UniProtKB - P22209 (KIN3_YEAST)
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Protein
Serine/threonine-protein kinase KIN3
Gene
KIN3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
This protein is probably a serine/threonine protein kinase.
Catalytic activityi
ATP + a protein = ADP + a phosphoprotein.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 174 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 31 – 39 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: SGD
- protein serine/threonine kinase activity Source: UniProtKB-KW
GO - Biological processi
- chromosome segregation Source: SGD
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | YEAST:G3O-28874-MONOMER. |
BRENDAi | 2.7.11.1. 984. |
Reactomei | R-SCE-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:KIN3 Synonyms:NPK1 Ordered Locus Names:YAR018C ORF Names:FUN52 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YAR018C. |
SGDi | S000000071. KIN3. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086134 | 1 – 435 | Serine/threonine-protein kinase KIN3Add BLAST | 435 |
Proteomic databases
MaxQBi | P22209. |
PaxDbi | P22209. |
PRIDEi | P22209. |
PTM databases
iPTMneti | P22209. |
Interactioni
Protein-protein interaction databases
BioGridi | 31800. 300 interactors. |
DIPi | DIP-1646N. |
ELMi | P22209. |
IntActi | P22209. 26 interactors. |
MINTi | P22209. |
STRINGi | 4932.YAR018C. |
Structurei
3D structure databases
ProteinModelPortali | P22209. |
SMRi | P22209. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 343 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 319 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00760000118997. |
HOGENOMi | HOG000233029. |
InParanoidi | P22209. |
KOi | K20872. |
OMAi | AYNQKEL. |
OrthoDBi | EOG092C4RWB. |
Family and domain databases
InterProi | View protein in InterPro IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. |
Pfami | View protein in Pfam PF00069. Pkinase. 1 hit. |
SMARTi | View protein in SMART SM00220. S_TKc. 1 hit. |
SUPFAMi | SSF56112. SSF56112. 2 hits. |
PROSITEi | View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. |
i Sequence
Sequence statusi: Complete.
P22209-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHRRQFFQEY RSPQQQQGHP PRSEYQVLEE IGRGSFGSVR KVIHIPTKKL
60 70 80 90 100
LVRKDIKYGH MNSKERQQLI AECSILSQLK HENIVEFYNW DFDEQKEVLY
110 120 130 140 150
LYMEYCSRGD LSQMIKHYKQ EHKYIPEKIV WGILAQLLTA LYKCHYGVEL
160 170 180 190 200
PTLTTIYDRM KPPVKGKNIV IHRDLKPGNI FLSYDDSDYN INEQVDGHEE
210 220 230 240 250
VNSNYYRDHR VNSGKRGSPM DYSQVVVKLG DFGLAKSLET SIQFATTYVG
260 270 280 290 300
TPYYMSPEVL MDQPYSPLSD IWSLGCVIFE MCSLHPPFQA KNYLELQTKI
310 320 330 340 350
KNGKCDTVPE YYSRGLNAII HSMIDVNLRT RPSTFELLQD IQIRTARKSL
360 370 380 390 400
QLERFERKLL DYENELTNIE KILEKQAIEY ERELSQLKEQ FTQAVEERAR
410 420 430
EVISGKKVGK VPESINGYYG KKFAKPAYHW QTRYR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 92 | F → L in AAB04029 (PubMed:2199332).Curated | 1 | |
Sequence conflicti | 98 | V → L in AAB04029 (PubMed:2199332).Curated | 1 | |
Sequence conflicti | 121 | E → Q in AAB04029 (PubMed:2199332).Curated | 1 | |
Sequence conflicti | 130 | V → I in AAB04029 (PubMed:2199332).Curated | 1 | |
Sequence conflicti | 235 – 238 | AKSL → SQIS in AAB04029 (PubMed:2199332).Curated | 4 | |
Sequence conflicti | 358 | K → R in AAB04029 (PubMed:2199332).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M67445 Genomic DNA. Translation: AAA34399.2. X60549 Genomic DNA. Translation: CAA43042.1. L22015 Genomic DNA. Translation: AAC04964.1. M55416 Genomic DNA. Translation: AAB04029.1. BK006935 Genomic DNA. Translation: DAA06995.1. |
PIRi | S23580. |
RefSeqi | NP_009410.1. NM_001178217.1. |
Genome annotation databases
EnsemblFungii | YAR018C; YAR018C; YAR018C. |
GeneIDi | 851273. |
KEGGi | sce:YAR018C. |
Similar proteinsi
Entry informationi
Entry namei | KIN3_YEAST | |
Accessioni | P22209Primary (citable) accession number: P22209 Secondary accession number(s): D6VPM5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1992 | |
Last modified: | March 28, 2018 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |