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P22143

- CYAH_MYRVE

UniProt

P22143 - CYAH_MYRVE

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Protein

Cyanamide hydratase

Gene

CAH

Organism
Myrothecium verrucaria
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

When used as herbicide in agriculture, cyanamide can be transformed, after sowing, in soil fertilizing ammonia by the combined action of M.verrucaria cyanamide hydratase and urease.

Catalytic activityi

Urea = cyanamide + H2O.

Cofactori

Zinc.

GO - Molecular functioni

  1. cyanamide hydratase activity Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cyanamide metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cyanamide hydratase (EC:4.2.1.69)
Alternative name(s):
Urea hydro-lyase
Gene namesi
Name:CAH
OrganismiMyrothecium verrucaria
Taxonomic identifieri5532 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesmitosporic HypocrealesMyrothecium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Cyanamide hydratasePRO_0000079747Add
BLAST

Interactioni

Subunit structurei

Homohexamer.

Structurei

3D structure databases

ProteinModelPortaliP22143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
InterProiIPR017771. Cyanamide_hydratase_HD.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]
PfamiPF01966. HD. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03401. cyanamide_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

P22143-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSEVKANG WTAVPVSAKA IVDSLGKLGD VSSYSVEDIA FPAADKLVAE
60 70 80 90 100
AQAFVKARLS PETYNHSMRV FYWGTVIARR LLPEQAKDLS PSTWALTCLL
110 120 130 140 150
HDVGTAEAYF TSTRMSFDIY GGIKAMEVLK VLGSSTDQAE AVAEAIIRHE
160 170 180 190 200
DVGVDGNITF LGQLIQLATL YDNVGAYDGI DDFGSWVDDT TRNSINTAFP
210 220 230 240
RHGWCSWFAC TVRKEESNKP WCHTTHIPQF DKQMEANTLM KPWE
Length:244
Mass (Da):26,966
Last modified:August 1, 1991 - v1
Checksum:i880FA11F30E31CE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59078 Genomic DNA. Translation: AAA33429.1.
PIRiA39365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59078 Genomic DNA. Translation: AAA33429.1 .
PIRi A39365.

3D structure databases

ProteinModelPortali P22143.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.3210.10. 1 hit.
InterProi IPR017771. Cyanamide_hydratase_HD.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view ]
Pfami PF01966. HD. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03401. cyanamide_fam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation and properties of a nitrile hydratase from the soil fungus Myrothecium verrucaria that is highly specific for the fertilizer cyanamide and cloning of its gene."
    Maier-Greiner U.M., Obermaier-Skrobranek B.M.M., Estermaier L.M., Kammerloher W., Freund C., Wuelfing C., Burkert U.I., Matern D.H., Breuer M., Eulitz M., Kuefrevioglu O.I., Hartmann G.R.
    Proc. Natl. Acad. Sci. U.S.A. 88:4260-4264(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: DSM 2087.

Entry informationi

Entry nameiCYAH_MYRVE
AccessioniPrimary (citable) accession number: P22143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

This enzyme is highly specific for cyanamide.

Keywords - Technical termi

Direct protein sequencing

External Data

Dasty 3