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P22202

- HSP74_YEAST

UniProt

P22202 - HSP74_YEAST

Protein

Heat shock protein SSA4

Gene

SSA4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase activity Source: SGD
    2. ATP binding Source: UniProtKB-KW
    3. unfolded protein binding Source: SGD

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. cellular response to heat Source: SGD
    3. protein folding Source: SGD
    4. SRP-dependent cotranslational protein targeting to membrane, translocation Source: SGD

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30268-MONOMER.
    ReactomeiREACT_219346. HSF1-dependent transactivation.
    REACT_221137. Attenuation phase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock protein SSA4
    Gene namesi
    Name:SSA4
    Ordered Locus Names:YER103W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    SGDiS000000905. SSA4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 642642Heat shock protein SSA4PRO_0000078388Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei552 – 5521Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP22202.
    PaxDbiP22202.
    PeptideAtlasiP22202.
    PRIDEiP22202.

    Expressioni

    Inductioni

    HSP SSA4 expression is restricted to conditions of stress.

    Gene expression databases

    GenevestigatoriP22202.

    Interactioni

    Protein-protein interaction databases

    BioGridi36849. 41 interactions.
    DIPiDIP-3916N.
    IntActiP22202. 19 interactions.
    MINTiMINT-523139.
    STRINGi4932.YER103W.

    Structurei

    Secondary structure

    1
    642
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi637 – 6393

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3UPVX-ray1.60B636-642[»]
    ProteinModelPortaliP22202.
    SMRiP22202. Positions 1-605.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Phylogenomic databases

    eggNOGiCOG0443.
    GeneTreeiENSGT00750000117918.
    HOGENOMiHOG000228135.
    KOiK03283.
    OMAiCITEYLA.
    OrthoDBiEOG728916.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22202-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKAVGIDLG TTYSCVAHFA NDRVEIIAND QGNRTTPSYV AFTDTERLIG    50
    DAAKNQAAMN PHNTVFDAKR LIGRKFDDPE VTNDAKHYPF KVIDKGGKPV 100
    VQVEYKGETK TFTPEEISSM ILTKMKETAE NFLGTEVKDA VVTVPAYFND 150
    SQRQATKDAG TIAGLNVLRI INEPTAAAIA YGLDKKSQKE HNVLIFDLGG 200
    GTFDVSLLSI DEGVFEVKAT AGDTHLGGED FDSRLVNFLA EEFKRKNKKD 250
    LTTNQRSLRR LRTAAERAKR TLSSSAQTSI EIDSLFEGID FYTSITRARF 300
    EELCADLFRS TLEPVEKVLA DSKLDKSQID EIVLVGGSTR IPKVQKLVSD 350
    FFNGKEPNRS INPDEAVAYG AAVQAAILTG DQSSTTQDLL LLDVAPLSLG 400
    IETAGGIMTK LIPRNSTIPT KKSEVFSTYA DNQPGVLIQV FEGERTRTKD 450
    NNLLGKFELS GIPPAPRGVP QIEVTFDIDA NGILNVSAVE KGTGKSNKIT 500
    ITNDKGRLSK EDIDKMVAEA EKFKAEDEQE AQRVQAKNQL ESYAFTLKNS 550
    VSENNFKEKV GEEDARKLEA AAQDAINWLD ASQAASTEEY KERQKELEGV 600
    ANPIMSKFYG AAGGAPGAGP VPGAGAGPTG APDNGPTVEE VD 642
    Length:642
    Mass (Da):69,651
    Last modified:January 23, 2007 - v3
    Checksum:i7A976357AC35C352
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05637 Genomic DNA. Translation: AAA63574.1.
    U18839 Genomic DNA. Translation: AAB64658.1.
    BK006939 Genomic DNA. Translation: DAA07764.1.
    PIRiB36590.
    RefSeqiNP_011029.3. NM_001178994.3.

    Genome annotation databases

    EnsemblFungiiYER103W; YER103W; YER103W.
    GeneIDi856840.
    KEGGisce:YER103W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05637 Genomic DNA. Translation: AAA63574.1 .
    U18839 Genomic DNA. Translation: AAB64658.1 .
    BK006939 Genomic DNA. Translation: DAA07764.1 .
    PIRi B36590.
    RefSeqi NP_011029.3. NM_001178994.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3UPV X-ray 1.60 B 636-642 [» ]
    ProteinModelPortali P22202.
    SMRi P22202. Positions 1-605.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36849. 41 interactions.
    DIPi DIP-3916N.
    IntActi P22202. 19 interactions.
    MINTi MINT-523139.
    STRINGi 4932.YER103W.

    Proteomic databases

    MaxQBi P22202.
    PaxDbi P22202.
    PeptideAtlasi P22202.
    PRIDEi P22202.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER103W ; YER103W ; YER103W .
    GeneIDi 856840.
    KEGGi sce:YER103W.

    Organism-specific databases

    SGDi S000000905. SSA4.

    Phylogenomic databases

    eggNOGi COG0443.
    GeneTreei ENSGT00750000117918.
    HOGENOMi HOG000228135.
    KOi K03283.
    OMAi CITEYLA.
    OrthoDBi EOG728916.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30268-MONOMER.
    Reactomei REACT_219346. HSF1-dependent transactivation.
    REACT_221137. Attenuation phase.

    Miscellaneous databases

    NextBioi 983153.

    Gene expression databases

    Genevestigatori P22202.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and regulation of the SSA4 HSP70 gene of Saccharomyces cerevisiae."
      Boorstein W.R., Craig E.A.
      J. Biol. Chem. 265:18912-18921(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DS10.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHSP74_YEAST
    AccessioniPrimary (citable) accession number: P22202
    Secondary accession number(s): D3DM10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 137 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 17900 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3