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P22202

- HSP74_YEAST

UniProt

P22202 - HSP74_YEAST

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Protein
Heat shock protein SSA4
Gene
SSA4, YER103W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: SGD
  3. unfolded protein binding Source: SGD
Complete GO annotation...

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. SRP-dependent cotranslational protein targeting to membrane, translocation Source: SGD
  3. cellular response to heat Source: SGD
  4. protein folding Source: SGD
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30268-MONOMER.
ReactomeiREACT_219346. HSF1-dependent transactivation.
REACT_221137. Attenuation phase.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein SSA4
Gene namesi
Name:SSA4
Ordered Locus Names:YER103W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

SGDiS000000905. SSA4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Heat shock protein SSA4
PRO_0000078388Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei552 – 5521Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP22202.
PaxDbiP22202.
PeptideAtlasiP22202.
PRIDEiP22202.

Expressioni

Inductioni

HSP SSA4 expression is restricted to conditions of stress.

Gene expression databases

GenevestigatoriP22202.

Interactioni

Protein-protein interaction databases

BioGridi36849. 41 interactions.
DIPiDIP-3916N.
IntActiP22202. 19 interactions.
MINTiMINT-523139.
STRINGi4932.YER103W.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi637 – 6393

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UPVX-ray1.60B636-642[»]
ProteinModelPortaliP22202.
SMRiP22202. Positions 1-605.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0443.
GeneTreeiENSGT00750000117918.
HOGENOMiHOG000228135.
KOiK03283.
OMAiCITEYLA.
OrthoDBiEOG728916.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22202-1 [UniParc]FASTAAdd to Basket

« Hide

MSKAVGIDLG TTYSCVAHFA NDRVEIIAND QGNRTTPSYV AFTDTERLIG    50
DAAKNQAAMN PHNTVFDAKR LIGRKFDDPE VTNDAKHYPF KVIDKGGKPV 100
VQVEYKGETK TFTPEEISSM ILTKMKETAE NFLGTEVKDA VVTVPAYFND 150
SQRQATKDAG TIAGLNVLRI INEPTAAAIA YGLDKKSQKE HNVLIFDLGG 200
GTFDVSLLSI DEGVFEVKAT AGDTHLGGED FDSRLVNFLA EEFKRKNKKD 250
LTTNQRSLRR LRTAAERAKR TLSSSAQTSI EIDSLFEGID FYTSITRARF 300
EELCADLFRS TLEPVEKVLA DSKLDKSQID EIVLVGGSTR IPKVQKLVSD 350
FFNGKEPNRS INPDEAVAYG AAVQAAILTG DQSSTTQDLL LLDVAPLSLG 400
IETAGGIMTK LIPRNSTIPT KKSEVFSTYA DNQPGVLIQV FEGERTRTKD 450
NNLLGKFELS GIPPAPRGVP QIEVTFDIDA NGILNVSAVE KGTGKSNKIT 500
ITNDKGRLSK EDIDKMVAEA EKFKAEDEQE AQRVQAKNQL ESYAFTLKNS 550
VSENNFKEKV GEEDARKLEA AAQDAINWLD ASQAASTEEY KERQKELEGV 600
ANPIMSKFYG AAGGAPGAGP VPGAGAGPTG APDNGPTVEE VD 642
Length:642
Mass (Da):69,651
Last modified:January 23, 2007 - v3
Checksum:i7A976357AC35C352
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05637 Genomic DNA. Translation: AAA63574.1.
U18839 Genomic DNA. Translation: AAB64658.1.
BK006939 Genomic DNA. Translation: DAA07764.1.
PIRiB36590.
RefSeqiNP_011029.3. NM_001178994.3.

Genome annotation databases

EnsemblFungiiYER103W; YER103W; YER103W.
GeneIDi856840.
KEGGisce:YER103W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05637 Genomic DNA. Translation: AAA63574.1 .
U18839 Genomic DNA. Translation: AAB64658.1 .
BK006939 Genomic DNA. Translation: DAA07764.1 .
PIRi B36590.
RefSeqi NP_011029.3. NM_001178994.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UPV X-ray 1.60 B 636-642 [» ]
ProteinModelPortali P22202.
SMRi P22202. Positions 1-605.
ModBasei Search...

Protein-protein interaction databases

BioGridi 36849. 41 interactions.
DIPi DIP-3916N.
IntActi P22202. 19 interactions.
MINTi MINT-523139.
STRINGi 4932.YER103W.

Proteomic databases

MaxQBi P22202.
PaxDbi P22202.
PeptideAtlasi P22202.
PRIDEi P22202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER103W ; YER103W ; YER103W .
GeneIDi 856840.
KEGGi sce:YER103W.

Organism-specific databases

SGDi S000000905. SSA4.

Phylogenomic databases

eggNOGi COG0443.
GeneTreei ENSGT00750000117918.
HOGENOMi HOG000228135.
KOi K03283.
OMAi CITEYLA.
OrthoDBi EOG728916.

Enzyme and pathway databases

BioCyci YEAST:G3O-30268-MONOMER.
Reactomei REACT_219346. HSF1-dependent transactivation.
REACT_221137. Attenuation phase.

Miscellaneous databases

NextBioi 983153.

Gene expression databases

Genevestigatori P22202.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and regulation of the SSA4 HSP70 gene of Saccharomyces cerevisiae."
    Boorstein W.R., Craig E.A.
    J. Biol. Chem. 265:18912-18921(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DS10.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHSP74_YEAST
AccessioniPrimary (citable) accession number: P22202
Secondary accession number(s): D3DM10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 17900 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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