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P22202 (HSP74_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock protein SSA4
Gene names
Name:SSA4
Ordered Locus Names:YER103W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm.

Induction

HSP SSA4 expression is restricted to conditions of stress.

Miscellaneous

Present with 17900 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the heat shock protein 70 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642Heat shock protein SSA4
PRO_0000078388

Amino acid modifications

Modified residue5521Phosphoserine Ref.5

Secondary structure

... 642
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P22202 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 7A976357AC35C352

FASTA64269,651
        10         20         30         40         50         60 
MSKAVGIDLG TTYSCVAHFA NDRVEIIAND QGNRTTPSYV AFTDTERLIG DAAKNQAAMN 

        70         80         90        100        110        120 
PHNTVFDAKR LIGRKFDDPE VTNDAKHYPF KVIDKGGKPV VQVEYKGETK TFTPEEISSM 

       130        140        150        160        170        180 
ILTKMKETAE NFLGTEVKDA VVTVPAYFND SQRQATKDAG TIAGLNVLRI INEPTAAAIA 

       190        200        210        220        230        240 
YGLDKKSQKE HNVLIFDLGG GTFDVSLLSI DEGVFEVKAT AGDTHLGGED FDSRLVNFLA 

       250        260        270        280        290        300 
EEFKRKNKKD LTTNQRSLRR LRTAAERAKR TLSSSAQTSI EIDSLFEGID FYTSITRARF 

       310        320        330        340        350        360 
EELCADLFRS TLEPVEKVLA DSKLDKSQID EIVLVGGSTR IPKVQKLVSD FFNGKEPNRS 

       370        380        390        400        410        420 
INPDEAVAYG AAVQAAILTG DQSSTTQDLL LLDVAPLSLG IETAGGIMTK LIPRNSTIPT 

       430        440        450        460        470        480 
KKSEVFSTYA DNQPGVLIQV FEGERTRTKD NNLLGKFELS GIPPAPRGVP QIEVTFDIDA 

       490        500        510        520        530        540 
NGILNVSAVE KGTGKSNKIT ITNDKGRLSK EDIDKMVAEA EKFKAEDEQE AQRVQAKNQL 

       550        560        570        580        590        600 
ESYAFTLKNS VSENNFKEKV GEEDARKLEA AAQDAINWLD ASQAASTEEY KERQKELEGV 

       610        620        630        640 
ANPIMSKFYG AAGGAPGAGP VPGAGAGPTG APDNGPTVEE VD 

« Hide

References

« Hide 'large scale' references
[1]"Structure and regulation of the SSA4 HSP70 gene of Saccharomyces cerevisiae."
Boorstein W.R., Craig E.A.
J. Biol. Chem. 265:18912-18921(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DS10.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J05637 Genomic DNA. Translation: AAA63574.1.
U18839 Genomic DNA. Translation: AAB64658.1.
BK006939 Genomic DNA. Translation: DAA07764.1.
PIRB36590.
RefSeqNP_011029.3. NM_001178994.3.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3UPVX-ray1.60B636-642[»]
ProteinModelPortalP22202.
SMRP22202. Positions 1-605.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36849. 41 interactions.
DIPDIP-3916N.
IntActP22202. 19 interactions.
MINTMINT-523139.
STRING4932.YER103W.

Proteomic databases

MaxQBP22202.
PaxDbP22202.
PeptideAtlasP22202.
PRIDEP22202.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER103W; YER103W; YER103W.
GeneID856840.
KEGGsce:YER103W.

Organism-specific databases

SGDS000000905. SSA4.

Phylogenomic databases

eggNOGCOG0443.
GeneTreeENSGT00750000117918.
HOGENOMHOG000228135.
KOK03283.
OMACITEYLA.
OrthoDBEOG728916.

Enzyme and pathway databases

BioCycYEAST:G3O-30268-MONOMER.

Gene expression databases

GenevestigatorP22202.

Family and domain databases

Gene3D1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
SUPFAMSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio983153.

Entry information

Entry nameHSP74_YEAST
AccessionPrimary (citable) accession number: P22202
Secondary accession number(s): D3DM10
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references