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P22135 (ATP12_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ATP12, mitochondrial
Gene names
Name:ATP12
Ordered Locus Names:YJL180C
ORF Names:J0486
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for the assembly of the mitochondrial F1-F0 complex. Ref.1

Subunit structure

Exists either as a homo- or heterooligomer. Ref.1

Subcellular location

Mitochondrion. Note: Mitochondrial, either as a constituent of the matrix, or in tenous association with the internal side of the inner membrane. Ref.1

Miscellaneous

Present with 6370 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the ATP12 family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitochondrial proton-transporting ATP synthase complex assembly

Inferred from mutant phenotype PubMed 2142305. Source: SGD

   Cellular_componentmitochondrion

Inferred from direct assay Ref.1. Source: SGD

   Molecular_functionprotein domain specific binding

Inferred from physical interaction PubMed 10747017. Source: SGD

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BZZ1P388221EBI-3312,EBI-3889
FMC1P404911EBI-3312,EBI-25141

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?3232Mitochondrion Potential
Chain?33 – 325293Protein ATP12, mitochondrial
PRO_0000002421

Experimental info

Sequence conflict481S → N in AAA34442. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P22135 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 0571C6C493E12CB1

FASTA32536,554
        10         20         30         40         50         60 
MLPSLRKGCF IVNSIRLKLP RFYSLNAQPL GTDNTIENNT PTETNRLSKT SQKFWEKVSL 

        70         80         90        100        110        120 
NRDVEKGKIA LQLDGRTIKT PLGNGIIVDN AKSLLAYLLK LEWSSLSSLS IKTHSLPLTS 

       130        140        150        160        170        180 
LVARCIDLQM TNEPGCDPQL VAKIGGNSDV IKNQLLRYLD TDTLLVFSPM NEFEGRLRNA 

       190        200        210        220        230        240 
QNELYIPIIK GMEEFLRNFS SESNIRLQIL DADIHGLRGN QQSDIVKNAA KKYMSSLSPW 

       250        260        270        280        290        300 
DLAILEKTVL TTKSFICGVL LLENKKDTAN LIPALKTDMD NIVRAATLET IFQVEKWGEV 

       310        320 
EDTHDVDKRD IRRKIHTAAI AAFKQ 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of ATP12, a yeast nuclear gene required for the assembly of the mitochondrial F1-ATPase."
Bowman S., Ackerman S.H., Griffiths D.E., Tzagoloff A.
J. Biol. Chem. 266:7517-7523(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M61773 Genomic DNA. Translation: AAA34442.1.
Z49455 Genomic DNA. Translation: CAA89475.1.
BK006943 Genomic DNA. Translation: DAA08625.1.
PIRS56963.
RefSeqNP_012355.1. NM_001181613.1.

3D structure databases

ProteinModelPortalP22135.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33581. 83 interactions.
DIPDIP-3027N.
IntActP22135. 2 interactions.
MINTMINT-530096.
STRING4932.YJL180C.

Proteomic databases

MaxQBP22135.
PaxDbP22135.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL180C; YJL180C; YJL180C.
GeneID853259.
KEGGsce:YJL180C.

Organism-specific databases

CYGDYJL180c.
SGDS000003716. ATP12.

Phylogenomic databases

eggNOGCOG5387.
HOGENOMHOG000034184.
KOK07556.
OMAEDTHDVN.
OrthoDBEOG7D59ZK.

Enzyme and pathway databases

BioCycYEAST:G3O-31615-MONOMER.

Gene expression databases

GenevestigatorP22135.

Family and domain databases

Gene3D1.10.3580.10. 1 hit.
InterProIPR011419. ATP12_ATPase-F1F0-assembly.
IPR023335. ATPase_assmbl_ATP12_dom.
[Graphical view]
PANTHERPTHR21013. PTHR21013. 1 hit.
PfamPF07542. ATP12. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973514.

Entry information

Entry nameATP12_YEAST
AccessionPrimary (citable) accession number: P22135
Secondary accession number(s): D6VW09
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families