P22135 (ATP12_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein ATP12, mitochondrial

Gene names

Name:	ATP12
Ordered Locus Names:	YJL180C
ORF Names:	J0486

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for the assembly of the mitochondrial F1-F0 complex. Ref.1
Subunit structure	Exists either as a homo- or heterooligomer. Ref.1
Subcellular location	Mitochondrion. Note: Mitochondrial, either as a constituent of the matrix, or in tenous association with the internal side of the inner membrane. Ref.1
Miscellaneous	Present with 6370 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Belongs to the ATP12 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	mitochondrial proton-transporting ATP synthase complex assembly Inferred from mutant phenotype. Source: SGD
Cellular component	mitochondrion Inferred from direct assay Ref.1. Source: SGD
Molecular function	protein domain specific binding Inferred from physical interaction. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BZZ1	P38822	1	EBI-3312,EBI-3889
FMC1	P40491	1	EBI-3312,EBI-25141

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?32	32	Mitochondrion Potential
	Chain	?33 – 325	293	Protein ATP12, mitochondrial		PRO_0000002421
Experimental info
	Sequence conflict	48	1	S → N in AAA34442. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P22135 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 0571C6C493E12CB1	FASTA	325	36,554
	10 20 30 40 50 60 MLPSLRKGCF IVNSIRLKLP RFYSLNAQPL GTDNTIENNT PTETNRLSKT SQKFWEKVSL 70 80 90 100 110 120 NRDVEKGKIA LQLDGRTIKT PLGNGIIVDN AKSLLAYLLK LEWSSLSSLS IKTHSLPLTS 130 140 150 160 170 180 LVARCIDLQM TNEPGCDPQL VAKIGGNSDV IKNQLLRYLD TDTLLVFSPM NEFEGRLRNA 190 200 210 220 230 240 QNELYIPIIK GMEEFLRNFS SESNIRLQIL DADIHGLRGN QQSDIVKNAA KKYMSSLSPW 250 260 270 280 290 300 DLAILEKTVL TTKSFICGVL LLENKKDTAN LIPALKTDMD NIVRAATLET IFQVEKWGEV 310 320 EDTHDVDKRD IRRKIHTAAI AAFKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of ATP12, a yeast nuclear gene required for the assembly of the mitochondrial F1-ATPase." Bowman S., Ackerman S.H., Griffiths D.E., Tzagoloff A. J. Biol. Chem. 266:7517-7523(1991) [PubMed: 1826907] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M61773 Genomic DNA. Translation: AAA34442.1. Z49455 Genomic DNA. Translation: CAA89475.1. BK006943 Genomic DNA. Translation: DAA08625.1.
PIR	S56963.
RefSeq	NP_012355.1. NM_001181613.1.
3D structure databases
ProteinModelPortal	P22135.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3027N.
IntAct	P22135. 2 interactions.
MINT	MINT-530096.
STRING	P22135.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YJL180C; YJL180C; YJL180C.
GeneID	853259.
KEGG	sce:YJL180C.
NMPDR	fig|4932.3.peg.3319.
Organism-specific databases
CYGD	YJL180c.
SGD	S000003716. ATP12.
Phylogenomic databases
eggNOG	fuNOG04151.
GeneTree	EFGT00050000002903.
HOGENOM	HBG395432.
OMA	DTHDVDK.
OrthoDB	EOG498Z8W.
Gene expression databases
ArrayExpress	P22135.
Genevestigator	P22135.
GermOnline	YJL180C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011419. ATP12_ATPase-F1F0-assembly. IPR023335. ATPase_assmbl_ATP12_dom. [Graphical view]
Gene3D	G3DSA:1.10.3580.10. G3DSA:1.10.3580.10. 1 hit.
KO	K07556.
PANTHER	PTHR21013. ATP12. 1 hit.
Pfam	PF07542. ATP12. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	973514.

Entry information

Entry name

ATP12_YEAST

Accession

Primary (citable) accession number: P22135
Secondary accession number(s): D6VW09

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	November 1, 1995
Last modified:	December 14, 2011
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program