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P22135

- ATP12_YEAST

UniProt

P22135 - ATP12_YEAST

Protein

Protein ATP12, mitochondrial

Gene

ATP12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Essential for the assembly of the mitochondrial F1-F0 complex.1 Publication

    GO - Molecular functioni

    1. protein domain specific binding Source: SGD

    GO - Biological processi

    1. mitochondrial proton-transporting ATP synthase complex assembly Source: SGD

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31615-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ATP12, mitochondrial
    Gene namesi
    Name:ATP12
    Ordered Locus Names:YJL180C
    ORF Names:J0486
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL180c.
    SGDiS000003716. ATP12.

    Subcellular locationi

    Mitochondrion 1 Publication
    Note: Mitochondrial, either as a constituent of the matrix, or in tenous association with the internal side of the inner membrane.

    GO - Cellular componenti

    1. mitochondrion Source: SGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – ?3232MitochondrionSequence AnalysisAdd
    BLAST
    Chaini?33 – 325293Protein ATP12, mitochondrialPRO_0000002421Add
    BLAST

    Proteomic databases

    MaxQBiP22135.
    PaxDbiP22135.

    Expressioni

    Gene expression databases

    GenevestigatoriP22135.

    Interactioni

    Subunit structurei

    Exists either as a homo- or heterooligomer.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BZZ1P388221EBI-3312,EBI-3889
    FMC1P404911EBI-3312,EBI-25141

    Protein-protein interaction databases

    BioGridi33581. 84 interactions.
    DIPiDIP-3027N.
    IntActiP22135. 2 interactions.
    MINTiMINT-530096.
    STRINGi4932.YJL180C.

    Structurei

    3D structure databases

    ProteinModelPortaliP22135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP12 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG5387.
    HOGENOMiHOG000034184.
    KOiK07556.
    OMAiEDTHDVN.
    OrthoDBiEOG7D59ZK.

    Family and domain databases

    Gene3Di1.10.3580.10. 1 hit.
    InterProiIPR011419. ATP12_ATPase-F1F0-assembly.
    IPR023335. ATPase_assmbl_ATP12_dom.
    [Graphical view]
    PANTHERiPTHR21013. PTHR21013. 1 hit.
    PfamiPF07542. ATP12. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22135-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPSLRKGCF IVNSIRLKLP RFYSLNAQPL GTDNTIENNT PTETNRLSKT    50
    SQKFWEKVSL NRDVEKGKIA LQLDGRTIKT PLGNGIIVDN AKSLLAYLLK 100
    LEWSSLSSLS IKTHSLPLTS LVARCIDLQM TNEPGCDPQL VAKIGGNSDV 150
    IKNQLLRYLD TDTLLVFSPM NEFEGRLRNA QNELYIPIIK GMEEFLRNFS 200
    SESNIRLQIL DADIHGLRGN QQSDIVKNAA KKYMSSLSPW DLAILEKTVL 250
    TTKSFICGVL LLENKKDTAN LIPALKTDMD NIVRAATLET IFQVEKWGEV 300
    EDTHDVDKRD IRRKIHTAAI AAFKQ 325
    Length:325
    Mass (Da):36,554
    Last modified:November 1, 1995 - v2
    Checksum:i0571C6C493E12CB1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481S → N in AAA34442. (PubMed:1826907)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61773 Genomic DNA. Translation: AAA34442.1.
    Z49455 Genomic DNA. Translation: CAA89475.1.
    BK006943 Genomic DNA. Translation: DAA08625.1.
    PIRiS56963.
    RefSeqiNP_012355.1. NM_001181613.1.

    Genome annotation databases

    EnsemblFungiiYJL180C; YJL180C; YJL180C.
    GeneIDi853259.
    KEGGisce:YJL180C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61773 Genomic DNA. Translation: AAA34442.1 .
    Z49455 Genomic DNA. Translation: CAA89475.1 .
    BK006943 Genomic DNA. Translation: DAA08625.1 .
    PIRi S56963.
    RefSeqi NP_012355.1. NM_001181613.1.

    3D structure databases

    ProteinModelPortali P22135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33581. 84 interactions.
    DIPi DIP-3027N.
    IntActi P22135. 2 interactions.
    MINTi MINT-530096.
    STRINGi 4932.YJL180C.

    Proteomic databases

    MaxQBi P22135.
    PaxDbi P22135.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL180C ; YJL180C ; YJL180C .
    GeneIDi 853259.
    KEGGi sce:YJL180C.

    Organism-specific databases

    CYGDi YJL180c.
    SGDi S000003716. ATP12.

    Phylogenomic databases

    eggNOGi COG5387.
    HOGENOMi HOG000034184.
    KOi K07556.
    OMAi EDTHDVN.
    OrthoDBi EOG7D59ZK.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31615-MONOMER.

    Miscellaneous databases

    NextBioi 973514.

    Gene expression databases

    Genevestigatori P22135.

    Family and domain databases

    Gene3Di 1.10.3580.10. 1 hit.
    InterProi IPR011419. ATP12_ATPase-F1F0-assembly.
    IPR023335. ATPase_assmbl_ATP12_dom.
    [Graphical view ]
    PANTHERi PTHR21013. PTHR21013. 1 hit.
    Pfami PF07542. ATP12. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of ATP12, a yeast nuclear gene required for the assembly of the mitochondrial F1-ATPase."
      Bowman S., Ackerman S.H., Griffiths D.E., Tzagoloff A.
      J. Biol. Chem. 266:7517-7523(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
    2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiATP12_YEAST
    AccessioniPrimary (citable) accession number: P22135
    Secondary accession number(s): D6VW09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6370 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3