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P22108 (APA2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5',5'''-P-1,P-4-tetraphosphate phosphorylase 2
EC=2.7.7.53
Alternative name(s):
ATP adenylyltransferase
Ap4A phosphorylase II
Short name=AP,A phosphorylase
Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase
Short name=AP-4-A phosphorylase
Gene names
Name:APA2
Ordered Locus Names:YDR530C
ORF Names:D9719.33
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sustains the catabolism of Np-4-N' nucleotides, rather than their synthesis.

Catalytic activity

ADP + ATP = phosphate + P1,P(4)-bis(5'-adenosyl) tetraphosphate.

Cofactor

Divalent cations.

Subunit structure

Monomer.

Miscellaneous

Present with 1770 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

To yeast AP-4-A phosphorylase I.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3253255',5'''-P-1,P-4-tetraphosphate phosphorylase 2
PRO_0000064613

Sequences

Sequence LengthMass (Da)Tools
P22108 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: F2F2A2C900F1144F

FASTA32536,841
        10         20         30         40         50         60 
MIEENLKQKI HDKFVAAKKN GHLKVTHAES KKLKDPQTTT QYWVTFAPSL ALKPDANKNS 

        70         80         90        100        110        120 
DSKAEDPFAN PDEELVVTED LNGDGEYKLL LNKFPVVPEH SLLVTSEFKD QRSALTPSDL 

       130        140        150        160        170        180 
MTAYNVLCSL QGDKDDDVTC ERYLVFYNCG PHSGSSQDHK HLQIMQMPEK FIPFQDVLCN 

       190        200        210        220        230        240 
GKDHFLPTFN AEPLQDDKVS FAHFVLPLPE SSDQVDEDLL AMCYVSLMQR ALTFFQDWTN 

       250        260        270        280        290        300 
ESPELTKSYN VLLTKKWICV VPRSHAKSGP PLMLNINSTG YCGMILVKDR EKLENLTEDP 

       310        320 
HLVDKSLLQC GFPNTAGQKP TEYHY

« Hide

References

« Hide 'large scale' references
[1]"Catabolism of bis(5'-nucleosidyl) tetraphosphates in Saccharomyces cerevisiae."
Plateau P., Fromant M., Schmitter J.-M., Blanquet S.
J. Bacteriol. 172:6892-6899(1990) [PubMed: 2174863] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-11.
Strain: YPAL16.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed: 9169867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M60265 Genomic DNA. Translation: AAA34428.1.
U33057 Genomic DNA. Translation: AAB64969.1.
BK006938 Genomic DNA. Translation: DAA12361.1.
PIRA37836.
RefSeqNP_010819.1. NM_001180838.1.

3D structure databases

ProteinModelPortalP22108.
SMRP22108. Positions 73-170.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4729N.
MINTMINT-546233.
STRINGP22108.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR530C; YDR530C; YDR530C.
GeneID852143.
KEGGsce:YDR530C.
NMPDRfig|4932.3.peg.1596.

Organism-specific databases

CYGDYDR530c.
SGDS000002938. APA2.

Phylogenomic databases

eggNOGfuNOG08020.
GeneTreeEFGT00050000003278.
HOGENOMHBG397523.
OMAHFILATT.
OrthoDBEOG4WDHMW.

Gene expression databases

ArrayExpressP22108.
GenevestigatorP22108.
GermOnlineYDR530C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR009163. ATP_adenylyltransferase.
IPR019200. ATP_adenylylTrfase_C.
IPR011146. His_triad-like_motif.
IPR011151. His_triad_motif.
[Graphical view]
Gene3DG3DSA:3.30.428.10. His_triad_motif. 1 hit.
KOK00988.
PfamPF09830. ATP_transf. 1 hit.
[Graphical view]
PIRSFPIRSF000846. ATP_adenylyltr. 1 hit.
SUPFAMSSF54197. His_triad-like_motif. 1 hit.
ProtoNetSearch...

Other

NextBio970558.

Entry information

Entry nameAPA2_YEAST
AccessionPrimary (citable) accession number: P22108
Secondary accession number(s): D6VTF1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents