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P22189 (ATC3_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium-transporting ATPase 3
EC=3.6.3.8
Gene names
Name:cta3
ORF Names:SPBC24E9.06, SPBC839.06
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length1037 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.

Catalytic activity

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10371037Calcium-transporting ATPase 3
PRO_0000046238

Regions

Transmembrane62 – 8221Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane282 – 30221Helical; Potential
Transmembrane314 – 33421Helical; Potential
Transmembrane761 – 78121Helical; Potential
Transmembrane845 – 86521Helical; Potential
Transmembrane890 – 91021Helical; Potential
Transmembrane940 – 96021Helical; Potential
Transmembrane970 – 99021Helical; Potential

Sites

Active site36814-aspartylphosphate intermediate By similarity

Amino acid modifications

Modified residue10121Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
P22189 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 80D2BDF2292CE2B9

FASTA1,037115,327
        10         20         30         40         50         60 
MVTINISNPV YFSDIKDVES EFLTSIPNGL THEEAQNRLS EYGENRLEAD SGVSAWKVLL 

        70         80         90        100        110        120 
RQVLNAMCVV LILAAALSFG TTDWIEGGVI SAIIVLNITV GFIQEYKAEK TMDSLRTLAS 

       130        140        150        160        170        180 
PMAHVTRSSK TDAIDSHLLV PGDVVVLKTG DVVPADLRLV ETVNFETDEA LLTGESLPVI 

       190        200        210        220        230        240 
KDAHATFQMN EDVPIGDRIN LAYSSSIVTK GRAKGICYAT GMQTQIGAIA AGLRQKGKLF 

       250        260        270        280        290        300 
QRPEKDEPNY RRKLNKYYLK VTSYYVQRVL GLNVGTPLQR KLTVLAYILF CIAIILAIIV 

       310        320        330        340        350        360 
MAAHSFHVTN EVSIYAISLG ISIIPESLIA VLSITMAMGQ KNMSKRRVIV RKLEALEALG 

       370        380        390        400        410        420 
GVTDICSDKT GTITQGKMIT RRVWIPSYGY LSVDTSDANN PTIGTVSGLE AAMQDVLKEK 

       430        440        450        460        470        480 
KQEMKNIDPS NQPSDQFIPL LKTCALCNLS TVNQTETGEW VVKGEPTEIA LHVFSKRFNY 

       490        500        510        520        530        540 
GKEDLLKTNT FVREYPFDSE IKRMAVIYED QQGQYTVYAK GAVERILERC STSNGSTLEE 

       550        560        570        580        590        600 
PDRELIIAQM ETLAAEGLRV LALATKVIDK ADNWETLPRD VAESSLEFVS LVGIYDPPRT 

       610        620        630        640        650        660 
ESKGAVELCH RAGIRVHMLT GDHPETAKAI AREVGIIPPF ISDRDPNMSW MVMTGSQFDA 

       670        680        690        700        710        720 
LSDEEVDSLK ALCLVIARCA PQTKVKMIEA LHRRKAFVAM TGDGVNDSPS LKQANVGIAM 

       730        740        750        760        770        780 
GQNGSDVAKD ASDIVLTDDN FSSIVNAIEE GRRMFDNIMR FVLHLLVSNV GEVILLVVGL 

       790        800        810        820        830        840 
AFRDEVHLSV FPMSPVEILW CNMITSSFPS MGLGMELAQP DVMERLPHDN KVGIFQKSLI 

       850        860        870        880        890        900 
VDMMVYGFFL GVVSLMTWVV IMYGFGTGNL SYDCNAHYHA GCNDVFKARS AVFAVVTFCI 

       910        920        930        940        950        960 
LIMAVEVKNF DNSLFNLHGI PWGEWNFRYF LHTLVENKFL AWAIALAAVS VFPTIYIPVI 

       970        980        990       1000       1010       1020 
NRDVFKHTYI GWEWGVVAVA VMFYFFYVEI WKSIRRSLTN PQKKGKFRRT LSNTITTESK 

      1030 
LSEKDLEHRL FLQSRRA

« Hide

References

« Hide 'large scale' references
[1]"Calcium homeostasis and transport are affected by disruption of cta3, a novel gene encoding Ca2(+)-ATPase in Schizosaccharomyces pombe."
Ghislain M., Goffeau A., Halachmi D., Eilam Y.
J. Biol. Chem. 265:18400-18407(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1012, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J05634 Genomic DNA. Translation: AAA35290.1.
CU329671 Genomic DNA. Translation: CAB46699.1.
PIRA36096.
RefSeqNP_595246.1. NM_001021152.2.

3D structure databases

ProteinModelPortalP22189.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4687670.
STRING4896.SPBC839.06-1.

Protein family/group databases

TCDB3.A.3.9.2. P-type ATPase (P-ATPase) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC839.06.1; SPBC839.06.1:pep; SPBC839.06.
GeneID2541204.
KEGGspo:SPBC839.06.

Organism-specific databases

PomBaseSPBC839.06.

Phylogenomic databases

eggNOGCOG0474.
HOGENOMHOG000265621.
KOK01537.
OMAELLWINL.
OrthoDBEOG46X2HG.

Family and domain databases

Gene3D1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR006414. ATPase_P-typ_Na/Ca.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PANTHERPTHR24093. PTHR24093. 1 hit.
PTHR24093:SF105. PTHR24093:SF105. 1 hit.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF81660. ATPase_cation_domN. 1 hit.
SSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01523. ATPase-IID_K-Na. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802316.

Entry information

Entry nameATC3_SCHPO
AccessionPrimary (citable) accession number: P22189
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 29, 2013
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents