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Protein

Calcium-transporting ATPase 3

Gene

cta3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei368 – 36814-aspartylphosphate intermediateBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium-transporting ATPase activity Source: PomBase
  • metal ion binding Source: InterPro
  • potassium-transporting ATPase activity Source: PomBase

GO - Biological processi

  • calcium ion transmembrane transport Source: PomBase
  • potassium ion export across plasma membrane Source: PomBase
  • sequestering of calcium ion Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-418359. Reduction of cytosolic Ca++ levels.
R-SPO-5578775. Ion homeostasis.
R-SPO-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.9.2. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase 3 (EC:3.6.3.8)
Gene namesi
Name:cta3
ORF Names:SPBC24E9.06, SPBC839.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC839.06.
PomBaseiSPBC839.06. cta3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence analysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Transmembranei314 – 33421HelicalSequence analysisAdd
BLAST
Transmembranei761 – 78121HelicalSequence analysisAdd
BLAST
Transmembranei845 – 86521HelicalSequence analysisAdd
BLAST
Transmembranei890 – 91021HelicalSequence analysisAdd
BLAST
Transmembranei940 – 96021HelicalSequence analysisAdd
BLAST
Transmembranei970 – 99021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: PomBase
  • vacuole Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10371037Calcium-transporting ATPase 3PRO_0000046238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1012 – 10121Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP22189.

PTM databases

iPTMnetiP22189.

Interactioni

Protein-protein interaction databases

BioGridi277718. 9 interactions.
MINTiMINT-4687670.

Structurei

3D structure databases

ProteinModelPortaliP22189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000265621.
InParanoidiP22189.
OMAiILIMAVE.
OrthoDBiEOG092C0DMA.
PhylomeDBiP22189.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006414. P-type_ATPase_IID.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01523. ATPase-IID_K-Na. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTINISNPV YFSDIKDVES EFLTSIPNGL THEEAQNRLS EYGENRLEAD
60 70 80 90 100
SGVSAWKVLL RQVLNAMCVV LILAAALSFG TTDWIEGGVI SAIIVLNITV
110 120 130 140 150
GFIQEYKAEK TMDSLRTLAS PMAHVTRSSK TDAIDSHLLV PGDVVVLKTG
160 170 180 190 200
DVVPADLRLV ETVNFETDEA LLTGESLPVI KDAHATFQMN EDVPIGDRIN
210 220 230 240 250
LAYSSSIVTK GRAKGICYAT GMQTQIGAIA AGLRQKGKLF QRPEKDEPNY
260 270 280 290 300
RRKLNKYYLK VTSYYVQRVL GLNVGTPLQR KLTVLAYILF CIAIILAIIV
310 320 330 340 350
MAAHSFHVTN EVSIYAISLG ISIIPESLIA VLSITMAMGQ KNMSKRRVIV
360 370 380 390 400
RKLEALEALG GVTDICSDKT GTITQGKMIT RRVWIPSYGY LSVDTSDANN
410 420 430 440 450
PTIGTVSGLE AAMQDVLKEK KQEMKNIDPS NQPSDQFIPL LKTCALCNLS
460 470 480 490 500
TVNQTETGEW VVKGEPTEIA LHVFSKRFNY GKEDLLKTNT FVREYPFDSE
510 520 530 540 550
IKRMAVIYED QQGQYTVYAK GAVERILERC STSNGSTLEE PDRELIIAQM
560 570 580 590 600
ETLAAEGLRV LALATKVIDK ADNWETLPRD VAESSLEFVS LVGIYDPPRT
610 620 630 640 650
ESKGAVELCH RAGIRVHMLT GDHPETAKAI AREVGIIPPF ISDRDPNMSW
660 670 680 690 700
MVMTGSQFDA LSDEEVDSLK ALCLVIARCA PQTKVKMIEA LHRRKAFVAM
710 720 730 740 750
TGDGVNDSPS LKQANVGIAM GQNGSDVAKD ASDIVLTDDN FSSIVNAIEE
760 770 780 790 800
GRRMFDNIMR FVLHLLVSNV GEVILLVVGL AFRDEVHLSV FPMSPVEILW
810 820 830 840 850
CNMITSSFPS MGLGMELAQP DVMERLPHDN KVGIFQKSLI VDMMVYGFFL
860 870 880 890 900
GVVSLMTWVV IMYGFGTGNL SYDCNAHYHA GCNDVFKARS AVFAVVTFCI
910 920 930 940 950
LIMAVEVKNF DNSLFNLHGI PWGEWNFRYF LHTLVENKFL AWAIALAAVS
960 970 980 990 1000
VFPTIYIPVI NRDVFKHTYI GWEWGVVAVA VMFYFFYVEI WKSIRRSLTN
1010 1020 1030
PQKKGKFRRT LSNTITTESK LSEKDLEHRL FLQSRRA
Length:1,037
Mass (Da):115,327
Last modified:August 1, 1991 - v1
Checksum:i80D2BDF2292CE2B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05634 Genomic DNA. Translation: AAA35290.1.
CU329671 Genomic DNA. Translation: CAB46699.1.
PIRiA36096.
RefSeqiNP_595246.1. NM_001021152.2.

Genome annotation databases

EnsemblFungiiSPBC839.06.1; SPBC839.06.1:pep; SPBC839.06.
GeneIDi2541204.
KEGGispo:SPBC839.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05634 Genomic DNA. Translation: AAA35290.1.
CU329671 Genomic DNA. Translation: CAB46699.1.
PIRiA36096.
RefSeqiNP_595246.1. NM_001021152.2.

3D structure databases

ProteinModelPortaliP22189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277718. 9 interactions.
MINTiMINT-4687670.

Protein family/group databases

TCDBi3.A.3.9.2. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiP22189.

Proteomic databases

MaxQBiP22189.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC839.06.1; SPBC839.06.1:pep; SPBC839.06.
GeneIDi2541204.
KEGGispo:SPBC839.06.

Organism-specific databases

EuPathDBiFungiDB:SPBC839.06.
PomBaseiSPBC839.06. cta3.

Phylogenomic databases

HOGENOMiHOG000265621.
InParanoidiP22189.
OMAiILIMAVE.
OrthoDBiEOG092C0DMA.
PhylomeDBiP22189.

Enzyme and pathway databases

ReactomeiR-SPO-418359. Reduction of cytosolic Ca++ levels.
R-SPO-5578775. Ion homeostasis.
R-SPO-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiP22189.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006414. P-type_ATPase_IID.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01523. ATPase-IID_K-Na. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATC3_SCHPO
AccessioniPrimary (citable) accession number: P22189
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: September 7, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.