P22220 (SPE1_AVESA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine decarboxylase
Short name=ADC
Short name=ARGDC
EC=4.1.1.19

Gene names

Name:

SPE1

Organism

Avena sativa (Oat)

Taxonomic identifier

4498 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Pooideae › Poeae › Aveninae › Avena

Protein attributes

Sequence length	607 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2.
Cofactor	Pyridoxal phosphate. Magnesium.
Pathway	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Ontologies

Keywords
Biological process	Putrescine biosynthesis Spermidine biosynthesis
Ligand	Magnesium Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro putrescine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 607	607	Arginine decarboxylase		PRO_0000149948
Regions
	Region	290 – 300	11	Substrate-binding By similarity
Amino acid modifications
	Modified residue	104	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P22220 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 757114B2C02EF8A5	FASTA	607	66,706
	10 20 30 40 50 60 MAKNYGDVYH VEGWGEPYFA VNKDGHLCVR IYGRETLPGQ EIDVLSVIEQ ATSADGTGKK 70 80 90 100 110 120 LQFPMILRFP DVLRHRINSL HTAFANAIKY TQYGSVYQGV FPVKVNQHKD VVQDMVHFGY 130 140 150 160 170 180 DHSYGLEAGS KPELLIAMSC LTKAKPGAYL VCNGYKDSAY VALALAARAM GLNVIIVLEM 190 200 210 220 230 240 EEELDIVIEE SSKLGVEPVI GVRAKLLTKI PGHFGSTAGK HGKFGLPAEK IYEVAKKLKA 250 260 270 280 290 300 LNKLHWLKLL HFHVGSMIPT TDIVFKAASE ASDIYCALVK EYGVETMTTL DCGGGLGVDY 310 320 330 340 350 360 DGTRSGSSDM SVAYGLEEYA SSIVQAVRLK CDYHGVPHPV LCTESGRAMA SYHSMIILEA 370 380 390 400 410 420 LSAIPEPKDD EDEATTEQLH GRIRDLSSKL QPTGLSMSSH AVHIKKHGIE MYKLGKKLSK 430 440 450 460 470 480 SVTTDAHTIY NYHMNLSVFS LMPDYWGIQH LFPMMPVSRL DEKPTHKATL VDVTCDSDGK 490 500 510 520 530 540 VDKFIRDTET MPLHPLDPKL GGYYVAVLLT GAYQEALSNK HNLFGGPSLV RVVGTGNGGA 550 560 570 580 590 600 FNVEAALLGS TTEELIGTVS YDVKQDISSV IEERARENKV WEMVEKLVES GLHTMPYLAD YKPPPMA

References

[1]

"Analysis of a cDNA encoding arginine decarboxylase from oat reveals similarity to the Escherichia coli arginine decarboxylase and evidence of protein processing." Bell E., Malmberg R.L. Mol. Gen. Genet. 224:431-436(1990) [PubMed: 2266946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 427-437. Tissue: Leaf.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56802 mRNA. Translation: CAA40137.1.
PIR	S12265.
3D structure databases
ProteinModelPortal	P22220.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Gramene	P22220.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-14981.
Family and domain databases
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR002985. Arg_decrbxlase. IPR022643. De-COase2_C. IPR022657. De-COase2_CS. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 2 hits.
PANTHER	PTHR11482:SF3. Arg_decrbxlase. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PIRSF	PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTS	PR01180. ARGDCRBXLASE. PR01179. ODADCRBXLASE.
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPE1_AVESA

Accession

Primary (citable) accession number: P22220

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	May 31, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program