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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Gene

RPB10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Zinc
Metal bindingi10 – 101Zinc
Metal bindingi44 – 441Zinc
Metal bindingi45 – 451Zinc

GO - Molecular functioni

  • DNA binding Source: InterPro
  • RNA polymerase I activity Source: UniProtKB
  • zinc ion binding Source: SGD

GO - Biological processi

  • ribosome biogenesis Source: UniProtKB-KW
  • transcription, RNA-templated Source: GOC
  • transcription from RNA polymerase III promoter Source: SGD
  • transcription from RNA polymerase II promoter Source: SGD
  • transcription from RNA polymerase I promoter Source: UniProtKB
  • tRNA transcription from RNA polymerase III promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, Transcription

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33712-MONOMER.
ReactomeiREACT_273109. Formation of the Early Elongation Complex.
REACT_273984. Dual incision reaction in TC-NER.
REACT_277632. mRNA Capping.
REACT_294700. mRNA Splicing - Minor Pathway.
REACT_296055. RNA Polymerase II Promoter Escape.
REACT_300180. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_310018. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_315180. RNA Polymerase II Pre-transcription Events.
REACT_317581. Processing of Capped Intron-Containing Pre-mRNA.
REACT_319823. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_320683. RNA Polymerase III Chain Elongation.
REACT_322294. RNA Pol II CTD phosphorylation and interaction with CE.
REACT_328223. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_330471. RNA Polymerase III Abortive And Retractive Initiation.
REACT_331999. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_335551. RNA Polymerase III Transcription Termination.
REACT_341636. Transcription-coupled NER (TC-NER).
REACT_345860. RNA Polymerase II Transcription Initiation.
REACT_348423. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Short name:
RNA polymerases I, II, and III subunit ABC5
Alternative name(s):
ABC10-beta
ABC8
DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide
Gene namesi
Name:RPB10
Ordered Locus Names:YOR210W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XV

Organism-specific databases

CYGDiYOR210w.
EuPathDBiFungiDB:YOR210W.
SGDiS000005736. RPB10.

Subcellular locationi

GO - Cellular componenti

  • DNA-directed RNA polymerase I complex Source: UniProtKB
  • DNA-directed RNA polymerase II, core complex Source: SGD
  • DNA-directed RNA polymerase III complex Source: SGD
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070DNA-directed RNA polymerases I, II, and III subunit RPABC5PRO_0000121342Add
BLAST

Proteomic databases

MaxQBiP22139.
PaxDbiP22139.
PeptideAtlasiP22139.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.6 Publications

Protein-protein interaction databases

BioGridi34605. 75 interactions.
DIPiDIP-825N.
IntActiP22139. 17 interactions.
MINTiMINT-384345.

Structurei

Secondary structure

1
70
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni8 – 103Combined sources
Helixi15 – 173Combined sources
Helixi18 – 269Combined sources
Turni27 – 293Combined sources
Helixi32 – 387Combined sources
Helixi44 – 518Combined sources
Helixi57 – 615Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I3QX-ray3.10J1-70[»]
1I50X-ray2.80J1-70[»]
1I6HX-ray3.30J1-70[»]
1K83X-ray2.80J1-70[»]
1NIKX-ray4.10J1-70[»]
1NT9X-ray4.20J1-70[»]
1PQVX-ray3.80J1-70[»]
1R5UX-ray4.50J1-70[»]
1R9SX-ray4.25J1-70[»]
1R9TX-ray3.50J1-70[»]
1SFOX-ray3.61J1-70[»]
1TWAX-ray3.20J1-70[»]
1TWCX-ray3.00J1-70[»]
1TWFX-ray2.30J1-70[»]
1TWGX-ray3.30J1-70[»]
1TWHX-ray3.40J1-70[»]
1WCMX-ray3.80J1-70[»]
1Y1VX-ray3.80J1-70[»]
1Y1WX-ray4.00J1-70[»]
1Y1YX-ray4.00J1-70[»]
1Y77X-ray4.50J1-70[»]
2B63X-ray3.80J1-70[»]
2B8KX-ray4.15J1-70[»]
2E2HX-ray3.95J1-70[»]
2E2IX-ray3.41J1-70[»]
2E2JX-ray3.50J1-70[»]
2JA5X-ray3.80J1-70[»]
2JA6X-ray4.00J1-70[»]
2JA7X-ray3.80J/V1-70[»]
2JA8X-ray3.80J1-70[»]
2NVQX-ray2.90J1-70[»]
2NVTX-ray3.36J1-70[»]
2NVXX-ray3.60J1-70[»]
2NVYX-ray3.40J1-70[»]
2NVZX-ray4.30J1-70[»]
2R7ZX-ray3.80J1-70[»]
2R92X-ray3.80J1-70[»]
2R93X-ray4.00J1-70[»]
2VUMX-ray3.40J1-70[»]
2YU9X-ray3.40J1-70[»]
3CQZX-ray2.80J1-70[»]
3FKIX-ray3.88J1-70[»]
3GTGX-ray3.78J1-70[»]
3GTJX-ray3.42J1-70[»]
3GTKX-ray3.80J1-70[»]
3GTLX-ray3.38J1-70[»]
3GTMX-ray3.80J1-70[»]
3GTOX-ray4.00J1-70[»]
3GTPX-ray3.90J1-70[»]
3GTQX-ray3.80J1-70[»]
3H3VX-ray4.00K1-70[»]
3HOUX-ray3.20J/V1-70[»]
3HOVX-ray3.50J1-70[»]
3HOWX-ray3.60J1-70[»]
3HOXX-ray3.65J1-70[»]
3HOYX-ray3.40J1-70[»]
3HOZX-ray3.65J1-70[»]
3I4MX-ray3.70J1-70[»]
3I4NX-ray3.90J1-70[»]
3J0Kelectron microscopy36.00J1-70[»]
3J1Nelectron microscopy16.00J1-70[»]
3K1FX-ray4.30J1-70[»]
3K7AX-ray3.80J1-70[»]
3M3YX-ray3.18J1-70[»]
3M4OX-ray3.57J1-70[»]
3PO2X-ray3.30J1-70[»]
3PO3X-ray3.30J1-70[»]
3QT1X-ray4.30J1-70[»]
3RZDX-ray3.30J1-70[»]
3RZOX-ray3.00J1-70[»]
3S14X-ray2.85J1-70[»]
3S15X-ray3.30J1-70[»]
3S16X-ray3.24J1-70[»]
3S17X-ray3.20J1-70[»]
3S1MX-ray3.13J1-70[»]
3S1NX-ray3.10J1-70[»]
3S1QX-ray3.30J1-70[»]
3S1RX-ray3.20J1-70[»]
3S2DX-ray3.20J1-70[»]
3S2HX-ray3.30J1-70[»]
4A3BX-ray3.50J1-70[»]
4A3CX-ray3.50J1-70[»]
4A3DX-ray3.40J1-70[»]
4A3EX-ray3.40J1-70[»]
4A3FX-ray3.50J1-70[»]
4A3GX-ray3.50J1-70[»]
4A3IX-ray3.80J1-70[»]
4A3JX-ray3.70J1-70[»]
4A3KX-ray3.50J1-70[»]
4A3LX-ray3.50J1-70[»]
4A3MX-ray3.90J1-70[»]
4A93X-ray3.40J1-70[»]
4BBRX-ray3.40J1-70[»]
4BBSX-ray3.60J1-70[»]
4BXXX-ray3.28J1-70[»]
4BXZX-ray4.80J1-70[»]
4BY1X-ray3.60J1-70[»]
4BY7X-ray3.15J1-70[»]
4C2MX-ray2.80J/Y1-70[»]
4C3HX-ray3.27J1-70[»]
4C3IX-ray3.0J1-70[»]
4C3JX-ray3.35J1-70[»]
4V1Melectron microscopy6.60J1-70[»]
4V1Nelectron microscopy7.80J1-70[»]
4V1Oelectron microscopy9.70J1-70[»]
4X67X-ray4.10J1-70[»]
4X6AX-ray3.96J1-70[»]
ProteinModelPortaliP22139.
SMRiP22139. Positions 1-69.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22139.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1644.
GeneTreeiENSGT00390000007087.
HOGENOMiHOG000109502.
InParanoidiP22139.
KOiK03007.
OMAiQLKRYCC.
OrthoDBiEOG7V76KX.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00250. RNApol_arch_N.
InterProiIPR009057. Homeodomain-like.
IPR023580. RNA_pol_su_RPB10.
IPR020789. RNA_pol_suN_Zn-BS.
IPR000268. RNAP_N/Rpb10.
[Graphical view]
PfamiPF01194. RNA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005653. RNA_pol_N/8_sub. 1 hit.
ProDomiPD006539. RNA_pol_N/8_sub. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46924. SSF46924. 1 hit.
PROSITEiPS01112. RNA_POL_N_8KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVPVRCFSC GKVVGDKWES YLNLLQEDEL DEGTALSRLG LKRYCCRRMI
60 70
LTHVDLIEKF LRYNPLEKRD
Length:70
Mass (Da):8,278
Last modified:October 1, 1993 - v2
Checksum:iE1F5733E8F466BE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60479 Genomic DNA. Translation: AAA34995.1. Sequence problems.
S62098 Genomic DNA. Translation: AAB27020.1.
L11274 Genomic DNA. Translation: AAB59318.1.
Z75118 Genomic DNA. Translation: CAA99425.1.
AY558433 Genomic DNA. Translation: AAS56759.1.
BK006948 Genomic DNA. Translation: DAA10982.1.
PIRiS48885.
RefSeqiNP_014853.3. NM_001183629.3.

Genome annotation databases

EnsemblFungiiYOR210W; YOR210W; YOR210W.
GeneIDi854385.
KEGGisce:YOR210W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60479 Genomic DNA. Translation: AAA34995.1. Sequence problems.
S62098 Genomic DNA. Translation: AAB27020.1.
L11274 Genomic DNA. Translation: AAB59318.1.
Z75118 Genomic DNA. Translation: CAA99425.1.
AY558433 Genomic DNA. Translation: AAS56759.1.
BK006948 Genomic DNA. Translation: DAA10982.1.
PIRiS48885.
RefSeqiNP_014853.3. NM_001183629.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I3QX-ray3.10J1-70[»]
1I50X-ray2.80J1-70[»]
1I6HX-ray3.30J1-70[»]
1K83X-ray2.80J1-70[»]
1NIKX-ray4.10J1-70[»]
1NT9X-ray4.20J1-70[»]
1PQVX-ray3.80J1-70[»]
1R5UX-ray4.50J1-70[»]
1R9SX-ray4.25J1-70[»]
1R9TX-ray3.50J1-70[»]
1SFOX-ray3.61J1-70[»]
1TWAX-ray3.20J1-70[»]
1TWCX-ray3.00J1-70[»]
1TWFX-ray2.30J1-70[»]
1TWGX-ray3.30J1-70[»]
1TWHX-ray3.40J1-70[»]
1WCMX-ray3.80J1-70[»]
1Y1VX-ray3.80J1-70[»]
1Y1WX-ray4.00J1-70[»]
1Y1YX-ray4.00J1-70[»]
1Y77X-ray4.50J1-70[»]
2B63X-ray3.80J1-70[»]
2B8KX-ray4.15J1-70[»]
2E2HX-ray3.95J1-70[»]
2E2IX-ray3.41J1-70[»]
2E2JX-ray3.50J1-70[»]
2JA5X-ray3.80J1-70[»]
2JA6X-ray4.00J1-70[»]
2JA7X-ray3.80J/V1-70[»]
2JA8X-ray3.80J1-70[»]
2NVQX-ray2.90J1-70[»]
2NVTX-ray3.36J1-70[»]
2NVXX-ray3.60J1-70[»]
2NVYX-ray3.40J1-70[»]
2NVZX-ray4.30J1-70[»]
2R7ZX-ray3.80J1-70[»]
2R92X-ray3.80J1-70[»]
2R93X-ray4.00J1-70[»]
2VUMX-ray3.40J1-70[»]
2YU9X-ray3.40J1-70[»]
3CQZX-ray2.80J1-70[»]
3FKIX-ray3.88J1-70[»]
3GTGX-ray3.78J1-70[»]
3GTJX-ray3.42J1-70[»]
3GTKX-ray3.80J1-70[»]
3GTLX-ray3.38J1-70[»]
3GTMX-ray3.80J1-70[»]
3GTOX-ray4.00J1-70[»]
3GTPX-ray3.90J1-70[»]
3GTQX-ray3.80J1-70[»]
3H3VX-ray4.00K1-70[»]
3HOUX-ray3.20J/V1-70[»]
3HOVX-ray3.50J1-70[»]
3HOWX-ray3.60J1-70[»]
3HOXX-ray3.65J1-70[»]
3HOYX-ray3.40J1-70[»]
3HOZX-ray3.65J1-70[»]
3I4MX-ray3.70J1-70[»]
3I4NX-ray3.90J1-70[»]
3J0Kelectron microscopy36.00J1-70[»]
3J1Nelectron microscopy16.00J1-70[»]
3K1FX-ray4.30J1-70[»]
3K7AX-ray3.80J1-70[»]
3M3YX-ray3.18J1-70[»]
3M4OX-ray3.57J1-70[»]
3PO2X-ray3.30J1-70[»]
3PO3X-ray3.30J1-70[»]
3QT1X-ray4.30J1-70[»]
3RZDX-ray3.30J1-70[»]
3RZOX-ray3.00J1-70[»]
3S14X-ray2.85J1-70[»]
3S15X-ray3.30J1-70[»]
3S16X-ray3.24J1-70[»]
3S17X-ray3.20J1-70[»]
3S1MX-ray3.13J1-70[»]
3S1NX-ray3.10J1-70[»]
3S1QX-ray3.30J1-70[»]
3S1RX-ray3.20J1-70[»]
3S2DX-ray3.20J1-70[»]
3S2HX-ray3.30J1-70[»]
4A3BX-ray3.50J1-70[»]
4A3CX-ray3.50J1-70[»]
4A3DX-ray3.40J1-70[»]
4A3EX-ray3.40J1-70[»]
4A3FX-ray3.50J1-70[»]
4A3GX-ray3.50J1-70[»]
4A3IX-ray3.80J1-70[»]
4A3JX-ray3.70J1-70[»]
4A3KX-ray3.50J1-70[»]
4A3LX-ray3.50J1-70[»]
4A3MX-ray3.90J1-70[»]
4A93X-ray3.40J1-70[»]
4BBRX-ray3.40J1-70[»]
4BBSX-ray3.60J1-70[»]
4BXXX-ray3.28J1-70[»]
4BXZX-ray4.80J1-70[»]
4BY1X-ray3.60J1-70[»]
4BY7X-ray3.15J1-70[»]
4C2MX-ray2.80J/Y1-70[»]
4C3HX-ray3.27J1-70[»]
4C3IX-ray3.0J1-70[»]
4C3JX-ray3.35J1-70[»]
4V1Melectron microscopy6.60J1-70[»]
4V1Nelectron microscopy7.80J1-70[»]
4V1Oelectron microscopy9.70J1-70[»]
4X67X-ray4.10J1-70[»]
4X6AX-ray3.96J1-70[»]
ProteinModelPortaliP22139.
SMRiP22139. Positions 1-69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34605. 75 interactions.
DIPiDIP-825N.
IntActiP22139. 17 interactions.
MINTiMINT-384345.

Proteomic databases

MaxQBiP22139.
PaxDbiP22139.
PeptideAtlasiP22139.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR210W; YOR210W; YOR210W.
GeneIDi854385.
KEGGisce:YOR210W.

Organism-specific databases

CYGDiYOR210w.
EuPathDBiFungiDB:YOR210W.
SGDiS000005736. RPB10.

Phylogenomic databases

eggNOGiCOG1644.
GeneTreeiENSGT00390000007087.
HOGENOMiHOG000109502.
InParanoidiP22139.
KOiK03007.
OMAiQLKRYCC.
OrthoDBiEOG7V76KX.

Enzyme and pathway databases

BioCyciYEAST:G3O-33712-MONOMER.
ReactomeiREACT_273109. Formation of the Early Elongation Complex.
REACT_273984. Dual incision reaction in TC-NER.
REACT_277632. mRNA Capping.
REACT_294700. mRNA Splicing - Minor Pathway.
REACT_296055. RNA Polymerase II Promoter Escape.
REACT_300180. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_310018. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_315180. RNA Polymerase II Pre-transcription Events.
REACT_317581. Processing of Capped Intron-Containing Pre-mRNA.
REACT_319823. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_320683. RNA Polymerase III Chain Elongation.
REACT_322294. RNA Pol II CTD phosphorylation and interaction with CE.
REACT_328223. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_330471. RNA Polymerase III Abortive And Retractive Initiation.
REACT_331999. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_335551. RNA Polymerase III Transcription Termination.
REACT_341636. Transcription-coupled NER (TC-NER).
REACT_345860. RNA Polymerase II Transcription Initiation.
REACT_348423. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Miscellaneous databases

EvolutionaryTraceiP22139.
NextBioi976532.
PROiP22139.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00250. RNApol_arch_N.
InterProiIPR009057. Homeodomain-like.
IPR023580. RNA_pol_su_RPB10.
IPR020789. RNA_pol_suN_Zn-BS.
IPR000268. RNAP_N/Rpb10.
[Graphical view]
PfamiPF01194. RNA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005653. RNA_pol_N/8_sub. 1 hit.
ProDomiPD006539. RNA_pol_N/8_sub. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46924. SSF46924. 1 hit.
PROSITEiPS01112. RNA_POL_N_8KD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RNA polymerase II subunit RPB10 is essential for yeast cell viability."
    Woychik N.A., Young R.A.
    J. Biol. Chem. 265:17816-17819(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-27.
  2. Erratum
    Woychik N.A., Young R.A.
    J. Biol. Chem. 268:12230-12230(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Interactions between three common subunits of yeast RNA polymerases I and III."
    Lalo D., Carles C., Sentenac A., Thuriaux P.
    Proc. Natl. Acad. Sci. U.S.A. 90:5524-5528(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 28383 / FL100 / VTT C-80102.
  4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  7. "The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation."
    Chedin S., Ferri M.L., Peyroche G., Andrau J.-C., Jourdain S., Lefebvre O., Werner M., Carles C., Sentenac A.
    Cold Spring Harb. Symp. Quant. Biol. 63:381-389(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON THE RNA POL III COMPLEX.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  10. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "RNA polymerase II/TFIIF structure and conserved organization of the initiation complex."
    Chung W.H., Craighead J.L., Chang W.H., Ezeokonkwo C., Bareket-Samish A., Kornberg R.D., Asturias F.J.
    Mol. Cell 12:1003-1013(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ELECTRON MICROSCOPY OF THE RNA POL II/TFIIF COMPLEX.
  12. "Structural basis of transcription: RNA polymerase II at 2.8 A resolution."
    Cramer P., Bushnell D.A., Kornberg R.D.
    Science 292:1863-1876(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  13. "Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution."
    Gnatt A.L., Cramer P., Fu J., Bushnell D.A., Kornberg R.D.
    Science 292:1876-1882(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  14. "Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution."
    Bushnell D.A., Cramer P., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:1218-1222(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX IN COMPLEX WITH ALPHA-AMANITIN.
  15. "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage."
    Kettenberger H., Armache K.J., Cramer P.
    Cell 114:347-357(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH DST1.
  16. "Architecture of initiation-competent 12-subunit RNA polymerase II."
    Armache K.J., Kettenberger H., Cramer P.
    Proc. Natl. Acad. Sci. U.S.A. 100:6964-6968(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.2 ANGSTROMS) OF THE RNA POL II COMPLEX.
  17. "Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription."
    Bushnell D.A., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 100:6969-6973(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  18. "Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center."
    Westover K.D., Bushnell D.A., Kornberg R.D.
    Cell 119:481-489(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  19. "Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS."
    Kettenberger H., Armache K.J., Cramer P.
    Mol. Cell 16:955-965(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS).
  20. "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms."
    Bushnell D.A., Westover K.D., Davis R.E., Kornberg R.D.
    Science 303:983-988(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  21. "Structures of complete RNA polymerase II and its subcomplex, Rpb4/7."
    Armache K.J., Mitterweger S., Meinhart A., Cramer P.
    J. Biol. Chem. 280:7131-7134(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX.
  22. "Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model."
    Jasiak A.J., Armache K.J., Martens B., Jansen R.P., Cramer P.
    Mol. Cell 23:71-81(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF THE POL III CORE COMPLEX.
  23. "Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs."
    Kettenberger H., Eisenfuhr A., Brueckner F., Theis M., Famulok M., Cramer P.
    Nat. Struct. Mol. Biol. 13:44-48(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH INHIBITING NON-CODING RNA.
  24. "Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model."
    Meyer P.A., Ye P., Zhang M., Suh M.H., Fu J.
    Structure 14:973-982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.15 ANGSTROMS) OF THE RNA POL II COMPLEX.
  25. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (12.00 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  26. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  27. "RNA polymerase I structure and transcription regulation."
    Engel C., Sainsbury S., Cheung A.C., Kostrewa D., Cramer P.
    Nature 502:650-655(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, ZINC-BINDING, SUBUNIT.

Entry informationi

Entry nameiRPAB5_YEAST
AccessioniPrimary (citable) accession number: P22139
Secondary accession number(s): D6W2R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1993
Last modified: July 22, 2015
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.