Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arginine decarboxylase

Gene

SPE1

Organism
Avena sativa (Oat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.
Proteins known to be involved in this subpathway in this organism are:
  1. Arginine decarboxylase (SPE1)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPutrescine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14981
BRENDAi4.1.1.19 588
SABIO-RKiP22220
UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Short name:
ARGDC
Gene namesi
Name:SPE1
OrganismiAvena sativa (Oat)
Taxonomic identifieri4498 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaePoodaePoeaeAveninaeAvena

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499481 – 607Arginine decarboxylaseAdd BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104N6-(pyridoxal phosphate)lysineBy similarity1

Structurei

3D structure databases

ProteinModelPortaliP22220
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni290 – 300Substrate-bindingBy similarityAdd BLAST11

Sequence similaritiesi

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P22220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNYGDVYH VEGWGEPYFA VNKDGHLCVR IYGRETLPGQ EIDVLSVIEQ
60 70 80 90 100
ATSADGTGKK LQFPMILRFP DVLRHRINSL HTAFANAIKY TQYGSVYQGV
110 120 130 140 150
FPVKVNQHKD VVQDMVHFGY DHSYGLEAGS KPELLIAMSC LTKAKPGAYL
160 170 180 190 200
VCNGYKDSAY VALALAARAM GLNVIIVLEM EEELDIVIEE SSKLGVEPVI
210 220 230 240 250
GVRAKLLTKI PGHFGSTAGK HGKFGLPAEK IYEVAKKLKA LNKLHWLKLL
260 270 280 290 300
HFHVGSMIPT TDIVFKAASE ASDIYCALVK EYGVETMTTL DCGGGLGVDY
310 320 330 340 350
DGTRSGSSDM SVAYGLEEYA SSIVQAVRLK CDYHGVPHPV LCTESGRAMA
360 370 380 390 400
SYHSMIILEA LSAIPEPKDD EDEATTEQLH GRIRDLSSKL QPTGLSMSSH
410 420 430 440 450
AVHIKKHGIE MYKLGKKLSK SVTTDAHTIY NYHMNLSVFS LMPDYWGIQH
460 470 480 490 500
LFPMMPVSRL DEKPTHKATL VDVTCDSDGK VDKFIRDTET MPLHPLDPKL
510 520 530 540 550
GGYYVAVLLT GAYQEALSNK HNLFGGPSLV RVVGTGNGGA FNVEAALLGS
560 570 580 590 600
TTEELIGTVS YDVKQDISSV IEERARENKV WEMVEKLVES GLHTMPYLAD

YKPPPMA
Length:607
Mass (Da):66,706
Last modified:August 1, 1991 - v1
Checksum:i757114B2C02EF8A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56802 mRNA Translation: CAA40137.1
PIRiS12265

Similar proteinsi

Entry informationi

Entry nameiSPE1_AVESA
AccessioniPrimary (citable) accession number: P22220
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health