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Protein

Trifunctional purine biosynthetic protein adenosine-3

Gene

GART

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.
ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.
10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (PFAS)
  2. Trifunctional purine biosynthetic protein adenosine-3, Trifunctional purine biosynthetic protein adenosine-3 (GART), Trifunctional purine biosynthetic protein adenosine-3 (GART)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Amidophosphoribosyltransferase (PPAT), Amidophosphoribosyltransferase (PPAT)
  2. Trifunctional purine biosynthetic protein adenosine-3, Trifunctional purine biosynthetic protein adenosine-3 (GART), Trifunctional purine biosynthetic protein adenosine-3 (GART)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route).
Proteins known to be involved in this subpathway in this organism are:
  1. Trifunctional purine biosynthetic protein adenosine-3, Trifunctional purine biosynthetic protein adenosine-3 (GART), Trifunctional purine biosynthetic protein adenosine-3 (GART)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi288ManganeseBy similarity1
Metal bindingi290ManganeseBy similarity1
Binding sitei87110-formyltetrahydrofolate1
Binding sitei91310-formyltetrahydrofolate1
Active sitei915Proton donorBy similarity1
Sitei951Raises pKa of active site HisBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi137 – 199ATPBy similarityAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS08358-MONOMER.
ZFISH:HS08358-MONOMER.
BRENDAi2.1.2.2. 2681.
ReactomeiR-HSA-73817. Purine ribonucleoside monophosphate biosynthesis.
SIGNORiP22102.
UniPathwayiUPA00074; UER00125.
UPA00074; UER00126.
UPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Trifunctional purine biosynthetic protein adenosine-3
Including the following 3 domains:
Phosphoribosylamine--glycine ligase (EC:6.3.4.13)
Alternative name(s):
Glycinamide ribonucleotide synthetase
Short name:
GARS
Phosphoribosylglycinamide synthetase
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
Short name:
AIRS
Phosphoribosyl-aminoimidazole synthetase
Phosphoribosylglycinamide formyltransferase (EC:2.1.2.2)
Alternative name(s):
5'-phosphoribosylglycinamide transformylase
GAR transformylase
Short name:
GART
Gene namesi
Name:GART
Synonyms:PGFT, PRGS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:4163. GART.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi2618.
OpenTargetsiENSG00000159131.
PharmGKBiPA28576.

Chemistry databases

ChEMBLiCHEMBL3972.
DrugBankiDB00642. Pemetrexed.

Polymorphism and mutation databases

BioMutaiGART.
DMDMi131616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000749372 – 1010Trifunctional purine biosynthetic protein adenosine-3Add BLAST1009

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei350N6-acetyllysineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei682PhosphothreonineCombined sources1
Modified residuei796PhosphoserineCombined sources1
Modified residuei802PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP22102.
MaxQBiP22102.
PaxDbiP22102.
PeptideAtlasiP22102.
PRIDEiP22102.

PTM databases

iPTMnetiP22102.
PhosphoSitePlusiP22102.
SwissPalmiP22102.

Expressioni

Gene expression databases

BgeeiENSG00000159131.
CleanExiHS_GART.
ExpressionAtlasiP22102. baseline and differential.
GenevisibleiP22102. HS.

Organism-specific databases

HPAiHPA002119.
HPA005779.

Interactioni

Protein-protein interaction databases

BioGridi108888. 65 interactors.
IntActiP22102. 23 interactors.
MINTiMINT-1143007.
STRINGi9606.ENSP00000371236.

Chemistry databases

BindingDBiP22102.

Structurei

Secondary structure

11010
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 9Combined sources8
Helixi12 – 21Combined sources10
Beta strandi27 – 34Combined sources8
Helixi37 – 39Combined sources3
Beta strandi40 – 47Combined sources8
Helixi55 – 65Combined sources11
Beta strandi69 – 72Combined sources4
Helixi76 – 79Combined sources4
Helixi82 – 88Combined sources7
Beta strandi93 – 95Combined sources3
Turni98 – 101Combined sources4
Helixi102 – 105Combined sources4
Helixi107 – 116Combined sources10
Beta strandi124 – 129Combined sources6
Helixi130 – 139Combined sources10
Beta strandi144 – 151Combined sources8
Beta strandi158 – 160Combined sources3
Helixi164 – 174Combined sources11
Beta strandi187 – 191Combined sources5
Beta strandi195 – 204Combined sources10
Beta strandi209 – 211Combined sources3
Beta strandi215 – 222Combined sources8
Turni223 – 225Combined sources3
Beta strandi226 – 238Combined sources13
Helixi244 – 253Combined sources10
Helixi255 – 264Combined sources10
Beta strandi271 – 280Combined sources10
Beta strandi283 – 292Combined sources10
Turni295 – 297Combined sources3
Helixi298 – 301Combined sources4
Helixi302 – 304Combined sources3
Helixi309 – 317Combined sources9
Helixi321 – 324Combined sources4
Beta strandi333 – 340Combined sources8
Turni342 – 345Combined sources4
Helixi357 – 362Combined sources6
Beta strandi366 – 375Combined sources10
Beta strandi378 – 381Combined sources4
Beta strandi383 – 395Combined sources13
Helixi396 – 409Combined sources14
Helixi423 – 428Combined sources6
Turni479 – 483Combined sources5
Beta strandi485 – 494Combined sources10
Helixi499 – 506Combined sources8
Helixi512 – 525Combined sources14
Turni526 – 528Combined sources3
Beta strandi530 – 542Combined sources13
Helixi545 – 562Combined sources18
Beta strandi565 – 573Combined sources9
Turni575 – 577Combined sources3
Beta strandi583 – 594Combined sources12
Helixi595 – 597Combined sources3
Helixi602 – 604Combined sources3
Beta strandi610 – 615Combined sources6
Beta strandi617 – 619Combined sources3
Helixi624 – 633Combined sources10
Beta strandi648 – 650Combined sources3
Helixi651 – 655Combined sources5
Helixi663 – 671Combined sources9
Beta strandi677 – 680Combined sources4
Helixi685 – 689Combined sources5
Helixi691 – 693Combined sources3
Beta strandi698 – 703Combined sources6
Helixi704 – 706Combined sources3
Helixi711 – 720Combined sources10
Helixi724 – 730Combined sources7
Beta strandi735 – 741Combined sources7
Helixi743 – 745Combined sources3
Helixi746 – 755Combined sources10
Beta strandi760 – 768Combined sources9
Beta strandi776 – 779Combined sources4
Helixi781 – 785Combined sources5
Beta strandi809 – 816Combined sources8
Helixi819 – 828Combined sources10
Beta strandi836 – 844Combined sources9
Helixi848 – 855Combined sources8
Beta strandi860 – 862Combined sources3
Helixi865 – 867Combined sources3
Beta strandi868 – 870Combined sources3
Helixi871 – 884Combined sources14
Beta strandi888 – 894Combined sources7
Helixi901 – 906Combined sources6
Turni907 – 909Combined sources3
Beta strandi910 – 917Combined sources8
Turni919 – 922Combined sources4
Helixi927 – 934Combined sources8
Beta strandi937 – 945Combined sources9
Beta strandi955 – 962Combined sources8
Helixi969 – 992Combined sources24
Beta strandi995 – 998Combined sources4
Beta strandi1002 – 1006Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MEJX-ray2.00A/B/C810-1010[»]
1MENX-ray2.23A/B/C810-1010[»]
1MEOX-ray1.72A808-1010[»]
1NJSX-ray1.98A/B808-1010[»]
1RBMX-ray2.30A/B808-1010[»]
1RBQX-ray2.10A/B/C/D808-1010[»]
1RBYX-ray2.10A/B/C/D808-1010[»]
1RBZX-ray2.10A/B808-1010[»]
1RC0X-ray2.05A/B808-1010[»]
1RC1X-ray2.25A/B808-1010[»]
1ZLXX-ray2.20A808-1010[»]
1ZLYX-ray2.07A808-1010[»]
2QK4X-ray2.45A/B1-430[»]
2V9YX-ray2.10A/B467-794[»]
4EW1X-ray1.52A810-1010[»]
4EW2X-ray1.60A808-1010[»]
4EW3X-ray1.70A808-1010[»]
4ZYTX-ray1.70A808-1010[»]
4ZYUX-ray1.95A808-1010[»]
4ZYVX-ray2.05A808-1010[»]
4ZYWX-ray2.05A808-1010[»]
4ZYXX-ray1.65A808-1010[»]
4ZYYX-ray1.85A808-1010[»]
4ZYZX-ray1.60A808-1010[»]
4ZZ0X-ray1.65A808-1010[»]
4ZZ1X-ray1.35A808-1010[»]
4ZZ2X-ray1.45A808-1010[»]
4ZZ3X-ray2.50A808-1010[»]
5J9FX-ray2.10A808-1010[»]
ProteinModelPortaliP22102.
SMRiP22102.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22102.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 318ATP-graspAdd BLAST208

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni434 – 809AIRSAdd BLAST376
Regioni810 – 1010GARTAdd BLAST201
Regioni818 – 8205'-phosphoribosylglycinamide binding3
Regioni896 – 89910-formyltetrahydrofolate binding4
Regioni947 – 95110-formyltetrahydrofolate binding5
Regioni977 – 9805'-phosphoribosylglycinamide binding4

Sequence similaritiesi

In the N-terminal section; belongs to the GARS family.Curated
In the central section; belongs to the AIR synthase family.Curated
In the C-terminal section; belongs to the GART family.Curated
Contains 1 ATP-grasp domain.Curated

Phylogenomic databases

eggNOGiKOG0237. Eukaryota.
KOG3076. Eukaryota.
COG0150. LUCA.
COG0151. LUCA.
COG0299. LUCA.
GeneTreeiENSGT00390000000292.
HOVERGENiHBG008333.
InParanoidiP22102.
KOiK11787.
OMAiYRTDIAQ.
OrthoDBiEOG091G026D.
PhylomeDBiP22102.
TreeFamiTF106368.

Family and domain databases

CDDicd08645. FMT_core_GART. 1 hit.
cd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.170. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
MF_00138. GARS. 1 hit.
MF_01930. PurN. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR002376. Formyl_transf_N.
IPR001555. GART_AS.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR016188. PurM-like_N.
IPR004733. PurM_cligase.
IPR004607. PurN.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SMARTiSM01210. GARS_C. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00877. purD. 1 hit.
TIGR00878. purM. 1 hit.
TIGR00639. PurN. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
PS00373. GART. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P22102-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARVLIIGS GGREHTLAWK LAQSHHVKQV LVAPGNAGTA CSEKISNTAI
60 70 80 90 100
SISDHTALAQ FCKEKKIEFV VVGPEAPLAA GIVGNLRSAG VQCFGPTAEA
110 120 130 140 150
AQLESSKRFA KEFMDRHGIP TAQWKAFTKP EEACSFILSA DFPALVVKAS
160 170 180 190 200
GLAAGKGVIV AKSKEEACKA VQEIMQEKAF GAAGETIVIE ELLDGEEVSC
210 220 230 240 250
LCFTDGKTVA PMPPAQDHKR LLEGDGGPNT GGMGAYCPAP QVSNDLLLKI
260 270 280 290 300
KDTVLQRTVD GMQQEGTPYT GILYAGIMLT KNGPKVLEFN CRFGDPECQV
310 320 330 340 350
ILPLLKSDLY EVIQSTLDGL LCTSLPVWLE NHTALTVVMA SKGYPGDYTK
360 370 380 390 400
GVEITGFPEA QALGLEVFHA GTALKNGKVV THGGRVLAVT AIRENLISAL
410 420 430 440 450
EEAKKGLAAI KFEGAIYRKD VGFRAIAFLQ QPRSLTYKES GVDIAAGNML
460 470 480 490 500
VKKIQPLAKA TSRSGCKVDL GGFAGLFDLK AAGFKDPLLA SGTDGVGTKL
510 520 530 540 550
KIAQLCNKHD TIGQDLVAMC VNDILAQGAE PLFFLDYFSC GKLDLSVTEA
560 570 580 590 600
VVAGIAKACG KAGCALLGGE TAEMPDMYPP GEYDLAGFAV GAMERDQKLP
610 620 630 640 650
HLERITEGDV VVGIASSGLH SNGFSLVRKI VAKSSLQYSS PAPDGCGDQT
660 670 680 690 700
LGDLLLTPTR IYSHSLLPVL RSGHVKAFAH ITGGGLLENI PRVLPEKLGV
710 720 730 740 750
DLDAQTWRIP RVFSWLQQEG HLSEEEMART FNCGVGAVLV VSKEQTEQIL
760 770 780 790 800
RDIQQHKEEA WVIGSVVARA EGSPRVKVKN LIESMQINGS VLKNGSLTNH
810 820 830 840 850
FSFEKKKARV AVLISGTGSN LQALIDSTRE PNSSAQIDIV ISNKAAVAGL
860 870 880 890 900
DKAERAGIPT RVINHKLYKN RVEFDSAIDL VLEEFSIDIV CLAGFMRILS
910 920 930 940 950
GPFVQKWNGK MLNIHPSLLP SFKGSNAHEQ ALETGVTVTG CTVHFVAEDV
960 970 980 990 1000
DAGQIILQEA VPVKRGDTVA TLSERVKLAE HKIFPAALQL VASGTVQLGE
1010
NGKICWVKEE
Length:1,010
Mass (Da):107,767
Last modified:August 1, 1991 - v1
Checksum:i9A4213F746EB17A2
GO
Isoform Short (identifier: P22102-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     434-1010: Missing.

Show »
Length:433
Mass (Da):46,033
Checksum:i45289299B5E9B397
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01181721L → F.Corresponds to variant rs1804387dbSNPEnsembl.1
Natural variantiVAR_011818421V → I.2 PublicationsCorresponds to variant rs8788dbSNPEnsembl.1
Natural variantiVAR_051882510D → G.Corresponds to variant rs35927582dbSNPEnsembl.1
Natural variantiVAR_051883641P → A.Corresponds to variant rs34588874dbSNPEnsembl.1
Natural variantiVAR_011819752D → G.Corresponds to variant rs8971dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005517434 – 1010Missing in isoform Short. 1 PublicationAdd BLAST577

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54199 mRNA. Translation: CAA38119.1.
AK292560 mRNA. Translation: BAF85249.1.
AK292897 mRNA. Translation: BAF85586.1.
CH471079 Genomic DNA. Translation: EAX09826.1.
CH471079 Genomic DNA. Translation: EAX09827.1.
CH471079 Genomic DNA. Translation: EAX09828.1.
CH471079 Genomic DNA. Translation: EAX09829.1.
BC038958 mRNA. Translation: AAH38958.1.
BC093641 mRNA. Translation: AAH93641.1.
BC101565 mRNA. Translation: AAI01566.1.
AF008653 Genomic DNA. Translation: AAB70812.1.
M32082 mRNA. Translation: AAA60077.1.
CCDSiCCDS13627.1. [P22102-1]
CCDS13628.1. [P22102-2]
PIRiS12616. AJHUPR.
RefSeqiNP_000810.1. NM_000819.4. [P22102-1]
NP_001129477.1. NM_001136005.1. [P22102-1]
NP_001129478.1. NM_001136006.1. [P22102-1]
NP_780294.1. NM_175085.2. [P22102-2]
XP_005260998.1. XM_005260941.1. [P22102-1]
XP_006724052.1. XM_006723989.1. [P22102-1]
XP_006724053.1. XM_006723990.1. [P22102-1]
XP_011527828.1. XM_011529526.1. [P22102-1]
UniGeneiHs.473648.

Genome annotation databases

EnsembliENST00000361093; ENSP00000354388; ENSG00000159131. [P22102-2]
ENST00000381815; ENSP00000371236; ENSG00000159131. [P22102-1]
ENST00000381831; ENSP00000371253; ENSG00000159131. [P22102-1]
ENST00000381839; ENSP00000371261; ENSG00000159131. [P22102-1]
ENST00000571089; ENSP00000459532; ENSG00000262473.
ENST00000573055; ENSP00000459391; ENSG00000262473.
ENST00000575273; ENSP00000461700; ENSG00000262473.
GeneIDi2618.
KEGGihsa:2618.
UCSCiuc002yrx.4. human. [P22102-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54199 mRNA. Translation: CAA38119.1.
AK292560 mRNA. Translation: BAF85249.1.
AK292897 mRNA. Translation: BAF85586.1.
CH471079 Genomic DNA. Translation: EAX09826.1.
CH471079 Genomic DNA. Translation: EAX09827.1.
CH471079 Genomic DNA. Translation: EAX09828.1.
CH471079 Genomic DNA. Translation: EAX09829.1.
BC038958 mRNA. Translation: AAH38958.1.
BC093641 mRNA. Translation: AAH93641.1.
BC101565 mRNA. Translation: AAI01566.1.
AF008653 Genomic DNA. Translation: AAB70812.1.
M32082 mRNA. Translation: AAA60077.1.
CCDSiCCDS13627.1. [P22102-1]
CCDS13628.1. [P22102-2]
PIRiS12616. AJHUPR.
RefSeqiNP_000810.1. NM_000819.4. [P22102-1]
NP_001129477.1. NM_001136005.1. [P22102-1]
NP_001129478.1. NM_001136006.1. [P22102-1]
NP_780294.1. NM_175085.2. [P22102-2]
XP_005260998.1. XM_005260941.1. [P22102-1]
XP_006724052.1. XM_006723989.1. [P22102-1]
XP_006724053.1. XM_006723990.1. [P22102-1]
XP_011527828.1. XM_011529526.1. [P22102-1]
UniGeneiHs.473648.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MEJX-ray2.00A/B/C810-1010[»]
1MENX-ray2.23A/B/C810-1010[»]
1MEOX-ray1.72A808-1010[»]
1NJSX-ray1.98A/B808-1010[»]
1RBMX-ray2.30A/B808-1010[»]
1RBQX-ray2.10A/B/C/D808-1010[»]
1RBYX-ray2.10A/B/C/D808-1010[»]
1RBZX-ray2.10A/B808-1010[»]
1RC0X-ray2.05A/B808-1010[»]
1RC1X-ray2.25A/B808-1010[»]
1ZLXX-ray2.20A808-1010[»]
1ZLYX-ray2.07A808-1010[»]
2QK4X-ray2.45A/B1-430[»]
2V9YX-ray2.10A/B467-794[»]
4EW1X-ray1.52A810-1010[»]
4EW2X-ray1.60A808-1010[»]
4EW3X-ray1.70A808-1010[»]
4ZYTX-ray1.70A808-1010[»]
4ZYUX-ray1.95A808-1010[»]
4ZYVX-ray2.05A808-1010[»]
4ZYWX-ray2.05A808-1010[»]
4ZYXX-ray1.65A808-1010[»]
4ZYYX-ray1.85A808-1010[»]
4ZYZX-ray1.60A808-1010[»]
4ZZ0X-ray1.65A808-1010[»]
4ZZ1X-ray1.35A808-1010[»]
4ZZ2X-ray1.45A808-1010[»]
4ZZ3X-ray2.50A808-1010[»]
5J9FX-ray2.10A808-1010[»]
ProteinModelPortaliP22102.
SMRiP22102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108888. 65 interactors.
IntActiP22102. 23 interactors.
MINTiMINT-1143007.
STRINGi9606.ENSP00000371236.

Chemistry databases

BindingDBiP22102.
ChEMBLiCHEMBL3972.
DrugBankiDB00642. Pemetrexed.

PTM databases

iPTMnetiP22102.
PhosphoSitePlusiP22102.
SwissPalmiP22102.

Polymorphism and mutation databases

BioMutaiGART.
DMDMi131616.

Proteomic databases

EPDiP22102.
MaxQBiP22102.
PaxDbiP22102.
PeptideAtlasiP22102.
PRIDEiP22102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361093; ENSP00000354388; ENSG00000159131. [P22102-2]
ENST00000381815; ENSP00000371236; ENSG00000159131. [P22102-1]
ENST00000381831; ENSP00000371253; ENSG00000159131. [P22102-1]
ENST00000381839; ENSP00000371261; ENSG00000159131. [P22102-1]
ENST00000571089; ENSP00000459532; ENSG00000262473.
ENST00000573055; ENSP00000459391; ENSG00000262473.
ENST00000575273; ENSP00000461700; ENSG00000262473.
GeneIDi2618.
KEGGihsa:2618.
UCSCiuc002yrx.4. human. [P22102-1]

Organism-specific databases

CTDi2618.
DisGeNETi2618.
GeneCardsiGART.
HGNCiHGNC:4163. GART.
HPAiHPA002119.
HPA005779.
MIMi138440. gene.
neXtProtiNX_P22102.
OpenTargetsiENSG00000159131.
PharmGKBiPA28576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0237. Eukaryota.
KOG3076. Eukaryota.
COG0150. LUCA.
COG0151. LUCA.
COG0299. LUCA.
GeneTreeiENSGT00390000000292.
HOVERGENiHBG008333.
InParanoidiP22102.
KOiK11787.
OMAiYRTDIAQ.
OrthoDBiEOG091G026D.
PhylomeDBiP22102.
TreeFamiTF106368.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00125.
UPA00074; UER00126.
UPA00074; UER00129.
BioCyciMetaCyc:HS08358-MONOMER.
ZFISH:HS08358-MONOMER.
BRENDAi2.1.2.2. 2681.
ReactomeiR-HSA-73817. Purine ribonucleoside monophosphate biosynthesis.
SIGNORiP22102.

Miscellaneous databases

ChiTaRSiGART. human.
EvolutionaryTraceiP22102.
GenomeRNAii2618.
PROiP22102.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159131.
CleanExiHS_GART.
ExpressionAtlasiP22102. baseline and differential.
GenevisibleiP22102. HS.

Family and domain databases

CDDicd08645. FMT_core_GART. 1 hit.
cd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.170. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
MF_00138. GARS. 1 hit.
MF_01930. PurN. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR002376. Formyl_transf_N.
IPR001555. GART_AS.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR016188. PurM-like_N.
IPR004733. PurM_cligase.
IPR004607. PurN.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SMARTiSM01210. GARS_C. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00877. purD. 1 hit.
TIGR00878. purM. 1 hit.
TIGR00639. PurN. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
PS00373. GART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPUR2_HUMAN
AccessioniPrimary (citable) accession number: P22102
Secondary accession number(s): A8K945
, A8KA32, D3DSF3, D3DSF4, O14659, Q52M77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 30, 2016
This is version 189 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.