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P22139

- RPAB5_YEAST

UniProt

P22139 - RPAB5_YEAST

Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Gene

RPB10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi7 – 71Zinc
    Metal bindingi10 – 101Zinc
    Metal bindingi44 – 441Zinc
    Metal bindingi45 – 451Zinc

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. RNA polymerase I activity Source: UniProtKB
    3. zinc ion binding Source: SGD

    GO - Biological processi

    1. ribosome biogenesis Source: UniProtKB-KW
    2. transcription, RNA-templated Source: GOC
    3. transcription from RNA polymerase III promoter Source: SGD
    4. transcription from RNA polymerase II promoter Source: SGD
    5. transcription from RNA polymerase I promoter Source: UniProtKB
    6. tRNA transcription from RNA polymerase III promoter Source: SGD

    Keywords - Biological processi

    Ribosome biogenesis, Transcription

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33712-MONOMER.
    ReactomeiREACT_191540. mRNA Splicing - Minor Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC5
    Short name:
    RNA polymerases I, II, and III subunit ABC5
    Alternative name(s):
    ABC10-beta
    ABC8
    DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide
    Gene namesi
    Name:RPB10
    Ordered Locus Names:YOR210W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR210w.
    SGDiS000005736. RPB10.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. DNA-directed RNA polymerase I complex Source: UniProtKB
    2. DNA-directed RNA polymerase II, core complex Source: SGD
    3. DNA-directed RNA polymerase III complex Source: SGD
    4. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7070DNA-directed RNA polymerases I, II, and III subunit RPABC5PRO_0000121342Add
    BLAST

    Proteomic databases

    MaxQBiP22139.
    PaxDbiP22139.
    PeptideAtlasiP22139.

    Expressioni

    Gene expression databases

    GenevestigatoriP22139.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.6 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RBA50Q044181EBI-15802,EBI-38743

    Protein-protein interaction databases

    BioGridi34605. 74 interactions.
    DIPiDIP-825N.
    IntActiP22139. 17 interactions.
    MINTiMINT-384345.
    STRINGi4932.YOR210W.

    Structurei

    Secondary structure

    1
    70
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni8 – 103
    Helixi15 – 173
    Helixi18 – 269
    Turni27 – 293
    Helixi32 – 387
    Helixi44 – 518
    Helixi57 – 615

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1I3QX-ray3.10J1-70[»]
    1I50X-ray2.80J1-70[»]
    1I6HX-ray3.30J1-70[»]
    1K83X-ray2.80J1-70[»]
    1NIKX-ray4.10J1-70[»]
    1NT9X-ray4.20J1-70[»]
    1PQVX-ray3.80J1-70[»]
    1R5UX-ray4.50J1-70[»]
    1R9SX-ray4.25J1-70[»]
    1R9TX-ray3.50J1-70[»]
    1SFOX-ray3.61J1-70[»]
    1TWAX-ray3.20J1-70[»]
    1TWCX-ray3.00J1-70[»]
    1TWFX-ray2.30J1-70[»]
    1TWGX-ray3.30J1-70[»]
    1TWHX-ray3.40J1-70[»]
    1WCMX-ray3.80J1-70[»]
    1Y1VX-ray3.80J1-70[»]
    1Y1WX-ray4.00J1-70[»]
    1Y1YX-ray4.00J1-70[»]
    1Y77X-ray4.50J1-70[»]
    2B63X-ray3.80J1-70[»]
    2B8KX-ray4.15J1-70[»]
    2E2HX-ray3.95J1-70[»]
    2E2IX-ray3.41J1-70[»]
    2E2JX-ray3.50J1-70[»]
    2JA5X-ray3.80J1-70[»]
    2JA6X-ray4.00J1-70[»]
    2JA7X-ray3.80J/V1-70[»]
    2JA8X-ray3.80J1-70[»]
    2NVQX-ray2.90J1-70[»]
    2NVTX-ray3.36J1-70[»]
    2NVXX-ray3.60J1-70[»]
    2NVYX-ray3.40J1-70[»]
    2NVZX-ray4.30J1-70[»]
    2R7ZX-ray3.80J1-70[»]
    2R92X-ray3.80J1-70[»]
    2R93X-ray4.00J1-70[»]
    2VUMX-ray3.40J1-70[»]
    2YU9X-ray3.40J1-70[»]
    3CQZX-ray2.80J1-70[»]
    3FKIX-ray3.88J1-70[»]
    3GTGX-ray3.78J1-70[»]
    3GTJX-ray3.42J1-70[»]
    3GTKX-ray3.80J1-70[»]
    3GTLX-ray3.38J1-70[»]
    3GTMX-ray3.80J1-70[»]
    3GTOX-ray4.00J1-70[»]
    3GTPX-ray3.90J1-70[»]
    3GTQX-ray3.80J1-70[»]
    3H3VX-ray4.00K1-70[»]
    3HOUX-ray3.20J/V1-70[»]
    3HOVX-ray3.50J1-70[»]
    3HOWX-ray3.60J1-70[»]
    3HOXX-ray3.65J1-70[»]
    3HOYX-ray3.40J1-70[»]
    3HOZX-ray3.65J1-70[»]
    3I4MX-ray3.70J1-70[»]
    3I4NX-ray3.90J1-70[»]
    3J0Kelectron microscopy36.00J1-70[»]
    3J1Nelectron microscopy16.00J1-70[»]
    3K1FX-ray4.30J1-70[»]
    3K7AX-ray3.80J1-70[»]
    3M3YX-ray3.18J1-70[»]
    3M4OX-ray3.57J1-70[»]
    3PO2X-ray3.30J1-70[»]
    3PO3X-ray3.30J1-70[»]
    3QT1X-ray4.30J1-70[»]
    3RZDX-ray3.30J1-70[»]
    3RZOX-ray3.00J1-70[»]
    3S14X-ray2.85J1-70[»]
    3S15X-ray3.30J1-70[»]
    3S16X-ray3.24J1-70[»]
    3S17X-ray3.20J1-70[»]
    3S1MX-ray3.13J1-70[»]
    3S1NX-ray3.10J1-70[»]
    3S1QX-ray3.30J1-70[»]
    3S1RX-ray3.20J1-70[»]
    3S2DX-ray3.20J1-70[»]
    3S2HX-ray3.30J1-70[»]
    4A3BX-ray3.50J1-70[»]
    4A3CX-ray3.50J1-70[»]
    4A3DX-ray3.40J1-70[»]
    4A3EX-ray3.40J1-70[»]
    4A3FX-ray3.50J1-70[»]
    4A3GX-ray3.50J1-70[»]
    4A3IX-ray3.80J1-70[»]
    4A3JX-ray3.70J1-70[»]
    4A3KX-ray3.50J1-70[»]
    4A3LX-ray3.50J1-70[»]
    4A3MX-ray3.90J1-70[»]
    4A93X-ray3.40J1-70[»]
    4BBRX-ray3.40J1-70[»]
    4BBSX-ray3.60J1-70[»]
    4BXXX-ray3.28J1-70[»]
    4BXZX-ray4.80J1-70[»]
    4BY1X-ray3.60J1-70[»]
    4BY7X-ray3.15J1-70[»]
    4C2MX-ray2.80J/Y1-70[»]
    4C3HX-ray3.27J1-70[»]
    4C3IX-ray3.0J1-70[»]
    4C3JX-ray3.35J1-70[»]
    ProteinModelPortaliP22139.
    SMRiP22139. Positions 1-69.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP22139.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1644.
    GeneTreeiENSGT00390000007087.
    HOGENOMiHOG000109502.
    KOiK03007.
    OMAiDSISSAW.
    OrthoDBiEOG7V76KX.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    HAMAPiMF_00250. RNApol_arch_N.
    InterProiIPR009057. Homeodomain-like.
    IPR023580. RNA_pol_su_RPB10.
    IPR020789. RNA_pol_suN_Zn-BS.
    IPR000268. RNAP_N/Rpb10.
    [Graphical view]
    PfamiPF01194. RNA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005653. RNA_pol_N/8_sub. 1 hit.
    ProDomiPD006539. RNA_pol_N/8_sub. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF46924. SSF46924. 1 hit.
    PROSITEiPS01112. RNA_POL_N_8KD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22139-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVPVRCFSC GKVVGDKWES YLNLLQEDEL DEGTALSRLG LKRYCCRRMI   50
    LTHVDLIEKF LRYNPLEKRD 70
    Length:70
    Mass (Da):8,278
    Last modified:October 1, 1993 - v2
    Checksum:iE1F5733E8F466BE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60479 Genomic DNA. Translation: AAA34995.1. Sequence problems.
    S62098 Genomic DNA. Translation: AAB27020.1.
    L11274 Genomic DNA. Translation: AAB59318.1.
    Z75118 Genomic DNA. Translation: CAA99425.1.
    AY558433 Genomic DNA. Translation: AAS56759.1.
    BK006948 Genomic DNA. Translation: DAA10982.1.
    PIRiS48885.
    RefSeqiNP_014853.3. NM_001183629.3.

    Genome annotation databases

    EnsemblFungiiYOR210W; YOR210W; YOR210W.
    GeneIDi854385.
    KEGGisce:YOR210W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60479 Genomic DNA. Translation: AAA34995.1 . Sequence problems.
    S62098 Genomic DNA. Translation: AAB27020.1 .
    L11274 Genomic DNA. Translation: AAB59318.1 .
    Z75118 Genomic DNA. Translation: CAA99425.1 .
    AY558433 Genomic DNA. Translation: AAS56759.1 .
    BK006948 Genomic DNA. Translation: DAA10982.1 .
    PIRi S48885.
    RefSeqi NP_014853.3. NM_001183629.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1I3Q X-ray 3.10 J 1-70 [» ]
    1I50 X-ray 2.80 J 1-70 [» ]
    1I6H X-ray 3.30 J 1-70 [» ]
    1K83 X-ray 2.80 J 1-70 [» ]
    1NIK X-ray 4.10 J 1-70 [» ]
    1NT9 X-ray 4.20 J 1-70 [» ]
    1PQV X-ray 3.80 J 1-70 [» ]
    1R5U X-ray 4.50 J 1-70 [» ]
    1R9S X-ray 4.25 J 1-70 [» ]
    1R9T X-ray 3.50 J 1-70 [» ]
    1SFO X-ray 3.61 J 1-70 [» ]
    1TWA X-ray 3.20 J 1-70 [» ]
    1TWC X-ray 3.00 J 1-70 [» ]
    1TWF X-ray 2.30 J 1-70 [» ]
    1TWG X-ray 3.30 J 1-70 [» ]
    1TWH X-ray 3.40 J 1-70 [» ]
    1WCM X-ray 3.80 J 1-70 [» ]
    1Y1V X-ray 3.80 J 1-70 [» ]
    1Y1W X-ray 4.00 J 1-70 [» ]
    1Y1Y X-ray 4.00 J 1-70 [» ]
    1Y77 X-ray 4.50 J 1-70 [» ]
    2B63 X-ray 3.80 J 1-70 [» ]
    2B8K X-ray 4.15 J 1-70 [» ]
    2E2H X-ray 3.95 J 1-70 [» ]
    2E2I X-ray 3.41 J 1-70 [» ]
    2E2J X-ray 3.50 J 1-70 [» ]
    2JA5 X-ray 3.80 J 1-70 [» ]
    2JA6 X-ray 4.00 J 1-70 [» ]
    2JA7 X-ray 3.80 J/V 1-70 [» ]
    2JA8 X-ray 3.80 J 1-70 [» ]
    2NVQ X-ray 2.90 J 1-70 [» ]
    2NVT X-ray 3.36 J 1-70 [» ]
    2NVX X-ray 3.60 J 1-70 [» ]
    2NVY X-ray 3.40 J 1-70 [» ]
    2NVZ X-ray 4.30 J 1-70 [» ]
    2R7Z X-ray 3.80 J 1-70 [» ]
    2R92 X-ray 3.80 J 1-70 [» ]
    2R93 X-ray 4.00 J 1-70 [» ]
    2VUM X-ray 3.40 J 1-70 [» ]
    2YU9 X-ray 3.40 J 1-70 [» ]
    3CQZ X-ray 2.80 J 1-70 [» ]
    3FKI X-ray 3.88 J 1-70 [» ]
    3GTG X-ray 3.78 J 1-70 [» ]
    3GTJ X-ray 3.42 J 1-70 [» ]
    3GTK X-ray 3.80 J 1-70 [» ]
    3GTL X-ray 3.38 J 1-70 [» ]
    3GTM X-ray 3.80 J 1-70 [» ]
    3GTO X-ray 4.00 J 1-70 [» ]
    3GTP X-ray 3.90 J 1-70 [» ]
    3GTQ X-ray 3.80 J 1-70 [» ]
    3H3V X-ray 4.00 K 1-70 [» ]
    3HOU X-ray 3.20 J/V 1-70 [» ]
    3HOV X-ray 3.50 J 1-70 [» ]
    3HOW X-ray 3.60 J 1-70 [» ]
    3HOX X-ray 3.65 J 1-70 [» ]
    3HOY X-ray 3.40 J 1-70 [» ]
    3HOZ X-ray 3.65 J 1-70 [» ]
    3I4M X-ray 3.70 J 1-70 [» ]
    3I4N X-ray 3.90 J 1-70 [» ]
    3J0K electron microscopy 36.00 J 1-70 [» ]
    3J1N electron microscopy 16.00 J 1-70 [» ]
    3K1F X-ray 4.30 J 1-70 [» ]
    3K7A X-ray 3.80 J 1-70 [» ]
    3M3Y X-ray 3.18 J 1-70 [» ]
    3M4O X-ray 3.57 J 1-70 [» ]
    3PO2 X-ray 3.30 J 1-70 [» ]
    3PO3 X-ray 3.30 J 1-70 [» ]
    3QT1 X-ray 4.30 J 1-70 [» ]
    3RZD X-ray 3.30 J 1-70 [» ]
    3RZO X-ray 3.00 J 1-70 [» ]
    3S14 X-ray 2.85 J 1-70 [» ]
    3S15 X-ray 3.30 J 1-70 [» ]
    3S16 X-ray 3.24 J 1-70 [» ]
    3S17 X-ray 3.20 J 1-70 [» ]
    3S1M X-ray 3.13 J 1-70 [» ]
    3S1N X-ray 3.10 J 1-70 [» ]
    3S1Q X-ray 3.30 J 1-70 [» ]
    3S1R X-ray 3.20 J 1-70 [» ]
    3S2D X-ray 3.20 J 1-70 [» ]
    3S2H X-ray 3.30 J 1-70 [» ]
    4A3B X-ray 3.50 J 1-70 [» ]
    4A3C X-ray 3.50 J 1-70 [» ]
    4A3D X-ray 3.40 J 1-70 [» ]
    4A3E X-ray 3.40 J 1-70 [» ]
    4A3F X-ray 3.50 J 1-70 [» ]
    4A3G X-ray 3.50 J 1-70 [» ]
    4A3I X-ray 3.80 J 1-70 [» ]
    4A3J X-ray 3.70 J 1-70 [» ]
    4A3K X-ray 3.50 J 1-70 [» ]
    4A3L X-ray 3.50 J 1-70 [» ]
    4A3M X-ray 3.90 J 1-70 [» ]
    4A93 X-ray 3.40 J 1-70 [» ]
    4BBR X-ray 3.40 J 1-70 [» ]
    4BBS X-ray 3.60 J 1-70 [» ]
    4BXX X-ray 3.28 J 1-70 [» ]
    4BXZ X-ray 4.80 J 1-70 [» ]
    4BY1 X-ray 3.60 J 1-70 [» ]
    4BY7 X-ray 3.15 J 1-70 [» ]
    4C2M X-ray 2.80 J/Y 1-70 [» ]
    4C3H X-ray 3.27 J 1-70 [» ]
    4C3I X-ray 3.0 J 1-70 [» ]
    4C3J X-ray 3.35 J 1-70 [» ]
    ProteinModelPortali P22139.
    SMRi P22139. Positions 1-69.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34605. 74 interactions.
    DIPi DIP-825N.
    IntActi P22139. 17 interactions.
    MINTi MINT-384345.
    STRINGi 4932.YOR210W.

    Proteomic databases

    MaxQBi P22139.
    PaxDbi P22139.
    PeptideAtlasi P22139.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR210W ; YOR210W ; YOR210W .
    GeneIDi 854385.
    KEGGi sce:YOR210W.

    Organism-specific databases

    CYGDi YOR210w.
    SGDi S000005736. RPB10.

    Phylogenomic databases

    eggNOGi COG1644.
    GeneTreei ENSGT00390000007087.
    HOGENOMi HOG000109502.
    KOi K03007.
    OMAi DSISSAW.
    OrthoDBi EOG7V76KX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33712-MONOMER.
    Reactomei REACT_191540. mRNA Splicing - Minor Pathway.

    Miscellaneous databases

    EvolutionaryTracei P22139.
    NextBioi 976532.
    PROi P22139.

    Gene expression databases

    Genevestigatori P22139.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    HAMAPi MF_00250. RNApol_arch_N.
    InterProi IPR009057. Homeodomain-like.
    IPR023580. RNA_pol_su_RPB10.
    IPR020789. RNA_pol_suN_Zn-BS.
    IPR000268. RNAP_N/Rpb10.
    [Graphical view ]
    Pfami PF01194. RNA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005653. RNA_pol_N/8_sub. 1 hit.
    ProDomi PD006539. RNA_pol_N/8_sub. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF46924. SSF46924. 1 hit.
    PROSITEi PS01112. RNA_POL_N_8KD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RNA polymerase II subunit RPB10 is essential for yeast cell viability."
      Woychik N.A., Young R.A.
      J. Biol. Chem. 265:17816-17819(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-27.
    2. Erratum
      Woychik N.A., Young R.A.
      J. Biol. Chem. 268:12230-12230(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "Interactions between three common subunits of yeast RNA polymerases I and III."
      Lalo D., Carles C., Sentenac A., Thuriaux P.
      Proc. Natl. Acad. Sci. U.S.A. 90:5524-5528(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 28383 / FL100 / VTT C-80102.
    4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    7. "The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation."
      Chedin S., Ferri M.L., Peyroche G., Andrau J.-C., Jourdain S., Lefebvre O., Werner M., Carles C., Sentenac A.
      Cold Spring Harb. Symp. Quant. Biol. 63:381-389(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON THE RNA POL III COMPLEX.
    8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    10. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "RNA polymerase II/TFIIF structure and conserved organization of the initiation complex."
      Chung W.H., Craighead J.L., Chang W.H., Ezeokonkwo C., Bareket-Samish A., Kornberg R.D., Asturias F.J.
      Mol. Cell 12:1003-1013(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ELECTRON MICROSCOPY OF THE RNA POL II/TFIIF COMPLEX.
    12. "Structural basis of transcription: RNA polymerase II at 2.8 A resolution."
      Cramer P., Bushnell D.A., Kornberg R.D.
      Science 292:1863-1876(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    13. "Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution."
      Gnatt A.L., Cramer P., Fu J., Bushnell D.A., Kornberg R.D.
      Science 292:1876-1882(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    14. "Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution."
      Bushnell D.A., Cramer P., Kornberg R.D.
      Proc. Natl. Acad. Sci. U.S.A. 99:1218-1222(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX IN COMPLEX WITH ALPHA-AMANITIN.
    15. "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage."
      Kettenberger H., Armache K.J., Cramer P.
      Cell 114:347-357(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH DST1.
    16. "Architecture of initiation-competent 12-subunit RNA polymerase II."
      Armache K.J., Kettenberger H., Cramer P.
      Proc. Natl. Acad. Sci. U.S.A. 100:6964-6968(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.2 ANGSTROMS) OF THE RNA POL II COMPLEX.
    17. "Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription."
      Bushnell D.A., Kornberg R.D.
      Proc. Natl. Acad. Sci. U.S.A. 100:6969-6973(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    18. "Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center."
      Westover K.D., Bushnell D.A., Kornberg R.D.
      Cell 119:481-489(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    19. "Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS."
      Kettenberger H., Armache K.J., Cramer P.
      Mol. Cell 16:955-965(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS).
    20. "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms."
      Bushnell D.A., Westover K.D., Davis R.E., Kornberg R.D.
      Science 303:983-988(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    21. "Structures of complete RNA polymerase II and its subcomplex, Rpb4/7."
      Armache K.J., Mitterweger S., Meinhart A., Cramer P.
      J. Biol. Chem. 280:7131-7134(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX.
    22. "Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model."
      Jasiak A.J., Armache K.J., Martens B., Jansen R.P., Cramer P.
      Mol. Cell 23:71-81(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF THE POL III CORE COMPLEX.
    23. "Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs."
      Kettenberger H., Eisenfuhr A., Brueckner F., Theis M., Famulok M., Cramer P.
      Nat. Struct. Mol. Biol. 13:44-48(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH INHIBITING NON-CODING RNA.
    24. "Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model."
      Meyer P.A., Ye P., Zhang M., Suh M.H., Fu J.
      Structure 14:973-982(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.15 ANGSTROMS) OF THE RNA POL II COMPLEX.
    25. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (12.00 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
    26. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
    27. "RNA polymerase I structure and transcription regulation."
      Engel C., Sainsbury S., Cheung A.C., Kostrewa D., Cramer P.
      Nature 502:650-655(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, ZINC-BINDING, SUBUNIT.

    Entry informationi

    Entry nameiRPAB5_YEAST
    AccessioniPrimary (citable) accession number: P22139
    Secondary accession number(s): D6W2R6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 149 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 5300 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3