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P22139

- RPAB5_YEAST

UniProt

P22139 - RPAB5_YEAST

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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Gene

RPB10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Zinc
Metal bindingi10 – 101Zinc
Metal bindingi44 – 441Zinc
Metal bindingi45 – 451Zinc

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. RNA polymerase I activity Source: UniProtKB
  3. zinc ion binding Source: SGD

GO - Biological processi

  1. ribosome biogenesis Source: UniProtKB-KW
  2. transcription, RNA-templated Source: GOC
  3. transcription from RNA polymerase III promoter Source: SGD
  4. transcription from RNA polymerase II promoter Source: SGD
  5. transcription from RNA polymerase I promoter Source: UniProtKB
  6. tRNA transcription from RNA polymerase III promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, Transcription

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33712-MONOMER.
ReactomeiREACT_191540. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Short name:
RNA polymerases I, II, and III subunit ABC5
Alternative name(s):
ABC10-beta
ABC8
DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide
Gene namesi
Name:RPB10
Ordered Locus Names:YOR210W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR210w.
SGDiS000005736. RPB10.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. DNA-directed RNA polymerase I complex Source: UniProtKB
  2. DNA-directed RNA polymerase II, core complex Source: SGD
  3. DNA-directed RNA polymerase III complex Source: SGD
  4. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070DNA-directed RNA polymerases I, II, and III subunit RPABC5PRO_0000121342Add
BLAST

Proteomic databases

MaxQBiP22139.
PaxDbiP22139.
PeptideAtlasiP22139.

Expressioni

Gene expression databases

GenevestigatoriP22139.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RBA50Q044181EBI-15802,EBI-38743

Protein-protein interaction databases

BioGridi34605. 74 interactions.
DIPiDIP-825N.
IntActiP22139. 17 interactions.
MINTiMINT-384345.
STRINGi4932.YOR210W.

Structurei

Secondary structure

1
70
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni8 – 103
Helixi15 – 173
Helixi18 – 269
Turni27 – 293
Helixi32 – 387
Helixi44 – 518
Helixi57 – 615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I3QX-ray3.10J1-70[»]
1I50X-ray2.80J1-70[»]
1I6HX-ray3.30J1-70[»]
1K83X-ray2.80J1-70[»]
1NIKX-ray4.10J1-70[»]
1NT9X-ray4.20J1-70[»]
1PQVX-ray3.80J1-70[»]
1R5UX-ray4.50J1-70[»]
1R9SX-ray4.25J1-70[»]
1R9TX-ray3.50J1-70[»]
1SFOX-ray3.61J1-70[»]
1TWAX-ray3.20J1-70[»]
1TWCX-ray3.00J1-70[»]
1TWFX-ray2.30J1-70[»]
1TWGX-ray3.30J1-70[»]
1TWHX-ray3.40J1-70[»]
1WCMX-ray3.80J1-70[»]
1Y1VX-ray3.80J1-70[»]
1Y1WX-ray4.00J1-70[»]
1Y1YX-ray4.00J1-70[»]
1Y77X-ray4.50J1-70[»]
2B63X-ray3.80J1-70[»]
2B8KX-ray4.15J1-70[»]
2E2HX-ray3.95J1-70[»]
2E2IX-ray3.41J1-70[»]
2E2JX-ray3.50J1-70[»]
2JA5X-ray3.80J1-70[»]
2JA6X-ray4.00J1-70[»]
2JA7X-ray3.80J/V1-70[»]
2JA8X-ray3.80J1-70[»]
2NVQX-ray2.90J1-70[»]
2NVTX-ray3.36J1-70[»]
2NVXX-ray3.60J1-70[»]
2NVYX-ray3.40J1-70[»]
2NVZX-ray4.30J1-70[»]
2R7ZX-ray3.80J1-70[»]
2R92X-ray3.80J1-70[»]
2R93X-ray4.00J1-70[»]
2VUMX-ray3.40J1-70[»]
2YU9X-ray3.40J1-70[»]
3CQZX-ray2.80J1-70[»]
3FKIX-ray3.88J1-70[»]
3GTGX-ray3.78J1-70[»]
3GTJX-ray3.42J1-70[»]
3GTKX-ray3.80J1-70[»]
3GTLX-ray3.38J1-70[»]
3GTMX-ray3.80J1-70[»]
3GTOX-ray4.00J1-70[»]
3GTPX-ray3.90J1-70[»]
3GTQX-ray3.80J1-70[»]
3H3VX-ray4.00K1-70[»]
3HOUX-ray3.20J/V1-70[»]
3HOVX-ray3.50J1-70[»]
3HOWX-ray3.60J1-70[»]
3HOXX-ray3.65J1-70[»]
3HOYX-ray3.40J1-70[»]
3HOZX-ray3.65J1-70[»]
3I4MX-ray3.70J1-70[»]
3I4NX-ray3.90J1-70[»]
3J0Kelectron microscopy36.00J1-70[»]
3J1Nelectron microscopy16.00J1-70[»]
3K1FX-ray4.30J1-70[»]
3K7AX-ray3.80J1-70[»]
3M3YX-ray3.18J1-70[»]
3M4OX-ray3.57J1-70[»]
3PO2X-ray3.30J1-70[»]
3PO3X-ray3.30J1-70[»]
3QT1X-ray4.30J1-70[»]
3RZDX-ray3.30J1-70[»]
3RZOX-ray3.00J1-70[»]
3S14X-ray2.85J1-70[»]
3S15X-ray3.30J1-70[»]
3S16X-ray3.24J1-70[»]
3S17X-ray3.20J1-70[»]
3S1MX-ray3.13J1-70[»]
3S1NX-ray3.10J1-70[»]
3S1QX-ray3.30J1-70[»]
3S1RX-ray3.20J1-70[»]
3S2DX-ray3.20J1-70[»]
3S2HX-ray3.30J1-70[»]
4A3BX-ray3.50J1-70[»]
4A3CX-ray3.50J1-70[»]
4A3DX-ray3.40J1-70[»]
4A3EX-ray3.40J1-70[»]
4A3FX-ray3.50J1-70[»]
4A3GX-ray3.50J1-70[»]
4A3IX-ray3.80J1-70[»]
4A3JX-ray3.70J1-70[»]
4A3KX-ray3.50J1-70[»]
4A3LX-ray3.50J1-70[»]
4A3MX-ray3.90J1-70[»]
4A93X-ray3.40J1-70[»]
4BBRX-ray3.40J1-70[»]
4BBSX-ray3.60J1-70[»]
4BXXX-ray3.28J1-70[»]
4BXZX-ray4.80J1-70[»]
4BY1X-ray3.60J1-70[»]
4BY7X-ray3.15J1-70[»]
4C2MX-ray2.80J/Y1-70[»]
4C3HX-ray3.27J1-70[»]
4C3IX-ray3.0J1-70[»]
4C3JX-ray3.35J1-70[»]
ProteinModelPortaliP22139.
SMRiP22139. Positions 1-69.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22139.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1644.
GeneTreeiENSGT00390000007087.
HOGENOMiHOG000109502.
InParanoidiP22139.
KOiK03007.
OMAiDSISSAW.
OrthoDBiEOG7V76KX.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00250. RNApol_arch_N.
InterProiIPR009057. Homeodomain-like.
IPR023580. RNA_pol_su_RPB10.
IPR020789. RNA_pol_suN_Zn-BS.
IPR000268. RNAP_N/Rpb10.
[Graphical view]
PfamiPF01194. RNA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005653. RNA_pol_N/8_sub. 1 hit.
ProDomiPD006539. RNA_pol_N/8_sub. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46924. SSF46924. 1 hit.
PROSITEiPS01112. RNA_POL_N_8KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22139-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVPVRCFSC GKVVGDKWES YLNLLQEDEL DEGTALSRLG LKRYCCRRMI
60 70
LTHVDLIEKF LRYNPLEKRD
Length:70
Mass (Da):8,278
Last modified:October 1, 1993 - v2
Checksum:iE1F5733E8F466BE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60479 Genomic DNA. Translation: AAA34995.1. Sequence problems.
S62098 Genomic DNA. Translation: AAB27020.1.
L11274 Genomic DNA. Translation: AAB59318.1.
Z75118 Genomic DNA. Translation: CAA99425.1.
AY558433 Genomic DNA. Translation: AAS56759.1.
BK006948 Genomic DNA. Translation: DAA10982.1.
PIRiS48885.
RefSeqiNP_014853.3. NM_001183629.3.

Genome annotation databases

EnsemblFungiiYOR210W; YOR210W; YOR210W.
GeneIDi854385.
KEGGisce:YOR210W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60479 Genomic DNA. Translation: AAA34995.1 . Sequence problems.
S62098 Genomic DNA. Translation: AAB27020.1 .
L11274 Genomic DNA. Translation: AAB59318.1 .
Z75118 Genomic DNA. Translation: CAA99425.1 .
AY558433 Genomic DNA. Translation: AAS56759.1 .
BK006948 Genomic DNA. Translation: DAA10982.1 .
PIRi S48885.
RefSeqi NP_014853.3. NM_001183629.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1I3Q X-ray 3.10 J 1-70 [» ]
1I50 X-ray 2.80 J 1-70 [» ]
1I6H X-ray 3.30 J 1-70 [» ]
1K83 X-ray 2.80 J 1-70 [» ]
1NIK X-ray 4.10 J 1-70 [» ]
1NT9 X-ray 4.20 J 1-70 [» ]
1PQV X-ray 3.80 J 1-70 [» ]
1R5U X-ray 4.50 J 1-70 [» ]
1R9S X-ray 4.25 J 1-70 [» ]
1R9T X-ray 3.50 J 1-70 [» ]
1SFO X-ray 3.61 J 1-70 [» ]
1TWA X-ray 3.20 J 1-70 [» ]
1TWC X-ray 3.00 J 1-70 [» ]
1TWF X-ray 2.30 J 1-70 [» ]
1TWG X-ray 3.30 J 1-70 [» ]
1TWH X-ray 3.40 J 1-70 [» ]
1WCM X-ray 3.80 J 1-70 [» ]
1Y1V X-ray 3.80 J 1-70 [» ]
1Y1W X-ray 4.00 J 1-70 [» ]
1Y1Y X-ray 4.00 J 1-70 [» ]
1Y77 X-ray 4.50 J 1-70 [» ]
2B63 X-ray 3.80 J 1-70 [» ]
2B8K X-ray 4.15 J 1-70 [» ]
2E2H X-ray 3.95 J 1-70 [» ]
2E2I X-ray 3.41 J 1-70 [» ]
2E2J X-ray 3.50 J 1-70 [» ]
2JA5 X-ray 3.80 J 1-70 [» ]
2JA6 X-ray 4.00 J 1-70 [» ]
2JA7 X-ray 3.80 J/V 1-70 [» ]
2JA8 X-ray 3.80 J 1-70 [» ]
2NVQ X-ray 2.90 J 1-70 [» ]
2NVT X-ray 3.36 J 1-70 [» ]
2NVX X-ray 3.60 J 1-70 [» ]
2NVY X-ray 3.40 J 1-70 [» ]
2NVZ X-ray 4.30 J 1-70 [» ]
2R7Z X-ray 3.80 J 1-70 [» ]
2R92 X-ray 3.80 J 1-70 [» ]
2R93 X-ray 4.00 J 1-70 [» ]
2VUM X-ray 3.40 J 1-70 [» ]
2YU9 X-ray 3.40 J 1-70 [» ]
3CQZ X-ray 2.80 J 1-70 [» ]
3FKI X-ray 3.88 J 1-70 [» ]
3GTG X-ray 3.78 J 1-70 [» ]
3GTJ X-ray 3.42 J 1-70 [» ]
3GTK X-ray 3.80 J 1-70 [» ]
3GTL X-ray 3.38 J 1-70 [» ]
3GTM X-ray 3.80 J 1-70 [» ]
3GTO X-ray 4.00 J 1-70 [» ]
3GTP X-ray 3.90 J 1-70 [» ]
3GTQ X-ray 3.80 J 1-70 [» ]
3H3V X-ray 4.00 K 1-70 [» ]
3HOU X-ray 3.20 J/V 1-70 [» ]
3HOV X-ray 3.50 J 1-70 [» ]
3HOW X-ray 3.60 J 1-70 [» ]
3HOX X-ray 3.65 J 1-70 [» ]
3HOY X-ray 3.40 J 1-70 [» ]
3HOZ X-ray 3.65 J 1-70 [» ]
3I4M X-ray 3.70 J 1-70 [» ]
3I4N X-ray 3.90 J 1-70 [» ]
3J0K electron microscopy 36.00 J 1-70 [» ]
3J1N electron microscopy 16.00 J 1-70 [» ]
3K1F X-ray 4.30 J 1-70 [» ]
3K7A X-ray 3.80 J 1-70 [» ]
3M3Y X-ray 3.18 J 1-70 [» ]
3M4O X-ray 3.57 J 1-70 [» ]
3PO2 X-ray 3.30 J 1-70 [» ]
3PO3 X-ray 3.30 J 1-70 [» ]
3QT1 X-ray 4.30 J 1-70 [» ]
3RZD X-ray 3.30 J 1-70 [» ]
3RZO X-ray 3.00 J 1-70 [» ]
3S14 X-ray 2.85 J 1-70 [» ]
3S15 X-ray 3.30 J 1-70 [» ]
3S16 X-ray 3.24 J 1-70 [» ]
3S17 X-ray 3.20 J 1-70 [» ]
3S1M X-ray 3.13 J 1-70 [» ]
3S1N X-ray 3.10 J 1-70 [» ]
3S1Q X-ray 3.30 J 1-70 [» ]
3S1R X-ray 3.20 J 1-70 [» ]
3S2D X-ray 3.20 J 1-70 [» ]
3S2H X-ray 3.30 J 1-70 [» ]
4A3B X-ray 3.50 J 1-70 [» ]
4A3C X-ray 3.50 J 1-70 [» ]
4A3D X-ray 3.40 J 1-70 [» ]
4A3E X-ray 3.40 J 1-70 [» ]
4A3F X-ray 3.50 J 1-70 [» ]
4A3G X-ray 3.50 J 1-70 [» ]
4A3I X-ray 3.80 J 1-70 [» ]
4A3J X-ray 3.70 J 1-70 [» ]
4A3K X-ray 3.50 J 1-70 [» ]
4A3L X-ray 3.50 J 1-70 [» ]
4A3M X-ray 3.90 J 1-70 [» ]
4A93 X-ray 3.40 J 1-70 [» ]
4BBR X-ray 3.40 J 1-70 [» ]
4BBS X-ray 3.60 J 1-70 [» ]
4BXX X-ray 3.28 J 1-70 [» ]
4BXZ X-ray 4.80 J 1-70 [» ]
4BY1 X-ray 3.60 J 1-70 [» ]
4BY7 X-ray 3.15 J 1-70 [» ]
4C2M X-ray 2.80 J/Y 1-70 [» ]
4C3H X-ray 3.27 J 1-70 [» ]
4C3I X-ray 3.0 J 1-70 [» ]
4C3J X-ray 3.35 J 1-70 [» ]
ProteinModelPortali P22139.
SMRi P22139. Positions 1-69.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34605. 74 interactions.
DIPi DIP-825N.
IntActi P22139. 17 interactions.
MINTi MINT-384345.
STRINGi 4932.YOR210W.

Proteomic databases

MaxQBi P22139.
PaxDbi P22139.
PeptideAtlasi P22139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR210W ; YOR210W ; YOR210W .
GeneIDi 854385.
KEGGi sce:YOR210W.

Organism-specific databases

CYGDi YOR210w.
SGDi S000005736. RPB10.

Phylogenomic databases

eggNOGi COG1644.
GeneTreei ENSGT00390000007087.
HOGENOMi HOG000109502.
InParanoidi P22139.
KOi K03007.
OMAi DSISSAW.
OrthoDBi EOG7V76KX.

Enzyme and pathway databases

BioCyci YEAST:G3O-33712-MONOMER.
Reactomei REACT_191540. mRNA Splicing - Minor Pathway.

Miscellaneous databases

EvolutionaryTracei P22139.
NextBioi 976532.
PROi P22139.

Gene expression databases

Genevestigatori P22139.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
HAMAPi MF_00250. RNApol_arch_N.
InterProi IPR009057. Homeodomain-like.
IPR023580. RNA_pol_su_RPB10.
IPR020789. RNA_pol_suN_Zn-BS.
IPR000268. RNAP_N/Rpb10.
[Graphical view ]
Pfami PF01194. RNA_pol_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF005653. RNA_pol_N/8_sub. 1 hit.
ProDomi PD006539. RNA_pol_N/8_sub. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF46924. SSF46924. 1 hit.
PROSITEi PS01112. RNA_POL_N_8KD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RNA polymerase II subunit RPB10 is essential for yeast cell viability."
    Woychik N.A., Young R.A.
    J. Biol. Chem. 265:17816-17819(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-27.
  2. Erratum
    Woychik N.A., Young R.A.
    J. Biol. Chem. 268:12230-12230(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Interactions between three common subunits of yeast RNA polymerases I and III."
    Lalo D., Carles C., Sentenac A., Thuriaux P.
    Proc. Natl. Acad. Sci. U.S.A. 90:5524-5528(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 28383 / FL100 / VTT C-80102.
  4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  7. "The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation."
    Chedin S., Ferri M.L., Peyroche G., Andrau J.-C., Jourdain S., Lefebvre O., Werner M., Carles C., Sentenac A.
    Cold Spring Harb. Symp. Quant. Biol. 63:381-389(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON THE RNA POL III COMPLEX.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  10. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "RNA polymerase II/TFIIF structure and conserved organization of the initiation complex."
    Chung W.H., Craighead J.L., Chang W.H., Ezeokonkwo C., Bareket-Samish A., Kornberg R.D., Asturias F.J.
    Mol. Cell 12:1003-1013(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ELECTRON MICROSCOPY OF THE RNA POL II/TFIIF COMPLEX.
  12. "Structural basis of transcription: RNA polymerase II at 2.8 A resolution."
    Cramer P., Bushnell D.A., Kornberg R.D.
    Science 292:1863-1876(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  13. "Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution."
    Gnatt A.L., Cramer P., Fu J., Bushnell D.A., Kornberg R.D.
    Science 292:1876-1882(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  14. "Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution."
    Bushnell D.A., Cramer P., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:1218-1222(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX IN COMPLEX WITH ALPHA-AMANITIN.
  15. "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage."
    Kettenberger H., Armache K.J., Cramer P.
    Cell 114:347-357(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH DST1.
  16. "Architecture of initiation-competent 12-subunit RNA polymerase II."
    Armache K.J., Kettenberger H., Cramer P.
    Proc. Natl. Acad. Sci. U.S.A. 100:6964-6968(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.2 ANGSTROMS) OF THE RNA POL II COMPLEX.
  17. "Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription."
    Bushnell D.A., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 100:6969-6973(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  18. "Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center."
    Westover K.D., Bushnell D.A., Kornberg R.D.
    Cell 119:481-489(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  19. "Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS."
    Kettenberger H., Armache K.J., Cramer P.
    Mol. Cell 16:955-965(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS).
  20. "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms."
    Bushnell D.A., Westover K.D., Davis R.E., Kornberg R.D.
    Science 303:983-988(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  21. "Structures of complete RNA polymerase II and its subcomplex, Rpb4/7."
    Armache K.J., Mitterweger S., Meinhart A., Cramer P.
    J. Biol. Chem. 280:7131-7134(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX.
  22. "Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model."
    Jasiak A.J., Armache K.J., Martens B., Jansen R.P., Cramer P.
    Mol. Cell 23:71-81(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF THE POL III CORE COMPLEX.
  23. "Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs."
    Kettenberger H., Eisenfuhr A., Brueckner F., Theis M., Famulok M., Cramer P.
    Nat. Struct. Mol. Biol. 13:44-48(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH INHIBITING NON-CODING RNA.
  24. "Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model."
    Meyer P.A., Ye P., Zhang M., Suh M.H., Fu J.
    Structure 14:973-982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.15 ANGSTROMS) OF THE RNA POL II COMPLEX.
  25. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (12.00 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  26. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  27. "RNA polymerase I structure and transcription regulation."
    Engel C., Sainsbury S., Cheung A.C., Kostrewa D., Cramer P.
    Nature 502:650-655(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, ZINC-BINDING, SUBUNIT.

Entry informationi

Entry nameiRPAB5_YEAST
AccessioniPrimary (citable) accession number: P22139
Secondary accession number(s): D6W2R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3