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P22209

- KIN3_YEAST

UniProt

P22209 - KIN3_YEAST

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Protein

Serine/threonine-protein kinase KIN3

Gene

KIN3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This protein is probably a serine/threonine protein kinase.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541ATPPROSITE-ProRule annotation
Active sitei174 – 1741Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: SGD
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. chromosome segregation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-28874-MONOMER.
BRENDAi2.7.11.1. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase KIN3 (EC:2.7.11.1)
Gene namesi
Name:KIN3
Synonyms:NPK1
Ordered Locus Names:YAR018C
ORF Names:FUN52
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAR018c.
SGDiS000000071. KIN3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Serine/threonine-protein kinase KIN3PRO_0000086134Add
BLAST

Proteomic databases

MaxQBiP22209.
PaxDbiP22209.

Expressioni

Gene expression databases

GenevestigatoriP22209.

Interactioni

Protein-protein interaction databases

BioGridi31800. 191 interactions.
DIPiDIP-1646N.
IntActiP22209. 22 interactions.
MINTiMINT-397142.
STRINGi4932.YAR018C.

Structurei

3D structure databases

ProteinModelPortaliP22209.
SMRiP22209. Positions 24-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 343319Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118997.
HOGENOMiHOG000233029.
InParanoidiP22209.
KOiK08857.
OMAiEFATTYV.
OrthoDBiEOG7VB2QQ.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22209-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHRRQFFQEY RSPQQQQGHP PRSEYQVLEE IGRGSFGSVR KVIHIPTKKL
60 70 80 90 100
LVRKDIKYGH MNSKERQQLI AECSILSQLK HENIVEFYNW DFDEQKEVLY
110 120 130 140 150
LYMEYCSRGD LSQMIKHYKQ EHKYIPEKIV WGILAQLLTA LYKCHYGVEL
160 170 180 190 200
PTLTTIYDRM KPPVKGKNIV IHRDLKPGNI FLSYDDSDYN INEQVDGHEE
210 220 230 240 250
VNSNYYRDHR VNSGKRGSPM DYSQVVVKLG DFGLAKSLET SIQFATTYVG
260 270 280 290 300
TPYYMSPEVL MDQPYSPLSD IWSLGCVIFE MCSLHPPFQA KNYLELQTKI
310 320 330 340 350
KNGKCDTVPE YYSRGLNAII HSMIDVNLRT RPSTFELLQD IQIRTARKSL
360 370 380 390 400
QLERFERKLL DYENELTNIE KILEKQAIEY ERELSQLKEQ FTQAVEERAR
410 420 430
EVISGKKVGK VPESINGYYG KKFAKPAYHW QTRYR
Length:435
Mass (Da):51,203
Last modified:August 1, 1992 - v2
Checksum:i7CB49CD6A93CA019
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921F → L in AAB04029. (PubMed:2199332)Curated
Sequence conflicti98 – 981V → L in AAB04029. (PubMed:2199332)Curated
Sequence conflicti121 – 1211E → Q in AAB04029. (PubMed:2199332)Curated
Sequence conflicti130 – 1301V → I in AAB04029. (PubMed:2199332)Curated
Sequence conflicti235 – 2384AKSL → SQIS in AAB04029. (PubMed:2199332)Curated
Sequence conflicti358 – 3581K → R in AAB04029. (PubMed:2199332)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M67445 Genomic DNA. Translation: AAA34399.2.
X60549 Genomic DNA. Translation: CAA43042.1.
L22015 Genomic DNA. Translation: AAC04964.1.
M55416 Genomic DNA. Translation: AAB04029.1.
BK006935 Genomic DNA. Translation: DAA06995.1.
PIRiS23580.
RefSeqiNP_009410.1. NM_001178217.1.

Genome annotation databases

EnsemblFungiiYAR018C; YAR018C; YAR018C.
GeneIDi851273.
KEGGisce:YAR018C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M67445 Genomic DNA. Translation: AAA34399.2 .
X60549 Genomic DNA. Translation: CAA43042.1 .
L22015 Genomic DNA. Translation: AAC04964.1 .
M55416 Genomic DNA. Translation: AAB04029.1 .
BK006935 Genomic DNA. Translation: DAA06995.1 .
PIRi S23580.
RefSeqi NP_009410.1. NM_001178217.1.

3D structure databases

ProteinModelPortali P22209.
SMRi P22209. Positions 24-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31800. 191 interactions.
DIPi DIP-1646N.
IntActi P22209. 22 interactions.
MINTi MINT-397142.
STRINGi 4932.YAR018C.

Proteomic databases

MaxQBi P22209.
PaxDbi P22209.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAR018C ; YAR018C ; YAR018C .
GeneIDi 851273.
KEGGi sce:YAR018C.

Organism-specific databases

CYGDi YAR018c.
SGDi S000000071. KIN3.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118997.
HOGENOMi HOG000233029.
InParanoidi P22209.
KOi K08857.
OMAi EFATTYV.
OrthoDBi EOG7VB2QQ.

Enzyme and pathway databases

BioCyci YEAST:G3O-28874-MONOMER.
BRENDAi 2.7.11.1. 984.

Miscellaneous databases

NextBioi 968254.
PROi P22209.

Gene expression databases

Genevestigatori P22209.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the FUN52 gene, whose product has homology to protein kinases."
    Barton A.B., Davies C.J., Hutchison C.A. III, Kaback D.B.
    Gene 117:137-140(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "NPK1, a nonessential protein kinase gene in Saccharomyces cerevisiae with similarity to Aspergillus nidulans nimA."
    Schweitzer B., Philippsen P.
    Mol. Gen. Genet. 234:164-167(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
    Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
    Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. "Isolation of a novel protein kinase-encoding gene from yeast by oligodeoxyribonucleotide probing."
    Jones D.G.L., Rosamond J.
    Gene 90:87-92(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-369.
    Strain: SB303.

Entry informationi

Entry nameiKIN3_YEAST
AccessioniPrimary (citable) accession number: P22209
Secondary accession number(s): D6VPM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3