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P22135

- ATP12_YEAST

UniProt

P22135 - ATP12_YEAST

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Protein

Protein ATP12, mitochondrial

Gene

ATP12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Essential for the assembly of the mitochondrial F1-F0 complex.1 Publication

GO - Molecular functioni

  1. protein domain specific binding Source: SGD

GO - Biological processi

  1. mitochondrial proton-transporting ATP synthase complex assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-31615-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ATP12, mitochondrial
Gene namesi
Name:ATP12
Ordered Locus Names:YJL180C
ORF Names:J0486
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL180c.
SGDiS000003716. ATP12.

Subcellular locationi

Mitochondrion 1 Publication
Note: Mitochondrial, either as a constituent of the matrix, or in tenous association with the internal side of the inner membrane.

GO - Cellular componenti

  1. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – ?3232MitochondrionSequence AnalysisAdd
BLAST
Chaini?33 – 325293Protein ATP12, mitochondrialPRO_0000002421Add
BLAST

Proteomic databases

MaxQBiP22135.
PaxDbiP22135.

Expressioni

Gene expression databases

GenevestigatoriP22135.

Interactioni

Subunit structurei

Exists either as a homo- or heterooligomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BZZ1P388221EBI-3312,EBI-3889
FMC1P404911EBI-3312,EBI-25141

Protein-protein interaction databases

BioGridi33581. 84 interactions.
DIPiDIP-3027N.
IntActiP22135. 2 interactions.
MINTiMINT-530096.
STRINGi4932.YJL180C.

Structurei

3D structure databases

ProteinModelPortaliP22135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP12 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG5387.
HOGENOMiHOG000034184.
InParanoidiP22135.
KOiK07556.
OMAiEDTHDVN.
OrthoDBiEOG7D59ZK.

Family and domain databases

Gene3Di1.10.3580.10. 1 hit.
InterProiIPR011419. ATP12_ATPase-F1F0-assembly.
IPR023335. ATPase_assmbl_ATP12_dom.
[Graphical view]
PANTHERiPTHR21013. PTHR21013. 1 hit.
PfamiPF07542. ATP12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22135-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPSLRKGCF IVNSIRLKLP RFYSLNAQPL GTDNTIENNT PTETNRLSKT
60 70 80 90 100
SQKFWEKVSL NRDVEKGKIA LQLDGRTIKT PLGNGIIVDN AKSLLAYLLK
110 120 130 140 150
LEWSSLSSLS IKTHSLPLTS LVARCIDLQM TNEPGCDPQL VAKIGGNSDV
160 170 180 190 200
IKNQLLRYLD TDTLLVFSPM NEFEGRLRNA QNELYIPIIK GMEEFLRNFS
210 220 230 240 250
SESNIRLQIL DADIHGLRGN QQSDIVKNAA KKYMSSLSPW DLAILEKTVL
260 270 280 290 300
TTKSFICGVL LLENKKDTAN LIPALKTDMD NIVRAATLET IFQVEKWGEV
310 320
EDTHDVDKRD IRRKIHTAAI AAFKQ
Length:325
Mass (Da):36,554
Last modified:November 1, 1995 - v2
Checksum:i0571C6C493E12CB1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481S → N in AAA34442. (PubMed:1826907)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61773 Genomic DNA. Translation: AAA34442.1.
Z49455 Genomic DNA. Translation: CAA89475.1.
BK006943 Genomic DNA. Translation: DAA08625.1.
PIRiS56963.
RefSeqiNP_012355.1. NM_001181613.1.

Genome annotation databases

EnsemblFungiiYJL180C; YJL180C; YJL180C.
GeneIDi853259.
KEGGisce:YJL180C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61773 Genomic DNA. Translation: AAA34442.1 .
Z49455 Genomic DNA. Translation: CAA89475.1 .
BK006943 Genomic DNA. Translation: DAA08625.1 .
PIRi S56963.
RefSeqi NP_012355.1. NM_001181613.1.

3D structure databases

ProteinModelPortali P22135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33581. 84 interactions.
DIPi DIP-3027N.
IntActi P22135. 2 interactions.
MINTi MINT-530096.
STRINGi 4932.YJL180C.

Proteomic databases

MaxQBi P22135.
PaxDbi P22135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL180C ; YJL180C ; YJL180C .
GeneIDi 853259.
KEGGi sce:YJL180C.

Organism-specific databases

CYGDi YJL180c.
SGDi S000003716. ATP12.

Phylogenomic databases

eggNOGi COG5387.
HOGENOMi HOG000034184.
InParanoidi P22135.
KOi K07556.
OMAi EDTHDVN.
OrthoDBi EOG7D59ZK.

Enzyme and pathway databases

BioCyci YEAST:G3O-31615-MONOMER.

Miscellaneous databases

NextBioi 973514.

Gene expression databases

Genevestigatori P22135.

Family and domain databases

Gene3Di 1.10.3580.10. 1 hit.
InterProi IPR011419. ATP12_ATPase-F1F0-assembly.
IPR023335. ATPase_assmbl_ATP12_dom.
[Graphical view ]
PANTHERi PTHR21013. PTHR21013. 1 hit.
Pfami PF07542. ATP12. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of ATP12, a yeast nuclear gene required for the assembly of the mitochondrial F1-ATPase."
    Bowman S., Ackerman S.H., Griffiths D.E., Tzagoloff A.
    J. Biol. Chem. 266:7517-7523(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATP12_YEAST
AccessioniPrimary (citable) accession number: P22135
Secondary accession number(s): D6VW09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6370 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3