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Protein

RNA-directed RNA polymerase

Gene

VP1

Organism
Infectious pancreatic necrosis virus (strain Sp) (IPNV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi248 – 255GTPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RDRP
Alternative name(s):
Protein VP1
Gene namesi
Name:VP1
OrganismiInfectious pancreatic necrosis virus (strain Sp) (IPNV)
Taxonomic identifieri11005 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesBirnaviridaeAquabirnavirus
Virus hostiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) [TaxID: 8022]
Salmo [TaxID: 8028]
Proteomesi
  • UP000007213 Componenti: Genome

Subcellular locationi

  • Virion By similarity
  • Note: Minor amounts are incorporated in the virion.By similarity

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002219641 – 844RNA-directed RNA polymeraseAdd BLAST844

Post-translational modificationi

Exists in multiple phosphorylated forms.

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRIDEiP22174.

Interactioni

Subunit structurei

Interacts with VP3 in the cytoplasm.By similarity

Structurei

3D structure databases

ProteinModelPortaliP22174.
SMRiP22174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini384 – 588RdRp catalyticPROSITE-ProRule annotationAdd BLAST205

Phylogenomic databases

OrthoDBiVOG0900001R.

Family and domain databases

InterProiView protein in InterPro
IPR007100. RNA-dir_pol_birnavirus.
IPR007098. RNA-dir_pol_mononegavirus.
PfamiView protein in Pfam
PF04197. Birna_RdRp. 1 hit.
PROSITEiView protein in PROSITE
PS50524. RDRP_DSRNA_BIR. 1 hit.

Sequencei

Sequence statusi: Complete.

P22174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIFNSPQN KASILNALMK STQGDVEDVL IPKRFRPAKD PLDSPQAAAA
60 70 80 90 100
FLKEHKYRIL RPRAIPTMVE IETDAALPRL AAMVDDGKLK EMVNVPEGTT
110 120 130 140 150
AFYPKYYPFH RPDHDDVGTF GAPDITLLKQ LTFFLLENDF PTGPETLRQV
160 170 180 190 200
REAIATLQYG SGSYSGQLNR LLAMKGVATG RNPNKTPLAV GYTNEQMARL
210 220 230 240 250
MEQTLPINPP KNEDPDLRWA PSWLIQYTGD ASTDKSYLPH VTAKSSAGLP
260 270 280 290 300
YIGKTKGDTT AEALVLADSF IRDLGKAATS ADPGAAAKKV LSDFWYLSCG
310 320 330 340 350
LLFPKGERYT QKDWDLKTRN IWSAPYPTHL LLSMVSSPVM DESKLNITNT
360 370 380 390 400
QTPSLYGFSP FHGGINRIMT IIREHLDQEQ DLVMIYADNI YILQDNTWYS
410 420 430 440 450
IDLEKGEANC TPQHMQAMMY YRLTREWTNE DGSPRYNPTW ATFAMYVGPS
460 470 480 490 500
MVVDSTCLLM NLQLKTTGQG SGNAFTFLNN HLMSTIVVAE WHKAGRPNPM
510 520 530 540 550
SKEFMDLEAK TGINFKIERE LKDLRSIIME AVDTAPLDGY LADGSDLPPR
560 570 580 590 600
VPGKAVELDL LGWSAVYSRQ LEMFVPVLEN ERLIASVAYP KGLENKSLAR
610 620 630 640 650
KPGAEIAYQI VRYEAIRLIG GWNNPLIETA AKHMSLDKRK RLEVKGIDVT
660 670 680 690 700
GFLDDWNTMS EFGGDLEGIS LTAPLTNQTL LDINTPETEF DVKDRPPTPR
710 720 730 740 750
SPGKTLAEVT AAITSGTYKD PKSAVWRLLD QRTKLRVSTL RDHAHALKPA
760 770 780 790 800
ASTSDFWGDA TEELAEQQQL LMKANNLLKS SLTEAREALE TVQSDKIISG
810 820 830 840
KTSPEKNPGT AANPVVAYGE FSEKIPLTPT QKKNAKRREK QRRN
Length:844
Mass (Da):94,089
Last modified:August 1, 1991 - v1
Checksum:i0E8D7B9553A7A456
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58757 Genomic RNA. Translation: AAA46244.1.
PIRiB37946. RRXSSP.

Similar proteinsi

Entry informationi

Entry nameiRDRP_IPNVS
AccessioniPrimary (citable) accession number: P22174
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: March 15, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome