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P22209 (KIN3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase KIN3

EC=2.7.11.1
Gene names
Name:KIN3
Synonyms:NPK1
Ordered Locus Names:YAR018C
ORF Names:FUN52
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is probably a serine/threonine protein kinase.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Serine/threonine-protein kinase KIN3
PRO_0000086134

Regions

Domain25 – 343319Protein kinase
Nucleotide binding31 – 399ATP By similarity

Sites

Active site1741Proton acceptor By similarity
Binding site541ATP By similarity

Experimental info

Sequence conflict921F → L in AAB04029. Ref.6
Sequence conflict981V → L in AAB04029. Ref.6
Sequence conflict1211E → Q in AAB04029. Ref.6
Sequence conflict1301V → I in AAB04029. Ref.6
Sequence conflict235 – 2384AKSL → SQIS in AAB04029. Ref.6
Sequence conflict3581K → R in AAB04029. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P22209 [UniParc].

Last modified August 1, 1992. Version 2.
Checksum: 7CB49CD6A93CA019

FASTA43551,203
        10         20         30         40         50         60 
MHRRQFFQEY RSPQQQQGHP PRSEYQVLEE IGRGSFGSVR KVIHIPTKKL LVRKDIKYGH 

        70         80         90        100        110        120 
MNSKERQQLI AECSILSQLK HENIVEFYNW DFDEQKEVLY LYMEYCSRGD LSQMIKHYKQ 

       130        140        150        160        170        180 
EHKYIPEKIV WGILAQLLTA LYKCHYGVEL PTLTTIYDRM KPPVKGKNIV IHRDLKPGNI 

       190        200        210        220        230        240 
FLSYDDSDYN INEQVDGHEE VNSNYYRDHR VNSGKRGSPM DYSQVVVKLG DFGLAKSLET 

       250        260        270        280        290        300 
SIQFATTYVG TPYYMSPEVL MDQPYSPLSD IWSLGCVIFE MCSLHPPFQA KNYLELQTKI 

       310        320        330        340        350        360 
KNGKCDTVPE YYSRGLNAII HSMIDVNLRT RPSTFELLQD IQIRTARKSL QLERFERKLL 

       370        380        390        400        410        420 
DYENELTNIE KILEKQAIEY ERELSQLKEQ FTQAVEERAR EVISGKKVGK VPESINGYYG 

       430 
KKFAKPAYHW QTRYR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the FUN52 gene, whose product has homology to protein kinases."
Barton A.B., Davies C.J., Hutchison C.A. III, Kaback D.B.
Gene 117:137-140(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"NPK1, a nonessential protein kinase gene in Saccharomyces cerevisiae with similarity to Aspergillus nidulans nimA."
Schweitzer B., Philippsen P.
Mol. Gen. Genet. 234:164-167(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[4]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[6]"Isolation of a novel protein kinase-encoding gene from yeast by oligodeoxyribonucleotide probing."
Jones D.G.L., Rosamond J.
Gene 90:87-92(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-369.
Strain: SB303.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M67445 Genomic DNA. Translation: AAA34399.2.
X60549 Genomic DNA. Translation: CAA43042.1.
L22015 Genomic DNA. Translation: AAC04964.1.
M55416 Genomic DNA. Translation: AAB04029.1.
BK006935 Genomic DNA. Translation: DAA06995.1.
PIRS23580.
RefSeqNP_009410.1. NM_001178217.1.

3D structure databases

ProteinModelPortalP22209.
SMRP22209. Positions 1-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31800. 190 interactions.
DIPDIP-1646N.
IntActP22209. 22 interactions.
MINTMINT-397142.
STRING4932.YAR018C.

Proteomic databases

MaxQBP22209.
PaxDbP22209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAR018C; YAR018C; YAR018C.
GeneID851273.
KEGGsce:YAR018C.

Organism-specific databases

CYGDYAR018c.
SGDS000000071. KIN3.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00720000108402.
HOGENOMHOG000233029.
KOK08857.
OMAEFATTYV.
OrthoDBEOG7VB2QQ.

Enzyme and pathway databases

BioCycYEAST:G3O-28874-MONOMER.
BRENDA2.7.11.1. 984.

Gene expression databases

GenevestigatorP22209.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968254.
PROP22209.

Entry information

Entry nameKIN3_YEAST
AccessionPrimary (citable) accession number: P22209
Secondary accession number(s): D6VPM5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1992
Last modified: June 11, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families