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Reviewed, UniProtKB/Swiss-Prot P22196 (PER2_ARAHY)

Last modified June 16, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cationic peroxidase 2
    EC=1.11.1.7
Alternative name(s):
    PNPC2
Gene names
Name: PNC2
OrganismArachis hypogaea (Peanut)
Taxonomic identifier3818 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Dalbergieae › Arachis

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Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activity

Donor + H2O2 = oxidized donor + 2 H2O.

Cofactor

Binds 2 calcium ions per subunit.

Binds 1 heme B (iron-protoporphyrin IX) group per subunit.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.

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Ontologies

Keywords
   Biological processHydrogen peroxide
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Heme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

electron carrier activity

Inferred from electronic annotation. Source: InterPro

heme binding

Inferred from electronic annotation. Source: InterPro

peroxidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 330307Cationic peroxidase 2
PRO_0000023747

Sites

Active site721Proton acceptor By similarity
Metal binding731Calcium 1 By similarity
Metal binding761Calcium 1; via carbonyl oxygen By similarity
Metal binding781Calcium 1; via carbonyl oxygen By similarity
Metal binding801Calcium 1 By similarity
Metal binding821Calcium 1 By similarity
Metal binding1941Iron (heme axial ligand) By similarity
Metal binding1951Calcium 2 By similarity
Metal binding2461Calcium 2 By similarity
Metal binding2491Calcium 2 By similarity
Metal binding2541Calcium 2 By similarity
Binding site1641Substrate; via carbonyl oxygen By similarity
Site681Transition state stabilizer By similarity

Amino acid modifications

Glycosylation2121N-linked (GlcNAc...) Potential
Disulfide bond41 ↔ 117 By similarity
Disulfide bond74 ↔ 79 By similarity
Disulfide bond123 ↔ 326 By similarity
Disulfide bond201 ↔ 233 By similarity

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Sequences

Sequence LengthMass (Da)Tools
P22196-1 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: A751978FDD9B63D2

FASTA33035,556
        10         20         30         40         50         60 
MEGVFNNKKF ILVFVFMLGL CIGITTVHGQ GTRVGFYSRT CPRAESIVRS TVRSHVNSDP 

        70         80         90        100        110        120 
TLAAKILRMH FHDCFVQGCD GSILISGPAT EKTAFANLGL RGYEIIDDAK TQLEAACPGV 

       130        140        150        160        170        180 
VSCADILALA ARDSVVLSGG LSWQVPTGRR DGRVSQASDV SNLPAPSDSV DVQKQKFAAK 

       190        200        210        220        230        240 
GLNTQDLVTL VGGHTIGTSE CQFFSNRLFN FNGTAAADPA IDPSFVSNLQ ALCPQNTGAA 

       250        260        270        280        290        300 
NRVALDTGSQ FKFDTSYFSN LRNRRGVLQS DQALWNDPST KSFVQRYLGL RGFLGLTFNV 

       310        320        330 
EFGKSMVKMS NIGVKTGTDG EIRKICSAFN

« Hide

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References

[1]"Molecular cloning of complementary DNAs encoding two cationic peroxidases from cultivated peanut cells."
Buffard D., Breda C., van Huystee R.B., Asemota O., Pierre M., Dang Ha D.B., Esnault R.
Proc. Natl. Acad. Sci. U.S.A. 87:8874-8878(1990) [PubMed: 2247460] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

M37637 mRNA. Translation: AAA32676.1.
PIRB38265.

3D structure databases

HSSPHSSP built from PDB template 1PA2 based on UniProtKB Q42578.
ModBaseSearch...

Protein family/group databases

PeroxiBase103. AhPrx05.

Enzyme and pathway databases

BRENDA1.11.1.7. 569.

Family and domain databases

InterProIPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
PROSITEPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePER2_ARAHY
AccessionPrimary (citable) accession number: P22196
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents