Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein ATP12, mitochondrial

Gene

ATP12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the assembly of the mitochondrial F1-F0 complex.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: SGD

GO - Biological processi

  • mitochondrial proton-transporting ATP synthase complex assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-31615-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ATP12, mitochondrial
Gene namesi
Name:ATP12
Ordered Locus Names:YJL180C
ORF Names:J0486
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome X

Organism-specific databases

CYGDiYJL180c.
EuPathDBiFungiDB:YJL180C.
SGDiS000003716. ATP12.

Subcellular locationi

  • Mitochondrion 1 Publication

  • Note: Mitochondrial, either as a constituent of the matrix, or in tenous association with the internal side of the inner membrane.

GO - Cellular componenti

  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – ?3232MitochondrionSequence AnalysisAdd
BLAST
Chaini?33 – 325293Protein ATP12, mitochondrialPRO_0000002421Add
BLAST

Proteomic databases

MaxQBiP22135.
PaxDbiP22135.

Interactioni

Subunit structurei

Exists either as a homo- or heterooligomer.1 Publication

Protein-protein interaction databases

BioGridi33581. 84 interactions.
DIPiDIP-3027N.
IntActiP22135. 2 interactions.
MINTiMINT-530096.
STRINGi4932.YJL180C.

Structurei

3D structure databases

ProteinModelPortaliP22135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP12 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG5387.
HOGENOMiHOG000034184.
InParanoidiP22135.
KOiK07556.
OMAiEDTHDVN.
OrthoDBiEOG7D59ZK.

Family and domain databases

Gene3Di1.10.3580.10. 1 hit.
InterProiIPR011419. ATP12_ATPase-F1F0-assembly.
IPR023335. ATPase_assmbl_ATP12_dom.
[Graphical view]
PANTHERiPTHR21013. PTHR21013. 1 hit.
PfamiPF07542. ATP12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSLRKGCF IVNSIRLKLP RFYSLNAQPL GTDNTIENNT PTETNRLSKT
60 70 80 90 100
SQKFWEKVSL NRDVEKGKIA LQLDGRTIKT PLGNGIIVDN AKSLLAYLLK
110 120 130 140 150
LEWSSLSSLS IKTHSLPLTS LVARCIDLQM TNEPGCDPQL VAKIGGNSDV
160 170 180 190 200
IKNQLLRYLD TDTLLVFSPM NEFEGRLRNA QNELYIPIIK GMEEFLRNFS
210 220 230 240 250
SESNIRLQIL DADIHGLRGN QQSDIVKNAA KKYMSSLSPW DLAILEKTVL
260 270 280 290 300
TTKSFICGVL LLENKKDTAN LIPALKTDMD NIVRAATLET IFQVEKWGEV
310 320
EDTHDVDKRD IRRKIHTAAI AAFKQ
Length:325
Mass (Da):36,554
Last modified:November 1, 1995 - v2
Checksum:i0571C6C493E12CB1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481S → N in AAA34442 (PubMed:1826907).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61773 Genomic DNA. Translation: AAA34442.1.
Z49455 Genomic DNA. Translation: CAA89475.1.
BK006943 Genomic DNA. Translation: DAA08625.1.
PIRiS56963.
RefSeqiNP_012355.1. NM_001181613.1.

Genome annotation databases

EnsemblFungiiYJL180C; YJL180C; YJL180C.
GeneIDi853259.
KEGGisce:YJL180C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61773 Genomic DNA. Translation: AAA34442.1.
Z49455 Genomic DNA. Translation: CAA89475.1.
BK006943 Genomic DNA. Translation: DAA08625.1.
PIRiS56963.
RefSeqiNP_012355.1. NM_001181613.1.

3D structure databases

ProteinModelPortaliP22135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33581. 84 interactions.
DIPiDIP-3027N.
IntActiP22135. 2 interactions.
MINTiMINT-530096.
STRINGi4932.YJL180C.

Proteomic databases

MaxQBiP22135.
PaxDbiP22135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL180C; YJL180C; YJL180C.
GeneIDi853259.
KEGGisce:YJL180C.

Organism-specific databases

CYGDiYJL180c.
EuPathDBiFungiDB:YJL180C.
SGDiS000003716. ATP12.

Phylogenomic databases

eggNOGiCOG5387.
HOGENOMiHOG000034184.
InParanoidiP22135.
KOiK07556.
OMAiEDTHDVN.
OrthoDBiEOG7D59ZK.

Enzyme and pathway databases

BioCyciYEAST:G3O-31615-MONOMER.

Miscellaneous databases

NextBioi973514.
PROiP22135.

Family and domain databases

Gene3Di1.10.3580.10. 1 hit.
InterProiIPR011419. ATP12_ATPase-F1F0-assembly.
IPR023335. ATPase_assmbl_ATP12_dom.
[Graphical view]
PANTHERiPTHR21013. PTHR21013. 1 hit.
PfamiPF07542. ATP12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of ATP12, a yeast nuclear gene required for the assembly of the mitochondrial F1-ATPase."
    Bowman S., Ackerman S.H., Griffiths D.E., Tzagoloff A.
    J. Biol. Chem. 266:7517-7523(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATP12_YEAST
AccessioniPrimary (citable) accession number: P22135
Secondary accession number(s): D6VW09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6370 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.