TIHRSTGTIS VISSGLDREK VPEYTLTIQA
310 320 330 340 350
TDMDGDGSTT TAVAVVEILD ANDNAPMFDP QKYEAHVPEN AVGHEVQRLT
360 370 380 390 400
VTDLDAPNSP AWRATYLIMG GDDGDHFTIT THPESNQGIL TTRKGLDFEA
410 420 430 440 450
KNQHTLYVEV TNEAPFVLKL PTSTATIVVH VEDVNEAPVF VPPSKVVEVQ
460 470 480 490 500
EGIPTGEPVC VYTAEDPDKE NQKISYRILR DPAGWLAMDP DSGQVTAVGT
510 520 530 540 550
LDREDEQFVR NNIYEVMVLA MDNGSPPTTG TGTLLLTLID VNDHGPVPEP
560 570 580 590 600
RQITICNQSP VRQVLNITDK DLSPHTSPFQ AQLTDDSDIY WTAEVNEEGD
610 620 630 640 650
TVVLSLKKFL KQDTYDVHLS LSDHGNKEQL TVIRATVCDC HGHVETCPGP
660 670 680 690 700
WKGGFILPVL GAVLALLFLL LVLLLLVRKK RKIKEPLLLP EDDTRDNVFY
710 720 730 740 750
YGEEGGGEED QDYDITQLHR GLEARPEVVL RNDVAPTIIP TPMYRPRPAN
760 770 780 790 800
PDEIGNFIIE NLKAANTDPT APPYDTLLVF DYEGSGSDAA SLSSLTSSAS
810 820
DQDQDYDYLN EWGSRFKKLA DMYGGGEDD
Length:829
Mass (Da):91,418
Last modified:May 1, 2007 - v2
Checksum:i7C03C8536CD98C7B
GO
Isoform 2 (identifier: P22223-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     761-829: NLKAANTDPT...ADMYGGGEDD → GRGERGSQRGNGGLQLARGRTRRS

Note: No experimental confirmation available.

Show »
Length:784
Mass (Da):86,552
Checksum:i0BE52C6E9C281154
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti237 – 2371V → M.1 Publication
Corresponds to variant rs17854171 [ dbSNP | Ensembl ].
VAR_031929
Natural varianti322 – 3221N → I in EEM. 1 Publication
VAR_033010
Natural varianti477 – 4771R → H.
Corresponds to variant rs34494880 [ dbSNP | Ensembl ].
VAR_031930
Natural varianti503 – 5031R → H in HJMD. 1 Publication
VAR_015422
Natural varianti563 – 5631Q → H.4 Publications
Corresponds to variant rs1126933 [ dbSNP | Ensembl ].
VAR_031931

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei761 – 82969NLKAA…GGEDD → GRGERGSQRGNGGLQLARGR TRRS in isoform 2. 1 PublicationVSP_024820Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63629 mRNA. Translation: CAA45177.1.
AK312554 mRNA. Translation: BAG35451.1.
CH471092 Genomic DNA. Translation: EAW83238.1.
BC014462 mRNA. Translation: AAH14462.1.
BC041846 mRNA. Translation: AAH41846.1.
X95824 Genomic DNA. Translation: CAA65093.1.
CCDSiCCDS10868.1. [P22223-1]
PIRiA33659. IJHUCP.
RefSeqiNP_001784.2. NM_001793.4. [P22223-1]
UniGeneiHs.191842.

Genome annotation databases

EnsembliENST00000264012; ENSP00000264012; ENSG00000062038. [P22223-1]
ENST00000429102; ENSP00000398485; ENSG00000062038. [P22223-2]
GeneIDi1001.
KEGGihsa:1001.
UCSCiuc002ewf.2. human. [P22223-1]

Polymorphism databases

DMDMi146345382.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Mutations of the CDH3 gene

Retina International's Scientific Newsletter

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63629 mRNA. Translation: CAA45177.1 .
AK312554 mRNA. Translation: BAG35451.1 .
CH471092 Genomic DNA. Translation: EAW83238.1 .
BC014462 mRNA. Translation: AAH14462.1 .
BC041846 mRNA. Translation: AAH41846.1 .
X95824 Genomic DNA. Translation: CAA65093.1 .
CCDSi CCDS10868.1. [P22223-1 ]
PIRi A33659. IJHUCP.
RefSeqi NP_001784.2. NM_001793.4. [P22223-1 ]
UniGenei Hs.191842.

3D structure databases

ProteinModelPortali P22223.
SMRi P22223. Positions 108-647, 729-822.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107436. 7 interactions.
IntActi P22223. 5 interactions.
STRINGi 9606.ENSP00000264012.

PTM databases

PhosphoSitei P22223.

Polymorphism databases

DMDMi 146345382.

Proteomic databases

MaxQBi P22223.
PaxDbi P22223.
PRIDEi P22223.

Protocols and materials databases

DNASUi 1001.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264012 ; ENSP00000264012 ; ENSG00000062038 . [P22223-1 ]
ENST00000429102 ; ENSP00000398485 ; ENSG00000062038 . [P22223-2 ]
GeneIDi 1001.
KEGGi hsa:1001.
UCSCi uc002ewf.2. human. [P22223-1 ]

Organism-specific databases

CTDi 1001.
GeneCardsi GC16P068679.
H-InvDB HIX0026973.
HGNCi HGNC:1762. CDH3.
HPAi CAB002487.
HPA001767.
MIMi 114021. gene.
225280. phenotype.
601553. phenotype.
neXtProti NX_P22223.
Orphaneti 1897. EEM syndrome.
1573. Hypotrichosis with juvenile macular degeneration.
PharmGKBi PA26299.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG328838.
GeneTreei ENSGT00760000118906.
HOGENOMi HOG000231254.
HOVERGENi HBG106438.
InParanoidi P22223.
KOi K06796.
OMAi KQDTYDV.
OrthoDBi EOG7PS1DS.
PhylomeDBi P22223.
TreeFami TF316817.

Enzyme and pathway databases

Reactomei REACT_19195. Adherens junctions interactions.

Miscellaneous databases

ChiTaRSi CDH3. human.
GeneWikii CDH3_(gene).
GenomeRNAii 1001.
NextBioi 4208.
PROi P22223.
SOURCEi Search...

Gene expression databases

Bgeei P22223.
CleanExi HS_CDH3.
ExpressionAtlasi P22223. baseline and differential.
Genevestigatori P22223.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 4 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues."
    Shimoyama Y., Yoshida T., Terada M., Shimosato Y., Abe O., Hirohashi S.
    J. Cell Biol. 109:1787-1794(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT HIS-563.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-563.
    Tissue: Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-563.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-237.
    Tissue: Skin and Testis.
  5. "P-cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer."
    Jarrard D.F., Paul R., Van Bokhoven A., Nguyen S.H., Bova G.S., Wheelock M.J., Johnson K.R., Schalken J., Bussemakers M., Isaacs W.B.
    Clin. Cancer Res. 3:2121-2128(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15.
    Tissue: Fetal brain.
  6. "Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas."
    Shimoyama Y., Hirohashi S., Hirano S., Noguchi M., Shimosato Y., Takeichi M., Abe O.
    Cancer Res. 49:2128-2133(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Adhesion signaling by a novel mitotic substrate of src kinases."
    Bhatt A.S., Erdjument-Bromage H., Tempst P., Craik C.S., Moasser M.M.
    Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDCP1.
  8. "Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin."
    Sprecher E., Bergman R., Richard G., Lurie R., Shalev S., Petronius D., Shalata A., Anbinder Y., Leibu R., Perlman I., Cohen N., Szargel R.
    Nat. Genet. 29:134-136(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN HJMD.
  9. "Crystal structure of a beta-catenin/BCL9/Tcf4 complex."
    Sampietro J., Dahlberg C.L., Cho U.S., Hinds T.R., Kimelman D., Xu W.
    Mol. Cell 24:293-300(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTNNB1.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy."
    Indelman M., Bergman R., Lurie R., Richard G., Miller B., Petronius D., Ciubutaro D., Leibu R., Sprecher E.
    J. Invest. Dermatol. 119:1210-1213(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HJMD HIS-503.
  12. "Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome)."
    Kjaer K.W., Hansen L., Schwabe G.C., Marques-de-Faria A.P., Eiberg H., Mundlos S., Tommerup N., Rosenberg T.
    J. Med. Genet. 42:292-298(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT EEM ILE-322, VARIANT HIS-563.

Entry informationi

Entry nameiCADH3_HUMAN
AccessioniPrimary (citable) accession number: P22223
Secondary accession number(s): B2R6F4, Q05DI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3