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P22209

- KIN3_YEAST

UniProt

P22209 - KIN3_YEAST

Protein

Serine/threonine-protein kinase KIN3

Gene

KIN3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    This protein is probably a serine/threonine protein kinase.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541ATPPROSITE-ProRule annotation
    Active sitei174 – 1741Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein kinase activity Source: SGD
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. chromosome segregation Source: SGD

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28874-MONOMER.
    BRENDAi2.7.11.1. 984.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase KIN3 (EC:2.7.11.1)
    Gene namesi
    Name:KIN3
    Synonyms:NPK1
    Ordered Locus Names:YAR018C
    ORF Names:FUN52
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAR018c.
    SGDiS000000071. KIN3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Serine/threonine-protein kinase KIN3PRO_0000086134Add
    BLAST

    Proteomic databases

    MaxQBiP22209.
    PaxDbiP22209.

    Expressioni

    Gene expression databases

    GenevestigatoriP22209.

    Interactioni

    Protein-protein interaction databases

    BioGridi31800. 190 interactions.
    DIPiDIP-1646N.
    IntActiP22209. 22 interactions.
    MINTiMINT-397142.
    STRINGi4932.YAR018C.

    Structurei

    3D structure databases

    ProteinModelPortaliP22209.
    SMRiP22209. Positions 1-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 343319Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00720000108402.
    HOGENOMiHOG000233029.
    KOiK08857.
    OMAiEFATTYV.
    OrthoDBiEOG7VB2QQ.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22209-1 [UniParc]FASTAAdd to Basket

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    MHRRQFFQEY RSPQQQQGHP PRSEYQVLEE IGRGSFGSVR KVIHIPTKKL    50
    LVRKDIKYGH MNSKERQQLI AECSILSQLK HENIVEFYNW DFDEQKEVLY 100
    LYMEYCSRGD LSQMIKHYKQ EHKYIPEKIV WGILAQLLTA LYKCHYGVEL 150
    PTLTTIYDRM KPPVKGKNIV IHRDLKPGNI FLSYDDSDYN INEQVDGHEE 200
    VNSNYYRDHR VNSGKRGSPM DYSQVVVKLG DFGLAKSLET SIQFATTYVG 250
    TPYYMSPEVL MDQPYSPLSD IWSLGCVIFE MCSLHPPFQA KNYLELQTKI 300
    KNGKCDTVPE YYSRGLNAII HSMIDVNLRT RPSTFELLQD IQIRTARKSL 350
    QLERFERKLL DYENELTNIE KILEKQAIEY ERELSQLKEQ FTQAVEERAR 400
    EVISGKKVGK VPESINGYYG KKFAKPAYHW QTRYR 435
    Length:435
    Mass (Da):51,203
    Last modified:August 1, 1992 - v2
    Checksum:i7CB49CD6A93CA019
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921F → L in AAB04029. (PubMed:2199332)Curated
    Sequence conflicti98 – 981V → L in AAB04029. (PubMed:2199332)Curated
    Sequence conflicti121 – 1211E → Q in AAB04029. (PubMed:2199332)Curated
    Sequence conflicti130 – 1301V → I in AAB04029. (PubMed:2199332)Curated
    Sequence conflicti235 – 2384AKSL → SQIS in AAB04029. (PubMed:2199332)Curated
    Sequence conflicti358 – 3581K → R in AAB04029. (PubMed:2199332)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M67445 Genomic DNA. Translation: AAA34399.2.
    X60549 Genomic DNA. Translation: CAA43042.1.
    L22015 Genomic DNA. Translation: AAC04964.1.
    M55416 Genomic DNA. Translation: AAB04029.1.
    BK006935 Genomic DNA. Translation: DAA06995.1.
    PIRiS23580.
    RefSeqiNP_009410.1. NM_001178217.1.

    Genome annotation databases

    EnsemblFungiiYAR018C; YAR018C; YAR018C.
    GeneIDi851273.
    KEGGisce:YAR018C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M67445 Genomic DNA. Translation: AAA34399.2 .
    X60549 Genomic DNA. Translation: CAA43042.1 .
    L22015 Genomic DNA. Translation: AAC04964.1 .
    M55416 Genomic DNA. Translation: AAB04029.1 .
    BK006935 Genomic DNA. Translation: DAA06995.1 .
    PIRi S23580.
    RefSeqi NP_009410.1. NM_001178217.1.

    3D structure databases

    ProteinModelPortali P22209.
    SMRi P22209. Positions 1-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31800. 190 interactions.
    DIPi DIP-1646N.
    IntActi P22209. 22 interactions.
    MINTi MINT-397142.
    STRINGi 4932.YAR018C.

    Proteomic databases

    MaxQBi P22209.
    PaxDbi P22209.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAR018C ; YAR018C ; YAR018C .
    GeneIDi 851273.
    KEGGi sce:YAR018C.

    Organism-specific databases

    CYGDi YAR018c.
    SGDi S000000071. KIN3.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00720000108402.
    HOGENOMi HOG000233029.
    KOi K08857.
    OMAi EFATTYV.
    OrthoDBi EOG7VB2QQ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28874-MONOMER.
    BRENDAi 2.7.11.1. 984.

    Miscellaneous databases

    NextBioi 968254.
    PROi P22209.

    Gene expression databases

    Genevestigatori P22209.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the FUN52 gene, whose product has homology to protein kinases."
      Barton A.B., Davies C.J., Hutchison C.A. III, Kaback D.B.
      Gene 117:137-140(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "NPK1, a nonessential protein kinase gene in Saccharomyces cerevisiae with similarity to Aspergillus nidulans nimA."
      Schweitzer B., Philippsen P.
      Mol. Gen. Genet. 234:164-167(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
      Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
      Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. "Isolation of a novel protein kinase-encoding gene from yeast by oligodeoxyribonucleotide probing."
      Jones D.G.L., Rosamond J.
      Gene 90:87-92(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-369.
      Strain: SB303.

    Entry informationi

    Entry nameiKIN3_YEAST
    AccessioniPrimary (citable) accession number: P22209
    Secondary accession number(s): D6VPM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3