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Protein

Protein ATP12, mitochondrial

Gene

ATP12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the assembly of the mitochondrial F1-F0 complex.1 Publication

Miscellaneous

Present with 6370 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: SGD

GO - Biological processi

  • mitochondrial proton-transporting ATP synthase complex assembly Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-31615-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ATP12, mitochondrial
Gene namesi
Name:ATP12
Ordered Locus Names:YJL180C
ORF Names:J0486
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL180C
SGDiS000003716 ATP12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – ?32MitochondrionSequence analysisAdd BLAST32
ChainiPRO_0000002421?33 – 325Protein ATP12, mitochondrialAdd BLAST293

Proteomic databases

MaxQBiP22135
PaxDbiP22135
PRIDEiP22135

Interactioni

Subunit structurei

Exists either as a homo- or heterooligomer.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: SGD

Protein-protein interaction databases

BioGridi33581, 142 interactors
DIPiDIP-3027N
IntActiP22135, 1 interactor
MINTiP22135
STRINGi4932.YJL180C

Structurei

3D structure databases

ProteinModelPortaliP22135
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP12 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000034184
InParanoidiP22135
KOiK07556
OMAiWAEKRYG
OrthoDBiEOG092C4P7U

Family and domain databases

Gene3Di1.10.3580.10, 1 hit
InterProiView protein in InterPro
IPR011419 ATP12_ATP_synth-F1-assembly
IPR023335 ATP12_ortho_dom_sf
PANTHERiPTHR21013 PTHR21013, 1 hit
PfamiView protein in Pfam
PF07542 ATP12, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSLRKGCF IVNSIRLKLP RFYSLNAQPL GTDNTIENNT PTETNRLSKT
60 70 80 90 100
SQKFWEKVSL NRDVEKGKIA LQLDGRTIKT PLGNGIIVDN AKSLLAYLLK
110 120 130 140 150
LEWSSLSSLS IKTHSLPLTS LVARCIDLQM TNEPGCDPQL VAKIGGNSDV
160 170 180 190 200
IKNQLLRYLD TDTLLVFSPM NEFEGRLRNA QNELYIPIIK GMEEFLRNFS
210 220 230 240 250
SESNIRLQIL DADIHGLRGN QQSDIVKNAA KKYMSSLSPW DLAILEKTVL
260 270 280 290 300
TTKSFICGVL LLENKKDTAN LIPALKTDMD NIVRAATLET IFQVEKWGEV
310 320
EDTHDVDKRD IRRKIHTAAI AAFKQ
Length:325
Mass (Da):36,554
Last modified:November 1, 1995 - v2
Checksum:i0571C6C493E12CB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48S → N in AAA34442 (PubMed:1826907).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61773 Genomic DNA Translation: AAA34442.1
Z49455 Genomic DNA Translation: CAA89475.1
BK006943 Genomic DNA Translation: DAA08625.1
PIRiS56963
RefSeqiNP_012355.1, NM_001181613.1

Genome annotation databases

EnsemblFungiiYJL180C; YJL180C; YJL180C
GeneIDi853259
KEGGisce:YJL180C

Similar proteinsi

Entry informationi

Entry nameiATP12_YEAST
AccessioniPrimary (citable) accession number: P22135
Secondary accession number(s): D6VW09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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